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Publications

Groopman JE.
Much progress, still many challenges.
AIDS. 2012 Jun 19;26(10):1197.
PubMed PMID: 22706003.

Zhang X, Yu J, Kuzontkoski PM, Zhu W, Li DY, Groopman JE.
Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability.
PLoS Pathog. 2012 Jan;8(1):e1002461. Epub 2012 Jan 5.
PubMed PMID: 22241990

Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A.
Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy.
Mol Cancer Ther. 2011 Jul;10(7):1161-72. Epub 2011 May 12.
PubMed PMID: 21566064.

Preet A, Qamri Z, Nasser MW, Prasad A, Shilo K, Zou X, Groopman JE, Ganju RK.
Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis.
Cancer Prev Res (Phila). 2011 Jan;4(1):65-75. Epub 2010 Nov 19.
PubMed PMID: 21097714

Zhang X, Maor Y, Wang JF, Kunos G, Groopman JE.
Endocannabinoid-like N-arachidonoyl serine is a novel pro-angiogenic mediator.
Br J Pharmacol. 2010 Aug;160(7):1583-94.
PubMed PMID: 20649563

Prasad A, Park IW, Allen H, Zhang X, Reddy MV, Boominathan R, Reddy EP, Groopman JE.
Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells.
Oncogene. 2009 Mar 26;28(12):1518-28. Epub 2009 Feb 9.
PubMed PMID: 19198627.

Preet A, Ganju RK, Groopman JE.
Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo.
Oncogene. 2008 Jan 10;27(3):339-46. Epub 2007 Jul 9.
PubMed PMID: 17621270.

Balasubramanian A, Groopman JE, Ganju RK.
Underlying pathophysiology of HCV infection in HIV-positive drug users.
J Addict Dis. 2008;27(2):75-82. Review.
PubMed PMID: 18681194

Park IW, Reddy MV, Reddy EP, Groopman JE.
Evaluation of novel cell cycle inhibitors in mantle cell lymphoma.
Oncogene. 2007 Aug 16;26(38):5635-42. Epub 2007 Mar 19.
PubMed PMID: 17369860.

Zhang X, Wang JF, Kunos G, Groopman JE.
Cannabinoid modulation of Kaposi's sarcoma-associated herpesvirus infection and transformation.
Cancer Res. 2007 Aug 1;67(15):7230-7.
PubMed PMID: 17671191.

Balasubramanian A, Ganju RK, Groopman JE.
Signal transducer and activator of transcription factor 1 mediates apoptosis induced by hepatitis C virus and HIV envelope proteins in hepatocytes.
J Infect Dis. 2006 Sep 1;194(5):670-81. Epub 2006 Jul 18.
PubMed PMID: 16897667.

Ghosh S, Preet A, Groopman JE, Ganju RK.
Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes.
Mol Immunol. 2006 Jul;43(14):2169-79. Epub 2006 Feb 28.
PubMed PMID: 16503355.

Balasubramanian A, Munshi N, Koziel MJ, Hu Z, Liang TJ, Groopman JE, Ganju RK.
Structural proteins of Hepatitis C virus induce interleukin 8 production and apoptosis in human endothelial cells.
J Gen Virol. 2005 Dec;86(Pt 12):3291-301.
PubMed PMID: 16298974.

Zhang X, Wang JF, Chandran B, Persaud K, Pytowski B, Fingeroth J, Groopman JE.
Kaposi's sarcoma-associated herpesvirus activation of vascular endothelial growth factor receptor 3 alters endothelial function and enhances infection.
J Biol Chem. 2005 Jul 15;280(28):26216-24. Epub 2005 May 4.
PubMed PMID: 15878864.

Balasubramanian A, Koziel M, Groopman JE, Ganju RK.
Molecular mechanism of hepatic injury in coinfection with hepatitis C virus and HIV.
Clin Infect Dis. 2005 Jul 1;41 Suppl 1:S32-7.
PubMed PMID: 16265611.

Groopman JE.
A strategy for hope: a commentary on necessary collusion.
J Clin Oncol. 2005 May 1;23(13):3151-2.
PubMed PMID: 15860877.

Zhang X, Groopman JE, Wang JF.
Extracellular matrix regulates endothelial functions through interaction of VEGFR-3 and integrin α5β1.
J Cell Physiol. 2005 Jan;202(1):205-14.
PubMed PMID: 15389531.

Wang JF, Zhang X, Groopman JE.
Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.
J Biol Chem. 2004 Jun 25;279(26):27088-97. Epub 2004 Apr 21.
PubMed PMID: 15102829.

Munshi N, Balasubramanian A, Koziel M, Ganju RK, Groopman JE.
Hepatitis C and human immunodeficiency virus envelope proteins cooperatively induce hepatocytic apoptosis via an innocent bystander mechanism.
J Infect Dis. 2003 Oct 15;188(8):1192-204. Epub 2003 Sep 30.
PubMed PMID: 14551890.

Balasubramanian A, Ganju RK, Groopman JE.
Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes.
J Biol Chem. 2003 Sep 12;278(37):35755-66. Epub 2003 Jun 24.
PubMed PMID: 12824191.

Choe EY, Schoenberger ES, Groopman JE, Park IW.
HIV Nef inhibits T cell migration.
J Biol Chem. 2002 Nov 29;277(48):46079-84. Epub 2002 Sep 26.
PubMed PMID: 12354773.

Wang JF, Zhang XF, Groopman JE.
Stimulation of beta 1 integrin induces tyrosine phosphorylation of vascular endothelial growth factor receptor-3 and modulates cell migration.
J Biol Chem. 2001 Nov 9;276(45):41950-7. Epub 2001 Sep 11.
PubMed PMID: 11553610.

Park IW, Ullrich CK, Schoenberger E, Ganju RK, Groopman JE.
HIV-1 Tat induces microvascular endothelial apoptosis through caspase activation.
J Immunol. 2001 Sep 1;167(5):2766-71.
PubMed PMID: 11509621.

Zhang XF, Wang JF, Matczak E, Proper JA, Groopman JE.
Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells.
Blood. 2001 Jun 1;97(11):3342-8.
PubMed PMID: 11369622.

Yang YM, Hatch WC, Liu ZY, Du B, Groopman JE.
β-chemokine induction of activation protein-1 and cyclic AMP responsive element activation in human myeloid cells.
Cell Growth Differ. 2001 Apr;12(4):211-21.
PubMed PMID: 11331250.

Park IW, Wang JF, Groopman JE.
HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.
Blood. 2001 Jan 15;97(2):352-8.
PubMed PMID: 11154208.

Ullrich CK, Groopman JE, Ganju RK.
HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases.
Blood. 2000 Aug 15;96(4):1438-42.
PubMed PMID: 10942389.

Ganju RK, Brubaker SA, Chernock RD, Avraham S, Groopman JE.
β-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk.
J Biol Chem. 2000 Jun 9;275(23):17263-8.
PubMed PMID: 10747947.

Contact Information

Division of Experimental Medicine
Department of Medicine
Beth Israel Deaconess Medical Center
Research North RN325D
330 Brookline Avenue
Boston, MA 02215
617.667.0070
617.667.5243
nbreslin@bidmc.harvard.edu

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