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Lamont Lab

Dr. John T. Lamont received his medical degree in 1965 from the University of Rochester, and was intern, resident and chief resident in Medicine at UCLA. Following GI Fellowship at Massachusetts Hospital, he joined the faculty of Harvard Medical School in 1974. From 1980 to 1995 he was Chief of GI at Boston University School of Medicine, and from 1996 to 2012 was the GI Division Chief at Beth Israel Deaconess Medical Center. He is the Charlotte F. and Irving W. Rabb Distinguished Professor of Medicine.

Dr. Lamont's research interests are in the area of intestinal infections, particularly the pathophysiology and clinical features of Clostridum difficile infections. Studies from his laboratory have focused on the nature of the cell membrane receptor for toxin A of C difficile. This toxin ( MW 308 kd ) binds to surface receptors on all nucleated cells. No cell type has yet been discovered which is insensitive to this toxin , or to the closely related toxin B. Recent evidence suggests that the cell surface receptor on human enterocytes is a member of the heat shock family of proteins. GP 96 is located on the luminal-facing membrane of colonocytes. Pull down studies with labeled toxin indicate that this protein binds avidly to toxin A but not toxin B. Cells with diminished expression of GP96 are less sensitive to the biologic effects of the toxin.

Dr. Lamont recently closed his research laboratory after 35 years of continuous NIH support including two separate research projects on intestinal mucin and C difficile toxins, as well as an NIH T32 training grant. However, he continues to be active as a mentor for young scientists and junior faculty members in the GI Division. Dr Lamont is serving as a resource for manuscript and grant preparation , and for career planning for medical students, post-doctoral PhD fellows, residents and GI fellows. He currently serves as Associate Editor for GI and Liver Diseases at the New England Journal of Medicine, and as Editor-in-Chief for Gastroenterology for "UpToDate in Medicine".