Kenneth J. Mukamal, MD, MPH
• Cardiovascular Health
• Alcohol Consumption
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Dr. Mukamal's primary research interests are investigating the role of dietary and lifestyle factors - particularly alcohol consumption - on the incidence and prognosis of cardiovascular and neurovascular disease and its risk factors. As a general internist and clinical investigator, his research has incorporated ongoing epidemiological studies, utilized hospital-based clinical data, and interventional studies. The outcomes of this research have been broad-based and include diverse health effects of alcohol ranging from novel cardiovascular risk factors and subclinical vascular disease to falls and suicide. Recent work in collaboration with Murray Mittleman of BIDMC's Cardiovascular Division and Eric Rimm of the Harvard School of Public Health seeks to examine novel biomarkers in important candidate pathways leading to cardiovascular disease and diabetes in large, ongoing cohort studies.
Current Research Support
R01 HL094555 (Mukamal, Djousse, Ix, Kizer, Zieman)
Determinants and Cardiovascular Consequences of Diabetes in Older Adults
This multiple PI project has evaluated promising pathways in the development and cardiovascular prognosis of diabetes in older adults, including pathways related to adipocyte function, calcium metabolism, advanced glycation endproducts, and fibrosis. I am Principal Investigator of the lead site, chair the Diabetes Working Group that developed this project, and have led analyses of fibrotic pathways.
R01 HL035464 (Rimm)
Dietary Etiologies of Heart Disease and Cancer
This project explores the role of several broad markers of oxidation or susceptibility to oxidation in predicting risk of coronary heart disease in a large cohort of men, the Health Professionals Follow-Up Study.
Interventional and Feeding Studies of Alcohol
This proposal established a satellite conference at the 2014 ISBRA / RSA Annual Meeting in Bellevue, Washington, devoted to scientific and operational issues confronting ongoing and future studies of the health effects of moderate alcohol consumption.
Planning Grant for a Multi-Center RCT of Moderate Alcohol Use on Chronic Disease
This proposal currently funds a planning period to develop the operational protocol for a randomized trial of moderate alcohol use on common chronic disease outcomes, including diabetes, coronary heart disease, and cancer.
U01OD019771-01 (Freedman, Mukamal, O’Donnell)
NIH/Common Fund, 2014-2019
Racial and Ethnic Diversity in Human Extracellular RNA
This multiple PI project, part of the ExRNA Communication Program, aims to define the expression of circulating extracellular RNAs in healthy adults from the MESA and Framingham Heart Study cohorts.
Selected Peer-Reviewed Publications
1. Jensen MK, Bertoia ML, Cahill LE, Agarwal I, Rimm EB, Mukamal KJ. Novel metabolic biomarkers of cardiovascular disease. Nat Rev Endocrinol. 2014 Nov;10(11):659-672.
2. Naqvi AZ, Hasturk H, Mu L, Phillips RS, Davis RB, Halem S, Campos H, Goodson JM, Van Dyke TE, Mukamal KJ. Docosahexaenoic acid and periodontitis in adults: a randomized controlled trial. J Dent Res. 2014 Jun 26;93(8):767-773.
3. Agarwal I, Glazer NL, Barasch E, Biggs ML, Djousse L, Fitzpatrick AL, Gottdiener JS, Ix JH, Kizer JR, Rimm EB, Sicovick DS, Tracy RP, Mukamal KJ. Fibrosis-related biomarkers and incident cardiovascular disease in older adults: the Cardiovascular Health Study. Circ Arrhythm Electrophysiol. 2014 Aug;7(4):583-9.
4. Genetically elevated fetuin-A levels, fasting glucose levels, and risk of type 2 diabetes: the cardiovascular health study. Jensen MK, Bartz TM, Djoussé L, Kizer JR, Zieman SJ, Rimm EB, Siscovick DS, Psaty BM, Ix JH, Mukamal KJ. Diabetes Care. 2013 Oct;36(10):3121-7.
5. Oxidation-specific biomarkers and risk of peripheral artery disease. Bertoia ML, Pai JK, Lee JH, Taleb A, Joosten MM, Mittleman MA, Yang X, Witztum JL, Rimm EB, Tsimikas S, Mukamal KJ. J Am Coll Cardiol. 2013 May 28;61(21):2169-79
6. Healthcare and lifestyle practices of healthcare workers: do healthcare workers practice what they preach? Helfand BK, Mukamal KJ. JAMA Intern Med. 2013 Feb 11;173(3):242-4..