The Center for Vascular Biology Research (CVRB) is supported by the Departments of
Emergency Medicine and
Pathology. The Center is led by a Director. The Director, in turn reports to an Executive Committee comprising the Chairs of the three Departments.
William C. Aird, MD
Dr. William Aird is currently Professor of Medicine at Harvard Medical School and Chief,
Division of Molecular and Vascular Medicine at the BIDMC. He has devoted most of his career to promoting an awareness of the endothelium as a systemically distributed organ. He has employed a highly integrative and interdisciplinary approach to develop the field of endothelial biomedicine. His research has centered on the proximate and evolutionary mechanisms of endothelial cell heterogeneity, with the goal of understanding the pathophysiology and therapeutic potential of vascular bed-specific diseases. Dr. Aird is founder and first chairman of the bi-annual Gordon Research Conference on Endothelial Cell Phenotypes in Health and Disease. He has edited two books, including Endothelial Cells in Health and Disease (Taylor and Francis, New York, 2005) and Endothelial Biomedicine (Cambridge University Press, Cambridge 2007). He received his medical degree from the University of Western Ontario in 1985. After completing his internal medicine and chief medical residency at the University of Toronto, he undertook a Hematology fellowship at the Brigham and Women's Hospital, Harvard Medical School. Dr. Aird received his postdoctoral training in Robert Rosenberg's laboratory at the Massachusetts Institute of Technology.
Jeffrey E. Saffitz, MD, PhD
Dr. Jeffrey E. Saffitz is Chairman of the
Department of Pathology at Beth Israel Deaconess Medical Center and Mallinckrodt Professor of Pathology at Harvard Medical School. The Department of Pathology comprises a large clinical component, involving both Anatomic and Clinical Pathology. In addition, the Department has a strong research component with investigators located in the Center for Vascular Biology Research and the Center for Life Sciences Building. Investigators have varied interests, including the molecular and cellular mechanisms that are involved in tumor progression, angiogenesis, inflammation, and neuronal and cardiac muscle cell physiology. Ongoing studies are elucidating the molecular mechanisms that regulate the survival, migration, invasion, metastasis, and apoptosis of tumor cells, stromal fibroblasts, endothelial cells and immune cells within the tumor microenvironment. Dr. Saffitz's research is focused on cell-cell communication via gap junctions in the heart.
Richard E. Wolfe, MD
Dr. Richard E. Wolfe is Chief of
Emergency Medicine at Beth Israel Deaconess Medical Center and Associate Professor of Medicine at Harvard Medical School. An active clinician and teacher, Dr. Wolfe was previously director of the residency in emergency medicine at Brigham and Women's Hospital and served as chair of the Education Committee for the American College of Emergency Physicians. He is currently a member of the Emergency Medicine Connections task force. The Emergency Medicine Department at BIDMC currently supports a strong basic and translational research program in sepsis and endothelial dysfunction at the Center for Vascular Biology Research. Dr. Wolfe's research interests include ultrasound applications in emergency medicine, use of the laboratory in the evaluation of sepsis, and education and structure in postgraduate emergency medicine training.
Mark L. Zeidel, MD
Dr. Mark L. Zeidel is Physician-in-Chief and Chairman of the
Department of Medicine at Beth Israel Deaconess Medical Center and Herrman Ludwig Blumgart Professor of Medicine at Harvard Medical School. There are 24 Divisions in the Department of Medicine, 11 involving clinical and research activities and 13 that are research-based. The Center for Vascular Biology Research is represented by Principle Investigators from the Divisions of Cardiology, Molecular and Vascular Medicine, Pulmonary Medicine, Nephrology, and Gastroenterology. The Department is recognized nationally for the excellence of its faculty and the magnitude and breadth of its research productivity. In fiscal year 2006, the Department had externally funded research of over $147 million, placing it among the ten best funded Medical School Departments of Medicine in the country. Dr. Zeidel's research interests include epithelial biology and water transport.