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Federica del Monte Laboratory

Federica del Monte, MD, PhD

Associate Professor in Medicine
Harvard Medical School
CardioVascular Institute
Beth Israel Deaconess Medical Center
3 Blackfan Circle, E/CLS906
Boston MA 02215
tel: 617.735.4246
fax: 617.735.4207

Education / Training / Appointments

Dr. del Monte received her MD degree and Cardiology Specialty degree from University of Rome Sapienza (Italy). Subsequently she was awarded a Bristol-Meyer Squibb fellowship to perform basic research at Cardiac Medicine research laboratories and enrolled in the PhD program. She obtained her PhD degree in Physiology and Pharmacology from the Imperial College of Science and Technology, London (UK) for her studies with Professor Sian Harding. She was also appointed as Senior Registrar at the Royal Brompton National Heart & Lung Institute where she worked with Professor Philip Poole-Wilson at the heart failure clinic and Professor Jane Somerville at the adult congenital heart disease clinic. She then returned to Italy where she was staff clinical cardiologist at the Italian National Hospital while continuing her research at the University of Rome Sapienza. Dr. del Monte interest in the basic mechanisms of heart failure brought her to work as post-doctoral fellow in the laboratory of Dr. Hajjar at Massachusetts General Hospital where she was soon promoted to Instructor and Assistant Professor in Medicine at Harvard Medical School. As junior faculty she was awarded the NIH K08 grant. She was then recruited at Beth Israel Deaconess Medical Center in 2008 where she is currently an Associate Professor in Medicine and directs the laboratory of cardiac muscle pathophysiology and the large animal laboratory. For her work Dr. del Monte has been awarded NIH, AHA and Harvard Stem Cell Institute grants. Dr. del Monte has been appointed as Visiting Professor at the University of Rome “Sapienza” and at the University of Sassari (Italy). Dr. del Monte is also an Associate Member of the Broad Institute.

Supporting activities: In addition to devoting time to research, and to administrative activities Dr. del Monte is actively involved in mentoring and teaching the new generations of clinician scientists from her experience as reviewer for K08 and K99-R00 NIH grants; she has co-organized the weekly seminar series and she is organizing (and lecturing at) the new T32 educational seminar series. In addition Dr. del Monte takes part in the training course organized by Professor Zeidel for residents in Internal Medicine and General Surgery. The course is hold at the Mount Desert Island Biological Laboratories and is aimed at understanding of basic physiological concepts through hands-on experiments in a research laboratory using model systems (toad, zebrafish, roundworm, shark, Xenopus oocyte, in an evolutionary comparative approach) combined with modern molecular techniques. Since 2007 Dr. del Monte has been invited to teach at the HST cardiovascular physiology course at MIT. Dr. del Monte is serving in the scientific community at national and international meetings, scientific associations and federal agencies.

Research Interest

Dr. del Monte's research program focuses on basic and translational mechanisms of dilated cardiomyopathy and heart failure. Our laboratory utilizes a number of approaches including: in-vivo organ physiology, mice models of heart failure and Alzheimer disease and large animal models of cardiovascular diseases, cell physiology (animal and human cardiomyocytes), genetic, genomics, proteomics, biochemical, biophysical and structural-chemistry approaches.

Our research interests include 1) the elucidation of the role of calcium handling abnormalities in the hypertrophic and failing heart; 2) the mechanisms of endoplasmic reticulum stress and the role of protein misfolding in heart failure; 3) the mechanisms of cell toxicity of misfolded protein aggregates.

Highlighted Publications

  • del Monte F (Corresponding Author), Lebeche D, Guerrero JL, Tsuji T, Doye AA, Gwathmey JK, Hajjar RJ. Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. PNAS 2004; 101 (15): 5622-5627.
  • del Monte F, Harding S, Dec GW, Gwathmey JK, Hajjar RJ. Targeting phospholamban in human heart failure by gene transfer. Circulation 2002; 105: 904-907.
  • Gorza L, del Monte F. Protein unfolding in cardiomyopathies. Heart Fail Clin. 2005 Jul;1(2):237-50.
  • Prunier F, Kawase Y, Gianni D, Scapin C, Danik SB, Ellinor PT, Hajjar RJ, del Monte F: Prevention of ventricular arrhythmias with SERCA2a overexpression in a porcine model of ischemia reperfusion. Circulation 2008; Aug 5;118(6):614-24.
  • Subramanian K, Gianni, D Balla C, Egidy Assenza G., Joshi M., Semigran M, Macgillivray T.E., Van Eyk J., Agnetti G, Paolocci N., Bamburg J.R., Agrawal P.B., del Monte F. Cofilin-2 Phosphorylation and Sequestration in Myocardial Aggregates: Novel Pathogenetic Mechanisms for Idiopathic Dilated Cardiomyopathy. JACC 2015, 65

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