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Publications

Tischkowitz M, Hamel N, Carvalho MA, Birrane G, Soni A, van Beers EH, Joosse SA, Wong N, Novak D, Quenneville LA, Grist SA; kConFab, Nederlof PM, Goldgar DE,  Tavtigian SV, Monteiro AN, Ladias JA, Foulkes WD. Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach. Eur J Hum Genet. 2008 Jul;16(7):820-32.

Meiyappan M, Birrane G, Ladias JA. Structural basis for polyproline recognition by the FE65 WW domain. J Mol Biol. 2007 Sep 28;372(4):970-80.

Birrane G, Varma AK, Soni A, Ladias JA. Crystal structure of the BARD1 BRCT domains. Biochemistry. 2007 Jul 3;46(26):7706-12.

Baek K, Brown RS, Birrane G, Ladias JA. Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9. J Mol Biol. 2007 Feb 16;366(2):563-73.

Varma AK, Brown RS, Birrane G, Ladias JA. Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex. Biochemistry. 2005 Aug 23;44(33):10941-6.

Ladias JA. Structural insights into the CFTR-NHERF interaction. J Membr Biol. 2003 Mar 15;192(2):79-88. Review.

Birrane G, Chung J, Ladias JA. Novel mode of ligand recognition by the Erbin PDZ domain. J Biol Chem. 2003 Jan 17;278(3):1399-402.

Karthikeyan S, Leung T, Ladias JA. Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors. J Biol Chem. 2002 May 24;277(21):18973-8. 

Karthikeyan S, Leung T, Birrane G, Webster G, Ladias JA. Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains. J Mol Biol. 2001 May 18;308(5):963-73.

Webster G, Leung T, Karthikeyan S, Birrane G, Ladias JA. Crystallographic characterization of the PDZ1 domain of the human Na+/H+ exchanger regulatory factor. Acta Crystallogr D Biol Crystallogr. 2001 May;57(Pt 5):714-6.

Karthikeyan S, Leung T, Ladias JA. Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator. J Biol Chem. 2001 Jun 8;276(23):19683-6.

Schlegel BP, Green VJ, Ladias JA, Parvin JD. BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10alpha in activated transcription. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3148-53.

del Río-Portilla F, Gaskell A, Gilbert D, Ladias JA, Wagner G. Solution structure of the hRPABC14.4 subunit of human RNA polymerases. Nat Struct Biol. 1999 Nov;6(11):1039-42.

Green VJ, Kokkotou E, Ladias JA. Critical structural elements and multitarget protein interactions of the transcriptional activator AF-1 of hepatocyte nuclear factor 4. J Biol Chem. 1998 Nov 6;273(45):29950-7.
Hiremath CN, Ladias JA. Expression and purification of recombinant hRPABC25, hRPABC17, and hRPABC14.4, three essential subunits of human RNA polymerases I, II, and III. Protein Expr Purif. 1998 Jul;13(2):198-204.

Hadzopoulou-Cladaras M, Kistanova E, Evagelopoulou C, Zeng S, Cladaras C, Ladias JA. Functional domains of the nuclear receptor hepatocyte nuclear factor 4. J Biol Chem. 1997 Jan 3;272(1):539-50.

Chan KW, Langan MN, Sui JL, Kozak JA, Pabon A, Ladias JA, Logothetis DE. A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. J Gen Physiol. 1996 Mar;107(3):381-97.

Ladias JA. Convergence of multiple nuclear receptor signaling pathways onto the long terminal repeat of human immunodeficiency virus-1. J Biol Chem. 1994 Feb 25;269(8):5944-51.

Carter ME, Gulick T, Raisher BD, Caira T, Ladias JA, Moore DD, Kelly DP. Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element. J Biol Chem. 1993 Jul 5;268(19):13805-10.

Ladias JA, Hadzopoulou-Cladaras M, Kardassis D, Cardot P, Cheng J, Zannis V,  Cladaras C. Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3. J Biol Chem. 1992 Aug 5;267(22):15849-60.

Mietus-Snyder M, Sladek FM, Ginsburg GS, Kuo CF, Ladias JA, Darnell JE Jr, Karathanasis SK. Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Mol Cell Biol. 1992 Apr;12(4):1708-18.

Heizmann C, Kirchgessner T, Kwiterovich PO, Ladias JA, Derby C, Antonarakis SE, Lusis AJ. DNA polymorphism haplotypes of the human lipoprotein lipase gene: possible association with high density lipoprotein levels. Hum Genet. 1991 Apr;86(6):578-84.

Ladias JA, Karathanasis SK. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science. 1991 Feb 1;251(4993):561-5.

Widom RL, Ladias JA, Kouidou S, Karathanasis SK. Synergistic interactions between transcription factors control expression of the apolipoprotein AI gene in liver cells. Mol Cell Biol. 1991 Feb;11(2):677-87.

Mietus-Snyder M, Charmley P, Korf B, Ladias JA, Gatti RA, Karathanasis SK. Genetic linkage of the human apolipoprotein AI-CIII-AIV gene cluster and the neural cell adhesion molecule (NCAM) gene. Genomics. 1990 Aug;7(4):633-7.

Ladias JA, Kwiterovich PO Jr, Smith HH, Karathanasis SK, Antonarakis SE. Apolipoprotein A1 Baltimore (Arg10->Leu), a new ApoA1 variant. Hum Genet. 1990 Apr;84(5):439-45.

Ladias JA, Kwiterovich PO Jr, Smith HH, Miller M, Bachorik PS, Forte T, Lusis AJ, Antonarakis SE. Apolipoprotein B-100 Hopkins (arginine4019->tryptophan). A new apolipoprotein B-100 variant in a family with premature atherosclerosis and hyperapobetalipoproteinemia. JAMA. 1989 Oct 13;262(14):1980-8.

Ma YH, Ladias JA, Bütler R, Schumaker VN, Antonarakis SE, Lusis AJ, Heinzman  C, Kwiterovich PO. Apolipoprotein B gene haplotypes. Association between Ag and DNA polymorphisms. Arteriosclerosis. 1988 Sep-Oct;8(5):521-4.

Heinzmann C, Ladias J, Antonarakis S, Diep A, Schotz M, Lusis AJ. Two polymorphisms for the human hepatic lipase (HL) gene. Nucleic Acids Res. 1988 May 25;16(10):4739.
 
Semenza GL, Ladias JA, Antonarakis SE. An Xba I polymorphism 3' to the human erythropoietin (EPO) gene. Nucleic Acids Res. 1987 Aug 25;15(16):6768.

Heinzmann C, Ladias J, Antonarakis S, Kirchgessner T, Schotz M, Lusis AJ. RFLP for the human lipoprotein lipase (LPL) gene: HindIII. Nucleic Acids Res. 1987 Aug 25;15(16):6763.

Contact Information

Division of Experimental Medicine
Department of Medicine
Beth Israel Deaconess Medical Center
Research North RN325D
330 Brookline Avenue
Boston, MA 02215
617.667.0070
617.667.5243
nbreslin@bidmc.harvard.edu

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