David J. Friedman, MD
Instructor in Medicine
Beth Israel Deaconess Medical Center
Harvard Medical School
330 Brookline Avenue, RN-227B
Boston, MA 02215
Friedman Lab >>
David Friedman received his medical degree from the Yale School of Medicine. He completed internal medicine residency and clinical fellowship in nephrology at BIDMC. After completing a research fellowship in nephrology, he was appointed Instructor in Medicine at Harvard Medical School in 2007 and joined the CVBR in 2008.
My laboratory studies three main topics: (1) Renal microvascular disease, particularly diabetic nephropathy, (2) Renovascular autoregulation and (3) Venous arterialization, with applications to arteriovenous fistula maturation and stenosis. The common theme linking these three topics is an interest in the puringeric signaling system. This system is composed of purinergic receptors (P2X and P2Y), adenosine receptors, and the ectonucleotidases that regulate extracellular purine levels. Purinergic signaling is important in many cellular processes including inflammation, thrombosis, apoptosis, cell growth, and blood vessel tone. We use knock-out and transgenic mice for various components of this system to investigate their roles in normal physiology and disease models. In addition, along with collaborators at the Broad Institute and Wake Forest School of Medicine, we test human variation in these genes to study their role in human disease.
New and Noteworthy Publications
View all publications via PubMed >>
Enjyoji K, Ko K, Thukral C, Blumel B, Sun X, Wu Y, Imai M,
Friedman D, Csizmadia E, Bleibel W, Kahn BB, Robson SC. (2008) Deletion of Cd39/Entpd1 results in hepatic insulin resistance. Diabetes. In Press.
Friedman DJ, Faulhaber-Walter R, Mizel D, Castrop H, Enjyoji K, Robson SC, Schnermann JB. (2008) Tubuloglomerular Feedback and Renin Secretion in NTPDase1/CD39-deficient Mice. Am J Physiol Renal Physiol. In Press.
Dwyer KM, Deaglio S, Gao W,
Friedman D, Strom TB, Robson SC. (2007) CD39 and control of cellular immune responses. Purinergic Signal. 2007 3:171-180.
Deaglio S, Dwyer KM, Gao W,
Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. (2007) Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 204:1257-65.
Friedman DJ, Rennke H, Csizmadia E, Enjyoji K, and Robson SC. (2007) The Vascular Ectonucleotidase ENTPD1 is a Novel Renoprotective Factor in Diabetic Nephropathy. Diabetes 56:2371-9.