Daniel Leffler MD MS
Daniel Leffler, MD, MS
Director of Clinical Research
The Celiac Center at BIDMC
Division of Gastroenterology
Beth Israel Deaconess Medical Center
My current focus, along with clinical care, is in clinical and translational research relating to celiac disease as well as quality improvement in the practice of gastroenterology. My major efforts to date have involved the study of factors which influence dietary adherence, reasons why some individuals with celiac disease do not respond to typical dietary modification, and the metabolic and immunologic changes which occur with celiac disease activation. I am also a close collaborator with Dr. Detlef Schuppan in the work of his lab in basic research activities into celiac disease. Additionally, we work closely with the celiac group at Children's Hospital in Boston and are actively involved with clinical trials of a number of novel treatments for celiac disease in conjunction with private industry.
This work has facilitated the creation of clinical algorithms which are used throughout the department of gastroenterology and primary care in the diagnosis and treatment of celiac disease. Collaborative projects in other overlapping disorders including irritable bowel syndrome, small intestinal bacterial overgrowth and allergic disorders are an important part of the Celiac Centers mission.
In my new role as Director of Clinical Research at the Celiac Center, I will continue my work to promote awareness of celiac disease and to improve the care of patients with celiac disease.