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Pandolfi Lab

Dr, Pandolfi and young associate

The research carried out in the laboratory of Pier Paolo Pandolfi, MD, PhD,has been seminal to elucidating the molecular mechanisms and the genetics underlying the pathogenesis of leukemias, lymphomas and solid tumors as well as in modeling these cancers in the mouse. The Pandolfi laboratory has characterized the function of the fusion oncoproteins and the genes involved in the chromosomal translocations of acute promyelocytic leukemia (APL), as well as of major tumor suppressors such as PTEN and p53, and novel cancer genes such as POKEMON and INPP4B. 

The elucidation of the molecular basis underlying APL pathogenesis has led to the development of novel and effective therapeutic strategies. As a result of these efforts, APL is now considered a curable disease. Additional novel therapeutic concepts have emerged from this work and are currently being tested in clinical trials. More recently, Dr. Pandolfi and colleagues have presented a new theory describing how mRNAs, both coding and non-coding, exert their biological functions with profound implications for human genetics, cell biology and cancer biology.

 

Contact Information

Pier Paolo Pandolfi, MD, PhD
Division of Genetics
Beth Israel Deaconess Medical Center
CLS Building, Room 401
330 Brookline Avenue
Boston, MA 02215
617-735-2121
617-735-2120 
ppandolf@bidmc.harvard.edu


Lauren Southwood
Executive Assistant to Dr. Pier Paolo Pandolfi
P: 617-735-2145
F: 617-735-2120
lsouthwoo@bidmc.harvard.edu


Elizabeth Stack
Administrative Coordinator
Pandolfi Lab
P: 617-735-2860
F: 617-735-2120
eastack@bidmc.harvard.edu