Publications
Complete list of Dr. Mantzoros' publications >>
Textbooks
Selected Publications
2011
Brinkoetter M, Magkos F, Vamvini M, Mantzoros CS. Leptin treatment may reduce body fat but does not affect lean body mass or the myostatin-follistatin-activin axis in lean hypoleptinemic women. Am J Physiol Endocrinol Metab. 2011 Apr 19. [Epub ahead of print]
Moon HS, Matarese G, Brennan A, Chamberland J, Liu X, Fiorenza C, Mylvaganam G, Abanni L, Carbone F, Williams C, De Paoli A, Schneider B, Mantzoros, C. Efficacy of Metreleptin in Obese Type II Diabetics: Cellular and Molecular Pathways underlying Leptin Tolerance. Diabetes. 2011. [In press]
Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R, Brinkoetter MT, Gong H, Arampatzi K, Mantzoros CS. Leptin is an effective treatment for hypothalamic amenorrhea. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6585-6590. Epub 2011 Apr 4.
Stuebe AM, Mantzoros C, Kleinman K, Gillman MW, Rifas-Shiman S, Gunderson EP, Rich-Edwards J. Duration of lactation and maternal adipokines at three years postpartum. Diabetes. 2011 Apr;60(4):1277-85. Epub 2011 Feb 24.
Moon HS, Chamberland J, Diakopoulos K, Fiorenza C, Ziemke F, Schneider B, Mantzoros C. Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues; in vitro and ex vivo studies in humans. Diabetes Care. 2011 Jan;34(1):132-8. Epub 2010 Sep 24.
Choi KM, Yannakoulia M, Park MS, Cho GJ, Kim JH, Lee SH, Hwang TG, Yang SJ, Kim TN, Yoo HJ, Baik SH, Kim SM, Mantzoros CS. Serum adipocyte-fatty acid binding protein, retinol binding protein 4, and adiponectin levels in relation to the development of metabolic syndrome in Korean boys: A 3-year long prospective cohort study. Am J Clin Nutr. 2011 Jan;93(1):19-26. Epub 2010 Nov 24.
2010
Kotsopoulos J, Tworoger SS, Campos H, Chung FL, Clevenger CV, Franke AA, Mantzoros CS, Ricchiuti V, Willett WC, Hankinson SE, Eliassen AH. Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses’ Health Studies. Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):938-46. Epub 2010 Mar 23.
Scheer FAJL, Chan JL, Fargnoli J, Chamberland J, Arampatzi K, Shea SA, Blackburn GL, Mantzoros CS. Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions. Diabetologia. 2010 Nov;53(11):2401-5. Epub 2010 Aug 12.
Friberg E, Orsini N, Mantzoros CS, Wolk A. Alcohol intake and endometrial cancer risk: a meta-analysis of prospective studies. Br J Cancer. 2010 Jun 29;103(1):127-31.
Taveras EM, Rifas-Shiman SL, Rich-Edwards JW, Gunderson EP, Stuebe AM, Mantzoros CS. Association of Maternal Short Sleep Duration With Adiposity and Cardiometabolic Status at 3 Years Postpartum. Obesity (Silver Spring). 2010 May 20. [Epub ahead of print]
Sun Q, Cornelis MC, Kraft P, Qi L, van Dam RM, Girman CJ, Laurie CC, Mirel DB, Gong H, Sheu CC, Christiani DC, Hunter DJ, Mantzoros CS, Hu FB. Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels. Hum Mol Genet. 2010 May 1;19(9):1846-55.
Ruschke K, Fishbein L, Dietrich A, Klöting N, Tönjes A, Oberbach A, Fasshauer M, Jenkner J, Schön MR, Stumvoll M, Blüher M, Mantzoros CS. Gene expression of PPAR{gamma} and PGC-1{alpha} in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training. Eur J Endocrinol. 2010 Mar;162(3):515-23. Epub 2009 Dec 4.
2009
Brennan AM, Sweeney LL, Liu X, Mantzoros CS. Walnut consumption increases satiation but has no effect on insulin resistance or the metabolic profile over a 4 day period. Obesity 2010 Jun; 18(6):1176-82.
Fung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB. Mediterranean diet and incidence and mortality of coronary heat disease and stroke in women. Circulation 2009 Feb 17; 119: 1067-8.
Scheer F, Hilton M, Mantzoros CS, Shea S. Adverse metabolic and cardiovascular consequences of circadian misalignment. PNAS. 2009; 106 (11) 4453-8.
Ligibel JA, Giobbie-Hurder A, Olenczuk A, Campbell N, Salinardi N, Winer EP, Mantzoros CS. Impact of a Mixed Strength and Endurance Exercise Intervention on Levels of Adiponectin, High Molecular Weight Adiponectin and Leptin in Breast Cancer Survivors. Cancer Causes and Control 2009 Oct;20(8):1523-8.
Brennan AM, Lee JH, Tsiodras S, Chan JL, Doweiko J, Chimienti SN, Wadhwa SG, Karchmer AW, Mantzoros CS . r-metHuLeptin improves highly active antiretroviral therapy-induced lipoatrophy and the metabolic syndrome, but not through altering circulating IGF and IGF-binding protein levels: observational and interventional studies in humans. Eur J Endo 2009; 160(2):173-6.
2008
Kaklamani VG, Wisinski KB, Sadim M, Gulden C, Do A, Offit K, Baron JA, Ahsan H, Mantzoros C, Pasche B. Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. JAMA 2008 Oct 1;300(13):1523-31.
Bluher S, Bullen J, Mantzoros CS. Altered levels of adiponectin and adiponectin receptors may underlie the effect of ciliary neutrotrophic factor (CNTF) to enhance insulin sensitivity in diet-induced obese mice. Horm Metab Res 2008; 40: 225-27.
Chan J, Wong S, Mantzoros CS. Pharmacokinetics of subcutaneous recombinant methionyl human leptin administration in healthy subjects in the fed and fasting states: regulation by gender and adiposity. Clin Pharmacokinet 2008; 47:753-64.
Chan J, Williams C, Raciti P, Blakeman J, Kelesidis T, Kelesidis I, Johnson M, Thorner M, Mantzoros CS. Leptin does not mediate short-term fasting-induced changes in GH pulsatility, but increases IGF-1 in leptin deficiency states. J Clin Endocrinol Metab 2008 Jul; 93:2819-27.
Heidemann C, Sun Q, van Dam RM, Meigs JB, Zhang C, Tworoger S, Mantzoros CS, Hu FB. Total and High-molecular Weight Adiponectin And Resistin In Relation To The Risk For Type 2 Diabetes In Women: A Prospective Study. Ann Intern Med 2008; 149:307-16.
Kaklamani V, Sadim M, Hsi A, Offit K, Oddoux C, Ostrer H, Ahsan H, Pasche B, Mantzoros CS. Variants of the adiponectin and Adiponectin Receptor 1 genes and breast cancer risk. Cancer Res 2008; 68:3178-3184.
Fargnoli J, Fung T, Olenczuk D, Chamberland J, Hu FB, Mantzoros CS. Adherence to healthy eating patterns is associated with increased circulating total and high molecular weight adiponectin and decreased resistin concentrations in women from the Nurses’ Health Study. Am J Clin Nutr 2008; 88(5):1213-24.
Orsini N, Mantzoros CS, Wolk A. Association of physical activity with cancer incidence, mortality, and survival: a population-based study of men. Br J Cancer 2008; 98:1864-1869.
Sher DS, Oh WK, Jacobus S, Regan MM, Lee G-S, Mantzoros CS. Relationship between serum adiponectin and prostate cancer grade. Prostate 2008; 68:1592-8.
2007
Alevizos I, Misra J, Bullen J, Basso G, Kelleher J, Mantzoros C, Stephanopoulos G. Linking hepatic transcriptional changes to high-fat diet induced physiology for diabetes-prone and obese-resistant mice. Cell Cycle. 2007 Jul; 6(13):1631-8. Epub 2007 May 1.
Williams CJ, Hu FB, Patel SR, Mantzoros CS. Sleep duration and snoring in relation to biomarkers of cardiovascular disease risk among women with type 2 diabetes. Diabetes Care. 2007 May;30(5):1233-40. Epub 2007 Feb 23.
Chan JL, Wong SL, Orlova C, Raciti P, Mantzoros CS. Pharmacokinetics of recombinant methionyl human leptin following subcutaneous administration: variation of concentration-dependent parameters according to assay. J Clin Endocrinol Metab. 2007 Jun;92(6):2307-11. Epub 2007 Apr 3.
Bullen JW Jr, Bluher S, Kelesidis T, Mantzoros CS. Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice. Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1079-86. Epub 2006 Dec 12.
Bluher M, Brennan AM, Kelesidis T, Kratzsch J, Fasshauer M, Kralisch S, Williams CJ, Mantzoros CS. Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays. Diabetes Care. 2007 Feb;30(2):280-5.
2006
Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol. 2006 Jun 15;176(12):7745-52.
Brennan AM, Mantzoros CS. Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications. Nat Clin Pract Endocrinol Metab. 2006 Jun;2(6):318-27. Review.
Chan JL, Matarese G, Shetty GK, Raciti P, Kelesidis I, Aufiero D, De Rosa V, Perna F, Fontana S, Mantzoros CS. Differential regulation of metabolic, neuroendocrine, and immune function by leptin in humans. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8481-6. Epub 2006 May 19.
2005
Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS. Low Plasma Adiponectin Levels and Risk of Colorectal Cancer in Men: A Prospective Study. J Natl Cancer Inst. 2005 Nov 16;97(22):1688-1694.
2004
Bullen JW Jr, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, Maratos-Flier E, Stephanopoulos G, Mantzoros CS. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E662-70.
Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med. 2004 Sep 2;351(10):987-97.
Bluher S, Ziotopoulou M, Bullen JW Jr, Moschos SJ, Ungsunan L, Kokkotou E, Maratos-Flier E, Mantzoros CS. Responsiveness to peripherally administered melanocortins in lean and obese mice. Diabetes. 2004 Jan;53(1):82-90.
2003
Jean L. Chan, M.D., Kathleen Heist, Alex M. DePaoli, M.D., Johannes D. Veldhuis, M.D., Christos S. Mantzoros, M.D., D.Sc. The role of falling leptin in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. J Clin Invest. 2003;111(9):1409-21.
2002
Chan J, Blueher S, Yiannakouris N, Suchard MA, Kratzsch J, Mantzoros C. Circulating leptin binding protein and free leptin levels in humans: observational and interventional studies in humans. Diabetes 2002; 51: 2105-12.
Pierroz D, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS, Mantzoros C. Effects of acute and chronic administrations of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes 2002; 51:1337-1345.
2001
Mantzoros CS, Ozata M, Negrao AB, Suchard MA, Ziotopoulou M, Caglayan S, Elashoff RM, Cogswell RJ, Negro P, Liberty V, Wong ML, Veldhuis J, Ozdemir IC, Gold PW, Flier JS, Licinio J. Synchronicity of frequently sampled, 24-h concentrations of circulating leptin and TSH in healthy men: evidence for a possible partial TSH regulation by leptin in humans. J Clin Endocrinol Metab 2001 Jul;86(7):3284-91.
2000
Wolk A, Andersson S-O, Mantzoros C, Trichopoulos D, Adami H-O. Can measurements of IGF-1 and IGFBP-3 improve the sensitivity of prostate-cancer screening? Lancet. 2000;356(9245):1902-3.
Ziotopoulou M, Erani D, Hileman S, Bjorbaek C, Mantzoros C. Unlike leptin, Ciliary Neurotrophic Factor does not reverse the starvation induced changes of serum corticosterone and hypothalamic neuropeptide levels, but induces expression of hypothalamioc inhibitors of leptin signaling. Diabetes 2000; 49(11):1890-6.
1999
Cittadini A, Mantzoros C, Hampton TG, Katz SH, Travers KE, Flier JS, Morgan JP, Douglas PS. Cardiovascular phenotype of transgenic mice with reduced brown fat. Circulation 1999;100-2177-218354.
1998
Wolk A, Mantzoros C, Andersson S-O, Signorello L, Lagiou P, Bergstrom R, Trichopoulos D, Adami H-O. Insulin Like Growth Factor I and prostate cancer risk: A population based case-control study. J Natl Cancer Inst 1998:90;911-915.
Licinio J, Negrao A, Mantzoros C, Kaklamani V, Wong M-L, Bongiorno P B, Mulla A, Cearnal L, Veldhuis J D, Flier J S, McCann S M, Gold P W. Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. P Natl Acad Sci 1998; 95;2541-2546.
1997
Mantzoros C*, Frederich R C*, Qu D, Maratos-Flier E, Lowell B B, Flier J S. Severe leptin resistance in brown fat deficient UCP-DTA mice despite suppression of hypothalamic NPY and serum corticosterone. Diabetes 1998;47:230-238.
Mantzoros C, Flier J S, Lesem M D, Brewerton T D, Jimerson D C. Cerebrospinal fluid leptin in anorexia nervosa: correlation with nutritional status and potential role in resistance to weight gain. J Clin Endocrinol Metab 1997;82:1845-1851.
Mantzoros C*, Licinio J*, Negrao A B, Cizza G, Bongiorno P, Karp B, Hoegland J M, Chrousos G P, Flier J S, Gold P W. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nature Med 1997;3:575-579.
Mantzoros C, Flier J S, Rogol A D. A longitudinal assessment of hormonal and physical alterations during puberty in boys: V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab 1997;82:1066-1070.
Mantzoros C, Tzonou A, Signorello L, Stampfer M, Trichopoulos D, Adami O. Insulin like Growth Factor - 1 in relation to prostate cancer and benign prostatic hyperplasia. Br J Cancer 1997;76:1115-1118.
1996
Houseknecht K, Mantzoros C, Kuliawat R, Hadro E, Flier J S, Khan B B. Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes 1996;45:1638-1643.
Ahima R, Prabakaran D, Mantzoros C, Lowell B B, Qu D, Maratos-Flier E, Flier J S. Role of leptin in the neuroendocrine response to fasting. Nature 1996;382:250-252.
Mantzoros C, Qu D, Frederich R, Maratos-Flier E, Flier J S. Activation of beta-3 adrenergic receptors suppresses leptin expression and mediates a leptin independent inhibition of food intake in mice. Diabetes 1996;45:909-914.
Reviews
Fiorenza C, Chou S, Mantzoros C. Lipodystrophy: Pathophysiology and Advances in Treatment. Nat Rev Endocrinol. 2011 Mar;7(3):137-50. Epub 2010 Nov 16.
Dardeno TA, Chou S, Moon H, Chamberland J, Fiorenza C, Mantzoros CS. Leptin in Human Physiology and Therapeutics. Frontiers in Neuroendocrinology. 2010 Jul;31(3):377-93.
Kelesidis T, Kelesidis I, Chou S, Mantzoros CS. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 2010 Jan 19;152(2):93-100.
Ziemke F, Mantzoros CS. Adiponectin and insulin resistance: lessons from translational research. American Journal of Clinical Nutrition. 2010 Jan;91(1):258S-261S. Epub 2009 Nov 11.
Brennan AM, Mantzoros CS. Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications. Nat Clin Pract Endocrinol Metab. 2006;2:318-327.
Chan JL, Mantzoros CS. Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet. 2005 Jul 2-8;366(9479):74-85. Review.
Matarese G, Moschos S, Mantzoros CS. Leptin in immunology. J Immunol. 2005 Mar 15;174(6):3137-42.
Gale SM, Castracane VD, Mantzoros CS. Energy homeostasis, obesity and eating disorders: recent advances in endocrinology. J Nutr. 2004 Feb;134(2):295-8.
Moschos S, Mantzoros CS. IGF system and malignancy: A review. Oncology 2002; 63(4):317-32.
Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med. 1999 Apr 20;130(8):671-80.
