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Angiogenesis

Angiogenesis, the sprouting and proliferation of endothelial cells from pre-existing blood vessels is a biological process on which all growing tissues rely. As an important corollary, angiogenesis may play a pathophysiological role in many diseases, including tumors, diabetic retinopathy and wound healing. Notably anti-angiogenesis therapy has recently emerged as an important adjunct to therapy of certain cancers.

A key focus of the Center for Vascular Biology Research at Beth Israel Deaconess Medical Center is to delineate molecular pathways underlying physiological and pathological angiogenesis, and to identify novel diagnostic and therapeutic targets. Areas of interest include placental growth, tumor angiogenesis, wound repair, retinopathy of prematurity, and neovascularization of ischemic tissue.

Angiogenesis Researcher Faculty
Ruhul Abid, MD, PhD Research area: Redox and Signal Transduction in the Endothelium Read his profile >>
Laura Benjamin, PhD Research area: Mechanisms of Blood and Lymphatic Angiogenesis Read her profile >>
Harold F. Dvorak, MD Research area: Vascular Permeability and Angiogenesis Read his profile >>
Marianne A. Grant, PhD Research area: Protein Structure-Function and Biomolecular Recognition Read her profile >>
Elzbieta Kaczmarek PhD Research area: P2 Receptor Signaling in Endothelial Cells Read her profile >>
Ananth Karumanchi, MD Research area: Pre-eclampsia Read his profile >>
Jack Lawler, PhD Research area: Tissue Remodeling and Angiogenesis by Thrombospondins Read his profile >>
Janice A. Nagy, PhD Research area: VEGF and Pathological Vascular Phenotype Read her profile >>
Donald R. Senger, PhD Research area: Capillary Morphogenesis Read his profile >>
Shou-Ching Shih, PhD Research area: Intercellular Communication and Angiogenesis Read her profile >>
Huiyan Zeng, PhD Research area: Signaling pathways of Angiogenesis Read her profile >>
Dezheng Zhao, PhD Research area: Signaling in Pathogenic Angiogenesis Read his profile >>