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Edward R. Marcantonio, MD, SM

Research Concentrations

• Clinical Epidemiology
• Delirium
• Cognitive Function 

Contact Information


Professional Biography

View Dr. Marcantonio's publication history at PubMed Author Search

View Dr. Marcantonio's professional research networking profile at Harvard Catalyst

Dr. Marcantonio is the Section Chief for Research in the Division of General Medicine and Primary Care at BIDMC, and Professor of Medicine at Harvard Medical School. Under Dr. Marcantonio's leadership over the last 8 years, the program has grown from 8 to 18 investigators, while extramural funding has increased from $2 million to over $9 million annually. He is an internationally recognized expert and clinical investigator in the area of delirium (acute confusion), in which he has performed numerous observational and interventional research studies. He currently leads two NIH-funded studies in this area (1 P01, 1 R01) focused on determining the impact of delirium on long term cognitive and functional outcomes, improving diagnostic strategies for delirium, and biomarker discovery for delirium. He also leads the Epidemiology Core for the first-ever NIH Program Project focused on delirium. Dr. Marcantonio's broader research interests include improving quality of care for vulnerable populations, particularly elders, predictors of hospitalization and unplanned hospital readmission, and outcomes of non-cardiac and cardiac surgery in older adults.

Dr. Marcantonio serves as BIDMC site director of the HMS Fellowship in General Internal Medicine and Primary Care, teaches Epidemiology in the Clinical Effectiveness Program at Harvard School of Public Health, and has mentored over 35 students, postdoctoral fellows and junior faculty members. He has received the BIDMC Center for Faculty Development's Excellence in Mentoring Award, and the HMS A. Clifford Barger Award for Excellence in Mentorship.  He has also been recognized with numerous national awards for his research, including the Paul Beeson Physician Scholarship in Aging Research, the American Geriatrics Society Outstanding Scientific Achievement in Clinical Investigation Award, and is a recipient of a Mid-Career Investigator Award in Patient-Oriented Research from the National Institute on Aging.

Current Research Support (selected)

R01AG030618, NIH/NIA, 2008-2013
3D-CAM: Deriving and Validating a 3-Minute Diagnostic Assessment for Delirium
The goal of this study is to develop and prospectively validate a new short diagnostic assessment for delirium-the 3D-CAM. The assessment will be derived from two large existing databases with over 5000 delirium assessments. It will be prospectively validated in a new sample of 200 hospitalized older adults.
Role: PI

P01 AG031720, NIH/NIA, 2010-2015
Interdisciplinary Study of Delirium and Its Long-Term Outcomes - Epidemiology Core
This Program Project entitled seeks to elucidate the correlates of delirium and to examine delirium's contribution to long-term cognitive and functional decline. The component projects will utilize a cohort of 550 patients undergoing scheduled non-cardiac surgery at Beth Israel Deaconess Medical Center and Brigham and Women's Hospital, and 120 BIDMC primary care patients who will serve as a non-surgical comparison group.  The Biomarker Discovery project applies two state-of-the-art biomarker discovery techniques, 1) simultaneous assessment of multiple inflammatory cytokines using a multiplex analyzer, and 2) proteomics using quantitative mass spectrometry, in matched samples of surgical patients who develop and do not develop delirium, to discern biomarker signatures for delirium.
Role: Overall Co-PI, Project Leader, Core Leader

K24 AG035075, NIH/NIA, 2010-8/31/2015
Mid-Career Mentoring Award for Patient-Oriented Research in Aging
The aim of my K24 are: 1. To continue to build a research program around improving the quality and outcomes of care for hospitalized older adults with delirium.  2. To build a mentorship program that will expand patient-oriented research in aging at BIDMC and HMS, with a focus on delirium and related conditions.  3. To expand my mentorship program to include translational, interdisciplinary work around biomarker discovery for delirium, and biomarker applications to improve risk stratification, diagnosis, and prognostication of older adults with delirium. 
Role: PI

Selected Peer-Reviewed Publications

1. Wachterman MW, Marcantonio ER, Davis RB, McCarthy EP.  Association of hospice agency profit status with patient diagnosis, location of care, and length of stay.  JAMA; 2011; 305(5): 472-9. PMCID: PMC3142476

2. Herzig SJ, Vaughn BP, Howell MD, Ngo LH, Marcantonio ER.  Acid-suppressive Medication Use and the Risk for Nosocomial Gastrointestinal Tract Bleeding.  Arch Intern Med 2011; 171(11): 991-7.  PMCID: PMC3142477

3. Schonberg MA, Davis RB, McCarthy EP, Marcantonio ER.  External validation of an index to predict up to 9-year mortality of Community-Dwelling Adults Aged 65 and Older.   J Am Geriatr Soc. 2011; 59(8): 1444-51 PMCID: PMC3158286

4. Saczynski JS*, Marcantonio ER* (co-first), Quach L, Fong TG, Gross A, Inouye SK†, Jones RN† (co-last).  Cognitive trajectories after postoperative delirium.  New Eng J Med. 2012; 367: 30-9.

5. Marcantonio ER.  Postoperative delirium: a 76 year old woman with delirium following surgery.  JAMA.  2012; 308: 73-81.