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Recent Publications

L. Poliseno, L. Salmena, J. Zhang, B. Carver, W. J. Haveman, and P.P. Pandolfi. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature, 465:1033-8, 2010. PMCID: PMC 2928066

M.S. Song, A. Carracedo, L. Salmena, S.J. Song, A. Egia, M. Malumbres and P.P. Pandolfi. Nuclear PTEN regulates the APC-CDH1 tumor suppressive complex in a phosphatase-independent manner. Cell, 144:187-99, 2011. PMCID: PMC3249980

L. Salmena , L. Poliseno L, Y. Tay, L. Kats, P.P. Pandolfi. A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language? Cell, 146:353-8, 2011. Epub 2011 Jul 28. PMCID: PMC3235919.

A.H. Berger, A.G. Knudson and P.P. Pandolfi. A Continuum Model for Tumour Suppression. Nature, 476:163-9, 2011. PMCID: PMC3206311

Y. Tay, L. Kats, L. Salmena, D. Weiss, S.M. Tan, U. Ala, F. Karreth, L. Poliseno, P. Provero, F. Di Cunto, J. Lieberman, I. Rigoutsos and P.P. Pandolfi.. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell, 147:344-57, 2011. PMCID: PMC3235920

F. A. Karreth, Y. Tay, D. Perna, U. Ala, A.G. Rust, K.A. Webster, D. Weiss, P.A. Perez-Mancera, M. Krauthammer, R. Halaban, P. Provero, D.J. Adams, D.A. Tuveson and P.P. Pandolfi.  In vivo identification of tumor suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell, 147:382-95, 2011. PMCID: PMC3236086

I. Garcia-Cao, M.S. Song, R.M. Hobbs, G. Laurent, C. Giorgi, V.C.J. de Boer, D. Anastasiou, K. Ito, A. Sasaki, L. Rameh, A. Carracedo, M.G.Vander Heiden, L.C. Cantley, P. Pinton, M.C Haigis, P.P. Pandolfi. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell, 149:49-62, 2012.  PMCID: PMC3319228

A. Lunardi, U. Ala, M.T. Epping, L. Salmena, J.G. Clohessy, K.A. Webster, G. Wang, R. Maxxucchelli, M. Bianconi, E.C. Stack, R. Lis, A. Patnaik, L.C. Cantley, G. Bubley, C. Cordon-Cardo, W.L. Gerald, R. Montironi, S. Signoretti, M. Loda, C. Nardella, P.P. Pandolfi.  A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer.  Nature Gen., 45:747-55, 2013. Epub June 2. PMCID: PMC3787876

S. J. Song, L. Poliseno, M.S. Song, U. Ala, L. Kats, G. Beringer, K. Webster, X. Yuan, J.E. Brock, A. L. Richardson, L. C. Cantley, P.P. Pandolfi.  MicroRNA-antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling.  Cell, 154:311-24, 2013. Epub July 2. PMCID: PMC3767186

A. Papa, L. Wan, M. Bonora, Salmena L, M.S. Song, R.M. Hobbs, A. Lunardi, K. Webster, C. Ng, N. Knoblauch,  R.H. Newton, J. Guarnerio, K. Ito, L.A. Turka, A.H. Beck, P. Pinton, R. Bronson, W. Wei, and P.P. Pandolfi. Cancer-associated PTEN mutants act in a dominant negative manner to suppress PTEN protein function. Cell, 157:595-610, 2014. PMCID: PMC4098792

F.A. Karreth, M. Reschke, A. Ruocco, C. Ng, B. Chapuy, V. Leopold, M. Sjoberg, T.M. Keane, A. Verma, U. Ala, Y. Tay, D. Wu, N. Seitzer, A.Bothmer, J. Fung, F. Langellotto, S.J. Rodig, O. Elemento, M.A. Shipp, D.J. Adams, R. Chiarle, P.P. Pandolfi. The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo. Cell, 161:319-32, 2015. Epub 2015 Apr 2. PMID: 25843629

Contact Information

Pier Paolo Pandolfi, MD, PhD
Division of Genetics
Beth Israel Deaconess Medical Center
CLS Building, Room 401
330 Brookline Avenue
Boston, MA 02215

Lauren Southwood
Executive Assistant to Dr. Pier Paolo Pandolfi
P: 617-735-2145
F: 617-735-2120

Elizabeth Stack
Administrative Coordinator
Pandolfi Lab
P: 617-735-2860
F: 617-735-2120