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The term atherothrombosis encompasses two overlapping areas of research, atherosclerosis and thrombosis. Atherosclerosis affects large arteries of the body, and when complicated by plaque rupture and/or thrombosis may lead to acute myocardial infarction or stroke. Thrombosis, which arises from a maladaptive shift in the hemostatic balance towards the procoagulant side may affect not only large arteries, but also veins and small vessels.

The Center for Vascular Biology Research at Beth Israel Deaconess Medical Center has expertise in several areas related to atherosclerosis and thrombosis. Most notably, structural biologists have been involved in solving the structure of clotting proteins, cell/molecular biologists are focused on the molecular basis of lipoprotein metabolism and the role of the endothelium in mediating hemostatic balance, and translational investigators are studying the hemostatic system in mouse models of sepsis.

Atherothrombosis Researcher Faculty

David J. Friedman, MD

Research area:
Renovascular Disease

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Olivier Kocher, MD, PhD

Research area:
Atherosclerosis, Cholesterol Metabolism and PDZK1

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Mourad Toporsian, PhD

Research area:
Endothelial Mechanisms in Pulmonary Vascular Disease

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Contact Information

Nicole Magner, Administrative Assistant
Center for Vascular Biology Research
Beth Israel Deaconess Medical Center
Research North
99 Brookline Avenue
Boston, MA 02215