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Recent Publications


Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G,Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P,Adams DJ, Tuveson DA, PandolfiPP. "In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-inducedmouse model of melanoma."  Cell .2011 Oct 14;147(2):382-95.

Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F,Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP. "Coding-independentregulation of the tumor suppressor PTEN by competing endogenous mRNAs . Cell . 2011 Oct 14;147(2):344-57.

Berger AH, Knudson AG, PandolfiPP. "Acontinuum model for tumour suppression."  Nature . 2011 Aug 10;476(7359):163-9. doi:10.1038/ Nature10275. Review.

Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. "A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?"  Cell . 2011 Aug 5;146(3):353-8. Epub 2011Jul 28.

Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M, Pandolfi PP. "NuclearPTEN regulates the APC-CDH1 tumor-suppressive complex in aphosphatase-independent manner."  Cell . 2011 Jan 21;144(2):187-99.

Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR,Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R,Tacchetti C, Pinton P, Pandolfi PP. "PMLregulates apoptosis at endoplasmic reticulum by modulating calcium release."  Science . 2010 Nov 26;330(6008):1247-51. Epub2010 Oct 28.

Hobbs RM, Seandel M, Falciatori I, Rafii S, Pandolfi PP. "Plzfregulates germline progenitor self-renewal by opposing mTORC1."  Cell . 2010 Aug 6;142(3):468-79.

Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP. "Acoding-independent function of gene and pseudogene mRNAs regulates tumourbiology."  Nature . 2010 Jun 24;465(7301):1033-8.

Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J,  Pandolfi PP. "Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence." Nature. 2010 Mar 18;464(7287):374-9.Clohessy JG, Pandolfi PP.beta-ttingon p63 as a metastatic suppressor. Cell . 2009 Apr 3;137(1):28-30.

Carver BS, Tran J, Chen Z, Carracedo-Perez A, Alimonti A,Nardella C, Gopalan A, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP. "ETS rearrangements and prostate cancer initiation." Nature . 2009 Feb 12;457(7231):E1; discussion E2-3.

M.S. Song, L. Salmena, A. Carracedo-Perez, A. Egia, F. Lo Coco, J. Teruya-Feldstein and P.P. Pandolfi. "The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network."  Nature 20 August, 2008.

K. Ito, R. Bernardi, A. Morotti, S. Matsuoka, G. Saglio, Y. Ikeda, J. Rosenblatt. D.E. Avigan, J. Teruya-Feldstein and P.P. Pandolfi. "PML targeting eradicates quiescent leukemia initiating cells." Nature 453(7198):1072-8, 2008.

L. Salmena, A. Carracedo and P.P. Pandolfi. "PTEN paradigms for tumor suppression." Cell 133(3): 403-414, 2008.

T. Maeda, T. Merghoub, L. Dong, R.M. Hobbs, L. Dong, M. Maeda, J. Zakrzewski, M.R.M. van den Brink, A. Zelent, H. Shigematsu, K. Akashi, J. Teruya-Feldstein, G. Cattoretti and P.P. Pandolfi. "Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF." Science 316: 860-866, 2007.

L.C. Trotman, X. Wang, A. Alimonti, Z. Chen, J. Teruya-Feldstein, S-G. Chi, H-J. Kim, H. Yang, N.P. Pavletich, B.S. Carver, H. Erdjument-Bromage, P. Tempst, C. Cordon-Cardo, T. Misteli. X. Jiang and P.P. Pandolfi. "Ubiquitination regulates nuclear PTEN import and tumor suppression." Cell 128:141-56, 2007.

T.H. Shen, H-K Lin, P.P. Scaglioni, T. Yung and P.P. Pandolfi. "The mechanisms of PML-nuclear body formation." Molecular Cell 24:331-339, 2006.

P.P. Scaglioni, T. Yung, L-F Cai, H. Erdjument-Bromage, B. Singh, J. Teruya-Feldstein, P. Tempst and P.P. Pandolfi. "A novel CK2-dependent pathway for PML degradation upon cellular and oncogenic stress." Cell 126:269-283, 2006.

Contact Information

Pier Paolo Pandolfi, MD, PhD
Division of Genetics
Beth Israel Deaconess Medical Center
CLS Building, Room 401
330 Brookline Avenue
Boston, MA 02215
617-735-2121
617-735-2120
ppandolf@bidmc.harvard.edu