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Publications by Faculty

FACULTY AND SELECTED PUBLICATIONS
ANATOMIC PATHOLOGY

Matthew P. Anderson, MD, PhD, Associate Professor, Harvard Medical School, Departments of Neurology and Pathology; Director of Neuropathology, Beth Israel Deaconess Medical Center; Co-Director, Harvard Longwood Neuropathology Training Program; and Faculty, Harvard Medical School, Neuroscience PhD Program. He recently took on additional responsibilities as the Director of Boston Autism BrainNet and as the Clinical Neuropathologist for the nation-wide Autism BrainNET.

Czupryn A*, Zhou Y-D*, Chen X*, McNay D, Anderson MP†, Flier JS†, Macklis JD†. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science. 2011; 334:1133-1137. *co-first authors; † co-senior authors

Boillot M, Huneau C, Marsan E, Lehongre K, Navarro V, Ishida S, Dufresnois B, Ekim Ozkaynak E, Garrigue J, Miles R, Martin B, Leguern E, , Anderson MP, Baulac S. Glutamatergic neuron-targeted loss of Lgi1-epilepsy gene results in seizures. Brain 2014 in press

Khoury MN, Alsop DC, Agnihotri SP, Pfannl R, Wuthrich C, Ho ML, Hackney D, Ngo L, Anderson MP, Koralnik IJ. Hyperintense cortical signal on magnetic resonance imaging reflects focal leukocortical encephalitis and seizure risk in progressive multifocal leukoencephalopathy. Ann Neurol. 2014;75:659-69.

Gamze Ayata, MD, Staff Pathologist, Director of Cytopathology Fellowship, Instructor in Pathology, HMS

Wang HH and Ayata G. Chapter 7: Gastrointestinal Tract. In: Cibas ES, Ducatman BS, eds. Cytology: Diagnostic principles and clinical correlates. 4th edn, Saunders/Elsevier (in press).

Wang HH and Ayata G. Chapter 3: Diagnostic Cytology of the GI tract. In: Odze RD, Goldblum JR, eds. Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. 3rd edition, Saunders/Elsevier (in press).

Karoly Balogh, MD, Staff Pathologist, Associate Professor of Pathology, HMS

Histology for Pathologists. Ed. by S.E. Mills, Chapter 15. Mouth, Nose, and Paranasal Sinuses. (in print) New York, Raven Press, 4th edition, 2012.

Lawrence F. Brown, MD, Staff Pathologist, Associate Professor of Pathology, HMS

Adini A, Doucette S, Brown LF, Benjamin LE. Prominin/CD133 is not just a marker, but regulates cancer cell survival. Submitted.

Li J, Wang E, Lau J, Schroeder MA, Rinaldo F, Brown LF, Mukhopadhyay D, O’Neill BP, Datta K. Factor inhibiting HIF (FIH) is essential for inhibiting HIF mediated gene transcription in glioblastoma multiforme. Submitted.

Kane SE, Liu FW, Brown LF, Awtrey CS, Hecht JL. Papillary Serous Borderline tumor of the ovary with significant ascites and Vascular Endothelial Growth Factor expression. submitted.

Tracy Challies, MD, Staff Pathologist, GI and Liver Pathology, Instructor in Pathology, Harvard Medical School

Klibansky DA, Mehta S, Curry M, Nasser I, Challies T, and Afdhal NH. Transient elastography for predicting clinical outcomes inpatients with chronic liver disease. J Viral Hepatitis. Article first published on line: 1 JUL 2011/ DOI:10.1111/j.1365-2893.2011.01493.x

Laura C. Collins, MD, Associate Director of Anatomic Pathology; Associate Professor of Pathology, Harvard Medical School

Aroner SA, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, Rosner BA, Hankinson SE, Tamimi RM. Radial scars and subsequent breast cancer risk: results from the Nurses' Health Studies. Breast Cancer Res Treat. 2013;139(1):277-85. PMID: 23609472

Collins LC, Achacoso N, Haque R, Nekhlyudov L, Fletcher SW, Quesenberry, Jr. CP, Schnitt SJ, Habel LA. Risk factors for non-invasive and invasive local recurrence in patients with ductal carcinoma in situ. Breast Cancer Res Treat. 2013;139(2):453-60. PMID: 23624751

Collins LC and Schnitt SJ. Pathology of Benign Breast Disorders. In: Diseases of the Breast. Philadelphia : Lippincott Williams & Wilkins;2014.In press.

James L. Connolly, MD, Staff Pathologist, Professor of Pathology, Harvard Medical School

Aroner SA, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, Rosner BA, Hankinson SE, Tamimi RM. Radial scars and subsequent breast cancer risk: Results from the Nurses’s Health Studies. Breast Cancer Res Treat 2013; 139:277-285.

Ahsen OO, Tao YK, Potsaid BM, Sheikine Y, Jiang J, Grulkowski I, Tsai TH, Jayaraman V, Kraus MF, Connolly JL, Hornegger J, Cable A, Fujimoto JG. Swept source optical coherence microscopy using a 1310 nm VCSEL light source. Opt Express 2013; 21:18021-18033.

Lee HC, Liu JJ, Sheikine Y, Aguirre AD, Connolly JL, Fujimoto JG. Ultrahigh speed sprectral-domain optical coherence microscopy. Biomed Opt Express 2013; 4:1236-1254.

Beverly Faulkner-Jones, MD, PhD, Staff Pathologist, Dermatopathology and Surgical Pathology, Instructor in Pathology, Harvard Medical School

Harris, A., Faulkner-Jones, B.E and Zimarowski, M.J. Epidermal panfolliculoma: A report of two cases. Am J Dermatopathol. 2011 Feb;33(1):e7-10.

Jeong, W; Schneider, J; Hansen, A; Lee, M; Turney, S; Faulkner-Jones, B; Hecht, J; Najarian, R; Yee, E; Lichtman, J; Pfister, H. "A Collaborative Digital Pathology System for Multi-Touch Mobile and Desktop Computing Platforms." Computer Graphics Forum. Vol. 32. Issue 6. Sept 2013

Jeffrey D. Goldsmith, MD, Staff Pathologist, Director of Surgical Pathology Laboratory and GI Pathology Fellowship, Assistant Professor of Pathology, Harvard Medical School

Dyhadalo K, Fitzgibbons P, Goldsmith JD, Souers RJ, Nakhleh RE. Laboratory Compliance with the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) Human Epidermal Growth Factor Receptor 2 Testing Guidelines: A 3-year Caomparison of Validation Procedures. Arch Pathol Lab Med. 2014. In press.

Manfredi MA, Jiang H, Borges LF, Deutsch AJ, Goldsmith JD, Lightdale JR. Good Agreement between Endoscopic Findings and Biopsy Reports Supports Limited Tissue Sampling During Pediatric Endoscopy. J Ped Gastroenterol Nutr. 2014. In press.

Fitzgibbons PL, Bradley LA, Fatheree LA, Alsabeh R, Fulton RS, Goldsmith JD, Haas TS, Karabakhtsian RG, Loykasek PA, Marolt MJ, Shen SS, Smith AT, Swanson PE. Principles of Analytic Validation of Immunohistochemical Assays. Guideline from the College of American Pathologists Pathology and Laboratory Quality Center. Arch Pathol Lab Med. 2014. In press.

Mamta Gupta, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Vang R, Gupta M, Wu LS, Yemelyanova AV, Kurman RJ, Murphy KM, Descipio C, Ronnett BM. Diagnostic Reproducibility of Hydatidiform Moles: Ancillary Techniques (p57 Immunohistochemistry and Molecular Genotyping) Improve Morphologic Diagnosis. Am J Surg Pathol. 2012 Mar;36(3):443-53.

Gupta M, Vang R, Yemelyanova AV, Kurman RJ, Li FR, Maambo EC, Murphy KM, DeScipio C, Thompson CB, Ronnett BM Diagnostic reproducibility of hydatidiform moles: ancillary techniques (p57 immunohistochemistry and molecular genotyping) improve morphologic diagnosis for both recently trained and experienced gynecologic pathologists. Am J Surg Pathol. 2012, Dec;36(12):1747-60.

Li RF, Gupta M, McCluggage WG, Ronnett BM. Embryonal rhabdomyosarcoma (botryoid type) of the uterine corpus and cervix in adult women: report of a case series and review of the literature. Am J Surg Pathol. 2013, Mar;37(3):344-55.

Cynthia Hayne, MD, PhD, Staff Pathologist, Instructor in Pathology, HMS

Hussain G, Tapper E, Mavrakis A, Krajewski K, Hayne C, Yagi Y, Lai M, Holder S, Challies T, Kane R, Afdhal N, Lau D. “Sensitivity of Ultrasound for Hepatic Steatosis Detection Based on Histological and
Digital Scores in Nonalcoholic Fatty Liver Disease.” Presented at Digestive Disease Week 2010.

Jonathan Hecht, MD, PhD, Staff Pathologist, Medical Director of Autopsy Service, Associate Professor of Pathology, Harvard Medical School

Hecht JL, Fichorova R, Allred EN, Leviton, A. The relationship between neonatal blood protein profiles and placenta histologic characteristics in ELGANs Pediatric Research, 2011;69:68-73.

Leviton A, Hecht JL, Allred EN, Yamamoto H, Fichorova RN, Dammann O, Persistence after birth of systemic inflammation associated with umbilical cord inflammation. J Reprod Immunol. 2011 Aug;90(2):235-43.

Hecht JL. Chapter 6: Techniques for Fetal and Placental Examination and Chapter 9: Pre-viable Terminations for Anomalies (with TK Boyd and R Padera). In Pathology of Fetal Death: Principles and Practical Evaluation. Theonia K. Boyd, ed. Springer, 2012.

Yael K. Heher, MD (formerly Yael B Kushner), Staff Pathologist, Director, Quality Assurance and Quality Improvement, Instructor in Pathology, Harvard Medical School

Glassock RJ, Khorashadi L, Kushner YB. Case records of the Massachusetts General Hospital. Case 32-2012. A 35-year-old man with respiratory and renal failure.N Engl J Med. 2012 Oct 18;367(16):1540-53

Spicer J, Benay C, Lee L, Rousseau M, Andalib A, Kushner Y, Marcus V, Ferri L. Diagnostic accuracy and utility of intraoperative microscopic margin analysis of gastric and esophageal adenocarcinoma.Ann Surg Oncol. 2014Aug;21(8):2580-6

Adam B, Randhawa P, Chan S, Zeng G, Regele H, Kushner YB, Colvin RB, Reeve J, Mengel M. Banff Initiative for Quality Assurance in Transplantation (BIFQUIT): Reproducibility of Polyomavirus Immunohistochemistry in Kidney Allografts. Am J Transplant 2014 Aug (e-pub ahead of print)

Nicole B. Johnson, MD, Staff Pathologist, Instructor in Pathology, HMS

Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, and Overholtzer M. A Non-genetic Route to Aneuploidy in Human Cancers. Nature Cell Biology, 2011; 13(3): 324-30.

Johnson NB, Collins LC. Less common variants and mimics of ductal carcinoma in-situ. Surgical Pathology Clinics, Breast Pathology, in press.

Olivier Kocher, MD, PhD, Staff Pathologist, Pulmonary Pathology, Associate Professor of Pathology, Harvard Medical School

Kaczmarek E, Bakker JP, Clarke DN, Csizmadia E, Kocher O, Veves A, Tecilazich F, O'Donnell CP, Ferran C, Malhotra A. Molecular biomarkers of vascular dysfunction in obstructive sleep apnea. PLoS One. 2013, 8:e70559.

Folch E, Yamaguchi N, Vanderlaan PA, Kocher O, Boucher DH, Goldstein MA, Huberman MS, Kent MS, Gangadharan SP, Costa DB, Majid A. Adequacy of Lymph Node Transbronchial Needle Aspirates Using Convex Probe Endobronchial Ultrasound for Multiple Tumor Genotyping Techniques in Non-Small-Cell Lung Cancer. J Thorac Oncol., 2013, 8:1438-1444.

VanderLaan PA, Yamaguchi N, Folch E, Boucher DH, Kent, MS, Gangadharan SP, Majid A, Goldstein MA, Huberman MS, Kocher O, Costa DB. Success and failure rates of tumor genotyping techniques in routine pathological samples with non-small-cell lung cancer. Lung Cancer, 2014, 84:39-44.

Douglas I. Lin, MD, PhD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Winham WM, Lin D, Stone PJ, Nucci MR, Quick CM. Architectural Versus Nuclear Atypia-defined FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma (EEC): A Clinicopathologic Comparison of 154 Cases With Clinical Follow-up. Int J Gynecol Pathol. 2014 Mar; 33(2):120-6.

Nguyen PL, Lin DI, Lei J, Fiorentino M, Mueller E, Weinstein MH, Pagano M, Loda M. The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy. Urol Oncol. 2011 May-Jun; 29(3):302-8.

Robert Najarian, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Ziogas DC, Karagiannis AK, Geiger BM, Gras-Miralles B, Najarian R, Reizes O, Fitzpatrick LR, Kokkotou E. Peptides 2014 May; 55:58-64.

Feuerstein JD, Najarian R, Cheifetz AS. Hickam’s dictum in a patient with diarrhea. Gastroenterology 2013 November; 145(5): 942.

Leffler D, Schuppan D, Pallav K, Najarian R, Goldsmith JD, Hansen J, Kabbani T, Dennis M, Kelly CP. Kinetics of the histological, serological, and symptomatic responses to gluten challenge in adults with celiac disease. Gut 2013 Jul; 62(7): 996-1004.

Imad Nasser, MD, Staff Pathologist Surgical Pathology, Liver Pathology and Cytopathology; Assistant Professor of Pathology, Harvard Medical School

Li S, Vriend LE, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley MA, Alatrakchi N. Hepatitis C virus-specific t-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis. Hepatology. 2012 Dec; 56(6):2094-105.

Turner BG, Sosa A, Nasser IA, Sawhney M. Use of an endobronchial US endoscope in a nearly obstructing esophageal tumor. Gastrointest Endosc. 2012 Nov;76(5):1045-6

Jon AF, Cheema A, Raptopoulos V, Hauser T, Nasser I, Welty F, Karellas A, Clouse M. Quantitative Assessment of Liver Fat in an Obese Patient Population Using Non-contrast CT Fat Percent Index. Clinical Imaging. 2014 May-Jun;38(3):259-64

Michiya Nishino, MD, PhD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Nishino M*, Mathai SK*, Schoenfeld D, Digumarthy S, and Kradin RL. Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. Human Pathology 2014; 45(2):342-351. *co-first authors

Nishino M and Wang HH (2014). Should the thyroid AUS/FLUS category be further stratified by malignancy risk? Cancer Cytopathology 2014 (DOI: 10.1002/cncy.21412).

Nishino M (2014). “Liver FNA biopsy.” Case Studies. American Society of Cytopathology, April 2014. Web. 20 June 2014.

Nishino M and Nosé V (2014). Endolymphatic Sac Tumor. In V. Nosé (Ed.), Familial Cancer Syndromes (pp. II.4.8-11). Amirsys Publishing, Inc.

Rolf Pfannl, MD, Associate Residency Program Director, Associate Director, Longwood Neuropathology Training Program, Assistant Professor of Pathology, Harvard Medical School

Kwak, E. S., Marrero, D. E., Pfannl, R. and Erbay, S. H. Sterile Brain Abscess due to Juvenile Xanthogranuloma:DWI Characteristics. Journal of Neuroimaging, 2012. doi: 10.1111/j.1552-6569 2012.00725.x

Powell M, Pfannl R, Nystrom JS. Looks Like Lung Cancer Acts Like Colon Cancer. Clin Colorectal Cancer. 2012 Oct 16. pii: S1533-0028(12)00111-9. doi: 10.1016/j.clcc.2012.09.004.

GM1-gangliosidosis in American black bears: Clinical, pathological, biochemical and molecular genetic characterization. Muthupalani S, Torres PA, Wang BC, Zeng BJ, Eaton S, Erdely I, Ducore R, Maganti R, Keating J, Perry BJ, Tseng FS, Waliszewski N, Pokras M, Causey R, Seger R, March P, Tidwell A, Pfannl R, Seyfried T, Kolodny EH, Alroy J. Molecular Genetics and Metabolism. February 2014. In press.

Seymour Rosen, MD, Staff Pathologist, Director of Surgical, Renal, and Genitourinary Pathology, Professor of Pathology, Harvard Medical School

Ward A, Konya C, Mark EJ, Rosen S. Granulomatosis With Polyangiitis Presenting as a Renal Tumor. Am J Surg Pathol. 2014 Jul 14. [Epub ahead of print]PMID: 25025447

Zsengellér ZK, Aljinovic N, Teot LA, Korson M, Rodig N, Sloan JL, Venditti CP, Berry GT, Rosen S. Methylmalonic acidemia: A megamitochondrial disorder affecting the kidney. Pediatr Nephrol. 2014 May 28. [Epub ahead of print]PMID: 24865477

Heyman SN, Rosenberger C, Rosen S, Khamaisi M. Why is diabetes mellitus a risk factor for contrast-induced nephropathy? Biomed Res Int. 2013;2013:123589. doi: 10.1155/2013/123589. Epub 2013 Nov 21. Review.PMID: 24350240

Jeffrey E. Saffitz, MD, PhD, is the Mallinckrodt Professor of Pathology at Harvard Medical School, and Chairman of the Department of Pathology at Beth Israel Deaconess Medical Center

Haspel RL, Saffitz JE: Genomic oncology education: An urgent need, a new approach. Cancer J, 2014, 20:91-95.

Asimaki A, Saffitz JE: Remodeling of Cell-Cell Junctions in Arrhythmogenic Cardiomyopathy. Cell Commun Adh, 2014, 21:13-23.

Saffitz JE, Sanders SP: Post-mortem analysis of structural heart defects in fetuses and children by magnetic resonance imaging – an alternative to autopsy? Circulation (invited editorial), 2014; 129:1909-1911.

Stuart J. Schnitt, MD, Director of the Division of Anatomic Pathology at Beth Israel Deaconess Medical Center, Co-leader of the Dana Farber Harvard Cancer Center Breast Program, Professor of Pathology at Harvard Medical School and an internationally recognized expert in breast pathology

Moran MS, Schnitt SJ, Giuliano AE, Harris JR, Khan SA, Horton J, Klimberg S, Chavez-MacGregor M, Freedman G, Houssami N, Johnson PL, Morrow M. Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer. Int J Radiat Oncol Biol Phys 2014;88:553-564.

Moran MS, Schnitt SJ, Giuliano AE, Harris JR, Khan SA, Horton J, Klimberg S, Chavez-MacGregor M, Freedman G, Houssami N, Johnson PL, Morrow M. Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer. Ann Surg Oncol 2014 (e-published ahead of print February 10, 2014).

Moran MS, Schnitt SJ, Giuliano AE, Harris JR, Khan SA, Horton J, Klimberg S, Chavez-MacGregor M, Freedman G, Houssami N, Johnson PL, Morrow M. Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer. J Clin Oncol 2014 (e-published ahead of print February 10, 2014).

Isaac E. Stillman, MD, Staff Pathologist, Renal Pathology, Director, Clinical Electron Microscopy, Associate Professor of Pathology, Harvard Medical School

Stillman IE, Karumanchi SA. Vasculitis is an antiangiogenic state. J Am Soc Nephrol 2012 Jan; 23(1):8-10. Epub 2011 Dec 15.

Rajakumar A, Cerdeira A, Hubel CA, Jeyabalan A, Rana S, Zsengellér Z, Stillman IE, Parikh SM, Karumanchi, S. A. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating sFlt1 in preeclampsia. Hypertension. 2012 Feb;59(2):256-64.

Zsengellér Z, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, and Pacher P. Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. J Histochem Cytochem, 2012 Jul;60(7).

Steven R. Tahan, MD, Director of Dermatopathology, Associate Professor of Pathology, Harvard Medical School

Roujeau JC, Mockenhaupt M, Tahan SR, Henshaw J, Martin EC, Harding M, van Baelen B, Bengtsson L, Singhal P, Kauffman RS, Stern RS. Telaprevir-Related Dermatitis. Arch Dermatol 2012 Nov 19:1-7. doi: 0.1001/jamadermatol.2013.938.

Park JJ, Hawryluk EB, Tahan SR, Flaherty K, Kim CC. Cutaneous granulomatous eruption and successful response to potent topical steroids in metastatic melanoma patients undergoing targeted BRAF inhibitor treatment. JAMA Dermatol 2013 Dec 18. doi: 10.1001/jamadermatol.2013.7919.

Korman JB, Burgin S, Tahan SR. Intralymphatic histiocytosis in association with severe osteoarthritis of the shoulder. J Am Acad Dermatol. 2013 Dec;69(6):e314-5. doi: 10.1016/j.jaad.2013.08.020. PubMed PMID: 24238195.

Paul A. VanderLaan, MD, PhD, Cytopathologist and Thoracic Pathologist, Instructor in Pathology, Harvard Medical School

VanderLaan PA, Yamaguchi N, Folch E, Boucher DH, Kent MS, Gangadharan SP, Majid A, Goldstein MA, Huberman MS, Kocher ON, Costa DB. Success and failure rates of tumor genotyping techniques in routine pathological samples with non-small-cell lung cancer. Lung Cancer. 2014;84:39-44. PMID: 24513263

VanderLaan PA, Wang HH, Majid A, Folch E. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): An overview and update for the cytopathologist. Cancer Cytopathol. 2014 [in press]. PMID: 24760496

VanderLaan PA, Krane JF. Head and Neck: Thyroid. In: Atlas of Fine Needle Aspiration Cytology. Domanski HA editor. Springer-Verlag London, England. 2014.

Helen H. Wang, MD, MPH, DrPH, Medical Director of Cytology, Professor of Pathology, Harvard Medical School

VanderLaan PA, Wang HH, Majid A, Folch E. Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA): An overview and update for the cytopathologist. Cancer Cytopathol, in press.

Wang HH, Ayata G. Gastrointestinal tract. In: Cibas ES and Ducatman BS, eds. Cytology. Diagnostic Principles and Clinical Correlates, 4th Edition. Philadelphia: Elsevier, in print.

Wang HH, Ayata G. Diagnostic cytology of the GI tract. In: Odze RD, Goldblum JR, eds. Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas, 3rd Edition. Philadelphia: Elsevier, in print.

Hong Wu, MD, PhD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Chuang, GS., Lu, LK., Cummins, DL, Wu, H, Finn, D , Rogers,GS and Lee, D. Incidence of invasive squamous cell carcinomas in biopsy proven squamous cell carcinoma in-situ sent for Mohs micrographic surgery. Dermatol Surg. 38(9): 1456-60, 2012

Wu, H, Allan, AE, Harrist, TJ. Noninfectious Vesiculobullous and Vesiculopustular Diseases. 11th edition of Lever’s Histopathology of the Skin. Accepted for publication

Fulton, E, Larson, A, Wu, H. Cutaneous Orf. American Society of Dermatopathology. Accepted for poster presentation

Huihui Ye, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Ye H, Kong X, He TW, Jolis T, Choi K, Lepor H, Melamed J. Intraoperative frozen section analysis of apical margin biopsies during radical prostatectomy: ten year experience from a single institution. Urology. 2011 Aug;78(2):399-404. Epub 2011 May 31.

Ye H, Ulbright T. Difficult differential diagnoses in testicular pathology. Arch Pathol Lab Med. 2012 Apr;136(4):435-46.

Xu B… Ye H, … F Brimo. Biopsy Characteristics in Men with a Preoperative Diagnosis of Prostatic Adenocarcinoma with High Gleason Score (GS= 8-10) Predict Pathologic Outcome in Radical Prostatectomy. Hum Path. 2014. Accepted.

Eric Yee, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Yee, E; Goldsmith, J. "Diarrheal Illness in the Pediatric Population: A Review of Neonatal Enteropathies and Childhood Idiopathic Inflammatory Bowel Disease." Surgical Pathology Clinics. Vol. 6. No. 3. Sept 2013

Allard, F; Yee, E; Freitag, S. "Dacrocystitis Secondary to Intranasal Cocaine Abuse: A Case Report and Literature Review." Orbit. Vol. 30. No. 6. Dec 2013.

Millo, N; Yee, E; Mortele, K. "Mammary-type Myofibroblastoma of the Liver: Multi-modality imaging features with histopathologic correlation." Abdominal Imaging. Vol. 39. Issue 3. June 2014

Mary Jane Zimarowski, MD, Staff Pathologist, Dermatopathology and Surgical Pathology, Instructor in Pathology, Harvard Medical School

Chan MP, Zimarowski MJ. Lupus erythematosus-like reaction in imiquimod-treated skin: a report of two cases. Am J Dermatopathol. 2011 Jul;33(5):523-7.

Gee SN, Harris AC, Zimarowski MJ. Churg-Strauss syndrome presenting as scar reactivation: histopathologic features and an illustration of “locus minoris resistentiae”. J Cutan Pathol. 2013 May;40(5):491-6. doi: 10.1111/cup.12099.

Shalin SC, Cukras A, Zimarowski MJ. Granular Parakeratosis Mimicking Pustular Psoriasis: An Unusual Presentation. Poster presentation at the 48th Annual Meeting of The American Society of Dermatopathology (ASDP), 2011.

FACULTY AND SELECTED PUBLICATIONS
CLINICAL PATHOLOGY

Ramy A. Arnaout, MD, PhD, Associate Director of Clinical Microbiology, Director of Reference Lab Testing, Assistant Professor of Pathology, Harvard Medical School

Arnaout R, Lee W, Cahill P, Honan T, Sparrow T, Weiand M, et al. High-resolution description of antibody heavy-chain repertoires in humans. PLoS One. 2011;6(8):e22365. PMCID: 3150326.

Arnaout R, Buck T, Roulette P, Sukhatme V. Predicting the Cost and Pace of Pharmacogenomic Advances: An Evidence-Based Study. Clin Chem. 2013; 59(4):649-57.

da Baca M, Arnaout R, Brodsky V, Birdsong G. Ordo ab chao: Framework for an Integrated Disease Report. Arch Pathol. Lab Med. 2014; in press.

Anders Berg, MD, PhD, Assistant Director, Clinical Chemistry, Instructor in Pathology, Harvard Medical School

Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, Wenger J, Karumanchi SA, Thadhani R, Bhan I. Vitamin D binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011 Jul;26(7):1609-16. PMID: 21416506

Berg AH. Abstract Title: Vitamin D Binding Protein Modifies the Vitamin D-Bone Mineral Density Relationship. Presented at AACC Annual Conference in 2011. Received Distinguished Abstract award from the National Academy of Clinical Biochemistry, and the Best Abstract Award from the Nutrition Division of the American Academy of Clinical Chemistry.

Parul Bhargava, MD, Medical Director, Hematology, Assistant Professor of Pathology, Harvard Medical School

Bogusz A, Bhargava P. An Unusual Patient With Shortness of Breath- Clinical, radiologic and pathologic pitfalls. American Journal of Hematology 2014 May;89(5):558-63.

Bhargava P and Kadin ME; Chapter 5; Immunohistology of Hodgkin Lymphoma. Diagnostic Immunohistochemistry by Dabbs, 4th edition 2014. Publisher Elsevier.

Bhargava P and other members of the Hematology and Clinical Microscopy Resource Committee, College of American Pathologists, 2014 Hematology and Clinical Microscope Glossary

Christine Bryke, MD, Medical Director of Cytogenetics; Instructor in Pathology, Harvard Medical School

Dongli Huang, Christine Bryke, Zunyan Dai, JoAnn Kelly, John Cho Lee, Ya-Hsuan Hsu, Rhonda Mackendrick, Jennifer Otani and Philip Mowrey, Chromothripsis of 21q including deletion of 5' RUNX1 Revealed by Oligo-SNP Array in a Patient with AML and a Constitutional Ring Chromosome 21 (Poster presentation) ACMG Annual Clinical Genetics Meeting, 2014.

Dai Z, Kelly JC, Meloni-Ehrig A, Slovak ML, Boles D, Christacos NC, Bryke CR,
Schonberg SA, Otani-Rosa J, Pan Q, Ho AK, Sanders HR, Zhang ZJ, Jones D,
Mowrey PN.: Incidence and patterns of ALK FISH abnormalities seen in a large
unselected series of lung carcinomas. Mol Cytogenet. 2012 Dec 3;5(1):44. doi:
10.1186/1755-8166-5-44.

Chorzalska, A., Salloum, I., Shafqat, H., Khan, S., Marjon, P., Treaba, D., Schorl,
C., Morgan, J., Bryke, C.R., Falanga, V., Zhao, T., Reagan, J., Winer, E.,
Olszewski, A., Al-Homsi, S., Kouttab, N., Dubielecka, P.M.: Low expression of
Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced
leukemia. Leukemia 2014 in press.

Rajan Dewar, MD, PhD, Assistant Director, Hematopathology; Instructor in Pathology, Harvard Medical School

Dewar R, Chen ST, Yeckes-Rodin H, Miller K, Khosravi-Far R. Bortezomib treatment causes remission in a Ph+ ALL patient and reveals FoxO as a theranostic marker. Cancer Biol Ther. 2011 Mar 15;11(6). (Editorial Commentary & COVER PAGE ILLUSTRATION)

Dewar R, Fadare O, Gilmore H, Gown A. Best practices in diagnostic immunohistochemistry: Myoepithelial markers in breast pathology. Arch Pathol Lab Med., 2011. 135 (4): page 422-429. (COVER PAGE ILLUSTRATION)

Dewar R, Parkash V, Forrow L, Truog R. Apologies for Pathologists: Why, When and How to say Sorry after committing a medical error. Int. J Surg. Pathol. 2013. May 10 [Epub ahead of print]. PMID: 23667133.

Richard Haspel, MD, PhD, Pathology Residency Training Program Director; Medical Director, Stem Cell Processing Laboratory; Assistant Professor of Pathology, Harvard Medical School

Haspel RL, Lin Y, Fisher P, Ali A, Parks E. Development of a validated exam to assess physician transfusion medicine knowledge. Transfusion 2014; 54:1225-30.

Haspel RL, Ballen KK. Cord blood transplants: perinatal stem cells in clinical practice. In: Cetrulo CL, Cetrulo KJ and Cetrulo CL, Jr, eds. Perinatal Stem Cells, 2nd edition. Hoboken, NJ: John Wiley and Sons; 2013:17-36.

Haspel RL, Olsen RJ, Berry A, Hill CE, Pfeifer JD, Schrijver I, Kaul KL. Progress and potential: training in genomic pathology. Arch Pathol Lab Med. 2014; 138: 498-504.

Gary L. Horowitz, MD, Medical Director, Clinical Chemistry; Associate Professor of Pathology, Harvard Medical School

Saxena AR, Karumanchi AS, Fan SL, Horowitz GL, Hollenberg NK, Graves SW, and Seely EW., “Correlation of Cystatin-C with Glomerular Filtration Rate by Inulin Clearance in Pregnancy,” Hypertension in Pregnancy. Hypertens Pregnancy. 2012;31(1):22-30. Epub 2011 Oct 18.

James E. Kirby, MD, Medical Director, Clinical Microbiology; Assistant Professor of Pathology, Harvard Medical School

Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, and Lee JT. Xist RNA is a potent suppressor of hematologic cancer. Cell. 2013. Feb 14;152(4):727-42. PMCID: PMC3875356.

Cheng A and Kirby JE. Evaluation of the Hologic Gen-Probe PANTHER, APTIMA Combo 2 assay in a tertiary care teaching hospital. 2014. American Journal of Clinical Pathology. Mar;141(3):397-403.

Chiaraviglio L and Kirby JE. Evaluation of impermeant, DNA-binding dye fluorescence as a real-time readout of eukaryotic cell toxicity in a high throughput screening format. Assay Drug Dev Technol. 2014. May;12(4):219-28. PMCID: PMC4026211.

Kerry O’Brien, MD, Associate Medical Director, Blood Bank; Instructor in Pathology, Harvard Medical School

O’Brien KL, Pereira SE, Wagner J, Shadman M, Hendrie P, Nelson K, Gernsheimer TB, Price T, Reyes JD, Nester T. Transfusion-associated graft-versus-host disease in a liver transplant recipient: an unusual case presentation and review of the literature. Transfusion 2013;53:174-180.

O’Brien KL, Price TH, Howell C, Delaney M. The use of 50% albumin / plasma replacement fluid in therapeutic plasma exchange for thrombotic thrombocytopenic purpura. Journal of Clinical Apheresis 2013;28:416-421.

O’Brien KL, Haspel RL, Uhl, L. Anti-D alloimmunization after D incompatible platelet transfusions: A 14 year single institution retrospective review. Transfusion 2014;54:650-654.

O’Brien KL, Kim, YA. Haspel RL, Uhl, L. Provision of KEL1-negative blood to obstetric patients: A three-year single-institution retrospective review. (accepted to Transfusion July 9, 2014).

J Ryan Pena, MD, PhD, Assistant Clinical Director, HLA Laboratory, Instructor in Pathology, Harvard Medical School

Peña JA, Lewandrowski KB, Lewandrowski EL, Gregory K, Baron JM and Van Cott EM (2012). Evaluation of the i-STAT point-of-care capillary whole blood prothrombin time and international normalized ratio: comparison to the Tcoag MDAII coagulation analyzer in the central laboratory. Clin Chim Acta. Jun;413(11-12):955-9.

Peña JA, Ferraro MJ, Hoffman CG and Branda JA. (2012). Growth detection failures by the non-radiometric BACTEC MGIT 960 mycobacterial culture system. J Clin Microbiol. Jun;50(6):2092-5.

German Pihan, MD, Director, Hematopathology; Assistant Professor of Pathology, HMS

Zota V, Braza J, Pantanowitz L, Dezube BJ, Pihan G. A 57-year-old HIV-positive man with persistent fever, weight loss, and pancytopenia. Am J Hematol. 2009 Jul;84(7):443-6.

Li L, Wang H, Kim JS, Pihan G, Boussiotis VA. The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell Cycle. 2009 Jun 1;8(11):1794-802.

Pantanowitz L, Pihan G, Carbone A, Dezube BJ. Differentiating HIV-associated non-Hodgkin lymphomas with plasmacellular differentiation. Journal HIV Therapy 2009; 14:24-33.

Qinfang Qian, MD, PhD, Associate Director, Clinical Microbiology; Assistant Professor of Pathology, Harvard Medical School

Qian Q, Eichelberger K, Kirby JE. Rapid Identification of Staphylococcus aureus directly from BACTEC Blood Culture broth by BinaxNOW S. aureus test. J. Clin. Micro. 2014; 52:319-320

Qian Q, Urman G, Cederroth T, Najarian R, Kirby JE. Photo Quiz: A Man with Fever and Cough. J. Clin. Micro. In press.

Qian Q, Urman G, Cederroth T, Najarian R, Kirby JE. Answer to Photo Quiz: Fatal Pulmonary Blastomyces dermatitidis Infection. J. Clin. Micro. In press

Nicole V Tolan, PhD, Associate Director of Clinical Chemistry and the Medical Director of Point-of-Care Testing. Instructor in Pathology, Harvard Medical School

Nicole V. Tolan, Rafael J. Sierra, and Thomas P. Moyer. Evidence against implant-derived cobalt toxicity: case report and retrospective study of serum cobalt concentrations in an orthopedic implant population. Clinical Biochemistry, Accepted.

Nicole V. Tolan, Noemi Vidal-Folch, Alicia Algeciras-Schimnich, Ravinder J. Singh and Stefan K. Grebe. Individualized Correction of Neuron-Specific Enolase (NSE) Measurement in Hemolyzed Serum Samples. Clin Chim Acta, 2013; 424, 216-221.

Nicole V. Tolan and Loralie J. Langman. Carisoprodol: Now a Schedule IV Controlled Substance. Clinical and Forensic Toxicology News. 2012.

Lynne Uhl, MD, Director, Division of Clinical Pathology; Medical Director, Transfusion Medicine; Associate Professor of Pathology, Harvard Medical School

Goodell PP, Uhl L, Mohammed M, Powers AA. Risk of hemolytic transfusion reactions following emergency-release RBC transfusion.Am J Clin Pathol. 2010 Aug;134(2):202-6.

Wahl PM, Terrell DR, George JN, Rodgers JK, Uhl L, Cataland S, Bohn RL. Validation of claims-based diagnostic codes for idiopathic thrombotic thrombocytopenic purpura in a commercially-insured population. Thromb Haemost 2010 Mar 29;103(6).

Uhl L. Alternatives to transfusion: perioperative blood management. In: Simon TL,ed. Rossi’s Principles of Transfusion Medicine, 4th Edition. Oxford UK: Wiley-Blackwell, 2009. p 566-574.

EXPERIMENTAL PATHOLOGY

 
Ramy A. Arnaout, MD, PhD, see Clinical Pathology

Angeliki Asimaki, PhD, Instructor in Pathology, Harvard Medical School, Research Associate

Park JK, Rosen A, Saffitz JE, Asimaki A, Litovsky SH, Mackey-Bojack SM, Halushka MK. Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: systematic analysis. Rheumatology (Oxford) 2013;52(8):1529-1533. PMID:23674817

Noorman M, Hakim S, Asimaki A, Vreeker A, van Rijen HV, van der Heyden MA, de Jonge N, de Weger RA, Hauer RN, Saffitz JE, van Veen TA. Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations. Cardiovasc Pathol. 2013;22(5):314-318. PMID:23688911

Asimaki A, Kapoor S, Plovie E, Arndt AK, Adams E, Liu Z, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae AC, Kléber AG, Saffitz JE. An in-vivo drug screen in zebrafish identifies a novel modulator of intercalated disc remodeling in arrhythmogenic cardiomyopathy. Science Translational Medicine. 2014 June 4th [in press]

Andrew Beck, MD, PhD, Director of the Molecular Epidemiology Research Laboratory; Assistant Professor of Pathology, Harvard Medical School

Beck AH, Sangoi AR, Leung S, Marinelli RJ, Nielsen TO, van de Vijver MJ, West RB, van de Rijn M, Koller D. Systematic analysis of breast cancer morphology uncovers stromal features associated with survival. Sci Transl Med. 2011 Nov 9;3(108):108ra113.

Beck AH, Knoblauch NW, Hefti MM, Kaplan J, Schnitt SJ, Culhane AC, Schroeder MS, Risch T, Quackenbush J, Haibe-Kains B. Significance Analysis of Prognostic Signatures. PLoS Comput Biol. 2013;9(1):e1002875.

Hefti MM, Hu R, Knoblauch NW, Collins LC, Haibe-Kains B, Tamimi RM, Beck AH. Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. Breast Cancer Res. 2013 Aug 23;15(4):R68.

Katie Bentley, PhD, Group Leader of the Computational Biology Laboratory, Assistant Professor of Pathology, Harvard Medical School

Bentley, K., Jones, M., Cruys, B. (2013) Predicting the future: towards symbiotic computational and experimental angiogenesis research. Experimental Cell Research. In Press Doi: 10.1016/j.yexcr.2013.02.001.

Bentley, K., Gerhardt, H. and Bates, P. A. (2008) Agent-based simulation of notch mediated tip cell selection in angiogenic sprout initialisation. Journal of Theoretical Biology, 250(1):25-36.

Bentley, K., Mariggi, G., Gerhardt, H. and Bates, P. A. (2009) Tipping the balance: Robustness of Tip Cell Selection, Migration and Fusion in Angiogenesis. PLoS Computational Biology 5(10): e1000549. doi:10.1371/journal.pcbi.1000549.

Bentley, K., Franco, C.A. Philippides, A., Blanco, R., Dierkes, M., Gebala, V., Stanchi, F., Jones, M., Aspalter, I. M., Cagna, G., Kutschera, S., Claesson-Welsh, L., Vestweber, D., Gerhardt, H. (2014) The role of differential VE-cadherin dynamics in cell rearrangements in angiogenesis. Nature Cell Biology 16:309-321.

Bentley,K., Philippides, A., Ravasv Regan, E. (2014) Do Endothelial Cells Dream of Eclectic Shape? Developmental Cell 29(2):146-158.

Anders Berg, MD, PhD, see Clinical Pathology

Lawrence Brown, MD, see Anatomic Pathology

Ann M. Dvorak, MD, Professor of Pathology, Harvard Medical School

Nagy JA, Chang S-H, Shih S-C, Dvorak AM, Dvorak HF. Heterogeneity of tumor vascularture. Semin Throb Hemost 36:321-331, 2010.

Connolly JL, Goldsmith JD, Wang HH, Longtine JA, Dvorak AM, Dvorak HF, Hamilton SR. Cancer Pathology. In: Hong WK, Bast Jr RC, Hait WN, Kufe DW, Pollock RE, Weichselbaum RR , Holland JF, Frei IIIrd E, eds. Cancer Medicine, 8th Edition. BC Decker Inc, Hamilton, Ontario, 2010, 484-485.

Galli SJ, Metcalf DD, Arber DA, Dvorak AM. Basophils and mast cells and their disorders. 8th ed. Williams Hematology eds Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Prchal JT. McGraw-Hill, NY 2010, pp 915-932.

Harold F. Dvorak, MD, Director, Vascular Biology Research Center; Mallinckrodt Distinguished Professor of Pathology, Harvard Medical School

Shou-Ching Shih, Andrew Zukauskas, Dan Li, Guanmei Liu, Lay-Hong Ang, Janice A. Nagy, Lawrence F. Brown, and Harold F. Dvorak. The L6 Protein TM4SF1 Is Critical for Endothelial Cell Function and Tumor Angiogenesis. www.aacrjournals.org Cancer Res 2009; 69: (8). April 15, 2009.

Xue, Q., Nagy, JA, Manseau, EJ, Phung, TL, Dvorak, HF, Benjamin, LE. (2009) Rapamycin Inhibition of the Akt/mTOR Pathway Blocks Select Stages of VEGF-A 164 Driven Angiogenesis, in Part by Blocking S6Kinase. Arterioslerosis, Thrombosis, and Vascular Biology. 29: 1172-1178. PMCID: PMC2756965

Zhang, X., Kazerounian, S., Duquette, M., Perruzzi, C., Nagy, JA, Dvorak, HF, Parangi, S., Lawler, J. (2009) Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. The FASEB Journal. Vol. 23, 3368-3376.

Antoine E. Karnoub, PhD, Assistant Professor of Pathology, Harvard Medical School

Karnoub AE, Weinberg RA. Ras oncogenes: split personalities. Nat Rev Mol Cell Biol. 2008 Jul;9(7):517-31.

Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007 Oct 4;449(7162):557-63.

El-Haibi C and Karnoub AE. Mesenchymal stem cells in the initiation and progression. J Mammary Gland Biol Neoplasia 2010;15(4): 399-409.

Roya Khosravi-Far, PhD, Associate Professor of Pathology, Harvard Medical School 

Ren, B., Song, K., Parangi, S., Jin, T., Ye, M., Humphreys, R., Duquette, M., Zhang, X., Benhaga, N., Lawler, J., Khosravi-Far, R. 2009. A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. Cancer Res 69:3856-3865.

Weisberg E, Choi HG, Ray A, Barrett R, Zhang J, Sim T, Zhou W, Seeliger M, Cameron M, Azam M, Fletcher JA, Debiec-Rychter M, Mayeda M, Moreno D, Kung AL, Janne PA, Khosravi-Far R, Melo JV, Manley PW, Adamia S, Wu C, Gray N, Griffin JD. Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants. Blood. 2010 May 27;115(21):4206-16.

Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell. 2010 Mar;21(6):1140-52.

Jean-Pierre Kinet, MD, Professor of Pathology, Harvard Medical School

Calloway N, Vig M, Kinet JP, Holowka D, Baird B. Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions. Mol Biol Cell. 2009 Jan;20(1):389-99. Epub 2008 Nov 5.

Vig M, Kinet JP. Calcium signaling in immune cells. Nat Immunol. 2009 Jan;10(1):21-7. Review. Erratum in: Nat Immunol. 2009 Feb;10(2):223.

James Kirby, MD, see Clinical Pathology

Olivier Kocher, MD, PhD, see Anatomic Pathology

Jack Lawler, PhD, Director, Division of Experimental Pathology; Professor of Pathology, Harvard Medical School

Tan K, Duquette M, Joachimiak A, Lawler J. The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. FASEB J. 2009, 23(8): 2490-501.

Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J.Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 2009 Oct;23(10):3368-76.

Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10649-54.

Trista E. North, PhD, Assistant Professor of Pathology, Harvard Medical School

Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA. β-catenin determines developmental stage specific transformation to leukemia stem cells. 2010 Science 327: 1650-1653.

North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, and Goessling W. Prostaglandin E2-regulated wnt signaling and N-cetylcysteine act synergistically in zebrafish regeneration after acetaminophen liver injury. 2010. PNAS 107:17315-17320.

North TE and Goessling W. NOTCHing an arrow at cord blood: translating stem cell knowledge into clinical practice. 2010. Cell Stem Cell, 6: 186-187.

Pier Paolo Pandolfi, MD, PhD, Director, Cancer Genetics Program at BIDMC; Professor of Pathology and Medicine, Harvard Medical School

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24;508(7497):541-5. doi: 10.1038/nature13079. Epub 2014 Mar 9. PubMed PMID: 24670654; PubMed Central PMCID: PMC4076493.

Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 6;150(1):179-93. doi: 10.1016/j.cell.2012.05.038. PubMed PMID: 22770219; PubMed Central PMCID: PMC3595190.

Dipak Panigrahy, M.D., Center for Vascular Biology Research, Assistant Professor of Pathology, Harvard Medical School

Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, Barnés CM, Mammoto A, Mammoto T, Luria A, Benny O, Chaponis DM, Dudley AC, Greene ER, Vergilio J, Pietramaggiori G, Scherer-Pietramaggiori SS, Short SM, Seth M, Lih FB, Tomer KB, Yang J, Schwendener RA, Hammock, BD, Falck JR, Manthati VL, Ingber DE, Kaipainen A, D’Amore PA, Kieran MW, Zeldin DC. Epoxy-eicosanoids stimulate multi-organ metastasis and tumor dormancy escape in mice. The Journal of Clinical Investigation 2012, 122(1):178-191. PMID:22182838 (Featured with related commentary in The Journal of Clinical Investigation: Wang D, Dubois RN. Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer 2012, 122(1):19-22.)

Zhang G, Panigrahy D, Mahakian L, Yang J, Liu J, Lee K, Wettersten H, Ulu A, Hu X, Tam S, Hwang S, Ingham E, Kieran MW, Weiss RH, Ferrara KW, and Hammock BD. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proceedings of the National Academy of Sciences. 2013, April 3.

German Pihan, MD, see Clinical Pathology

Isaac Rabinovitz, MD, PhD, Assistant Professor of Medicine, Harvard Medical School

Kashyap, T., Germain E.C., Roche M., Lyle S., and Rabinovitz I. Role of integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration. Laboratory Investigation. 91(10):1414-26. 2011.

Sharma C, Rabinovitz I, and Hemler ME. Palmitoylation by DHHC3 is critical for the function expression and stability of integrin α6β4. EMBO J, 2011

Li Q, Yang XH, Xu F, Chandan C, Wang HX, Knoblich K, Rabinovitz I, Granter S, and Hemler ME.Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. EMBO J. 2011

John L. Rinn, PhD, Assistant Professor of Pathology, Harvard Medical School

Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA. Programming human pluripotent stem cells into white and brown adipocytes. Nature Cell Biol 14:209-19 (2012).

Kretz M, Webster DE, Flockhart RJ, Lee CS, Zehnder A, Lopez-Pajares V, Qu K, Zheng GX, Chow J, Kim GE, Rinn JL, Chang HY, Siprashvili Z, Khavari PA. Suppression of progenitor differentiation requires the long noncoding RNA ANCR. Genes Dev 26:338-43 (2012).

Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg SL, Rinn JL, Pachter L. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nature Protoc 7:562-78 (2012).

Jeffrey Saffitz, MD, PhD, see Anatomic Pathology

Donald R. Senger, PhD, Principal Associate in Pathology, Harvard Medical School

Senger, DR. Vascular endothelial growth factor: Much more than an angiogenesis factor. Mol Biol Cell 2010, 21: 377-379

Hoang MV, Nagy JA, Senger DR. Cdc42-mediated inhibition of GSK-3b improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis. Microvasc Res.2011 Jan;81(1):34-43.

Hoang MV, Nagy JA, Senger DR. Active Rac1 improves pathological VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1. Blood. 2011 Feb 3;117(5):1751-60. Epub 2010 Oct 28.

Shou-Ching Shih, PhD, Research Associate; Instructor in Pathology, HMS

Matsuda, K., Ohga, N., Hida, Y., Muraki, C., Tsuchiya, K., Kurosu, T., Akino, T., Shih, S.C., Totsuka, Y., Klagsbrun, M., et al. 2010. Isolated tumor endothelial cells maintain specific character during long-term culture. Biochem Biophys Res Commun 394:947-954.

Shapiro, N.I., Khankin, E.V., Van Meurs, M., Shih, S.C., Lu, S., Yano, M., Castro, P.R., Maratos-Flier, E., Parikh, S.M., Karumanchi, S.A., et al. 2010. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol 185:517-524.

Ismail, N.S., Pravda, E.A., Li, D., Shih, S.C., and Dallabrida, S.M. 2010. Angiopoietin-1 reduces H(2)O(2)-induced increases in reactive oxygen species and oxidative damage to skin cells. J Invest Dermatol 130:1307-1317.

Steven Tahan, MD, see Anatomic pathology

Alex Toker, PhD, Associate Professor of Pathology, Harvard Medical School

Chin YM, Yuan X, Balk SP, Toker A. Pten-deficient tumors depend on akt2 for
maintenance and survival. Cancer Discov. 2014 May 16. pii: CD-13-0873. [Epub
ahead of print] PubMed PMID: 24838891.

Toker A, Marmiroli S. Signaling specificity in the Akt pathway in biology and
disease. Adv Biol Regul. 2014 May;55:28-38. doi: 10.1016/j.jbior.2014.04.001.
Epub 2014 Apr 19. PubMed PMID: 24794538; PubMed Central PMCID: PMC4062840.

White CD, Toker A. Using phospho-motif antibodies to determine kinase
substrates. Curr Protoc Mol Biol. 2013 Jan;Chapter 18:Unit 18.20.. doi:
10.1002/0471142727.mb1820s101. PubMed PMID: 23288461.

Wenyi Wei, PhD, Associate Professor of Pathology, Harvard Medical School

Wei, W. and Kaelin, W.G., Jr. (2011) Good COP1 or Bad COP1? In Vivo Veritas. Journal of Clinical Investigation.

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24;508(7497):541-5. doi: 10.1038/nature13079. Epub 2014 Mar 9. PubMed PMID: 24670654; PubMed Central PMCID: PMC4076493.

Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 6;150(1):179-93. doi: 10.1016/j.cell.2012.05.038. PubMed PMID: 22770219; PubMed Central PMCID: PMC3595190.

Catherine T. Yan, PhD, Assistant Professor of Pathology, Harvard Medical School

Boboila C, Yan CT, Wesemann, DR, Jankovic M, Wang JH,, Manis J, Nussenzweig A, Nussenzweig M, At FW. (2010) Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA Ligase 4. Journal of Exp. Med, 207:417-27.

Boboila C*, Jankovic M, Yan CT*, Wang JH, Wesemann, DR, Zhang, T, Feldman L, Fazeli A, Nussenzweig A, Nussenzweig M, At FW. (2010) Alternative End-joining catalyzes robust IgH locus deletions and translocations in the absence of combined Ligase 4 and Ku70. PNAS, 107:3034-9. (equal contribution). PMID: 20133803 (equal contribution).

Eccleston, J, Yan, C, Yuan K, Alt FW, Selsing E. (2010). Mismatch repair proteins, MSH2, MLH1 and EXO1 are important for class switch recombination events occurring in B cells that lack non-homologous end joining. Journal of Immunology. 2011 Feb 15;186(4):2336-43. Epub 2011 Jan 17.