Kenneth J. Mukamal, MD, MPH
• Cardiovascular Health
• Alcohol Consumption
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Dr. Mukamal's primary research interests are investigating the role of dietary and lifestyle factors - particularly alcohol consumption - on the incidence and prognosis of cardiovascular and neurovascular disease and its risk factors. As a general internist and clinical investigator, his research has incorporated ongoing epidemiological studies, utilized hospital-based clinical data, and interventional studies. The outcomes of this research have been broad-based and include diverse health effects of alcohol ranging from novel cardiovascular risk factors and subclinical vascular disease to falls and suicide. Recent work in collaboration with Murray Mittleman of BIDMC's Cardiovascular Division and Eric Rimm of the Harvard School of Public Health seeks to examine novel biomarkers in important candidate pathways leading to cardiovascular disease and diabetes in large, ongoing cohort studies.
Current Research Support
R01 HL094555 (Mukamal, Djousse, Ix, Kizer, Zieman), NIH/NHLBI, 2009-2013
Determinants and Cardiovascular Consequences of Diabetes in Older Adults
This multiple PI project will evaluate promising pathways in the development and cardiovascular prognosis of diabetes in older adults, including pathways related to adipocyte function, calcium metabolism, advanced glycation endproducts, and fibrosis. I am Principal Investigator of the lead site, serve as chair of the Diabetes Working Group that developed this project, and will lead analyses of fibrotic pathways.
R01 HL091874 (Mukamal), NIH/NHLBI, 2009-2011
Endothelial Dysfunction, Oxidative Stress, and Risk of Peripheral Arterial Disease
The goal of this project is to evaluate the roles of endothelial function, oxidative stress, and their correlates in the development of peripheral arterial disease among women and men. As Principal Investigator, I developed the project and will lead all analyses.
Selected Peer-Reviewed Publications
1. Kizer JR, Arnold AM, Benkeser D, Ix JH, Djousse L, Zieman SJ, Barzilay JI, Tracy RP, Mantzoros CS, Siscovick DS, Mukamal KJ. Total and high-molecular-weight adiponectin and risk of incident diabetes in older people. Diabetes Care. 2012 Feb;35(2):415-23.
2. Breslow RA, Chen CM, Graubard BI, Mukamal KJ. Prospective study of alcohol consumption quantity and frequency and cancer-specific mortality in the US population. Am J Epidemiol. 2011 Nov 1;174(9):1044-53.
3. Mukamal KJ. A 42-year-old man considering whether to drink alcohol for his health. JAMA. 2010 May 26; 303(20):2065-2073..