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Original Articles

1. Uscheva A, Avramova Z, Tsanev R. Tightly bound somatic histones in mature ram sperm nuclei. FEBS Lett. 1982;138(1):50-4.

2. Avramova Z, Uscheva A, Stephanova E, Tsanev R. Trout sperm chromatin. I. Biochemical and immunological study of the protein composition. Eur J Cell Biol. 1983;31:137-42.

3. Uscheva A, Patriotis C, Avramova Z. An H1-like protein from the sperm chromatin of Mytilus galloprovincialis. Cell Biol Int Rep. 1985;3:253-63.

4. Pankov RG, Uscheva AA, Tasheva BT, Petrov PT, Markov GG. Actin participates in the structure of liver intermediate filaments. Cell Biol Int Rep. 1985;9(11):1003-11.

5. Stankov BM, Uscheva AA, Kanchev LN. The effect of the purity of the iodinated tracer on the specificity of a homologous assay of ovine follicle stimulating hormone. Biochem Int. 1986;12(1):11-9.

6. Uscheva AA, Stankov BM, Zachariev SG, Marinova CP, Kanchev LN. Possible synthesis of steroid-protein for immunization with a fixed narrow range of the hapten-protein ratio. J Steroid Biochem. 1986;24(3):699-702.

7. Ivanchenko E, Georgieva M, Uscheva A, Avramova Z. A study on the heterogeneity of histone H1 from dry maize embryos. Eur J Biochem ;162:339-344. 1987;162:339-344.

8. Pankov R, Uscheva A, Tasheva B, Markov G. Vertebrate liver cytokeratins: a comparative study. Biochem Cell Biol. 1987;65:547-557.

9. Alexciev K, Uscheva A, Pavlova M, Yavachev L, Ivanov I. Expression of synthetic calcitonin genes in plasmid vectors containing tandemly repeated non-overlapping ribosome binding sites. Int J Biochem. 1989;21(9):987-96.

10. Valkov NI, Ivanova MI, Uscheva AA, Krachmarov CP. Association of actin with DNA and nuclear matrix from Guerin ascites tumour cells. Mol Cell Biochem. 1989;87(1):47-56.

11. Gigova L, Wishart P, Uscheva A, Ivanova M, Bardarov S, Jay E, Ivanov I. Expression of repetitive human calcitonin genes in Escherichia coli. Biotechnol Appl Biochem. 1989;11(4):401-12.

12. Bachvarov D, Wistart P, Usheva A, Ivanov I, Jay E. Expression in E. coli of human valcalcitonin gene by fusion to the chloramphenicol acetyl transferase (CAT) gene. Biologisches Zentralblatt. 1990;109:113-117.

13. Valkov N, Usheva A. Topoisomerase II is not a component of the nuclear matrix. Comtes Rendus Acad Bulg Sci. 1990;43:1121-27.

14. Ivanov I, Rommens J, Sarafova A, Maximova V, Usheva A, Bardarov S, Papageorgiou A, Jay E. Chemical synthesis and characteristics of a hybrid phage T5-lac promoter. Microbiologica. 1990;13(2):85-90.

15. Usheva A, Maldonado E, Goldring A, Lu H, Houbavi C, Reinberg D, Aloni Y. Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein. Cell. 1992;69(5):871-81.

16. Seto E, Usheva A, Zambetti GP, Momand J, Horikoshi N, Weinmann R, Levine AJ, Shenk T. Wild-type p53 binds to the TATA-binding protein and represses transcription. Proc Natl Acad Sci U S A. 1992;89(24):12028-32.

17. Usheva A, Shenk T. TATA-binding protein-independent initiation: YY1, TFIIB, and RNA polymerase II direct basal transcription on supercoiled template DNA. Cell. 1994;76(6):1115-21.

18. Horikoshi N, Usheva A, Chen J, Levine AJ, Weinmann R, Shenk T. Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression. Mol Cell Biol. 1995;15(1):227-34.

19. Nikolov DB, Chen H, Halay ED, Usheva AA, Hisatake K, Lee DK, Roeder RG, Burley SK. Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature. 1995;377(6545):119-28.

20. Houbaviy HB, Usheva A, Shenk T, Burley SK. Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. Proc Natl Acad Sci U S A. 1996;93(24):13577-82.

21. Usheva A, Shenk T. YY1 transcriptional initiator: protein interactions and association with a DNA site containing unpaired strands. Proc Natl Acad Sci U S A. 1996;93(24):13571-6.

22. Ericsson J, Usheva A, Edwards PA. YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes. J Biol Chem. 1999;274(20):14508-13.

23. Kang PM, Haunstetter A, Aoki H, Usheva A, Izumo S. Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation. Circ Res. 2000;87(2):118-25.

24. Kasahara H, Usheva A, Ueyama T, Aoki H, Horikoshi N, Izumo S. Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein. J Biol Chem. 2001;276(7):4570-80.

25. Liao HS, Kang PM, Nagashima H, Yamasaki N, Usheva A, Ding B, Lorell BH, Izumo S. Cardiac-specific overexpression of cyclin-dependent kinase 2 increases smaller mononuclear cardiomyocytes. Circ Res. 2001;88(4):443-50.

26. Petkova V, Romanowski MJ, Sulijoadikusumo I, Rohne D, Kang P, Shenk T, Usheva A. Interaction between YY1 and the retinoblastoma protein. Regulation of cell cycle progression in differentiated cells. J Biol Chem. 2001;276(11):7932-6.

27. Sulijoadikusumo I, Horikoshi N, Usheva A. Another function for the mitochondrial ribosomal RNA: protein folding. Biochemistry. 2001;40(38):11559-64.

28. Soares MP, Usheva A, Brouard S, Berberat PO, Gunther L, Tobiasch E, Bach FH. Modulation of endothelial cell apoptosis by heme oxygenase-1-derived carbon monoxide. Antioxid Redox Signal. 2002;4(2):321-9.

29. Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N. A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF). FEBS Lett. 2002;524(1-3):163-71.

30. Bodyak N, Kang PM, Hiromura M, Sulijoadikusumo I, Horikoshi N, Khrapko K, Usheva A. Gene expression profiling of the aging mouse cardiac myocytes. Nucleic Acids Res. 2002;30(17):3788-94.

31. Ohiro Y, Usheva A, Kobayashi S, Duffy SL, Nantz R, Gius D, Horikoshi N. Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53. Mol Cell Biol. 2003;23(1):322-34.

32. Otterbein LE, Zuckerbraun BS, Haga M, Liu F, Song R, Usheva A, Stachulak C, Bodyak N, Smith RN, Csizmadia E, Tyagi S, Akamatsu Y, Flavell RJ, Billiar TR, Tzeng E, Bach FH, Choi AM, Soares MP. Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med. 2003;9(2):183-90.

33. Hiromura M, Choi CH, Sabourin NA, Jones H, Bachvarov D, Usheva A. YY1 is regulated by O-linked N-acetylglucosaminylation (O-glcNAcylation). J Biol Chem. 2003;278(16):14046-52.

34. Choi CH, Hiromura M, Usheva A. Transcription factor IIB acetylates itself to regulate transcription. Nature. 2003;424(6951):965-9.

35. Choi CH, Kalosakas G, Rasmussen KO, Hiromura M, Bishop AR, Usheva A. DNA dynamically directs its own transcription initiation. Nucleic Acids Res. 2004;32(4):1584-90.

36. Choi CH, Burton ZF, Usheva A. Auto-acetylation of transcription factors as a control mechanism in gene expression. Cell Cycle. 2004;3(2):114-5.

37. Sarady JK, Zuckerbraun BS, Bilban M, Wagner O, Usheva A, Liu F, Ifedigbo E, Zamora R, Choi AM, Otterbein LE. Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver. FASEB J. 2004.

38. Yamashita K, McDaid J, Ollinger R, Tsui TY, Berberat PO, Usheva A, Csizmadia E, Smith RN, Soares MP, Bach FH. Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts. FASEB J. 2004;18(6):765-7.

39. Kalosakas G. Rasmunssen K.O, Bishop A. R., Choi C.H., A. Usheva. Sequence specific thermal fluctuations identify start sites for DNA transcription. Europhys. Lett. 2004;68(1):127-133.

40. Choi CH, Sobourin N, Hiromura M, Usheva A. Electronic context of TBP-independent transcription initiation complex . Biophys Chem. 2004;111(1):9-14.

41. Lee BC, Lee TH, Zagozdzon R, Avraham S, Usheva A, Avraham HK. . Carboxyl-terminal Src kinase homologous kinase negatively regulates the chemokine receptor CXCR4 through YY1 and impairs CXCR4/CXCL12 (SDF-1alpha)-mediated breast cancer cell migration. Cancer Res. 2005;65(7):2840-5.

42. Angers M, Drouin R, Bachvarova M, Paradis I, Bissell B, Hiromura M, Usheva A, Bachvarov D. In vivo DNase I-mediated footprinting analysis along the human bradykinin B1 receptor (BDKRB1) gene promoter: evidence for cell-specific regulation. Biochem J. 2005;389(Pt 1):37 -46.

43. Ollinger R, Bilban M, Erat A, Froio A, McDaid J, Tyagi S, Csizmadia E, Graca-Souza AV, Liloia A, Soares MP, Otterbein LE, Usheva A, Yamashita K, Bach FH. Bilirubin: a natural inhibitor of vascular smooth muscle cell proliferation. Circulation. 2005;112(7):1030 -1038.

44. Wu Y, Sun X, Kaczmarek E, Dwyer KM, Bianchi E, Usheva A, Robson SC. RanBPM associates with CD39 and modulates ecto-nucleotidase activity. Biochem J. 2006 May 15;Sect. Biochem J.

45. Bilban M, Bach FH, Otterbein SL, Ifedigbo E, de Costa d'Avila J, Esterbauer H, Chin BY, Usheva A, Robson SC, Wagner O, Otterbein LE. Carbon monoxide orchestrates a protective response through PPARgamma. Immunity. 2006;24(5 Pt 1):601.

46. Rapti Z, Smerzi A, Rasmussen KO, Bishop AR, Choi CH, Usheva A. Healing length and bubble formation in DNA. Phys Rev E Stat Nonlin Soft Matter Phys. . 2006 Jun 6;Sect. Phys Rev E Stat.

47. Choi CH, Usheva A, Kalosakas G, Rasmussen KO, Bishop AR. Comment on "can one predict DNA transcription start sites by studying bubbles?". Phys. Rev. Lett. 2006 Jun 16;Sect. Phys Rev Lett.

48. Zimon, Anna Erat, Tiffany Von Wald, Brad Bissell, Bliss S. Lee, Anna Koulova, Chu H. Choi, Dimcho Bachvarov, Richard Reindollar and Anny Usheva. Genes invoked in the aging-related ovarian menopausal transition. Nucleic Acid Research. 2006;34(11):3279-87.

49. Gelev V, Aktas H, Marintchev A, Ito T, Frueh D, Hemond M, Rovnyak D, Debus M, Hyberts S, Usheva A, Halperin J, Wagner G. Mapping of the auto-inhibitory interactions of protein kinase R by nuclear magnetic resonance. J Mol Biol. 2006;364(3):352-363.

50. Ollinger R, Yamashita K, Bilban M, Erat A, Kogler P, Thomas M, Csizmadia E, Usheva A, Margreiter R, Bach FH. Bilirubin and biliverdin treatment of atherosclerotic diseases. Cell Cycle. 2007;6(1):39-43.

51. Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007;204(6):1257-65.

52. B. Lannon, T. Von Wald, B. Malizia, A. Penzias, R. Reindollar, A. Usheva. Follicular fluid steroid hormone content a marker of decreased fertility potential? Fertility and Sterility. 2008;86:S387-S389.

53. Fukuyo Y, Inoue M, Nakajima T, Higashikubo R, Horikoshi NT, Hunt C, Usheva A, Freeman ML, Horikoshi N. Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives. Cancer Research. 2008;68(15).

54. B. Lannon, T. Von Wald, B. Malizia, A. Penzias, R. Reindollar, A. Usheva. P-689Is follicular fluid steroid hormone content a marker of decreased fertility potential. Fertility and Sterility. 2008;86:388.

55. Banz Y, Beldi G, Wu Y, Atkinson B, Usheva A, Robson SC. Profiling the thermodynamic softness of adenoviral promoters. Br J Haematology. 2008;142(4):627-637.

56. Choi CH, Rapti Z, Gelev V, Hacker MR, Alexandrov B, Park EJ, Park JS, Horikoshi N, Smerzi A, Rasmussen KØ, Bishop AR, Usheva A. Profiling the thermodynamic softness of adenoviral promoters. Biophys J. 2008;2(95):597-608.

57. Banz Y, Beldi G, Wu Y, Atkinson B, Usheva A, Robson SC. CD39 is incorporated into plasma microparticles where it maintains functional properties and impacts endothelial activation. Br J Haematol. 2008;142(4):627-37.

58. Y, Inoue M, Nakajima T, Higashikubo R, Horikoshi NT, Hunt C, Usheva A, Freeman ML, Horikoshi N. Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives. Cancer Res. 2008;68(15):6324-30.

59. Boian Alexandrov, Nikolaos K Voulgarakis, Kim Ø Rasmussen1, Anny Usheva and Alan R Bishop. Pre-melting dynamics of DNA and its relation to specific functions. J of Physics: Condens Matter. 2009;21(034107).

60. Smith LP, Nierstenhoefer M, Yoo SW, Penzias AS, Tobiasch E, Usheva A. The bile acid synthesis pathway is present and functional in the human ovary. PLoS One. 2009;4(10):e7333.

61. Von Wald T, Monisova Y, Hacker MR, Yoo SW, Penzias AS, Reindollar RR, Usheva A. Age-related variations in follicular apolipoproteins may influence human oocyte maturation and fertility potential. Fertil Steril. 2009.

62. Alexandrov BS, Gelev V, Yoo SW, Bishop AR, Rasmussen KØ, Usheva A. Toward a detailed description of the thermally induced dynamics of the core promoter. PLoS Comput Biol. 2009;5(3(e1000313).

63. Malizia BA, Wook YS, Penzias AS, Usheva A. The human ovarian follicular fluid level of interleukin-8 is associated with follicular size and patient age. Fertil Steril. 2009.

64. Alexandrov BS, Gelev V, Monisova Y, Alexandrov LB, Bishop AR, Rasmussen K�, Usheva A. A nonlinear dynamic model of DNA with a sequence-dependent stacking term. Nucleic Acids Res. 2009;37(7):2405-10.

65. Knosalla C, Yazawa K, Behdad A, Bodyak N, Shang H, Bühler L, Houser S, Gollackner B, Griesemer A, Schmitt-Knosalla I, Schuurman HJ, Awwad M, Sachs DH, Cooper DK, Yamada K, Usheva A, Robson SC. Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation. Am J Transplant. 2009;9(5):1006-16.

66. Behdad A, Sun X, Khalpey Z, Enjyoji K, Wink M, Wu Y, Usheva A, Robson SC. Vascular smooth muscle cell expression of ectonucleotidase CD39 (ENTPD1) is required for neointimal formation in mice. Purinergic Signal. 2009;5(3):335-42.

67. Kitamura T, Fukuyo Y, Inoue M, Horikoshi NT, Shindoh M, Rogers BE, Usheva A, Horikoshi N. Mutant p53 disrupts the stress MAPK activation circuit induced by ASK1-dependent stabilization of Daxx. Cancer Res. 2009;69(19):7681-8.

68. Fukuyo Y, Kitamura T, Inoue M, Horikoshi NT, Higashikubo R, Hunt CR, Usheva A, Horikoshi N. Phosphorylation-dependent Lys63-linked polyubiquitination of Daxx is essential for sustained TNF-{alpha}-induced ASK1 activation. Cancer Res. 2009;69(19):7512-7.

69. Alexandrov LB, Alexandrova S, Usheva A. Computer modeling describes gravity-related adaptation in cell cultures. PLoS One. 2009;4(12):e8336.

70. Alexandrov BS, Gelev V, Bishop AR, Usheva A, Rasmussen KO. DNA Breathing Dynamics in the Presence of a Terahertz Field. Phys Lett A. 2010;374(10):1214.

71. Alexandrov BS, Gelev V, Yoo SW, Alexandrov LB, Fukuyo Y, Bishop AR, Rasmussen KØ, Usheva A. DNA dynamics play a role as a basal transcription factor in the positioning and regulation of gene transcription initiation. Nucleic Acids Res. 2010;38(6):1790-5.

72. Sneeringer R, Penzias AS, Barrett B, Usheva A. High levels of mineralocorticoids in preovulatory follicular fluid could contribute to oocyte development. Fertil Steril. 2010;PMID: 20673890.

73. Savchev SI, Moragianni VA, Senger D, Penzias AS, Thornton K, Usheva A. Follicular fluid-specific distribution of vascular endothelial growth factor isoforms and sFlt-1 in patients undergoing IVF and their correlation with treatment outcomes. Reprod Sc. 2010;17(11):1036-42.

Contact Information

Usheva Lab
Beth Israel Deaconess Medical Center
Masco 4
330 Brookline Avenue
Boston, MA 02215