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Groopman Lab

Dr. Groopman's laboratory is pursuing a number of projects related to HIV in signal transduction. These include studies of Kaposi's sarcoma spindle cells, specifically the effects of exogenous cytokines and recently discovered virus KS/HHV8. The biology of normal endothelium is also being investigated with regard to regulation of nitric oxide production and pathways of programmed cell death (apoptosis).

A new program in the growth and chemotaxis of ovarian cancer cells has been initiated. Characterization of chemokine-mediated signal transduction pathways in blood cells and endothelium has become a major focus of the laboratory. Studies of dermal microvasculature also have been initiated.

In this past year, a number of high profile papers from the laboratory were published in the Journal of Biological Chemistry and Blood. These primarily identified new signal molecules operative in pathways of T-cell activation, Kaposi's sarcoma growth, and endothelial cell proliferation and spread.

Contact Information

Division of Experimental Medicine
Department of Medicine
Beth Israel Deaconess Medical Center
Research North RN325D
330 Brookline Avenue
Boston, MA 02215
617.667.0070
617.667.5243
nbreslin@bidmc.harvard.edu

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