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  • Dezheng Zhao, PhD
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Dezheng Zhao, PhD

Assistant Professor of Medicine
Beth Israel Deaconess Medical Center
Harvard Medical School

330 Brookline Avenue, RN-270J
Boston, MA 02215

Office: 617-667-0466
Email: dzhao@bidmc.harvard.edu

Zhao Lab >>

Education/Training/Appointments

Ph.D. in Biochemistry in 2000 from Boston University. Postdoctoral fellow at BIDMC from 2000-2002. Instructor of Medicine from 2002-2007. Appointed Assistant Professor of Medicine in 2007.

Research Interests

Signaling in Pathogenic Angiogenesis

Basic Research

This laboratory has two main research interests:

1. Function and molecular mechanism of orphan nuclear receptor Nur77 family members in pathological angiogenesis and related diseases particularly inflammatory bowel diseases and colon cancer.
   
   
2. Function and mechanism of neuropeptides in pathological angiogeneis, inflammatory bowel diseases and colon cancer.

New and Noteworthy Publications

View all publications via PubMed >>

1. Zhao D. Protein kinase C-delta-mediated CREB activation regulates ghrelin-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colonic epithelial cells. J Cell Biochem 2007, 102:1245-1255.
   
   
2. Qin L, Zeng H, Zhao D. Requirement of PKD tyrosine phosphorylation for VEGF-A165-induced angiogenesis through its interaction and regulation of phospholipase C? phosphorylation. J Biol Chem. 2006, 281(43): 32550-8.
   
   
3. Zhao D*, Zhan Y, Zeng H, Koon HK, Moyer MP, Pothoulakis C. Neurotensin stimulates expression of early growth response-gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. Int J Cancer, 2007, 120:1652-1656 (*Corresponding Author).
   
   
4. Zeng H, Qin LL, Zhao D, Tan X, Manseau EJ, Hoang MV, Senger DR, Brown LF, Nagy JA, Dvorak HD. Orphan Nuclear Receptor TR3/Nur77 regulates the early steps of VEGF-A-induced angiogenesis through its transcriptional activity. J Exp Med. 2006, 203: 719-729.
   
   
5. Zhao D, Zhan Y, Koon HW, Zeng H, Keates S, Moyer MP, Pothoulakis C. Metalloproteinase-dependent TGF-beta release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. J Biol Chem 2004, 279: 43547-54.