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Teaching Faculty

FACULTY AND SELECTED PUBLICATIONS
ANATOMIC PATHOLOGY

Matthew Anderson, MD, PhD, Director of Neuropathology; Assistant Professor of Neurology and Pathology, Harvard Medical School

Herbert MR, Anderson MP. Autism: Current Theories and Evidence. An expanding Spectrum of Autism Models: From Static Defects in Development to Reversible Impairments of Function. 2007.

Kasten MR, Rudy B, Anderson MP. Differential Regulation of Action Potential Firing in Adult Murine Thalamocortical Neurons by Kv3.2, Kv1, and SK Potassium and N-type Calcium Channel J Physiol. 2007 Aug 30.

Zhou Y-D, Lee S, Anderson MP (2007). Temporal lobe epilepsy-related protein LGI1 regulates hippocampal perforant pathway synaptic transmission by reducing the probability of transmitter release. Soc. Neurosci. Abstr. 2007: 165.6. Free online at www.sfn.org.

Anderson MP, Hooker BS, Herbert MR (2008). Bridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and Plasticity. Am. J. Biochem. Biotech. 4:167-176.

Herbert MR, Anderson MP (2008). An Expanding Spectrum of Autism Models: From Fixed Developmental Defects to Reversible Functional Impairments. In “Autism: Current Theories and Evidence,” Edited by A. W. Zimmerman, Humana Press, Totowa, NJ.

Zhou Y-D, Lee S, Jin Z, Wright M, Anderson MP (2008). Arrested Development down-regulation of excitatory synapses in ADLTE. Soc. Neurosci. Abstr. 2008: 147.12. Free online at www.sfn.org.

Kasten MR, Anderson MP (2008). Epilepsy impairs in vitro thalamic signal processing. Soc. Neurosci. Abstr. 2008: 448.14. Free online at www.sfn.org.

Zhou YD, Lee S, Jin Z, Wright M, Smith SE, Anderson MP. Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Nat Med. 2009 Aug 23.

Karoly Balogh MD, Staff Pathologist, Associate Professor of Pathology, HMS

Nagy P, Szabo, Z, Balogh, K. Wegener’s granulomatosis masquerading as chronic mastoiditis. Lege Artis Medicinae 2006.

Patologia. Ed. by L. Kopper and Z. Schaff. Chapter 14. Pathology of the Head and Neck Region. (pp. 681-714). Budapest, Medicine Pub. Co. (Hungarian textbook), 2nd edition, 2006.

Histology for Pathologists. Ed. by S. S. Sternberg. Chapter 15. Mouth, Nose and Paranasal Sinuses. New York, Raven Press, 3rd edition, 2007.

Lawrence F. Brown, MD, Staff Pathologist, Associate Professor of Pathology, HMS

Halin C, Tobler NE, Vigl B, Brown LF, Detmar M. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood. 2007 Jul 11.

Rosenberger C, Solovan C, Rosenberger AD, Jinping L, Treudler R, Frei U, Eckardt KU, Brown LF. Upregulation of Hypoxia-Inducible Factors in Normal and Psoriatic Skin. J Invest Dermatol. 2007 May 10.

Hirakawa S, Brown LF, Kodama S, Paavonen K, Alitalo K, Detmar M. Vascular endothelial growth factor C induced lymphangiogenesis in the sentinal lymph node promotes metastasis to distant sites. Blood, 2007; 109:1010-7.

Rahbar R, Vargas SO, Folkman J, McGill TJ, Healy GB, Tan X, Brown LF. Role of vascular endothelial growth factor-A in recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol. 2005 Apr;114(4):289-95.

Hirakawa S, Kodama S, Kunstfeld R, Brown L, Detmar M. Vascular endothelial growth factor-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med, 2005; 201: 1089-1099

Hong YK, Lange-Asschenfeldt B, Velasco P, Hirakawa S, Kunstfeld R, Brown LF, Bohlen P, Senger DR, Detmar M. VEGF-A induces tissue repair-associated lymphangiogenesis via VEGFR-2 and the alpha 1 beta 1 and alpha 2 beta 1 integrins. FASEB J, 2004; 18: 1111-1113.

Tracy Challies, MD, Staff Pathologist, GI and Liver Pathology, Instructor in Pathology, Harvard Medical School

Byrnes V, Afdhal N, Challies T, Greenstein PE. Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis. Ann Hepatol. 2006 Jan-Mar;5(1):56-9

Lai, M, Afdhal, N, and Challies T. Liver Masses and Eosinophilia. Liver International. 2008 Jan; 28(1):150.

David W. Cohen, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Cohen DW, Lane B, Jin T, Magi-Galluzzi C, Finke J, Rini BI, Bukowski RM, Zhou M. (2007) The Prognostic Significance of Epidermal Growth Factor Receptor Expression in Clear-Cell Renal Cell Carcinoma: A Call for Standardized Methodology for Immunohistochemical Evaluation. Clinical Genitourinary Cancer. 5(4): 264-270.

Cohen DW, Boos M, Oethinger M, Hall G, Yen-Lieberman B, Tomford W, Farver CF. (2008) Clinicopathologic Features of Non-Tuberculous Mycobacterial (NTM) Respiratory Isolates: The Cleveland Clinic Experience, 1989–1998. [manuscript in progress].

Cohen DW, Shorie J, Sabo D, Howard M, Biscotti CV. (November 2007) Glacial Acetic Acid Treatment and Atypical Endocervical Glandular Cells: An Analysis of 92 cases. Abstract presented as a platform at the 2007 American Society of Cytopathology Meeting in Houston.

Underwood D, Scheidemantel T, Dolar S, Cohen DW, Howard M, Dawson A. (November 2007) Shifting Practice Patterns in HPV Testing: Comparison of HPV Results, TIS Imaged ThinPrep Paps and Follow-up Data. Abstract presented as a poster at the 2007 American Society of Cytopathology Meeting in Houston.

Cohen DW, Boos M, Hall G, Thomford W, Farver CF. Clinical and pathologic features of non-tuberculous pulmonary isolates [abstract]. Modern Pathology 2008; 21:339A.

Underwood DL, Shorie J, Howard M, Cohen D, Kral M, Brainard JA, Booth CN. Utility of MonoPrep® slides in the evaluation of fine needle aspirate specimens: A direct to vial comparison with the ThinPrep® method [abstract]. Cancer Cytopathology 2008; 114:403.

Lai P, Cohen D, DeCamp M, Fazio S, Roberts D. Chest imaging and pathology for clinicians: 40-year-old woman with an asymptomatic cystic lesion in her right lung. Chest. 2009; 136:622-627.

Laura Collins, MD, Associate Director of Anatomic Pathology; Associate Professor of Pathology, Harvard Medical School

Collins LC, Achacoso NA, Nekhlyudov L, Fletcher SW, Haque R, Quesenberry CP, Alshak NS, Puligandla B, Brodsky GL, Schnitt SJ, Habel LA. Clinical and pathologic features of ductal carcinoma in situ associated with the presence of flat epithelial atypia: an analysis of 543 patients. Mod Pathol. 2007;20(11):1149-1155

Collins LC, Schnitt SJ. Papillary lesions of the breast: selected diagnostic and management issues. Histopathology. 2008;52(1):20-9.

Collins LC, Marotti JD, Baer HJ, Tamimi RM. Comparison of estrogen receptor results from pathology reports with results from central laboratory testing. J Natl Cancer Inst. 2008;100(3):218-21.

Tamimi RM, Baer HJ, Marotti J, Galan M, Galaburda L, Fu Y, Deitz AC, Connolly JL, Schnitt SJ, Colditz GA, Collins LC. Comparison of molecular phenotypes of ductal carcinoma in situ and invasive breast cancer. Breast Cancer Res. 2008;10(4):R67.

Hilson JB, Schnitt SJ, Collins LC. Phenotypic Alterations in Ductal Carcinoma In Situ-associated Myoepithelial Cells: Biologic and Diagnostic Implications. Am J Surg Pathol. 2009;33(2):227-32.

Baer HJ, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, Tamimi RM. Lobule type and subsequent breast cancer risk: results from the Nurses' Health Studies. Cancer. 2009;115(7):1404-11.

Collins LC, Martyniak AJ, Kandel MJ, Stadler ZK, Masciari S, Miron A, Richardson AL, Schnitt SJ, Garber JE. Basal Cytokeratin and Epidermal Growth Factor Receptor Expression Are Not Predictive of BRCA1 Mutation Status in Women With Triple-negative Breast Cancers. Am J Surg Pathol. 2009;33:1093-1097.

Collins LC, Achacoso N, Nekhlyudov L, Fletcher SW, Haque R, Quesenberry CP, Puligandla B, Alshak NS, Goldstein LC, Gown AM, Schnitt SJ and Habel LA. Relationship Between Clinical and Pathologic Features of Ductal Carcinoma in Situ and Patient Age: An Analysis of 657 Patients. Am J Surg Pathol. 2009;(In press).

Collins LC, Schnitt SJ . The Breast. In: Mills, SE, ed. Histology for Pathologists. Lippincott, Williams & Wilkins; 2005. pp. 57-71.

Schnitt SJ and Collins LC. Columnar Cell Lesions and Flat Epithelial Atypia of the Breast. Seminars in Diagnostic Pathology. 2005;8(2):100-111.

Collins LC and Schnitt SJ. Papillary Lesions of the Breast: Selected Diagnostic and Management Issues. Histopathology. 2008;52(1):20-9.

Johnson, NB and Collins, LC. Update on Percutaneous Needle Biopsy of Nonmalignant Breast Lesions. Adv Anat Pathol. 2009;16(4):183-95.

Schnitt SJ and Collins LC. Pathology of Benign Breast Disorders. In: Diseases of the Breast. Philadelphia: Lippincott Williams & Wilkins;2009. pp. 69-85.

SJ Schnitt and LC Collins. Breast Biopsy Interpretation. First Edition. Philadelphia, PA: LWW;2009.

Laura Collins, Editor. Surgical Pathology Clinics. In: Current Concepts in Breast Pathology. First Edition Philadelphia: WB Saunders;2009.

James L Connolly, MD, Residency Training Program Director, Staff Pathologist, Professor of Pathology, Harvard Medical School

Connolly JL. Changes and problematic areas in interpretation of the AJCC Cancer Staging Manual, 6th Edition, for Breast Cancer. Arch Pathol Lab Med 2006; 130:287-91.

Hsiung PL, Phatak DR, Chen Y, Aguirre AD, Fujimoto JG, Connolly JL. Benign and malignant lesions in the human breast depicted with ultrahigh resolution and three-dimensional optical coherence tomography. Radiology 2007; 244:865-874.

Evanson A, Mowschenson P, Wang H, Connolly J, Mendrinos S, Parangi S, Hasselgren P-O. Hyalinizing trabecular adenoma - an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surgery 2007; 193:707-712.

Collins LC, Baer HJ, Tamimi RM, Connolly JL, Colditz GA, Schnitt SJ. Magnitude and laterality of breast cancer risk according to histologic type of atypical hyperplasia: Results from the Nurses’ Health Study. Cancer 2007; 109:180-187.

Lester SC, Bose S, Chen YY, Connolly JL, de Baca ME, Fitzgibbons PL, Hayes DF, Kleer C, O'Malley FP, Page DL, Smith BL, Weaver DL, Winer E; Members of the Cancer Committee, College of American Pathologists. Protocol for the examination of specimens from patients with ductal carcinoma in situ of the breast. Arch Pathol Lab Med. 2009 Jan;133(1):15-25.

Lester SC, Connolly JL, Amin MB. College of American Pathologists protocol for the reporting of ductal carcinoma in situ. Arch Pathol Lab Med. 2009 Jan;133(1):13-4.

Goldfarb M, O'Neal P, Shih JL, Hartzband P, Connolly J, Hasselgren PO. Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. Endocr Pract. 2009 Jul-Aug;15(5):463-8.

Beverly Faulkner-Jones, MD, PhD, Staff Pathologist, Dermatopathology and Surgical Pathology, Instructor in Pathology, Harvard Medical School

Pashaei S, Wiss T, Lind AC and Faulkner-Jones BE. Recurrent leiomyosarcoma of skin. Pathology Case Reviews 2005;10(6):281-286.

Graves JE, Jones B, Lind AC and Heffernan MP. Non-scarring alopecia associated with the epidermal growth factor inhibitor Gefitinib. Journal of the American Academy of Dermatology 2006;55:349-353.

Klekotka PA, Faulkner-Jones BE and Heffernan MP. A Case of Mycosis Fungoides Cytotoxic Immunophenotype Variant (CD56+ Mycosis Fungoides) – Archives of Dermatology 2006;142(Pt10):1370-1372.

Gardiner DL, Pettit M, Palmer CH and Faulkner-Jones BE. CD10 immunoexpression in cutaneous spindle cell neoplasms. (2007). United States and Canadian Academy of Pathology 96th Meeting; San Diago, CA.

Faulkner-Jones, B.E., Foster, W., Harbor, J.M, Davila, R.N. and Smith, M.E. Fine Needle Aspiration Biopsy with Adjunct Immunohistochemistry in Intraocular Tumor management. (2005) Acta Cytologica 49(3):297-308.

Yineng Fu, MD, PhD, Staff Pathologist; Instructor in Pathology, Harvard Medical School

Tamimi RM, Baer HJ, Marotti J, Galan M, Galaburda L, Fu Y, Deitz AC, Connolly JL, Schnitt SJ, Colditz GA, Collins LC. Comparison of molecular phenotypes of ductal carcinoma in situ and invasive breast cancer. Breast Cancer Research 2008, 10:R67.
Fu Y, Nagy, J, Dvorak A, Dvorak H. Tumor Blood Vessels: Structure, Function and Classification. In: Teicher B and Ellis M. editor. Cancer Drug Discovery and Developmen: Antiangiogenic Agents in Cancer Therapy. Humana Press, p205-224; 2007

Wang YH, Fu Y. Renal Oncocytoma: A Clinicopathological Analysis of Thirty-Six Cases. USCAP annual meeting, Denver, CO 2008

Y Wang, EM Genega, S Signoretti, Y Fu. Immunohistochemical Analysis of Oncocytic Renal Tumors. USCAP annual meeting, Boston, MA 2009

EM Genega, M Ghebremichael, R Najarian, Y Fu, Y Wang, C Grisanzio, S Signoretti. CAIX Expression in Renal Neoplasms: Correlation with Tumor Type and Grade. USCAP annual meeting, Boston, MA 2009

R Elliott, NB Bloch, W Dewolf, Y Fu, M Sanda, J Tomaszewski, A Wagner, N Rofsky, EM Genega. Seminal Vesicle Invasion at Radical Prostatectomy: Correlation with Magnetic Reasonance Images. USCAP, Boston, MA 2009

EM Genega, NB Bloch, W Dewolf, R Elliot, Y Fu, M Sanda, J Tomaszewski, N Rofsky. Correlation of Gleason Score and Tumor Size with Magnetic Reasonance Image-Detected Prostate Cancer. USCAP annual meeting, Boston, MA 2009

Elizabeth Genega, MD, Staff Pathologist, Director of Surgical Pathology Fellowship Program, Subspeciality Genitourinary and Head and Neck Pathology, Assistant Professor of Pathology, Harvard Medical School

Mosquera JM, Mehra R, Regan MM, Perner S, Genega EM, Bueti G, Shah RB, Gaston S, Tomlins SA, Wei JT, Kearney MC, Johnson LA, Tang JM, Chinnaiyan AM, Rubin MA, Sanda MG. Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States.Clin Cancer Res. 2009 Jul 15;15(14):4706-11. Epub 2009 Jul 7.

Sun MR, Ngo L, Genega EM, Atkins MB, Finn ME, Rofsky NM, Pedrosa I.Renal cell carcinoma: dynamic contrast-enhanced MR imaging for differentiation of tumor subtypes--correlation with pathologic findings. Radiology. 2009 Mar;250(3):793-802.

Viswanath S, Bloch BN, Genega E, Rofsky N, Lenkinski R, Chappelow J, Toth R, Madabhushi A. A comprehensive segmentation, registration, and cancer detection scheme on 3 Tesla in vivo prostate DCE-MRI. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2008;11(Pt 1):662-9.

Lenkinski RE, Bloch BN, Liu F, Frangioni JV, Perner S, Rubin MA, Genega EM, Rofsky NM, Gaston SM. An illustration of the potential for mapping MRI/MRS parameters with genetic over-expression profiles in human prostate cancer. MAGMA. 2008 Nov;21(6):411-21. Epub 2008 Aug 28.

Pedrosa I, Sun MR, Spencer M, Genega EM, Olumi AF, Dewolf WC, Rofsky NM. MR imaging of renal masses: correlation with findings at surgery and pathologic analysis. Radiographics. 2008 Jul-Aug;28(4):985-1003.

Mosquera JM, Perner S, Genega EM, Sanda M, Hofer MD, Mertz KD, Paris PL, Simko J, Bismar TA, Ayala G, Shah RB, Loda M, Rubin MA. Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implications. Clin Cancer Res. 2008 Jun 1;14(11):3380-5.

Pedrosa I, Chou MT, Ngo L, H Baroni R, Genega EM, Galaburda L, DeWolf WC, Rofsky NM. MR classification of renal masses with pathologic correlation. Eur Radiol. 2008 Feb;18(2):365-75. Epub 2007 Sep 26.

Hannah Gilmore, MD, Staff Pathologist, Breast Pathology, Instructor in Pathology, HMS

Gilmore, H, Fleischhacker, D, Hecht, JL. Diagnosis of chronic endometritis in biopsies with stromal breakdown. Human Pathology 2007 Apr;38(4):581-4.

Gilmore, H, Fleischhacker, D, Hecht, JL. Diagnosis of chronic endometritis in biopsies with focal stromal breakdown. United States and Canadian Academy of Pathology Annual Conference, Atlanta, GA, February 2006.

Gilmore, H, Tamimi, R, Baer, H, Connolly, J, Colditz, G, Schnitt, S and Collins, L. Immunophenotype of invasive breast cancers in women with prior biopsy-confirmed benign breast disease: Results from the Nurses’ Health Study. International Academy of Pathology Congress, Montreal, Quebec, September 2006.

Gilmore, H, Lamontagne, D, Shaz, B, Uhl, L. Enumeration of CD34+ cells in Hematopoietic Progenitor Cells, Apheresis: Validation of Collection Bag Segments for Sampling. American Association of Blood Banking Annual Conference, Miami Beach, FL, October 2006.

Jeffrey Goldsmith, MD, Staff Pathologist, Medical Director, Histology Laboratory, Instructor in Pathology, Harvard Medical School

Oble DA, Mino-Kenudson M, Goldsmith JD, Hodi FS, Seliem RM, Dranoff G, Mihm M, Hasserjian R, Lauwers GY. Alpha-CTLA-4 mAb associated panenteritis: A histologic and immunohistochemical analysis. Am J Surg Pathol. In Press (accepted 7 January 2008).

Wu JS, Goldsmith JD, Horwich PJ, Shetty SK, Hochman MG. Image Guided Core Needle Biopsy of Bone and Soft Tissue Lesions: What factors affect diagnostic yield? Radiology. In press (accepted 9 April 2008).

Najarian RM, Hait EJ, Leichtner AM, Glickman JN, Antonioli DA, Goldsmith JD. Clinical Significance of Colonic Intraepithelial Lymphocytosis in a Pediatric Population. Mod Pathol. 2009 22:13-20.

Chen X, Katchar K, Goldsmith JD, Nanthakumar N, Cheknis A, Gerding DN, Kelly. A novel mouse model of Clostridium difficile associated disease. Gastroenterology. In press (accepted 4 September 2008).

Pedrosa I, Lafornara M, Pandharipande P, Goldsmith JD, Rofsky NM. MRI for Preganant Patients with Suspected Acute Appendicitis: Impact on Negative Appendectomy and Appendical Perforation Rates. Radiology. 2009 250:749-757.

Chen X, Fruehauf J, Goldsmith JD, Xu H, Katchar KK, Koon HW, Zhao D, Kokkotou E, Pothoulakis C, Kelly CP. Saccharomyces boulardii Inhibits EGF Receptor Signaling and Intestinal Tumor Growth in APCmin Mice. Gastroenterology. In press (accepted 14 May 2009).

Turner MS, Goldsmith JD, Best Practices in Diagnostic
Immunohistochemistry -- Spindle Cell Neoplasms of the Gastrointestinal
Tract. Arch Pathol Lab Med. In Press (accepted 13 February 2009).

Goldsmith JD, Siegel GP, Suster S, Wheeler TM, Brown RW. Reporting Guidelines for Clinical Laboratory Reports in Surgical Pathology. Arch Pathol Lab Med 2008 132:1608-1616.

McMahon C, Vollmer CM, Goldsmith JD, Brown A, Pleskow D, Pedrosa I. An Unusual Variant of Anomalous Pancreaticobililary Junction in a Patient with Pancreas Divisum Diagnosed with Secretin-MRCP. Pancreas. In Press (accepted 6 July 2009)

Turner MS, Wang HH, Beasley MB, Collins LC, Folpe AL, Hecht JL, Hunt JL, van de Rijn M, Goldsmith JD. Non-Gastrointestinal Pathologists are Highly Reproducible in Their Diagnosis of Serrated Polyps of the Colorectum Following Tutorial Instruction. USCAP Abstracts; Denver, CO 2008. Mod Pathol 2008; 21: 138A (#626).

Ross P, Vollmer CM, Goldsmith J, Pedrosa I, Sawhney M, Brown A, Callery MP. Non-Dysplastic Mucinous Cysts of the Pancreas. Oral Presentation at Pancreas Cancer 2008, Rome Italy, April 7, 2008.

Miller EC, Stevenson MA, Gebhardt MC, Anderson ME, Goldsmith JD. The Effect of Radiation/Chemotherapy on the Immunophenotype of Soft Tissue Sarcomas. USCAP Abstracts; Boston, MA 2009. Mod Pathol 2009; 22: 19A (#73).

Najarian RA, Leffler D, Goldsmith JD. Focal Duodenal Intraepithelial Lymphocytosis and Underlying Lymphoid Aggregates: The Utility of Deeper Histologic Sections. USCAP Abstracts; Boston, MA 2009. Mod Pathol 2009; 22: 141A (#635).

Jonathan Hecht, MD, Medical Director of Autopsy Service, Assistant Professor of Pathology, Harvard Medical School

Kotsopoulos J, Hecht JL, Marotti JD, Kelemen LE, Tworoger SS. Relationship between dietary and supplemental intake of folate, methionine, vitamin B(6) and folate receptor alpha expression in ovarian tumors. Int J Cancer. 2009 Jul 7.

McElrath TF, Hecht JL. Invited commentary: Intrauterine epidemiology. Am J Epidemiol. 2009 Jul 15;170(2):159-61; discussion 162-3. Epub 2009 Jun 9.

McElrath, TF, et al. "Pregnancy disorders that lead to delivery before the 28th week of gestation: An epidemiological approach to classification". American Journal of Epidemiology. 2008.

Fadare O, Orejudos MP, Jain R, Mariappan MR, Hecht JL, Renshaw IL, Hileeto D, Wang SA, Ghofrani M, Liang SX. A comparative analysis of lymphatic vessel density in ovarian serous tumors of low malignant potential (borderline tumors) with and without lymph node involvement. International Journal of Gynecological Pathology. 2008.

Esposito G, Imitola J, Lu J, DE Filippis D, Scuderi C, Ganesh VS, Folkerth R, Hecht, J, Shin S, Iuvone T, Chestnut J, Steardo L, Sheen V. Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and Aquaporin 4 in cell injury. Human Molecular Genetics 2008.

Hecht JL, Kliman H, Allred An, Leviton A. Histologic characteristics of placentas delivered before the 28th week of gestation. Pathology 2008.

Johnson, Nicole (Belsley), MD, Staff Pathologist, Instructor in Pathology, HMS

Jones SE, Belsley NA, McLoud TC, Mullins ME. Rheumatoid meningitis: radiologic and pathologic correlation. AJR Am J Roentgenol. 2006 Apr;186(4):1181-3.

Roth SI, Belsley NA, Abu-Jawdeh, G. Parathyroid Glands. In: Mills, SE editor. Histology for Pathologists. 3rd ed., Lippincott Williams & Wilkins, 2006.

Belsley NA, Mino-Kenudson M, Ban S, Park DY, Ochiai A, Kato Y, Muzikansky A, Deshpande V, Shimizu M, Vieth M, Lauwers GY. Endoscopic Mucosal Resection Does Not Improve Lingering Differences in the Evaluation of Gastric Neoplasia Between Eastern and Western Pathologists. Modern Pathology, Volume 19, Supplement 1, January 2006, p 102A.

Belsley NA, Lauwers GY, Pitman MB, Deshpande V. Serous Cystadenomas of the Pancreas: Diagnostic Performance of Imaging and Fine Needle Aspiration Biopsy. Modern Pathology, Volume 20, Supplement 2, March 2007, p 64A

Belsley NA, Pitman MB, Lauwers GY and Deshpande V. Serous cystadenoma of the pancreas: Limitations and pitfalls of EUS guided fine needle aspiration biopsy. Cancer Cytopathology, 2008 Feb 7.

Belsley NA, Tambouret RH, Misdraji J, Muzikansky A, Russell DK, and Wilbur DC. Cytologic features of Endocervical Glandular Lesions: Comparison of SurePath, ThinPrep, and Conventional Smear Specimen Preparations. Diagnostic Cytopathology, 2008; 36(4): 232-7.

Johnson NB, Collins LC. Update onpercutaneous needle biopsy of nonmalignant breast lesions. Adv Anat Pathol. 2009 Jul;16(4):183-95.

Kane, Sarah (Rollins), MD, Staff Pathologist, Instructor in Pathology, HMS

Rollins SE, Young RH, Bell DA. Autoimplants in serous borderline tumors of the ovary: a clinicopathologic study of 30 cases of a process to be distinguished from serous adenocarcinoma. Am J Surg Pathol. 2006 Apr;30(4):457-62.

Rollins SE, Clement PB, Young RH. Uterine Tumors Resembling Ovarian Sex Cord Tumors Frequently Have Incorporated Mature Smooth Muscle Imparting a Pseudoinfiltrative Appearance. 96th United States and Canadian Academy of Pathology, March 2007. San Diego, CA.

Olivier Kocher, MD, PhD, Staff Pathologist, Pulmonary Pathology, Associate Professor of Pathology, Harvard Medical School

Hillesheim J, Riederer B, Tuo B, Chen M, Manns M, Biber J, Yun C, Kocher O and Seidler U. Down regulation of small intestinal ion transport in PDZK1 (CAP70/NHERF3) deficient mice. Pflugers Archiv European Journal of Physiology. 2007, 454:575-586.

Kocher O, Cirovic C, Malynn E, Rowland CM, Bare LA, Young BA, Henslee JG, Laffler TG, Huff JB, Kruskall MS, Wong G, Bauer KA. Obstetric complications in patients with hereditary thrombophilia identified using the LCx microparticle enzyme immunoassay: a controlled study of 5,000 patients. Am J Clin Pathol. 2007 Jan;127(1):68-75.

Cinar A, Chen M, Riederer B, Bachmann O, Wiemann M, Manns M, Kocher O, Seidler U. NHE3 inhibition by cAMP and Ca2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes. J Physiol. 2007 Jun 15;581(Pt 3):1235-46. Epub 2007 Mar 29.

Costa DB, Li S, Kocher O, Feins RH, Keller SM, Schiller JH, Johnson DH, Tenen DG and Halmos B. Immunohistochemical analysis of C/EBPƒÑ in non-small cell lung cancer reveals frequent down-regulation in stage II and IIIA tumors: a correlative study of E3590. Lung Cancer. 2007, 56:97-103.

Kocher O, Yesilaltay A, Shen C, Zhang S, Daniels K, Pal R, Chen J and Krieger M. Influence of PDZK1 on Lipoprotein Metabolism and Atherosclerosis. Biochim Biophys Acta., 2008.

Fenske SA, Yesilaltay A, Pal R, Daniels K, Rigotti A, Krieger M and Kocher O. Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I (SR-BI) by altering its abundance and cellular localization. J Biol Chem. 2008, 283:22097-22104.

Fenske SA, Yesilaltay A, Pal R, Daniels K, Barker C, Quiñones V, Rigotti A., Krieger M. and Kocher O. Normal hepatic cell-surface localization of the high-density lipoprotein receptor, SR-BI, depends on all four PDZ domains of PDZK1.
J Biol Chem. 2009, 284:5797-5806.

Kocher O and Krieger M. Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI. Curr Opin Lipidol, 20:236-241, 2009.

Imad Nasser, MD, BS, Staff Pathologist Surgical Pathology, Liver Pathology and Cytopathology; Assistant Professor of Pathology, Harvard Medical School

Banff Working Group, Demetris AJ, Adeyi O, Bellamy CO, Clouston A, Charlotte F, Czaja A, Daskal I, El-Monayeri MS, Fontes P, Fung J, Gridelli B, Guido M, Haga H, Hart J, Honsova E, Hubscher S, Itoh T, Jhala N, Jungmann P, Khettry U, Lassman C, Ligato S, Lunz JG 3rd, Marcos A, Minervini MI, Molne J, Nalesnik M, Nasser I, Neil D, Ochoa E, Pappo O, Randhawa P, Reinholt FP, Ruiz P, Sebagh M, Spada M, Sonzogni A, Tsamandas AC, Wernerson A, Wu T, Yilmaz F. Liver biopsy interpretation for causes of late liver allograft dysfunction. Hepatology. 2006 Aug;44(2):489-501. Review.

Lai M, Hyatt BJ, Nasser I, Curry M, Afdhal NH. The clinical significance of persistently normal ALT in chronic hepatitis B infection. J Hepatol. 2007 Dec;47(6):760-7.

Becker L, Salameh W, Sferruzza A, Zhang K, Chen R, Malik R, Reitz R, Nasser I, Afdhal NH. Validation of Hepascore, compared to simple indices of fibrosis, in US patients with chronic hepatitis C virus infection. Clin Gastroenterol Hepatol. 2009 Jan 24. [Epub ahead of print]

Pihlajamäki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME. Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab. 2009 Sep;94(9):3521-9. Epub 2009 Jun 23.

Becker L, Salameh W, Sferruzza A, Zhang K, ng Chen R, Malik R, Reitz R, Nasser I, Afdhal NH. Validation of hepascore, compared with simple indices of with chronic hepatitis C virus infection in United States.fibrosis, in patients. Clin Gastroenterol Hepatol. 2009 Jun;7(6):696-701.

Malik R, Chang M, Bhaskar K, Nasser I, Curry M, Schuppan D, Byrnes V, Afdhal N. The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN liver biopsy scoring system in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2009 Apr;24(4):564-8.

Seymour Rosen, MD, Staff Pathologist, Director of Surgical, Renal, and Genito-urinary Pathology, Professor of Pathology, Harvard Medical School

Rosen S Peters CA Chevalier RL Huang WY The kidney in congenital ureteropelvic junction obstruction: a spectrum from normal to nephrectomy. J Urol (2008 Apr) 179(4):1257-63.

Rosenberger C Khamaisi M Abassi Z Shilo V Weksler-Zangen S Goldfarb M Shina A Zibertrest F Eckardt KU Rosen S Heyman SN Adaptation to hypoxia in the diabetic rat kidney. Kidney Int (2008 Jan) 73(1):34-42.

Heyman SN Khamaisi M Rosen S Rosenberger C Renal parenchymal hypoxia, hypoxia response and the progression of chronic kidney disease. Am J Nephrol (2008) 28(6):998-1006.

Rosenberger C Khamaisi M Goldfarb M Shina A Shilo V Zilbertrest F Rosen S Heyman SN. Acute kidney injury in the diabetic rat: studies in the isolated perfused and intact kidney. Am J Nephrol(2008)28(5):831-9.

Ho J Ng KH Rosen S Dostal A Gregory RI Kreidberg JA Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol (2008 Nov) 19(11):2069-75.

Rosen S Stillman IE. Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation. J Am Soc Nephrol (2008 May) 19(5):871-5.

Rosenberger C Rosen S Paliege A Heyman SN Pimonidazole adduct immunohistochemistry in the rat kidney: detection of tissue hypoxia. Methods Mol Biol (2009) 466:161-74.

Rosenberger C Rosen S Shina A Frei U Eckardt KU Flippin LA Arend M Klaus SJ Heyman SN. Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Nephrol Dial Transplant (2008 Nov) 23(11):3472-8.

Rosenberger C Goldfarb M Shina A Bachmann S Frei U Eckardt KU Schrader T Rosen S Heyman SN. Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant (2008 Apr) 23(4):1135-43.

Heyman SN Rosen S Rosenberger C. Renal parenchymal hypoxia, hypoxia adaptation, and the pathogenesis of radiocontrast nephropathy. Clin J Am Soc Nephrol (2008 Jan) 3(1):288-96.

Angela I. Ruiz, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Ruiz A, Reischl U, Swerdlow SH, Hartke M, Streubel B, Procop G, Tubbs RR, Cook JR. Extranodal Marginal Zone B-cell Lymphomas of the Ocular Adnexa: Multiparameter analysis of 34 cases including interphase molecular cytogenetics and PCR for Chlamydia psittaci. American Journal of Surgical Pathology 2007 May; 31(5):792-802.

Essential Thrombocythemia, MPLW515L positive and phospho-STAT5 positive. (November 2007) Case selected for discussion at the Workshop of Society for Hematopathology and European Association for Haematopathology, Indianapolis, Indiana.

Ruiz AI, Aboudola S, Hsi ED, Cotta CV. (March 2008) pSTAT5 Expression During Disease Progression in Polycythemia Vera. Abstract presented as a poster at the annual meeting of the United States and Canadian Academy of Pathology, Denver, Colorado.

Jeffrey E. Saffitz, MD, PhD, Chief of Pathology, Mallinckrodt Distinguished Professor of Pathology, Harvard Medical School

Tandri H, Asimaki A, Dalal D, Saffitz JE, Halushka M, Calkins H: Gap junction remodeling in a case of arrhythmogenic right ventricular dysplasia due to plakophilin-2 mutation. J Cardiovasc Electrophsiol, 2008; 19:1212-1214.

Huang H, Asimaki A, Lo D, McKenna WJ, Saffitz JE: Disparate effects of different mutations in plakoglobin on cell mechanical behavior. Cell Motil Cytoskel, 2008, 65:964-978.

Saffitz JE: “The Heart” in: Pathology, Rubin R and Strayer DS (eds), 5th Edition, Lippincott, Williams and Wilkins, Philadelphia, 2008; pp. 427-481.

Saffitz JE: Cardiac Remodeling. In: Electrical Diseases of the Heart and Sudden Cardiac Death: Genetics, Mechanisms, Treatment, and Prevention. Gussak I, Antzelevitch C, Wilde A, Friedman P, Ackerman M, Shen W-K (Eds), Springer-Verlag London Ltd., 2008, pp. 607-609.

Saffitz JE: Sympathetic neural activity and the pathogenesis of sudden cardiac death. Heart Rhythm, 2008; 5:140-141.

Saffitz JE, Kwaku K: The Pathology of Cardiac Arrhythmias. In: Atlas of CardiovascularPathology, 2nd Edition, McManus B, Ed., Current Medicine, Philadelphia, PA, 2008, pp. 285-307.

Saffitz JE: Expanding the spectrum of arrhythmogenic cardiomyopathy. (Invited Editorial Commentary) J Am Coll Cardiol, 52:2188-2189, 2008

Asimaki A, Tandri H, Huang H, Halushka MK, Gautam S, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, WcKenna WJ, Calkins H, Saffitz JE: A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Eng J Med, 2009, 360:1075-1084.

Saffitz JE: Arrhythmogenic cardiomyopathy and abnormalities of cell-to-cell coupling. Heart Rhythm, 6:S62-65, 2009.

Stuart J. Schnitt, MD, Director, Division of Anatomic Pathology; Professor of Pathology, Harvard Medical School

Turner RR, Weaver DL, Cserni G, Lester SC, Hirsch K, Elsahoff D, Fitzgibbons PL, Viale G, Mazzarol G, Ibarra JA, Schnitt SJ, Giuliano AE. Nodal stage classification for breast carcinoma: Improving interobserver reproducibility through standardized histologic criteria and image-based training. J Clin Oncol 2008;26:258-263.

Tamimi RM, Baer HJ, Marotti J, Galan M, Galaburda L, Fu Y, Deitz A, Connolly JL, Schnitt SJ, Colditz GA, Collins LC. Comparison of molecular phenotypes of ductal carcinoma in situ and invasive breast cancer. Breast Cancer Res 2008;10:R67.

Kleer CG, Bloushtain-Qimron N, Chen Y-H, Carrasco D, Hu M, Yao J, Kraeft S-K, Collins LC, Sabel MS, Argani P, Gelman R, Schnitt SJ, Krop IE, Polyak K. Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res 2008;14:5357-5367.

Jensen KC, Schaeffer DF, Nielsen TO, Cheang M, Montgomery K, West RB, Gilks CB, Ross D, Gulisa T, Schnitt S, van de Rijn M. Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue. Mod Pathol 2008;21:1413-1420.

Hu M, Yao J, CarrollDK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred DC, Bissell MJ, Schnitt S, Polyak K. Regulation of in situ to invasive breast carcinoma transition. Cancer Cell 2008;13:394-406.

Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: Biological and diagnostic implications. Am J Surg Pathol 2009;33:227-232.

Baer HJ, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, Tamimi RM. Lobule type and subsequent breast cancer risk: Results from the Nurses’ Health Studies. Cancer 2009;115:1404-1411.

Hu M, Peluffo G, Chen H, Gelman R, Schnitt S, Polyak K. The role of COX-2 in epithelial-stromal cell interactions and the progression of ductal carcinoma in situ (DCIS) of the breast. Proc Nat Acad Sci 2009;106:3372-3377.

Collins LC, Martyniak AJ, Kandel MJ, Stadler ZK, Masciari S, Miron A, Richardson AL, Schnitt SJ, Garber JG. Basal cytokeratin and epidermal growth factor receptor expression are not predictive of BRCA1 mutation status in women with triple negative breast cancers. Am J Surg Pathol 2009;33:1093-1097.

Nekhlyudov L, Habel LA, Achacoso NS, Jung I, Haque R, Collins LC, Schnitt SJ, Quesenberry Jr CP, Fletcher SW. Adherence to long-term surveillance mammography among women with ductal carcinoma in situ treated with breast conserving surgery. J Clin Oncol 2009;27:3211-3216.

Collins LC, Wang Y, Connolly JL, Baer HJ, Hu R, Schnitt SJ, Colditz GA, Tamimi RM. Potential role of tissue microarrays for the study of biomarker expression in benign breast disease and normal breast tissue. Appl Immunohistochem Mol Morphol (in press).

Chen Y-Y, Hwang ES, Roy R, DeVries S, Anderson J, Wa C, Fitzgibbons PL, Jacobs TW, MacGrogan G, Peterse H, Vincent-Salomon A, Tokuyasu T, Schnitt SJ, Waldman FM. Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ. Am J Surg Pathol (in press).

Su X, Colditz GA, Willett WC, Collins LC, Schnitt SJ, Connolly JL, Pollak MN, Rosner B, Tamimi RM. Genetic variation and circulating levels of IGF-1 and IGFBP-3 in relation to risk of proliferative benign breast disease. In J Cancer (in press).

Collins LC, Achacoso N, Nekhlyudov L, Fletcher SW, Haque R, Quesenberry CP, Puligandla B, Alshak NS, Goldstein LC, Gown AM, Schnitt SJ, Habel LA. Relationship between clinical and pathologic features of ductal carcinoma in situ and patient age: An analysis of 657 patients. Am J Surg Pathol (in press).

Su-jean Seo, MD, PhD, Staff Dermatopathologist, Instructor in Pathology, HMS

Liegeois NJ, Seo S, and Olbricht S. Squamous cell carcinoma. In: Evidence-based Dermatology. Blackwell BMJ Books, 2008, pp 248-55.

Seo, S and Hoang MP. Microcystic adnexal carcinoma. In: Cases in Dermatopathology: Diagnostic Pitfalls in Dermatopathology. Knowledge Books & Software, 2008, pp. 87-96.

Bergman H, Tsai KY, Seo SJ, Kvedar JC, and Watson AJ. Remote assessment of acne: the use of acne grading tools to evaluate digital skin images. Telemedicine Journal and E-Health 2009;15(5):426-30.

Alireza Sepehr, MD, Staff Dermatopathologist, Instructor in Pathology, HMS

Sepehr A and Mihm, J., MC. Dermatitis Herpetiformis. In: Zembowicz A et al., editors: Critical Diagnoses in Dermatopathology. (Eds). Brisbane: KBS; 2007.

Sepehr A, Deshpande V, Lauwers GY, and Mino-Kenudson M. An IgG4+ to IgG+ plasma cells ratio in ampullary tissue as a marker to differentiate autoimmune pancreatitis from pancreatic cancer and chronic pancreatitis. Am J Surg Pathol. 2008 Dec;32(12):1770-9.

Sepehr A, Kroshinsky D, and Mihm, Jr., MC. Acute Febrile Neutrophilic Dermatosis Mimicking Necrotizing Fasciitis. In Diagnostic Pitfalls in Dermatopathology. Hoang MP et al. (Eds). KBS, Brisbane, 2008.

Kroshinsky D, Stone JH, Bloch DB, Sepehr A. A 47-year-old woman with a rash and numbness and pain in the legs. N Engl J Med. 2009 Feb 12;360(7):711-20.

Harris A, Bigby M, and Sepehr A. Pemphigus Foliaceus with False Negative Direct Immunofluorescence (DIF) Studies. In Suboptimal Biopsies in Dermatopathology. Hoang MP et al. (Eds). KBS, Brisbane, 2009 (In Press).

Isaac E. Stillman, MD, Staff Pathologist, Renal Pathology, Director, Clinical Electron Microscopy, Assistant Professor of Pathology, Harvard Medical School

Bodyak, N., et al., Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals. Proc Natl Acad Sci U S A, 2007. 104(43): p. 16810-5.

Egbuna, O., M. Pavlakis, and I.E. Stillman, Acute crescentic glomerulonephritis in a renal allograft: an unusual complication of fungal infection. Am J Kidney Dis, 2007. 50(3): p. 468-70.

Stillman, I.E. and S.A. Karumanchi, The glomerular injury of preeclampsia. J Am Soc Nephrol, 2007. 18(8): p. 2281-4.

Cohen, R.A., et al., T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin Immunol, 2008. 128(1): p. 1-7.

Crispin, J.C., et al., Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol, 2008. 181(12): p. 8761-6.

Magee, C.C., et al., Case 2-2008 -- A 38-Year-Old Woman with Postpartum Visual Loss, Shortness of Breath, and Renal Failure. N Engl J Med, 2008. 358(3): p. 275-289.

Maki, T., et al., SV40 infection associated with rituximab treatment after kidney transplantation in nonhuman primates. Transplantation, 2008. 85(6): p. 893-902.

Rosen, S. and I.E. Stillman, Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation. J Am Soc Nephrol, 2008. 19(5): p. 871-5.

Shan, H.Y., et al., Use of circulating antiangiogenic factors to differentiate other hypertensive disorders from preeclampsia in a pregnant woman on dialysis. Am J Kidney Dis, 2008. 51(6): p. 1029-32.

Stillman, I.E., E.Q. Lima, and E.A. Burdmann, Renal biopsies in acute kidney injury: who are we missing? Clin J Am Soc Nephrol, 2008. 3(3): p. 647-8.

Mutter, W.P., I.E. Stillman, and N.K. Dahl, Thrombotic Microangiopathy and Renal Failure Exacerbated by [epsilon]-Aminocaproic Acid. American Journal of Kidney Diseases, 2009. 53(2): p. 346-350.

Steven R. Tahan, MD, Director of Dermatopathology, Associate Professor of Pathology, Harvard Medical School

Zembowicz A, Duncan LM, Mihm MC, Murphy GF, and Tahan SR. Cases in Dermatopathology: Critical Diagnoses in Dermatopathology. Brisbane: Knowledge Books and Software Publishing, 2007.

Negin B, Panka D, Wang W, Saddiqi M, Tawa N, Mullen J, Tahan SR, Mandato L, Polivy A, Mier J, and Atkins M: Effect of Melanoma on Immune Function of the Local Lymph Node Basin. Clin Cancer Res. 2008 Feb 1;14(3): 654-9.

Krause PJ, Grant-Kels JM, Tahan SR, Dardick KR, Alarcon-Chaidez F, Bouchard K, Visini C, Deriso C, Foppa IM, Wikel S. Dermatologic changes induced by repeated Ixodes scapularis bites and implications for prevention of tick-borne infection. Vector Borne Zoonotic Dis. 2009 Feb 5. [Epub ahead of print] PMID: 19196014.

Chan MM and Tahan SR. Low Affinity Nerve Growth Factor Receptor (P75 NGFR) as a Marker of Perineural Invasion in Malignant Melanomas. J of Cutaneous Pathol 2009 (in press).

Chan MM and Tahan SR: Patterns of Perineural Invasion in Cutaneous Neoplasms, CAP ’07, Archives of Pathology & Laboratory Medicine September 2007.

Miller EC and Tahan SR: Can Histology of Recurrence Distinguish Banal from Dysplastic Nevi? Modern Pathology 21(suppl 1): Jan 2008: 98A, poster presented at USCAP meeting March 2008.

Chan MM and Tahan SR: Low Affinity Nerve Growth Factor Receptor (P75NGFR) and Perineural Invasion in Cutaneous Neoplasms. Modern Pathology 21(suppl 1): Jan 2008: 92A, platform presented at USCAP meeting March 2008.

MP Chan, MM Chan, and SR Tahan: Superficial Micronodules of Pregnancy (SMOPs) and MIB-1 (Ki-67) Proliferation Index in Benign Nevi Excised During Pregnancy. Modern Pathology: Jan 2009: 22 (suppl1):101A; poster presented at USCAP meeting March 2009.

MM Chan, L Zhao, and SR Tahan: Histologic Features of Acute Ixodidae Tick Bites: Clues to Pathogenesis of Disease Transmission. Modern Pathology: Jan 2009: 22 (suppl1):101A; presented at USCAP meeting March 2009.

EC Miller, L Ang, M Dahiya, and SR Tahan: Quantitative Evaluation of Activated Cytotoxic Lymphocytes In Melanocytic Lesions Using Laser Confocal Microscopy. Modern Pathology: Jan 2009: 22 (suppl1):107A; presented at USCAP meeting March 2009.

Helen H. Wang, MD, MPH, DrPH, Medical Director of Cytology, Associate Professor of Pathology, Harvard Medical School

Evanson A, Mowschenson P, Wang H, Connolly J, Mendrinos A, Parangi S, Hasselgren P. Hyalinizing trabecular adenoma-an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg 2007;193:707-712.

Harton AM, Wang HH, Schnitt SJ, Jacobs TW. p63 Immunocytochemistry improves accuracy of diagnosis with fine-needle aspiration of the breast. Am J Clin Pathol. 2007 Jul;128(1):80-5.

Layfield LJ, Abrams J, Cochand-Priollet B, Evans D, Gharib H, Greenspan F, Henry M, LiVolsi V, Merino M, Michael CW, Wang H, Wells SA. Post-thyroid FNA testing and treatment options: a synopsis of the National Cancer Institute thyroid fine needle aspiration state of the science conference. Diagn Cytopathol 2008;36:442-8.

Peng Y, Wang HH. A meta-analysis of comparing fine needle aspiration and frozen section for evaluating thyroid nodules. Diagn Cytopathol 2008;36:916-20.

Shields HM, Recht A, Wang HH. Exposure to both radiation and chemotherapy increases the risk of Barrett's and multilayered epithelium. Dig Dis Sci in print.

Azabdaftari G, Goldberg SN, Wang HH. Efficacy of on-site specimen adequacy evaluation of image-guided fine and core needle biopsies. Acta Cytol in print.

Jain N, Wang HH. Core-biopsies are replacing FNAs in most organs. Mod Pathol 2008;21(Supplement 1):75A.

Schmidt JF, Joo M, Greenberg JA, Cerda S, Dendrinos K, Farraye F, Wang HH, Odze RD. Clinical and histologic predictors of outcome in patients with colonic Crohn’s disease. Mod Pathol 2008;21(Supplement 1):135A.

Turner MS, Wang HH, Beasley MB, Collins LC, Folpe AL, Hecht JL, Hunt JL, van de Rijn M, Goldsmith JD. Non-gastrointestinal pathologists are highly reproducible in their diagnosis of serrated polyps of the colorectum following tutorial instruction. Mod Pathol 2008;21(Supplement 1):138A.

Soucy G, Schmidt JF, Greenberg JA, Cerda S, Dendrinos K, Farraye F, Farris AB, Lauwers GY, Wang HH, Odze RD. Colonic Crohn’s disease: a clinical/pathologic and outcome study of 120 patients. Mod Pathol 2009; 22 (Supplement 1):149A.

Soucy G, Schmidt J, Greenberg J, Cerda SR, Agarwal S, Dendrinos K, Farraye FA, Farris AB, Lauwers GY, Wang HH, Odze RD. Ulcerative colitis-like Crohn’s disease: A clinical/pathologic and outcome study. Gastroenterology 2009;136 (supplement 1):A216-7.

Coco D, Goldblum JR, Hornick JL, Lauwers GY, Montgomery EA, Srivastava A, Wang HH, Odze RD. Interobserver variability in the diagnosis of crypt dysplasia in Barrett’s esophagus. Gastroenterology 2009;136(supplement 1):A-593.

Mary Jane Zimarowski, MD, Staff Pathologist, Dermatopathology and Surgical Pathology, Instructor in Pathology, Harvard Medical School

Zimarowski, M. Birt-Hogg-Dube syndrome. Pathology Services Newsletter 2006.

Zimarowski, M. Cowden syndrome. Cohen Dermatopathology. Newsletter 2007.

Chan M, Zimarowski MJ #298, "Lupus erythematosus-like reaction in imiquimod-treated skin", poster presentation at the 46th Annual Meeting of The American Society of Dermatopathology (ASDP), 2009.

Harris A, Faulkner-Jones B, Zimarowski MJ #87, "Epidermal Panfolliculoma", poster presentation at the 46th Annual Meeting of The American Society of Dermatopathology (ASDP), 2009.

Marsee D, Williams G, Lee J, Shofner J, Farhana J, Sepehr A, Zimarowski, MJ
#377, "Multinucleate Cell Angiohistiocytoma", poster presentation at the 46th Annual Meeting of The American Society of Dermatopathology (ASDP), 2009.

FACULTY AND SELECTED PUBLICATIONS
CLINICAL PATHOLOGY

Ramy A. Arnaout, MD, PhD, Associate Director, Clinical Microbiology, Instructor in Pathology, Harvard Medical School

Dostie J, Richmond TA, Arnaout RA, Selzer RR, Lee WL, Honan TA, Rubio ED, Krumm A, Lamb J, Nusbaum C, Green RD, Dekker J. Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res. 2006 Oct;16(10):1299-309. Epub 2006 Sep 5.

Sällström B, Arnaout RA, Davids W, Bjelkmar P, Andersson SG. Protein evolutionary rates correlate with expression independently of synonymous substitutions in Helicobacter pylori. J Mol Evol. 2006 May;62(5):600-14. Epub 2006 Apr 1.

Arnaout RA. Specificity and overlap in gene segment-defined antibody repertoires. BMC Genomics. 2005 Oct 28;6:148.

Anders Berg, MD, PhD, Assistant Director, Clinical Chemistry, Instructor in Pathology, Harvard Medical School

Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, Scherer PE, Bernlohr DA. Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. Am J Physiol Endocrinol Metab. 2006;290(5):E814-23.

Darabi K, Berg AH. Rituximab can be combined with daily plasma exchange to achieve effective B-cell depletion and clinical improvement in acute autoimmune TTP. Am J Clin Pathol. 2006 Apr;125(4):592-7.

Berg AH, Sacks DB. Haemoglobin A1c analysis in the management of patients with diabetes: from chaos to harmony. J Clin Pathol. 2008 Sep;61(9):983-7. Review.

Parul Bhargava, MD, Medical Director, Hematology, Instructor, Harvard Medical School

Bhargava P, Longhi LP. Images in clinical medicine. Peripheral smear with Malassezia furfur. N Engl J Med. 2007 Jun 14;356(24):e25. No abstract available.

Marotti J, Bryan B, Bhargava P. Mild anemia, microcytosis and target cells in a man from Thailand. Lab Medicine 2007.

Marzocchetti A, Wuthrich C, Tan CS, Tompkins T, Bernal-Cano F, Bhargava P, Sachdev R, Hinchey J, Ropper AH, Koralnik IJ. Bone Marrow Rearrangement of JC Virus Regulatory Region in Progressive Multifocal Leukoencephalopathy. IV International Meeting on Polyomaviruses and Human Diseases, Barcelona 2007.

Bhargava P, Kallakury BV, Ross JS, Azumi N, Bagg A. CD79a is heterogeneously expressed in neoplastic and normal myeloid precursors and megakaryocytes in an antibody clone-dependent manner. Am J Clin Pathol. 2007 Aug;128(2):306-13.

Bhargava P, Rushin JM, Rusnock EJ, Hefter LG, Franks TJ, Sabnis SG, Travis WD. Pulmonary light chain deposition disease: report of five cases and review of the literature. Am J Surg Pathol. 2007 Feb;31(2):267-76.

Bhargava P, Gautam S, Avigan D, Shih SC. Prognostic Markers in CLL Using Multi-Gene Transcriptional Profiling. Modern Pathology 2008; 21(1) 246A (Abstract 1128).

Bhargava P, Parker JA, Dezube BJ. Pitfalls of diagnosis based on abnormal flow cytometry and [(18)F]fluorodeoxyglucose positron emission tomography. Clin Lymphoma Myeloma. 2008 Apr;8(2):117-20.

Bhargava P, Pantanowitz L, Pinkus GS, Pinkus JL, Paessler ME, Roullet M, Gautam S, Bagg A, Kadin ME. Utility of Fascin and JunB in Distinguishing Nodular Lymphocyte Predominant From Classical Lymphocyte-rich Hodgkin Lymphoma. Appl Immunohistochem Mol Morphol. 2009 Jun 22.

Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol. 2009 Jun 20;27(18):3027-35. Epub 2009 May 26.

Tan CS, Dezube BJ, Bhargava P, Autissier P, Wüthrich C, Miller J, Koralnik IJ. Detection of JC virus DNA and proteins in the bone marrow of HIV-positive and HIV-negative patients: implications for viral latency and neurotropic transformation. J Infect Dis. 2009 Mar 15;199(6):881-8.

Rajan Dewar, MD, PhD, Assistant Director, Hematopathology; Instructor, HMS

Ayala F, Dewar R, Kieran M, Kalluri R. Contribution of bone microenvironment to leukemogenesis and leukemia progression. Leukemia. 2009 Sep 3.

Jagani Z, Song K, Kutok JL, Dewar MR, Melet A, Santos T, Grassian A, Ghaffari S, Wu C, Ren R, Rodin HY, Miller K, Khosravi-Far R. Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors. Cancer Res. 2009 Aug 15;69(16):6546-55.

Salama ME, Mariappan MR, Inamdar K, Tripp SR, Perkins SL. The Value of CD23 Expression as an Additional Marker in Distinguishing Mediastinal (Thymic) Large B-Cell Lymphoma From Hodgkin Lymphoma. Int J Surg Pathol. 2009 Feb 17. [Epub ahead of print]

Fadare O, Orejudos MP, Jain R, Mariappan MR, Hecht JL, Renshaw IL, Hileeto D, Wang SA, Ghofrani M, Liang SX. A comparative analysis of lymphatic vessel density in ovarian serous tumors of low malignant potential (borderline tumors) with and without lymph node involvement. Int J Gynecol Pathol. 2008 Oct;27(4):483-90.

Jensen KC, Mariappan MR, Putcha GV, Husain A, Chun N, Ford JM, Schrijver I, Longacre TA. Microsatellite instability and mismatch repair protein defects in ovarian epithelial neoplasms in patients 50 years of age and younger. Am J Surg Pathol. 2008 Jul;32(7):1029-37.

Fadare O, Mariappan MR. Mucocele-like tumor and columnar cell hyperplasia of the breast occurring in a morphologic continuum. J Med Case Reports. 2008 Apr 30;2:138.

Salama ME, Perkins SL, Mariappan MR. Images in HIV/AIDS. Primary bone marrow presentation of Epstein-Barr virus driven HIV-associated Hodgkin lymphoma. AIDS Read. 2007 Dec;17(12):604-5.

Richard Haspel, MD, PhD, Associate Residency Training Program Director; Medical Director, Stem Cell Processing Laboratory; Instructor in Pathology, HMS

Powers A, Mohammed M, Uhl L, Haspel RL. Apparent nonhemolytic alloantibody-induced red-cell antigen loss from transfused erythrocytes.Blood. 2007 May 15;109(10):4590. No abstract available.

Haspel R, Kao G, Yeap BY, Cutler C, Soiffer RJ, Alyea EP, Ho VT, Koreth J, Dey BR, McAfee SL, Attar EC, Spitzer T, Antin JH, Ballen KK. Preinfusion variables predict the predominant unit in the setting of reduced-intensity double cord blood transplantation. Bone Marrow Transplant (advance online publication). 2007.

Ballen KK, Spitzer TR, Yeap BY, McAfee S, Dey BR, Attar E, Haspel R, Kao G, Liney D, Alyea E, Lee S, Cutler C, Ho V, Soiffer R and Antin JH. Double unrelated reduced-intensity umbilical cord blood transplantation in adults. Biol Blood Marrow Transplant. 2007;13:82-9.

Delaney M, Haspel RL. Thawing and Infusion. In: Cellular Therapy: Principles, Methods and Regulations, 2008, chapter submitted.

Haspel RL, Ballen KK. Cord blood transplants: perinatal stem cells in clinical practice. In: Perinatal Stem Cells, 2008, chapter submitted.

O'Neill E, Richardson-Weber L, McCormack G, Uhl L, Haspel RL. Strict adherence to a blood bank specimen labeling policy by all clinical laboratories significantly reduces the incidence of "wrong blood in tube". Am J Clin Pathol. 2009 Aug;132(2):164-8; quiz 306.

Delaney M, Cutler CS, Haspel RL, Yeap BY, McAfee SL, Dey BR, Attar E, Kao G, Alyea EP, Koreth J, Ho VT, Saidman S, Liney D, Sese D, Soiffer RJ, Spitzer TR, Antin JH, Ballen KK. High-resolution HLA matching in double-umbilical-cord-blood reduced-intensity transplantation in adults. Transfusion. 2009 May;49(5):995-1002. Epub 2009 Jan 21.

Haspel RL, Miller KB. Hematopoietic stem cells: source matters. Curr Stem Cell Res Ther. 2008 Dec;3(4):229-36. Review.

Haspel RL, Hillmen P. Which patients with paroxysmal nocturnal hemoglobinuria (PNH) should be treated with eculizumab? ASH evidence-based review 2008. Hematology Am Soc Hematol Educ Program. 2008:35. No abstract available.

Lim W, Arnold DM, Bachanova V, Haspel RL, Rosovsky RP, Shustov AR, Crowther MA. Evidence-based guidelines--an introduction. Hematology Am Soc Hematol Educ Program. 2008:26-30.

Haspel RL, Kao G, Yeap BY, Cutler C, Soiffer RJ, Alyea EP, Ho VT, Koreth J, Dey BR, McAfee SL, Attar EC, Spitzer T, Antin JH, Ballen KK. Preinfusion variables predict the predominant unit in the setting of reduced-intensity double cord blood transplantation. Bone Marrow Transplant. 2008 Mar;41(6):523-9.

Gary L. Horowitz, MD, Medical Director, Clinical Chemistry; Associate Professor of Pathology, Harvard Medical School

Konstantinopoulos PA, Dezube BJ, Pantanowitz L, Horowitz GL, Beckwith BA. Protein electrophoresis and immunoglobulin analysis in human immunodeficiency virus-infected patients. Am J Clin Pathol 2007.

Wang Y, Beckwith B, Smith C, Horowitz G. Misleading glycated hemoglobin results in a patient with hemoglobin SC disease. Clin Chem 2007;53:1394-5.

Mocarelli P, Horowitz GL, Cecere R, Imdahl R, Ruinemans-Koerts J, Luthe H, Calatayud SP, Salve ML, Kunst A, McGovern M, Ng K, Stockmann W. Increasing efficiency and quality by consolidation of clinical chemistry and immunochemistry systems with MODULAR ANALYTICS SWA. Journal of Automated Methods and Management in Chemistry 2008. Article ID 498921.

Liang S, Bae H, Horowitz GL. Falsely elevated acetaminophen results in icteric and hemolyzed specimens. Clin Chem 2008;54;A223.

Levine R, Horowitz G, Qian C, Yai Y, Epstein F, Vatten L, Kaumanchi SA (for the CPEP Study Group). Soluble sFlt1 (sFlt1), preeclampsia and hypothyproidism. 2009 Annual Meeting Society for Maternal Fetal Medicine.

Nardin RA, Zarrin AR, Horowitz GL, Tarulli AW. Effect of newly proposed CK reference limits on neuromuscular diagnosis.Muscle Nerve2009Apr;39(4):494-7.

Sibel Kantarci, PhD, Director, Cytogenetics; Instructor in Pathology, HMS

Kantarci S, Al-Gazali L, Hill RS, Donnai D, Black GC, Bieth E, Chassaing N, Lacombe D, Devriendt K, Teebi A, Loscertales M, Robson C, Liu T, MacLaughlin DT, Noonan KM, Russell MK, Walsh CA, Donahoe PK, Pober BR. Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes. Nat Genet. 2007 Aug;39(8):957-9. Epub 2007 Jul 15.

Kantarci S, Donahoe PK. Congenital diaphragmatic hernia (CDH) etiology as revealed by pathway genetics. Am J Med Genet C Semin Med Genet. 2007 May 15;145(2):217-26. Review.

Kantarci S, Ragge NK, N Thomas S, Robinson DO, Noonan KM, Russell MK, Donnai D, F Raymond L, Walsh CA, Donahoe PK, Pober BR. Donnai-Barrow syndrome (DBS/FOAR) in a child with a homozygous LRP2 mutation due to complete chromosome 2 paternal isodisomy. Am J Med Genet A. 2008;146A (14):1842-1847.

Kantarci S, Donnai D, Noonan KM, Pober BR. Donnai-Barrow syndrome. GeneReviews (www.genetests.org) 2008.

Kantarci S, Mutations in LRP2, encoding the multiligand receptor megalin, cause Donnai-Barrow syndrome. VIII. National Medical Genetics Congress, Canakkale, Turkey [Invited Lecture]

Kantarci S, Donnai-Barrow syndrome (DBS/FOAR) in a child with a homozygous LRP2 mutation due to complete chromosome 2 paternal isodisomy. American College of Medical Genetics Annual Clinical Genetics Meeting (2008), Phoenix, AZ [Poster]

Kantarci S, 46,XY,i(18)(q10)/46,XY,del(18)(p11.1) mosaicism in an infant with mild congenital anomalies. The American Society of Human Genetics 58th Annual Meeting (2008), Philadelphia, PN [Poster]

Kantarci S, A submicroscopic unbalanced translocation resulting in del 4p and dup 17q leads to multiple congenital anomalies in a newborn female. American College of Medical Genetics Annual Clinical Genetics Meeting (2009), Tampa, FL [Poster]

James E. Kirby, MD, Medical Director, Clinical Microbiology, Assistant Professor of Pathology, Harvard Medical School

Wang Y, Doucette, S, Qian Q, and Kirby JE. Yield of primary and repeat induced sputum testing for Pneumocystis jiroveci in HIV positive and negative patients. Archives of Pathology and Laboratory Medicine. 2007;131(10),1582-4.

Chiaraviglio, L and Kirby JE. Infection of Cultured Human Endothelial Cells by Legionella pneumophila. PLoS-One. 2008 Apr 23;3(4):e2012.

Kirby JE, Delaney M, Qian Q, and Gold HS. Optimal Use of Myco/F Lytic and Standard BACTEC Blood Culture Bottles for Detection of Yeast and Mycobacteria. Archives of Pathology and Laboratory Medicine. 2009 Jan;133(1):93-6.

Duong S, Dezube, BJ, Desai G, Eichelberger K, Qian Q and Kirby JE. Limited Utility of Bone Marrow Culture: A Ten Year Retrospective Analysis. Laboratory Medicine. 2009. Jan 40, 37-38.

Pollock, N., Duong, S, Cheng A; Han L, Smole, S, and Kirby, JE. Ruling out novel H1N1 influenza with direct fluorescent antigen testing. Clin Infect Dis. 2009 Sep 15;49(6):e66-8.

Shu-Ling Liang, PhD, Assistant Director, Clinical Chemistry; Instructor, HMS

Liang SL, Lin MT, Hafez MJ, Gocke CD, Murphy KM, Sokoll LJ, Eshleman JR. Application of traditional clinical pathology quality control techniques to molecular pathology. J. of Molecular Diagnostics 2008;10:142-6.

Liang SL, Chan DW. Enzymes and related proteins as cancer biomarkers: A proteomic approach. Clin Chim Acta. 2007 Feb 20; [Epub ahead of print].

Liu W, Liang SL, Liu H, Silverman R, Zhou A. Tumour suppressor function of RNase L in a mouse model. Eur J Cancer. 2007 Jan;43(1):202-9.

Liang SL, Quirk D, Zhou A. RNase L: its biological roles and regulation. IUBMB Life. 2006 Sep;58(9):508-14.

Liang SL, Liu H, Zhou A. Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway. J Immunol. 2006 Jul 1;177(1):651-6.

Liang S, and Clarke W., *Urinalysis,* in Dufour R, and Clarke W. (Eds.), Contemporary Practice in Clinical Chemistry (p339-p350). Washington DC: AACC Press, 2006.

German Pihan, MD, Director, Hematopathology; Assistant Professor of Pathology, HMS

Ke Y, Zhou Y, Chen Y, Dezube B, Pihan G. A pan-HPV assay in the era of oligovalet vaccines: An opportunity to define the impact of prevention, vaccination and therapeutic interventions in the burden of HPV-induced diseases in diverse communities (2008).

Zhou Y, Fundyler O, Miller K, Pihan G. A highly multiplexed bead microarray assay for World Health Organization disease-defining chromosomal translocations/inversions in acute myeloid leukemia (2008).

Roberts M, Miller K, Pihan G. Rapid turn-around-time bead microarray assay for activated tyrosine kinases in chronic myeloproliferative disorders (in preparation).

Zhou Y, Chen Y, Miller K, Pihan G. Ultrafast, High-Throughput Sequencing-by-hybridization Assay For Insertion Mutations In The Nucleophosmin 1 Gene. Leukemia (in preparation). Miller K, and Pihan G. Treatment and Evaluation of High-risk Myelodysplastic Syndrome. Clin Adv Hematology Oncology 2008, 3(6):6 (in the press)

Pantanowitz L, Doweiko JP, Braza J, Pihan G, Dezube BJ, HIV-Associated Plasmablastic Lymphoma Following HAART Related Immune Reconstitution hiv & aids review. 2007, 7:31-4.

Maithel SK, Pratt W, Kelleher T, Avigan D, Goldman H, Pfeifer W, Pihan GA, Vollmer CM. Autoimmune pancreatitis in the setting of Castleman disease. Pancreas. 2007, 35:384-7.

Costa DB, Fisher CA, Miller KB, Pihan GA, Steensma DP, Gibbons RJ, Higgs DR. A novel mutation in the last exon of ATRX in a patient with alpha-thalassemia myelodysplastic syndrome. Eur J Haematol. 2006, 76:432-5.

CHAPTER 60: Cllinical Manifestations of Acute Myeloid Leukemia. In: Hematology: Basic Priniciples and Practice. Hoffman et al. 2008.

Amy Powers, MD, PhD, Assistant Director, Transfusion Medicine, Instructor, HMS

Powers A, Silberstein LE. Immune Haemolytic Anemia: Congenital and Acquired. In: Oxford Textbook of Medicine, 5th edition, (Warrel D, Cox T, Benz J eds). Oxford Press. 2009.

Powers A, Mohammed M, Uhl L, Haspel RL. Apparent nonhemolytic alloantibody-induced red-cell antigen loss from transfused erythrocytes. Blood. 2007 May 15;109(10):4590.

Qianfang Qian, MD, PhD, Assistant Director, Clinical Microbiology, Instructor, HMS

Qian Q, Eichelberger K, and Kirby JE. Rapid identification of Staphylococcus aureus in blood cultures by use of the direct tube coagulase testClin Microbiol. 2007 Jul;45(7):2267-9.

Wang Y, Doucette S, Qian Q, Kirby JE. Yield of primary and repeat induced sputum testing for Pneumocystis jiroveci in human immunodeficiency virus positive and negative patients. Arch. Pathol. Lab. Med. 2007; 131:1582-1584.

Wang, Y., J. E. Kirby and Q. Qian. Effective use of JC virus PCR for diagnosis of progressive multifocal leucoencephalopathy. J. Med. Micro. 2009. 58:253-255.

Kirby, J.E., M. Delaney, Q. Qian, and H. Gold. Optimal Use of the Myco/F Lytic and Standard BACTECTM Blood Culture Bottles for Detection of Yeast and Mycobacteria. Arch. Path. Lab. Med. 2009. 133:93-96.

Lynne Uhl, MD, Director, Division of Clinical Pathology; Medical Director, Transfusion Medicine; Assistant Professor of Pathology, Harvard Medical School

Cserti C, Landaw S, Uhl L. Do infections provoke exacerbations and relapses of thrombotic thrombocytopenic purpura? J Clin Apher 2007;22(1):21-5.

Powers A, Mohammed M, Uhl L, Haspel R. Apparent nonhemolytic alloantibody-induced red-cell antigen loss from transfused erythrocytes.Blood. 2007;109:4590 (letter).

Uhl L, Johnson ST. Evaluation and management of acute hemolytic transfusion reactions. Immunohematol. 2007;23:93-9.

Chan M, Malynn E, Shaz B, Uhl L. Utility of consecutive repeat HIT ELISA testing for heparin-induced thrombocytopenia. Am J Hematol. 2008;83:212-7.

Shaulov A, Yue S, Wang R, Joyce RM, Balk SP, Kim HT, Avigan DE, Uhl L, Sackstein R, Exley MA.. Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: Implications for posttransplant survival.Exp Hematol. 2008;36:464-72.

Gaines AR, Lee-Stroka H, Byrn K, Scott DE, Uhl L, Lazarus E, Stroncek DF. Investigation of whether the acute hemolysis associated with Rho(D) immune globulin intravenous (human) administration for treatment of immune thrombocytopenic purpura is consistent with the acute hemolytic transfusion reaction model. Transfusion 2009; 49: 1050-1058.

O’Neill E, Richardson-Weber L, McCormack G, Uhl L, and Haspel RL. Strict Adherence to a Blood Bank Specimen Labeling Policy by All Clinical Laboratories Significantly Reduces the Incidence of “Wrong Blood in Tube”. Am J Clin Pathol 2009;132:164-168

FACULTY AND SELECTED PUBLICATIONS
EXPERIMENTAL PATHOLOGY

Ramy A. Arnaout, MD, PhD, see Clinical Pathology

Laura Benjamin, PhD, Associate Professor of Pathology, Harvard Medical School

Phung TL, Eyiah-Mensah G, O’Donnell R, Shechter S, Walsh K, Kupperwasser C, and Benjamin LE. Endothelial Akt signaling is rate limiting for rapamycin inhibition of mouse mammary tumor progression. Cancer Res. 2007 Jun 1;67(11):5070-5.

Rao S, Lobov IB, Vallance JE, Tsujikawa K, Shiojima I, Akunuru S, Walsh K, Benjamin LE, Lang RA. Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development. 2007 Dec;134(24):4449-58.

Phung TL, Oble DA, Jia W, Benjamin LE, Mihm MC Jr, Nelson JS. Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks. Lasers Surg Med. 2008 Jan;40(1):1-5

Xue Q, Hopkins B, Perruzzi C, Udayakumar, D, Sherris D, Benjamin LE. Palomid 529, a novel small molecule drug, is a TORC1/TOR2 inhibitor that reduces tumor growth, tumor angiogenesis and vascular permeability. Cancer Research. 2008. (In press)

Benjamin, LE. “Retina.” The Endothelium. Ed. William Aird. Cambridge University Press. 2007. 125: 1154-1160.

Nagy JA, Benjamin LE, Zeng H, Dvorak AM, Dvorak HF. Vascular permeability, vascular hyperpermeability and angiogenesis. Angiogenesis. Springer. 2008. 11: 109-119.

Phung TL, Eyiah-Mensah G, O'Donnell RK, Bieniek R, Shechter S, Walsh K, Kuperwasser C, Benjamin LE. Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression. Cancer Res. 2007 Jun 1;67(11):5070-5.

Anders Berg, MD, PhD, see Clinical Pathology

Mark S. Boguski, MD, PhD, Associate Professor of Pathology, Harvard Medical School

Voshol, H. Cho, C.R., Vachon, T., Boguski, M.S., van Oostrum, J. and Peitsch, M.C. (2006), Systems Biology: Integrating in silico approached and experimental approaches to study signaling networks in Systems Biology: a User’s Guide, a Focus issue of Nature Cell Biology and Nature Reviews Molecular Cell Biology. 8(11).

Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., et al (2007) "Genome-wide atlas of gene expression in the adult mouse brain." Nature 455:168-176.

Boguski, M.S. (2008) Translational Research in Genetics and Genomics. New England Journal of Medicine 359:1969-1970

Boguski, M.S. (2009) Health information retrieval by consumers and the challenge of personal genomics. Chapter 21 in Genomics and Personalized Medicine, H.F Willard and G. Ginsberg, eds., Academic Press.

Boguski, M.S., Mandl, K.D. and Sukhatme, V.P. (2009) Drug discovery: Repurposing with a difference. Science 324(5933): 1394-1395.

Boguski, M.S., Arnaout, R. and Hill, C. (2009) Customized care 2020: How medical sequencing and network biology will enable personalized medicine. Faculty of 1000 (invited commentary), in press.

Lawrence Brown, MD, see Anatomic Pathology

Ann M. Dvorak, MD, Professor of Pathology, Harvard Medical School

Melo RCN, Dvorak AM, Weller PF. New aspects of piecemeal degranulation in human eosinophils. Chap 16 In: New Research in Innate Immunity, Durand M, Morel CV (eds) Hauppauge NY Nova Science 2008; 351-370.

Nagy JA, Chang S-H, Dvorak AM, Dvorak HF. Why are tumor blood vessels abnormal and why is it important to know? Brit J Ca 100:865-869, 2009.

Radke AL, Spencer LA, Reynolds LE, Melo RCN, Dvorak AM, Weller PF. Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation. Blood 113:3092-3101, 2009.

Melo RCN, Spencer LA, Perez SAC, Neves JS, Bafford SP, Morgan ES, Dvorak AM, Weller PF. Vesicle-mediated secretion of human eosinophil granule-derived major basic protein (MBP). Lab Invest 88:769-781, 2009.

Harold F. Dvorak, MD, Director, Vascular Biology Research Center; Mallinckrodt Distinguished Professor of Pathology, Harvard Medical School

Sung-Hee Chang, Keizo Kanasaki, Vasilena Gocheva, Galia Blum, Jay Harper, Marsha A. Moses, Shou-Ching Shih, Janice A. Nagy, Johanna Joyce, Matthew Bogyo, Raghu Kalluri, and Harold F. Dvorak. VEGF-A Induces Angiogenesis by Perturbing the Cathepsin-Cysteine Protease Inhibitor Balance in Venules, Causing Basement Membrane Degradation and Mother Vessel Formation. www.aacrjournals.org Cancer Res 2009; 69: (10). May 15, 2009.

JA Nagy, S-H Chang, AM Dvorak and HF Dvorak.Why are tumour blood vessels abnormal and why is it important to know? British Journal of Cancer (2009).

Shou-Ching Shih, Andrew Zukauskas, Dan Li, Guanmei Liu, Lay-Hong Ang, Janice A. Nagy, Lawrence F. Brown, and Harold F. Dvorak. The L6 Protein TM4SF1 Is Critical for Endothelial Cell Function and Tumor Angiogenesis. www.aacrjournals.org Cancer Res 2009; 69: (8). April 15, 2009.

Marie-Helene Jouvin, MD, Instructor in Pathology, Harvard Medical School

Hartman ML, Lin SY, Jouvin MH, Kinet JP. Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI. Mol Immunol. 2008 Apr;45(8):2307-11. Epub 2008 Jan 7.

Vig M, DeHaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol. 2008 Jan;9(1):89-96. Epub 2007 Dec 2.

Kraft S, Fleming T, Billingsley JM, Lin SY, Jouvin MH, Storz P, and Kinet JP. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J Exp Med 201:385-96 2005.

Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FceRI controls the formation of functional IgE-binding receptors. J Exp Med 201:267-77 2005.

Sibel Kantarci, PhD, see Clinical Pathology

Antoine E. Karnoub, PhD, Assistant Professor of Pathology, Harvard Medical School

Karnoub AE, Weinberg RA. Ras oncogenes: split personalities. Nat Rev Mol Cell Biol. 2008 Jul;9(7):517-31.

Scheel C, Onder T, Karnoub A, Weinberg RA. Adaptation versus selection: the origins of metastatic behavior. Cancer Res. 2007 Dec 15;67(24):11476-9; discussion 11479-80. Review. No abstract available.

Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007 Oct 4;449(7162):557-63.

Ince TA, Richardson AL, Bell GW, Saitoh M, Godar S, Karnoub AE, Iglehart JD, Weinberg RA. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell. 2007 Aug;12(2):160-70.

Karnoub AE, Weinberg RA. Chemokine networks and breast cancer metastasis. Breast Dis. 2006-2007;26:75-85.

Yohe ME, Rossman KL, Gardner OS, Karnoub AE, Snyder JT, Gershburg S, Graves LM, Der CJ, Sondek J. Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif. J Biol Chem. 2007 May 4;282(18):13813-23.

Roya Khosravi-Far, PhD, Associate Professor of Pathology, Harvard Medical School

Chalah, A., and Khosravi-Far, R. 2008. The mitochondrial death pathway. Adv Exp Med Biol 615:25-45.

Jagani, Z., and Khosravi-Far, R. 2008. Cancer stem cells and impaired apoptosis. Adv Exp Med Biol 615:331-344.

Jagani, Z., Singh, A., and Khosravi-Far, R. 2008. FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis. Biochim Biophys Acta 1785:63-84.

Khosravi-Far, R., Zakeri, Z., Lockshin, R.A., and Piacentini, M. 2008. Methods in enzymolology book on cell death. Methods Enzymol 446:xxi-xxii.

Matarrese, P., Manganelli, V., Garofalo, T., Tinari, A., Gambardella, L., Ndebele, K., Khosravi-Far, R., Sorice, M., Esposti, M.D., and Malorni, W. 2008. Endosomal compartment contributes to the propagation of CD95/Fas-mediated signals in type II cells. Biochem J 413:467-478.

Melet, A., Song, K., Bucur, O., Jagani, Z., Grassian, A.R., and Khosravi-Far, R. 2008. Apoptotic pathways in tumor progression and therapy. Adv Exp Med Biol 615:47-79.

Ndebele, K., Gona, P., Jin, T.G., Benhaga, N., Chalah, A., Degli-Esposti, M., and Khosravi-Far, R. 2008. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3. Apoptosis 13:845-856.

Plati, J., Bucur, O., and Khosravi-Far, R. 2008. Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities. J Cell Biochem 104:1124-1149.

Song, K., Mariappan, R., and Khosravi-Far, R. 2008. Analysis of TNF-related apoptosis-inducing ligand in vivo through bone marrow transduction and transplantation. Methods Enzymol 446:315-331.

Degli Esposti, M., Tour, J., Ouasti, S., Ivanova, S., Matarrese, P., Malorni, W., and Khosravi-Far, R. 2009. Fas death receptor enhances endocytic membrane traffic converging into the Golgi region. Mol Biol Cell 20:600-615.

Jagani, Z., Song, K., Kutok, J.L., Dewar, M.R., Melet, A., Santos, T., Grassian, A., Ghaffari, S., Wu, C., Ren, R., Rodin, H.Y., Miller, K., and Khosravi-Far, R. 2009. Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL-Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor Suppressors. Cancer Res.

Ren, B., Song, K., Parangi, S., Jin, T., Ye, M., Humphreys, R., Duquette, M., Zhang, X., Benhaga, N., Lawler, J., and Khosravi-Far, R. 2009. A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. Cancer Res 69:3856-3865.

Jean-Pierre Kinet, MD, Professor of Pathology, Harvard Medical School

Kinet JP. A new strategy to counter allergy. N Engl J Med. 2005 Jul 21;353(3):310-2.

Kraft S, Fleming T, Billingsley JM, Lin, SY, Jouvin MH, Storz, P, and Kinet JP. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J. Exp. Med. 201:385-396, 2005.

Peinelt C, Vig M, Koomoa DL, Beck A, Nadler MJ, Koblan-Huberson M, Lis A, Fleig A, Penner R, Kinet JP. Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol. 2006 Jul;8(7):771-3. Epub 2006 May 30.

Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science. 2006 May 26;312(5777):1220-3. Epub 2006 Apr 27.

Vig M, Kinet JP. The long and arduous road to CRAC. Cell Calcium. 2007 Aug;42(2):157-62. Epub 2007 May 22.

Kinet JP. The essential role of mast cells in orchestrating inflammation. Immunol Rev. 2007 Jun;217:5-7. Review.

Kraft S, Kinet JP. New developments in FcepsilonRI regulation, function and inhibition. Nat Rev Immunol. 2007 May;7(5):365-78.

Hartman ML, Lin SY, Jouvin MH, Kinet JP. Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI. Mol Immunol. 2008 Apr;45(8):2307-11. Epub 2008 Jan 7.

Vig M, DeHaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol. 2008 Jan;9(1):89-96. Epub 2007 Dec 2.

Calloway N, Vig M, Kinet JP, Holowka D, Baird B. Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions. Mol Biol Cell. 2009 Jan;20(1):389-99. Epub 2008 Nov 5.

Vig M, Kinet JP. Calcium signaling in immune cells. Nat Immunol. 2009 Jan;10(1):21-7. Review. Erratum in: Nat Immunol. 2009 Feb;10(2):223.

James Kirby, MD, see Clinical Pathology

Olivier Kocher, MD, PhD, see Anatomic Pathology

Jack Lawler, PhD; Director, Division of Experimental Pathology; Professor of Pathology, Harvard Medical School

Olerud J, Johansson M, Lawler J, Welsh N, Carlsson PO. Improved vascular engraftment and graft funtion following inhibition of the angiostatic factor Trombospondin-1 in mouse pancreatic islets. Diabetes 2008; 57(7):1870-1877

Posey KL, Hankenson K, Veerisetty AC, Bornstein P, Lawler J, Hect JT. Skeletal abnormalities in Mice lLacking Extracellular Matrix Proteins, Trombospondin-1, Thrombospondin-3, Thrombospondin-5, and Type IX Collagen. Am J Pathol 2008. 172(6):1664-1674

Tan K, Duqutte M, Liu JH, Lawler J, Wang JH. The crystal structure of the Heparin-Binding Reelin-N Domain of F-Spondin. J Mol Biol 2008. In Press

Tan K, Duquette M, Liu JH, Shanmugasundaram K, Joachimial A, Gallaher JT, Rigby AC, Wang JH, Lawler J. Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 Nterminal domain. J Biol Chem. 2008; 283(7): 3932-41

Punekar S, Zak S, Kalter VG, Dobransky L, Punekar I, Lawler JW, Gutierrez LS. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and inflammation in a murine model of inflammatory bowel disease. Pathobiology 2008; 75 (1): 9-21

Yee KO, Conolly CM, Duquette M, Kazerounian S, Washington R, Lawler J. The effect of throbmospondin-1 on breast cancer metastasis. Breast Cancer ResTreat.2008 Apr 13

Olerud J, Johansson M, Lawler J, Welsh N, Carlsson PO. Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes 2008; 57(7): 1870-7

Kazerounian S, Yee KO, Lawler J. Thrombospondins in cancer. Cell Mol Life Science 2008, 65(5): 700-12

Sun J, Hopkins BD, Tsujikawa K, Perruzzi C, Adini I, Swerlick R, Bornstein P, Lawler J, Benjamin LE. Thrombospondin-1 modulates VEGF-A mediated AKT signaling and capillary survival in the developing retina. Am. J. Physiol Heart Cir Physiol, 2009,296 (5): H 1344-51.

Ren B, Song K, Jin T, Parangi S, Duquette M, Zhang X, Lawler J, Khosravi-Far R. A double hit to kill tumor and endothelial cells by TRAIL and anti-angiogenic 3TSR. Cancer Res. 69 (9): 3856-3865

Tan K, Duquette M, Joachimiak A, Lawler J. The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. FASEB J. 2009, 23(8): 2490-501.

Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J.Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 2009 Jun 15. [Epub ahead of print]

Janice A. Nagy, PhD; Principal Associate in Pathology, Harvard Medical School

SC Shih, A Zukauskas, D Li, G Liu, L-H Ang, JA Nagy, LF Brown, and HF Dvorak. The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Cancer Res. 69:3272-7, 2009.

Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Nagy JA, Joyce J, Bogyo M, Kalluri R, Dvorak HF.VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res. 69:4537-44, 2009.

Xue Q, Nagy JA, Manseau EJ, Phung TL, Dvorak HF, Benjamin LE. Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase. Arterioscler Thromb Vasc Biol. 29:1172-8, 2009.

Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J.Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 2009 Jun 15. [Epub ahead of print].

Chang SH, Feng D, Nagy JA, Sciuto TE, Dvorak AM, Dvorak HF. Vascular Permeability and Pathological Angiogenesis in Caveolin-1-Null Mice. Am J Pathol. 2009 Sep 3. [Epub ahead of print].

Trista E. North, PhD, Assistant Professor of Pathology, Harvard Medical School

Goessling W*, North TE*, and Zon LI Ultrasound biomicroscopy enables in vivo characterization of zebrafish tumorigenesis and therapeutic response. 2007. Nature Methods 4: 551-553.

North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord A, Weber G, Bowman T, Jang IH, Grosser T, FitzGerald GA, Daley GQ, and Zon LI. Prostaglandin E2 regulates zebrafish hematopoietic stem cell homeostasis. 2007. Nature 447: 1007-1011.

Goessling W, North TE, Weidinger G, Lord A, Haramis AP, Clevers H, Moon RT, and Zon LI. APC mutant zebrafish uncover a biphasic requirement for wnt signaling in liver development. 2007. Developmental Biology 320: 161-174.

Upadhyay G, Goessling W, North TE, Zon LI, Yajnik V. Molecular association between b-catenin degradation complex and guanine exchange factor DOCK4 is essential for Wnt signaling. 2008. Oncogene 27: 5845-5855.

Goessling W*, North TE*, Schmitt S, Lord AM, Lee S, Stoick-Cooper C, Puder M, Daley GQ, Moon RT, and Zon LI. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. 2009. Cell 136: 1136-1147.

Dovey M, Patton EE, Bowman T, North T, Goessling W, Zhou Y, Zon LI. Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. 2009. Molecular and Cellular Biology 29: 3746-3753.

North, TE*, Goessling W*, Peeters M, Li P, Ceol C, Lord AM, Weber GJ, Harris J, Cutting CC, Huang P, Dzierzak E, Zon LI. 2009. Cell 137: 736-748.

Pier Paolo Pandolfi, MD, PhD, Director, Cancer Genetics Program at BIDMC, Professor of Pathology and Medicine, Harvard Medical School

Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Sci Signal. 2009 Aug 18;2(84):ra44.

Cheng K, Sportoletti P, Ito K, Clohessy JG, Teruya-Feldstein J, Kutok JL, Pandolfi PP. The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model. Blood. 2009 Aug 7. [Epub ahead of print]

Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell. 2009 Aug 4;16(2):115-25.

Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8. Epub 2009 Jul 15.

Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, Ahn Y, Dahlberg S, Neuberg D, Moreau LA, Winter SS, Larson R, Zhang J, Protopopov A, Chin L, Pandolfi PP, Silverman LB, Hunger SP, Sallan SE, Look AT. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood. 2009 Jul 16;114(3):647-50. Epub 2009 May 20.

Clohessy JG, Pandolfi PP. beta-tting on p63 as a metastatic suppressor. Cell. 2009 Apr 3;137(1):28-30.

Ito K, Bernardi R, Pandolfi PP. A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell. Curr Opin Genet Dev. 2009 Feb;19(1):51-9. Epub 2009 Feb 11. Review.

Carracedo A, Baselga J, Pandolfi PP. Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors. Cell Cycle. 2008 Dec 15;7(24):3805-9. Epub 2008 Dec 22. Review.

Bernardi R, Papa A, Pandolfi PP. Regulation of apoptosis by PML and the PML-NBs. Oncogene. 2008 Oct 20;27(48):6299-312. Review.

German Pihan, MD, see Clinical Pathology

Isaac Rabinovitz, MD, PhD, Instructor in Medicine, Harvard Medical School

Rabinovitz I. and Mercurio, AM, M. Dynamic Functions of theα6β4 Integrin in Carcinoma. In: A. Wells (ed.), Cell Motility in Cancer Invasion and Metastasis, 1st edition, Vol. 8, pp. 29. New York, NY: Springer, 2006.

Germain EC, Santos TM, Rabinovitz I. Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly. Mol Biol Cell. 2009 Jan;20(1):56-67. Epub 2008 Nov 12.

John Rinn, PhD, Assistant Professor of Pathology, Harvard Medical School

Su MA, Giang K, Zumer K, Jiang H, Oven I, Rinn JL, Devoss JJ, Johannes KP, Lu W, Gardner J, Chang A, Bubulya P, Chang HY, Peterlin BM, Anderson MS. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J Clin Invest. 2008 May;118(5):1712-26.

Rinn JL, Wang JK, Liu H, Montgomery K, van de Rijn M, Chang HY. A systems biology approach to anatomic diversity of skin. J Invest Dermatol. 2008 Apr;128(4):776-82. Review.

Rinn JL, Wang JK, Allen N, Brugmann SA, Mikels AJ, Liu H, Ridky TW, Stadler HS, Nusse R, Helms JA, Chang HY. A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev. 2008 Feb 1;22(3):303-7.

Chang W, Zaarour RF, Reck-Peterson S, Rinn J, Singer RH, Snyder M, Novick P, Mooseker MS. Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acid-protein complex that contains mRNAs and subunits of the RNA-processing body. RNA. 2008 Mar;14(3):491-502. Epub 2008 Jan 24.

Khavari TA, Rinn J. Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia. Cell Cycle. 2007 Sep;6(23):2928-31. Epub 2007 Sep 4. Review.

Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007 Oct 11;449(7163):689-94. Epub 2007 Sep 12.

Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.
Cell. 2007 Jun 29;129(7):1311-23.

O'Geen H, Squazzo SL, Iyengar S, Blahnik K, Rinn JL, Chang HY, Green R, Farnham PJ. Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs. PLoS Genet. 2007 Jun;3(6):e89. Epub 2007 Apr 19.

Jeffrey Saffitz, MD, PhD, see Anatomic Pathology

Donald R. Senger, PhD, Principal Associate in Pathology, Harvard Medical School

Davis GE, Senger DR. Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression. Current Opinion in Hematology 2008; 15: 197-203.

Nagy JA, Senger DR. VEGF-A, cytoskeletal dynamics, and the pathological vascular phenotype. Exp Cell Res 2006; 312: 538-548.
Davis GE, Senger DR. Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ Res. 2005 Nov 25;97(11):1093-107.

Hoang MV, Senger DR. In vivo and in vitro models of mammalian angiogenesis. Methods Mol Biol. 2005;294:269-85.

Shou-Ching Shih, PhD, Research Associate, Instructor in Pathology, HMS

English SB, Shih SC, Ramoni MF, Smith LE, Butte AJ. Use of Bayesian networks to probabilistically model and improve the likelihood of validation of microarray findings by RT-PCR. J Biomed Inform 2008.

Dudley AC, Khan ZA, Shih SC, Kang SY, Zwaans BM, Bischoff J, Klagsbrun M. Calcification of multipotent prostate tumor endothelium. Cancer Cell 2008; 14(3):201-11

Nagy JA, Feng D, Vasile E, Wong WH, Shih SC, Dvorak AM, Dvorak HF: Permeability properties of tumor surrogate blood vessels induced by VEGF-A, Lab Invest 2006, 86:767-780.

Steven Tahan, MD see Anatomic pathology

Alex Toker, PhD, Associate Professor of Pathology, Harvard Medical School

Yoeli-Lerner, M., Chin, Y. R., Hansen, K. C. and Toker, A. The Akt/PKB and GSK-3b Signaling Pathway Regulates Cell Migration through the NFAT1 transcription factor. Molecular Cancer Research 2009; 7(3): 425-432.

Gao, D., Inuzuka, H., Tseng, A., Chin Y. R., Toker, A. and Wei, W. Akt Phosphorylates Skp2, Promotes its Cytoplasmic Localization, and Impairs its Destruction by APC/Cdh1. Nature Cell Biology 2009; 11 (4): 397-408.

Storz, P., Döppler, H., Copland, J. A., Simpson, K. J. and Toker, A. The FOXO3a Transcription Factor Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases. Molecular and Cellular Biology 2009; 29 (18): 4906-4917.1.

Toker, A. mTOR and Akt signaling in cancer: SGK cycles in. Molecular Cell 2008;31: 6-8. Chin, Y. R. and Toker, A. Function of Akt Signaling in Cell Motility, Invasion and the Tumor Stroma in Cancer. Cellular Signaling, 2009; 21(4):470-476.

Mancini, M. L. and Toker, A. NFAT Proteins: Emerging Roles in Cancer Progression. Nature Reviews Cancer 2009; in press.

Wenyi Wei, PhD, Assistant Professor of Pathology, Harvard Medical School

Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin, WG Jr, Näär AM, and Dyson NJ. The Retinoblastoma protein and the Anaphase-promoting complex physically interact and functionally cooperate in G1 control. Nature Cell Biology 2007: 9(2): 225-32.

Wei W, Jin J, Schlisio S, Harper JW and Kaelin WG Jr. v-Jun escapes Fbw7 mediated protein degradation by disruption of GSK3-dependent phosphorylation. Cancer Cell 2005: 8(1): 25-33.

Catherine T. Yan, PhD, Assistant Professor of Pathology, Harvard Medical School

Yan C, Kaushal D, Murphy MM, Datta A, Lee CZ, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli A, Tepsuporn S, Mulligan R, Fox E., Bronson R, De Gerolami U, Lee C, Alt FW.XRCC4 suppresses medulloblastomas with recurrent translocations in p53 deficient mice. PNAS, 2006, 103 (19): 7378-7383.

Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, and Alt FW. Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism. Advances in Immunology, 2007, 94:157-214.

Yan CT, Boboila C, Souza EK, Franco S, Hickernell T, Murphy M, Gumaste S, Geyer M, Zarrin A, Manis JP, Rajewsky K and Alt FW. IgH Class Switching and Translocations Employ a Robust Non-classical End-joining Pathway. Nature, 2007, 449 (7161):478-82.

Xie A, Harlterode A, Stucki M, Odate S, Puget N, Nagaraju G, Yan CT, Alt FW, Chen, J, Jackson SP, and Scully, R. Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair. Molecular Cell, 2007, 28:1045-57.

Wang, JH*, Gostissa M*, Yan CT*, Goff P, Hickernell, T, Hansen E, Difilippantonio S, Zarrin A, Rajewsky K, Nussenzweig A, and Alt, FW. (2009) Mechanistic factors that promote recurrent translocations in peripheral B lymphocytes. Nature 460: 231-6. (*equal contribution).

Huiyan Zeng, PhD, Instructor in Pathology, Harvard Medical School

Zeng H, Qin L, Zhao D, Tan X, Manseau EJ, Van Hoang M, Senger DR, Brown LF, Nagy JA, Dvorak HF. Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity. J Exp Med. 2006 Mar 20;203(3):719-29. Epub 2006 Mar 6.

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