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Daniel Leffler MD MS

Daniel Leffler, MD, MS

Director of Clinical Research
The Celiac Center at BIDMC

Division of Gastroenterology
Beth Israel Deaconess Medical Center

My current research focuses on both Patient Safety and Quality Improvement and Clinical and Translational Research in Celiac Disease. Regarding Patient Safety and Quality Improvement, I am active as Director of Quality Improvement for the Division of Gastroenterology, Associate Director of Research for Quality Improvement in the Department of Medicine, a member of the Medical Peer Review Committee, Interventional Procedures Committee, and the Department of Medicine QI Leadership Council; and, most recently I elected to the Patient Safety Core Faculty of the Department of Medicine. I have been able to leverage my clinical research and QI skills to design and execute multiple effective interventions which have been published in high level peer reviewed journals including Archives of Internal Medicine, Gastroenterology and Gastrointestinal Endoscopy.

I am co-director of the patient safety and quality improvement curriculum across medicine sub-specialty fellowships at BIDMC and am engaged in a range of patient safety and quality improvement initiatives working closely with the Silverman Institute for Health Care Quality & Safety and the Center for Healthcare Delivery, both at BIDMC. Projects have included development of a multi-disciplinary clinical care algorithm for management of gastrointestinal hemorrhage, a system for improving adherence to follow up recommendations in gastrointestinal endoscopy, and ongoing work on peri-procedural anticoagulation management and quality improvement in procedural sedation.

My efforts in celiac disease span both clinical and translational areas involving clinical outcomes and the development of novel non-invasive tests of celiac disease activity including the creation of disease specific survey tools assessing diet adherence, symptoms, and quality of life. The survey instruments in particular are used worldwide and have been translated into a number of languages. I am currently the PI on a K23 grant assessing non-invasive markers of celiac disease activity, with a related R03 and R01 in review. I am also a close collaborator with both Dr. Detlef Schuppan in his work elucidating basic immunologic mechanisms of celiac disease, and with the celiac group at Children’s Hospital.

In addition, I am currently the PI on multiple industry-sponsored studies creating and evaluating celiac disease study outcomes and potential therapies. I have served as the Celiac Center Fellowship Director since 2010 and we currently train two fellows per year in a 1-2 year research and clinical training program. Papers I have authored on celiac disease have been published in top peer reviewed journals including JAMA, Gastroenterology, Gut and the American Journal of Gastroenterology. My book on celiac disease, ‘Real Life with Celiac Disease: Troubleshooting and Thriving Gluten Free’ was published by the American Gastroenterological Association Press in May 2010, won an ‘Indie Book Award’ in 2011 and currently is rated 4.9 out of 5 stars on Amazon. Finally, my work in celiac disease has led to both national and international recognition and I currently serve as the secretary for The North American Society for the Study of Celiac Disease (, and on the international ‘Oslo Group’ developing consensus statements for celiac disease and related disorders.

Contact Information

Celiac Disease Center
Beth Israel Deaconess Medical Center
East Campus, Dana 601
330 Brookline Avenue
Boston, MA 02215