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Publications by Faculty

FACULTY AND SELECTED PUBLICATIONS
ANATOMIC PATHOLOGY

Matthew P. Anderson, MD, PhD, Associate Professor, Harvard Medical School, Departments of Neurology and Pathology; Director of Neuropathology, Beth Israel Deaconess Medical Center; Co-Director, Harvard Longwood Neuropathology Training Program

Boillot M, Huneau C, Marsan E, Lehongre K, Navarro V, Ishida S, Dufresnois B, Ekim Ozkaynak E, Garrigue J, Miles R, Martin B, Leguern E, , Anderson MP, Baulac S. Glutamatergic neuron-targeted loss of Lgi1-epilepsy gene results in seizures. Brain 2014 in press

Khoury MN, Alsop DC, Agnihotri SP, Pfannl R, Wuthrich C, Ho ML, Hackney D, Ngo L, Anderson MP, Koralnik IJ. Hyperintense cortical signal on magnetic resonance imaging reflects focal leukocortical encephalitis and seizure risk in progressive multifocal leukoencephalopathy. Ann Neurol. 2014;75:659-69.

Gamze Ayata, MD, Staff Pathologist, Director of Cytopathology Fellowship; Instructor in Pathology, Harvard Medical School

Wang HH and Ayata G. Chapter 7: Gastrointestinal Tract. In: Cibas ES, Ducatman BS, eds. Cytology: Diagnostic principles and clinical correlates. 4th edn, Saunders/Elsevier (in press).

Wang HH and Ayata G. Chapter 3: Diagnostic Cytology of the GI tract. In: Odze RD, Goldblum JR, eds. Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. 3rd edition, Saunders/Elsevier (in press).

Karoly Balogh, MD, Staff Pathologist; Associate Professor of Pathology, HMS

Histology for Pathologists. Ed. by S.E. Mills, Chapter 15. Mouth, Nose, and Paranasal Sinuses. (in print) New York, Raven Press, 4th edition, 2012.

Lawrence F. Brown, MD, Staff Pathologist, Associate Professor of Pathology, HMS

Adini A, Doucette S, Brown LF, Benjamin LE. Prominin/CD133 is not just a marker, but regulates cancer cell survival. Submitted.

Li J, Wang E, Lau J, Schroeder MA, Rinaldo F, Brown LF, et al. Factor inhibiting HIF (FIH) is essential for inhibiting HIF mediated gene transcription in glioblastoma multiforme. Submitted.

Kane SE, Liu FW, Brown LF, Awtrey CS, Hecht JL. Papillary Serous Borderline tumor of the ovary with significant ascites and Vascular Endothelial Growth Factor expression. submitted.

Tracy Challies, MD, Staff Pathologist, GI and Liver Pathology; Instructor in Pathology, Harvard Medical School

Klibansky DA, Mehta S, Curry M, Nasser I, Challies T, and Afdhal NH. Transient elastography for predicting clinical outcomes inpatients with chronic liver disease. J Viral Hepatitis. Article first published on line: 1 JUL 2011/ DOI:10.1111/j.1365-2893.2011.01493.x

Laura C. Collins, MD, Associate Director of Anatomic Pathology; Associate Professor of Pathology, Harvard Medical School

Aroner SA, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, et al. Radial scars and subsequent breast cancer risk: results from the Nurses' Health Studies. Breast Cancer Res Treat. 2013;139(1):277-85. PMID: 23609472

Collins LC, Achacoso N, Haque R, et al. Risk factors for non-invasive and invasive local recurrence in patients with ductal carcinoma in situ. Breast Cancer Res Treat. 2013;139(2):453-60. PMID: 23624751

Collins LC and Schnitt SJ. Pathology of Benign Breast Disorders. In: Diseases of the Breast. Philadelphia : Lippincott Williams & Wilkins; 2014. In press.

James L. Connolly, MD, Staff Pathologist, Surgical Pathology and Breast Pathology; Professor of Pathology, Harvard Medical School

Aroner SA, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, et al. Radial scars and subsequent breast cancer risk: Results from the Nurses’s Health Studies. Breast Cancer Res Treat 2013; 139:277-285.

Ahsen OO, Tao YK, Potsaid BM, Sheikine Y, Jiang J, Grulkowski I, Tsai TH, Jayaraman V, Kraus MF, Connolly JL, et al. Swept source optical coherence microscopy using a 1310 nm VCSEL light source. Opt Express 2013; 21:18021-18033.

Lee HC, Liu JJ, Sheikine Y, Aguirre AD, Connolly JL, Fujimoto JG. Ultrahigh speed sprectral-domain optical coherence microscopy. Biomed Opt Express 2013; 4:1236-1254.

Beverly Faulkner-Jones, MD, PhD, Staff Pathologist, Dermatopathology and Surgical Pathology; Instructor in Pathology, Harvard Medical School

Harris, A., Faulkner-Jones, B.E and Zimarowski, M.J. Epidermal panfolliculoma: A report of two cases. Am J Dermatopathol. 2011 Feb;33(1):e7-10.

Jeong, W; Schneider, J; Hansen, A; Lee, M; Turney, S; Faulkner-Jones, B; Hecht, J; Najarian, R; Yee, E; et al. "A Collaborative Digital Pathology System for Multi-Touch Mobile and Desktop Computing Platforms." Computer Graphics Forum. Vol. 32. Issue 6. Sept 2013

Jeffrey D. Goldsmith, MD, Staff Pathologist, Director of Surgical Pathology Laboratory and GI Pathology Fellowship; Assistant Professor of Pathology, Harvard Medical School

Dyhadalo K, Fitzgibbons P, Goldsmith JD, et al. Laboratory Compliance with the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) Human Epidermal Growth Factor Receptor 2 Testing Guidelines: A 3-year Caomparison of Validation Procedures. Arch Pathol Lab Med. 2014. In press.

Manfredi MA, Jiang H, Borges LF, Deutsch AJ, Goldsmith JD, Lightdale JR. Good Agreement between Endoscopic Findings and Biopsy Reports Supports Limited Tissue Sampling During Pediatric Endoscopy. J Ped Gastroenterol Nutr. 2014. In press.

Fitzgibbons PL, Bradley LA, Fatheree LA, Alsabeh R, Fulton RS, Goldsmith JD, et al. Principles of Analytic Validation of Immunohistochemical Assays. Guideline from the College of American Pathologists Pathology and Laboratory Quality Center. Arch Pathol Lab Med. 2014. In press.

Mamta Gupta, MD, Staff Pathologist; Instructor in Pathology, Harvard Medical School

Vang R, Gupta M, Wu LS, et al. Diagnostic Reproducibility of Hydatidiform Moles: Ancillary Techniques (p57 Immunohistochemistry and Molecular Genotyping) Improve Morphologic Diagnosis. Am J Surg Pathol. 2012 Mar;36(3):443-53.

Gupta M, Vang R, Yemelyanova AV, et al. Diagnostic reproducibility of hydatidiform moles: ancillary techniques (p57 immunohistochemistry and molecular genotyping) improve morphologic diagnosis for both recently trained and experienced gynecologic pathologists. Am J Surg Pathol. 2012, Dec;36(12):1747-60.

Li RF, Gupta M, McCluggage WG, Ronnett BM. Embryonal rhabdomyosarcoma (botryoid type) of the uterine corpus and cervix in adult women: report of a case series and review of the literature. Am J Surg Pathol. 2013, Mar;37(3):344-55.

Cynthia Hayne, MD, PhD, Staff Pathologist; Instructor in Pathology, HMS

Hussain G, Tapper E, Mavrakis A, Krajewski K, Hayne C, et al. “Sensitivity of Ultrasound for Hepatic Steatosis Detection Based on Histological and Digital Scores in Nonalcoholic Fatty Liver Disease.” Presented at Digestive Disease Week 2010.

Jonathan Hecht, MD, PhD, Staff Pathologist; Medical Director of Autopsy Service; Associate Professor of Pathology, Harvard Medical School

Fadare O…Hecht JL. Utility of Alpha-methylacyl-CoA-racemase (p504s) Immunohistochemistry In Distinguishing Endometrial Clear Cell Carcinomas from Serous and Endometrioid Carcinomas. Hum Pathol. 2013 Dec;44(12):2814-21.

Schmolze D, Awtrey CS, Hecht JL. The value of additional level sections in the evaluation of lymph nodes for endometrial carcinoma staging. Am J Clin Pathol. 2013 Oct;140(4):516-8.

Hecht JL, Konstantinopoulos PA, Awtrey CA, et al. Immunohistochemical Loss of BRCA1 Protein in Uterine Serous Carcinoma. Int J Gynecol Pathol. 2014.

Yael K. Heher, MD (formerly Yael B Kushner), Staff Pathologist; Director, Quality Assurance and Quality Improvement; Instructor in Pathology, Harvard Medical School

Glassock RJ, Khorashadi L, Kushner YB. Case records of the Massachusetts General Hospital. Case 32-2012. A 35-year-old man with respiratory and renal failure.N Engl J Med. 2012 Oct 18;367(16):1540-53

Spicer J, Benay C, Lee L, Rousseau M, Andalib A, Kushner Y, et al. Diagnostic accuracy and utility of intraoperative microscopic margin analysis of gastric and esophageal adenocarcinoma.Ann Surg Oncol. 2014Aug;21(8):2580-6

Adam B, Randhawa P, Chan S, Zeng G, Regele H, Kushner YB, et al. Banff Initiative for Quality Assurance in Transplantation (BIFQUIT): Reproducibility of Polyomavirus Immunohistochemistry in Kidney Allografts. Am J Transplant 2014 Aug (e-pub ahead of print)

Nicole B. Johnson, MD, Associate Residency Program Director; Staff Pathologist, Breast Pathology and Cytopathology; Instructor in Pathology, HMS

Krajcovic M, Johnson NB, Sun Q, …Schnitt SJ, et al. A Non-genetic Route to Aneuploidy in Human Cancers. Nature Cell Biology, 2011; 13(3): 324-30.

Dialani V, Mani K, Johnson NB. Chronic Lymphocytic Leukemia involving the Breast Parenchyma – Mimicker of Invasive Breast Cancer – Differentiation on Breast MRI, Case Reports in Medicine, 2013: 603614.

Johnson NB, Collins LC. Less common variants and mimics of ductal carcinoma in-situ. Surgical Pathology Clinics, Breast Pathology, in press.

Olivier Kocher, MD, PhD, Staff Pathologist, Pulmonary Pathology; Associate Professor of Pathology, Harvard Medical School

Kaczmarek E, Bakker JP, Clarke DN, Csizmadia E, Kocher O, et al. Molecular biomarkers of vascular dysfunction in obstructive sleep apnea. PLoS One. 2013, 8:e70559.

Folch E, Yamaguchi N, Vanderlaan PA, Kocher O, et al. Adequacy of Lymph Node Transbronchial Needle Aspirates Using Convex Probe Endobronchial Ultrasound for Multiple Tumor Genotyping Techniques in Non-Small-Cell Lung Cancer. J Thorac Oncol., 2013, 8:1438-1444.

VanderLaan PA, Yamaguchi N, Folch E, Boucher DH, Kent, MS, Gangadharan SP, Majid A, Goldstein MA, Huberman MS, Kocher O, Costa DB. Success and failure rates of tumor genotyping techniques in routine pathological samples with non-small-cell lung cancer. Lung Cancer, 2014, 84:39-44.

Douglas I. Lin, MD, PhD, Staff Pathologist; Instructor in Pathology, Harvard Medical School

Winham WM, Lin D, Stone PJ, et al. Architectural Versus Nuclear Atypia-defined FIGO Grade 2 Endometrial Endometrioid Adenocarcinoma (EEC): A Clinicopathologic Comparison of 154 Cases With Clinical Follow-up. Int J Gynecol Pathol. 2014 Mar; 33(2):120-6.

Lynch KM, Katz JD, Weinberg DH, Lin DI, Folkerth RD. Isolated mononeuropathy multiplex--a rare manifestation of intravascular large B-cell lymphoma. J Clin Neuromuscul Dis. 2012 Sep;14(1):17-20.

Nguyen PL, Lin DI, Lei J, et al. The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy. Urol Oncol. 2011 May-Jun; 29(3):302-8.

Robert Najarian, MD, Staff Pathologist, Gastrointestinal Pathology; Instructor in Pathology, Harvard Medical School

Ziogas DC, Karagiannis AK, Geiger BM, Gras-Miralles B, Najarian R, et al. Peptides 2014 May; 55:58-64.

Feuerstein JD, Najarian R, Cheifetz AS. Hickam’s dictum in a patient with diarrhea. Gastroenterology 2013 November; 145(5): 942.

Leffler D, Schuppan D, Pallav K, Najarian R, Goldsmith JD, et al. Kinetics of the histological, serological, and symptomatic responses to gluten challenge in adults with celiac disease. Gut 2013 Jul; 62(7): 996-1004.

Imad Nasser, MD, Staff Pathologist, Surgical Pathology, Liver Pathology and Cytopathology; Assistant Professor of Pathology, Harvard Medical School

Li S, Vriend LE, Nasser IA, et al. Hepatitis C virus-specific t-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis. Hepatology. 2012 Dec; 56(6):2094-105.

Turner BG, Sosa A, Nasser IA, Sawhney M. Use of an endobronchial US endoscope in a nearly obstructing esophageal tumor. Gastrointest Endosc. 2012 Nov;76(5):1045-6

Jon AF, Cheema A, Raptopoulos V, Hauser T, Nasser I, et al. Quantitative Assessment of Liver Fat in an Obese Patient Population Using Non-contrast CT Fat Percent Index. Clinical Imaging. 2014 May-Jun;38(3):259-64

Michiya Nishino, MD, PhD, Staff Pathologist, Head & Neck and Cytopathology; Instructor in Pathology, Harvard Medical School

Nishino M*, Mathai SK*, Schoenfeld D, et al. Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia. Human Pathology 2014; 45(2):342-351. *co-first authors

Nishino M and Wang HH (2014). Should the thyroid AUS/FLUS category be further stratified by malignancy risk? Cancer Cytopathology 2014 (DOI: 10.1002/cncy.21412).

Nishino M (2014). “Liver FNA biopsy.” Case Studies. American Society of Cytopathology, April 2014. Web. 20 June 2014.

Nishino M and Nosé V (2014). Endolymphatic Sac Tumor. In V. Nosé (Ed.), Familial Cancer Syndromes (pp. II.4.8-11). Amirsys Publishing, Inc.

Rolf Pfannl, MD, Director of Selective Pathology Fellowship; Associate Director, Longwood Neuropathology Training Program; Assistant Professor of Pathology, Harvard Medical School

Kwak, E. S., Marrero, D. E., Pfannl, R. and Erbay, S. H. Sterile Brain Abscess due to Juvenile Xanthogranuloma:DWI Characteristics. Journal of Neuroimaging, 2012. doi: 10.1111/j.1552-6569 2012.00725.x

Khoury MN, Alsop DC, Agnihotri SP, Pfannl R, … Anderson MP, et al. Hyperintense cortical signal on magnetic resonance imaging reflects focal leukocortical encephalitis and seizure risk in progressive multifocal leukoencephalopathy. Ann Neurol. 2014 May;75(5):659-69. doi: 10.1002/ana.24144. Epub 2014 Apr 28. PMID: 24752885

Muthupalani S, Torres PA, Wang BC,… Pfannl R, et al. GM1-gangliosidosis in American black bears: Clinical, pathological, biochemical and molecular genetic characterization. Molecular Genetics and Metabolism. February 2014. In press.

Seymour Rosen, MD, Staff Pathologist; Director of Surgical, Renal, and Genitourinary Pathology; Professor of Pathology, Harvard Medical School

Ward A, Konya C, Mark EJ, Rosen S. Granulomatosis With Polyangiitis Presenting as a Renal Tumor. Am J Surg Pathol. 2014 Jul 14. [Epub ahead of print]PMID: 25025447

Zsengellér ZK, Aljinovic N, Teot LA,… Rosen S. Methylmalonic acidemia: A megamitochondrial disorder affecting the kidney. Pediatr Nephrol. 2014 May 28. [Epub ahead of print]PMID: 24865477

Heyman SN, Rosenberger C, Rosen S, Khamaisi M. Why is diabetes mellitus a risk factor for contrast-induced nephropathy? Biomed Res Int. 013;2013:123589. doi: 10.1155/2013/123589. Epub 2013 Nov 21. Review.PMID: 24350240

Jeffrey E. Saffitz, MD, PhD, is the Mallinckrodt Professor of Pathology at Harvard Medical School, and Chairman of the Department of Pathology at Beth Israel Deaconess Medical Center.

Haspel RL, Saffitz JE: Genomic oncology education: An urgent need, a new approach. Cancer J, 2014, 20:91-95.

Asimaki A, Saffitz JE: Remodeling of Cell-Cell Junctions in Arrhythmogenic Cardiomyopathy. Cell Commun Adh, 2014, 21:13-23.

Saffitz JE, Sanders SP: Post-mortem analysis of structural heart defects in fetuses and children by magnetic resonance imaging – an alternative to autopsy? Circulation (invited editorial), 2014; 129:1909-1911.

Stuart J. Schnitt, MD, Director of the Division of Anatomic Pathology at Beth Israel Deaconess Medical Center, Co-leader of the Dana Farber Harvard Cancer Center Breast Program, Professor of Pathology at Harvard Medical School and an internationally recognized expert in breast pathology

Moran MS, Schnitt SJ, Giuliano AE, et al. Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer. Int J Radiat Oncol Biol Phys 2014; 88:553-564.

Schnitt SJ, Collins LC. Biopsy Interpretation of the Breast, Second Edition, Philadelphia, Lippincott Williams & Wilkins, 2012 (Chinese edition in press).

Schnitt SJ, Lakhani SR, Anderson BO (reviewer), Mathew BS (reviewer), Rajkumar T (reviewer). Breast cancer. In: Stewart BW, Wild CP, eds. World Cancer Report 2014, Lyon, IARC 2014

Isaac E. Stillman, MD, Staff Pathologist, Renal Pathology; Director, Clinical Electron Microscopy; Associate Professor of Pathology, Harvard Medical School

Stillman IE, Karumanchi SA. Vasculitis is an antiangiogenic state. J Am Soc Nephrol 2012 Jan; 23(1):8-10. Epub 2011 Dec 15.

Rajakumar A, Cerdeira A, Hubel CA, Jeyabalan A, Rana S, Zsengellér Z, Stillman IE, et al. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating sFlt1 in preeclampsia. Hypertension. 2012 Feb;59(2):256-64.

Zsengellér Z, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, and Pacher P. Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. J Histochem Cytochem, 2012 Jul;60(7).

Steven R. Tahan, MD, Director of Dermatopathology; Associate Professor of Pathology, Harvard Medical School

Roujeau JC, Mockenhaupt M, Tahan SR, et al. Telaprevir-Related Dermatitis. Arch Dermatol 2012 Nov 19:1-7. doi: 0.1001/jamadermatol.2013.938.

Park JJ, Hawryluk EB, Tahan SR, et al. Cutaneous granulomatous eruption and successful response to potent topical steroids in metastatic melanoma patients undergoing targeted BRAF inhibitor treatment. JAMA Dermatol 2013 Dec 18. doi: 10.1001/jamadermatol.2013.7919.

Korman JB, Burgin S, Tahan SR. Intralymphatic histiocytosis in association with severe osteoarthritis of the shoulder. J Am Acad Dermatol. 2013 Dec;69(6):e314-5. doi: 10.1016/j.jaad.2013.08.020. PubMed PMID: 24238195.

Paul A. VanderLaan, MD, PhD, Cytopathologist and Thoracic Pathologist; Instructor in Pathology, Harvard Medical School

VanderLaan PA, Yamaguchi N, Folch E, Boucher DH, Kent MS, Gangadharan SP, Majid A, Goldstein MA, Huberman MS, Kocher ON, Costa DB. Success and failure rates of tumor genotyping techniques in routine pathological samples with non-small-cell lung cancer. Lung Cancer. 2014;84:39-44. PMID: 24513263

VanderLaan PA, Wang HH, Majid A, Folch E. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): An overview and update for the cytopathologist. Cancer Cytopathol. 2014 [in press]. PMID: 24760496

VanderLaan PA, Krane JF. Head and Neck: Thyroid. In: Atlas of Fine Needle Aspiration Cytology. Domanski HA editor. Springer-Verlag London, England. 2014.

Helen H. Wang, MD, MPH, DrPH, Medical Director of Cytology; Professor of Pathology, Harvard Medical School

VanderLaan PA, Wang HH, Majid A, Folch E. Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA): An overview and update for the cytopathologist. Cancer Cytopathol, in press.

Wang HH, Ayata G. Gastrointestinal tract. In: Cibas ES and Ducatman BS, eds. Cytology. Diagnostic Principles and Clinical Correlates, 4th Edition. Philadelphia: Elsevier, in print.

Wang HH, Ayata G. Diagnostic cytology of the GI tract. In: Odze RD, Goldblum JR, eds. Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas, 3rd Edition. Philadelphia: Elsevier, in print.

Hong Wu, MD, PhD, Staff Dermatopathologist; Instructor in Pathology, Harvard Medical School

Chuang, GS., Lu, LK., Cummins, DL, Wu, H, et al. Incidence of invasive squamous cell carcinomas in biopsy proven squamous cell carcinoma in-situ sent for Mohs micrographic surgery. Dermatol Surg. 38(9): 1456-60, 2012

Wu, H, Allan, AE, Harrist, TJ. Noninfectious Vesiculobullous and Vesiculopustular Diseases. 11th edition of Lever’s Histopathology of the Skin. Accepted for publication

Fulton, E, Larson, A, Wu, H. Cutaneous Orf. American Society of Dermatopathology. Accepted for poster presentation

Huihui Ye, MD, Staff Pathologist, Genitourinary Pathology; Instructor in Pathology, Harvard Medical School

Ye H, Kong X, He TW, et al. Intraoperative frozen section analysis of apical margin biopsies during radical prostatectomy: ten year experience from a single institution. Urology. 2011 Aug;78(2):399-404. Epub 2011 May 31.

Ye H, Ulbright T. Difficult differential diagnoses in testicular pathology. Arch Pathol Lab Med. 2012 Apr;136(4):435-46.

Xu B… Ye H, … F Brimo. Biopsy Characteristics in Men with a Preoperative Diagnosis of Prostatic Adenocarcinoma with High Gleason Score (GS= 8-10) Predict Pathologic Outcome in Radical Prostatectomy. Hum Path. 2014. Accepted.

Eric Yee, MD, Staff Pathologist, Gastrointestinal Pathology; Instructor in Pathology, Harvard Medical School

Yee, E; Goldsmith, J. "Diarrheal Illness in the Pediatric Population: A Review of Neonatal Enteropathies and Childhood Idiopathic Inflammatory Bowel Disease." Surgical Pathology Clinics. Vol. 6. No. 3. Sept 2013

Allard, F; Yee, E; Freitag, S. "Dacrocystitis Secondary to Intranasal Cocaine Abuse: A Case Report and Literature Review." Orbit. Vol. 30. No. 6. Dec 2013.

Millo, N; Yee, E; Mortele, K. "Mammary-type Myofibroblastoma of the Liver: Multi-modality imaging features with histopathologic correlation." Abdominal Imaging. Vol. 39. Issue 3. June 2014

Mary Jane Zimarowski, MD, Staff Pathologist, Dermatopathology and Surgical Pathology; Instructor in Pathology, Harvard Medical School

Chan MP, Zimarowski MJ. Lupus erythematosus-like reaction in imiquimod-treated skin: a report of two cases. Am J Dermatopathol. 2011 Jul;33(5):523-7.

Gee SN, Harris AC, Zimarowski MJ. Churg-Strauss syndrome presenting as scar reactivation: histopathologic features and an illustration of “locus minoris resistentiae”. J Cutan Pathol. 2013 May;40(5):491-6. doi: 10.1111/cup.12099.

Shalin SC, Cukras A, Zimarowski MJ. Granular Parakeratosis Mimicking Pustular Psoriasis: An Unusual Presentation. Poster presentation at the 48th Annual Meeting of The American Society of Dermatopathology (ASDP), 2011.

FACULTY AND SELECTED PUBLICATIONS
CLINICAL PATHOLOGY

Ramy A. Arnaout, MD, PhD, Associate Director of Clinical Microbiology, Director of Reference Lab Testing; Assistant Professor of Pathology, Harvard Medical School

Arnaout R, Lee W, Cahill P, et al. High-resolution description of antibody heavy-chain repertoires in humans. PLoS One. 2011;6(8):e22365. PMCID: 3150326.

Arnaout R, Buck T, Roulette P, Sukhatme V. Predicting the Cost and Pace of Pharmacogenomic Advances: An Evidence-Based Study. Clin Chem. 2013; 59(4):649-57.

da Baca M, Arnaout R, Brodsky V, Birdsong G. Ordo ab chao: Framework for an Integrated Disease Report. Arch Pathol. Lab Med. 2014; in press.

Anders Berg, MD, PhD, Assistant Director, Clinical Chemistry; Instructor in Pathology, Harvard Medical School

Berg AH (corresponding author), Drechsler C, Wenger J, et al. Carbamylation of Serum Albumin as a Risk Factor for Mortality in Patients with Kidney Failure. Science Translational Medicine. 2013 Mar 6;5(175):175ra29.

Felton F, Ganetsky M, Berg AH. Osmolal Gap without Anion Gap in a 43-year-old Man Clinical Chemistry (In Press).

Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, et al. Vitamin D-Binding Protein and Vitamin D Status of Black Americans and White Americans. New Engl J Med (In Press).

Parul Bhargava, MD, Medical Director, Hematology; Assistant Professor of Pathology, Harvard Medical School

Bogusz A, Bhargava P. An Unusual Patient With Shortness of Breath- Clinical, radiologic and pathologic pitfalls. American Journal of Hematology 2014 May;89(5):558-63.

Bhargava P and Kadin ME; Chapter 5; Immunohistology of Hodgkin Lymphoma. Diagnostic Immunohistochemistry by Dabbs, 4th edition 2014. Publisher Elsevier.

Bhargava P and other members of the Hematology and Clinical Microscopy Resource Committee, College of American Pathologists, 2014 Hematology and Clinical Microscope Glossary

Christine Bryke, MD, Medical Director of Cytogenetics; Instructor in Pathology, Harvard Medical School

Dongli Huang, Christine Bryke, Zunyan Dai, et al. Chromothripsis of 21q including deletion of 5' RUNX1 Revealed by Oligo-SNP Array in a Patient with AML and a Constitutional Ring Chromosome 21 (Poster presentation) ACMG Annual Clinical Genetics Meeting, 2014.

Dai Z, Kelly JC, Meloni-Ehrig A, Slovak ML, Boles D, Christacos NC, Bryke CR, et al. Incidence and patterns of ALK FISH abnormalities seen in a large unselected series of lung carcinomas. Mol Cytogenet. 2012 Dec 3;5(1):44. doi: 10.1186/1755-8166-5-44.

Chorzalska, A., Salloum, I., Shafqat, H., Khan, S., Marjon, P., Treaba, D., Schorl,C., Morgan, J., Bryke, C.R., et al. Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl-induced leukemia. Leukemia 2014 in press.

Rajan Dewar, MD, PhD, Assistant Director, Hematopathology; Instructor in Pathology, Harvard Medical School

Dewar R, Chen ST, Yeckes-Rodin H, Miller K, Khosravi-Far R. Bortezomib treatment causes remission in a Ph+ ALL patient and reveals FoxO as a theranostic marker. Cancer Biol Ther. 2011 Mar 15;11(6). (Editorial Commentary & COVER PAGE ILLUSTRATION)

Dewar R, Fadare O, Gilmore H, Gown A. Best practices in diagnostic immunohistochemistry: Myoepithelial markers in breast pathology. Arch Pathol Lab Med., 2011. 135 (4): page 422-429. (COVER PAGE ILLUSTRATION)

Dewar R, Parkash V, Forrow L, Truog R. Apologies for Pathologists: Why, When and How to say Sorry after committing a medical error. Int. J Surg. Pathol. 2013. May 10 [Epub ahead of print]. PMID: 23667133.

Richard Haspel, MD, PhD, Pathology Residency Training Program Director; Medical Director, Stem Cell Processing Laboratory; Assistant Professor of Pathology, Harvard Medical School

Haspel RL, Bhargava P, Gilmore H, et al. Successful implementation of a longitudinal, integrated pathology curriculum during the third year of medical school. Arch Pathol Lab Med. 2012; 136:1430-6.

Haspel RL, Lin Y, Fisher P, et al. Development of a validated exam to assess physician transfusion medicine knowledge. Transfusion 2014; 54:1225-30.

Haspel RL, Rinder HM, Frank KM, et al. The current state of resident training in genomic pathology: a comprehensive analysis using the resident in-service examination. Am J Clin Pathol. 2014; 142: 445-51.

Gary L. Horowitz, MD, Medical Director, Clinical Chemistry; Associate Professor of Pathology, Harvard Medical School

Saxena AR, Karumanchi AS, Fan SL, Horowitz GL, et al. “Correlation of Cystatin-C with Glomerular Filtration Rate by Inulin Clearance in Pregnancy,” Hypertension in Pregnancy. Hypertens Pregnancy. 2012;31(1):22-30.

James E. Kirby, MD, Medical Director, Clinical Microbiology; Assistant Professor of Pathology, Harvard Medical School

Yildirim E, Kirby JE, Brown DE, et al. Xist RNA is a potent suppressor of hematologic cancer. Cell. 2013. Feb 14;152(4):727-42. PMCID: PMC3875356.

Cheng A and Kirby JE. Evaluation of the Hologic Gen-Probe PANTHER, APTIMA Combo 2 assay in a tertiary care teaching hospital. 2014. American Journal of Clinical Pathology. Mar;141(3):397-403.

Chiaraviglio L and Kirby JE. Evaluation of impermeant, DNA-binding dye fluorescence as a real-time readout of eukaryotic cell toxicity in a high throughput screening format. Assay Drug Dev Technol. 2014. May;12(4):219-28. PMCID: PMC4026211.

Kerry O’Brien, MD, Associate Medical Director, Blood Bank; Instructor in Pathology, Harvard Medical School

O’Brien KL, Pereira SE, Wagner J, et al. Transfusion-associated graft-versus-host disease in a liver transplant recipient: an unusual case presentation and review of the literature. Transfusion 2013;53:174-180.

O’Brien KL, Price TH, Howell C, Delaney M. The use of 50% albumin / plasma replacement fluid in therapeutic plasma exchange for thrombotic thrombocytopenic purpura. Journal of Clinical Apheresis 2013;28:416-421.

O’Brien KL, Haspel RL, Uhl, L. Anti-D alloimmunization after D incompatible platelet transfusions: A 14 year single institution retrospective review. Transfusion 2014;54:650-654.

O’Brien KL, Kim, YA. Haspel RL, Uhl, L. Provision of KEL1-negative blood to obstetric patients: A three-year single-institution retrospective review. (accepted to Transfusion July 9, 2014).

J Ryan Pena, MD, PhD, Assistant Clinical Director, HLA Laboratory; Instructor in Pathology, Harvard Medical School

Peña JA, Lewandrowski KB, Lewandrowski EL, et al. Evaluation of the i-STAT point-of-care capillary whole blood prothrombin time and international normalized ratio: comparison to the Tcoag MDAII coagulation analyzer in the central laboratory. Clin Chim Acta. 2012; Jun;413(11-12):955-9.

Peña JA, Ferraro MJ, Hoffman CG and Branda JA. Growth detection failures by the non-radiometric BACTEC MGIT 960 mycobacterial culture system. J Clin Microbiol. 2012; Jun;50(6):2092-5.

German Pihan, MD, Director, Hematopathology; Assistant Professor of Pathology, HMS

Bogusz AM, Tierno B, Brown D, Pihan G. Extreme signet ring cell change in a large B-cell lymphoma of follicular origin. Int J Surg Pathol. 2013; 21:399-403.

Toni Peters, MD, and German Pihan, MD. Immune hemolysis with thrombotic diathesis: does the anti-complement arm play a role? Am. J. Hematology, submitted.

Sheykin Y, and Pihan G. Follicular Helpers Gone Rogue: The Increasing Number Of Lymphoma Subtypes Derived From Follicular Helper T Cells. In preparation.

Qinfang Qian, MD, PhD, Associate Director, Clinical Microbiology; Assistant Professor of Pathology, Harvard Medical School

Qian Q, Eichelberger K, Kirby JE. Rapid Identification of Staphylococcus aureus directly from BACTEC Blood Culture broth by BinaxNOW S. aureus test. J. Clin. Micro. 2014; 52:319-320

Qian Q, Urman G, Cederroth T, Najarian R, Kirby JE. Photo Quiz: A Man with Fever and Cough. J. Clin. Micro. In press.

Qian Q, Urman G, Cederroth T, Najarian R, Kirby JE. Answer to Photo Quiz: Fatal Pulmonary Blastomyces dermatitidis Infection. J. Clin. Micro. In press

Nicole V Tolan, PhD, Associate Director of Clinical Chemistry and the Medical Director of Point-of-Care Testing; Instructor in Pathology, Harvard Medical School

Nicole V. Tolan, Rafael J. Sierra, and Thomas P. Moyer. Evidence against implant-derived cobalt toxicity: case report and retrospective study of serum cobalt concentrations in an orthopedic implant population. Clinical Biochemistry, Accepted.

Nicole V. Tolan, Noemi Vidal-Folch, Alicia Algeciras-Schimnich, et al. Individualized Correction of Neuron-Specific Enolase (NSE) Measurement in Hemolyzed Serum Samples. Clin Chim Acta, 2013; 424, 216-221.

Nicole V. Tolan and Loralie J. Langman. Carisoprodol: Now a Schedule IV Controlled Substance. Clinical and Forensic Toxicology News. 2012.

Lynne Uhl, MD, Director, Division of Clinical Pathology; Medical Director, Transfusion Medicine; Associate Professor of Pathology, Harvard Medical School

Uhl L. Patient blood management. A 68-year-old woman contemplating autologous blood donation before elective surgery. JAMA 2011; 306:1902-1910.

Rosenblatt D, Vasir B, Uhl L, et al. Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma. Blood 2011;117(2):393-402.

Haspel RL, Uhl L. How do I audit hospital blood product utilization? Transfusion 2012; 52(2):227-230.

EXPERIMENTAL PATHOLOGY

Ramy A. Arnaout, MD, PhD, see Clinical Pathology

Angeliki Asimaki, PhD, Instructor in Pathology, Harvard Medical School; Research Associate

Park JK, Rosen A, Saffitz JE, Asimaki A, et al. Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: systematic analysis. Rheumatology (Oxford) 2013;52(8):1529-1533. PMID:23674817

Noorman M, Hakim S, Asimaki A, … Saffitz JE, et al. Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations. Cardiovasc Pathol. 2013;22(5):314-318. PMID:23688911

Asimaki A, Kapoor S, Plovie E, … Saffitz JE, et al. An in-vivo drug screen in zebrafish identifies a novel modulator of intercalated disc remodeling in arrhythmogenic cardiomyopathy. Science Translational Medicine. 2014 June 4th [in press]

Andrew Beck, MD, PhD, Director of the Molecular Epidemiology Research Laboratory; Assistant Professor of Pathology, Harvard Medical School

Beck AH, Sangoi AR, Leung S, et al. Systematic analysis of breast cancer morphology uncovers stromal features associated with survival. Sci Transl Med. 2011 Nov 9;3(108):108ra113.

Beck AH, Knoblauch NW, Hefti MM, Kaplan J, Schnitt SJ, et al. Significance Analysis of Prognostic Signatures. PLoS Comput Biol. 2013;9(1):e1002875.

Hefti MM, Hu R, Knoblauch NW, Collins LC, Haibe-Kains B, Tamimi RM, Beck AH. Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype. Breast Cancer Res. 2013 Aug 23;15(4):R68.

Katie Bentley, PhD, Group Leader of the Computational Biology Laboratory; Assistant Professor of Pathology, Harvard Medical School

Bentley, K., Jones, M., Cruys, B. (2013) Predicting the future: towards symbiotic computational and experimental angiogenesis research. Experimental Cell Research. In Press Doi: 10.1016/j.yexcr.2013.02.001.

Bentley, K., Franco, C.A. Philippides, A., et al. (2014) The role of differential VE-cadherin dynamics in cell rearrangements in angiogenesis. Nature Cell Biology 16:309-321.

Bentley,K., Philippides, A., Ravasv Regan, E. (2014) Do Endothelial Cells Dream of Eclectic Shape? Developmental Cell 29(2):146-158.

Anders Berg, MD, PhD, see Clinical Pathology

Lawrence Brown, MD, see Anatomic Pathology

Ann M. Dvorak, MD, Professor of Pathology, Harvard Medical School

Nagy JA, Chang S-H, Shih S-C, Dvorak AM, Dvorak HF. Heterogeneity of tumor vascularture. Semin Throb Hemost 36:321-331, 2010.

Galli SJ, Metcalf DD, Arber DA, Dvorak AM. Basophils and mast cells and their disorders. 8th ed. Williams Hematology eds Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Prchal JT. McGraw-Hill, NY 2010, pp 915-932.

Harold F. Dvorak, MD, Director, Vascular Biology Research Center; Mallinckrodt Distinguished Professor of Pathology, Harvard Medical School

Hoeppner LH, Phoenix KN, Clark KJ, Bhattacharya R, Gong X, Sciuto TE, Vohra P, Suresh S, Bhattacharya S, Dvorak AM, Ekker SC, Dvorak HF, et al. 2012. Revealing the role of phospholipase Cbeta3 in the regulation of VEGF-induced vascular permeability. Blood. 120(11): 2167-73. PMCID: PMC3447777

Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H. 2013. The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1. Blood. 2154-64. PMC3596973 (3/14/14)

Antoine E. Karnoub, PhD, Assistant Professor of Pathology, Harvard Medical School

El-Haibi CP, Bell GW, Zhang J, Wood D, Collmann AY, Scherber CM, Csizmadia E, Mariani O, Zhu C, CampagneA, TonerM, Bhatia SN, IrimiaD, Vincent-Salomon A and Karnoub AE. Critical role for lysyl oxidase in mesenchymal-stem-cell-driven breast cancer malignancy. PNAS 2012;109:17460-5.

Cuiffo BG and Karnoub AE. Mesenchymal stem cells in tumor development: Emerging roles and concepts. Cell Adh Migration, 2012; 6(3):220-30.

Thomas C and Karnoub AE. Lysyl oxidase at the crossroads of mesenchymal stem cells and epithelialmesenchymal transition. Oncotarget, 2013; 4:376-7.

James Kirby, MD, see Clinical Pathology

Olivier Kocher, MD, PhD, see Anatomic Pathology

Jack Lawler, PhD, Director, Division of Experimental Pathology; Professor of Pathology, Harvard Medical School

Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette C, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. SCFβ-TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF-Receptor-2. J. Exp. Med. 2012; 209(7):1289-1307.

Johnson CA, Kleshchenko YY, Ikejiani AO, Udoko AN, Cardenas TC, Pratap S, Duquette MA, Lima MF, Lawler J, et al. Thrombospondin-1 Interacts with Trypanosoma cruzi Surface Calreticulin to Enhanced Cellular Infection. PLoS One. 2012; 7(7): e40614.

Qin L, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H. The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1. Blood 2013; 121(11):2154-2164.

Trista E. North, PhD, Assistant Professor of Pathology, Harvard Medical School

Liu LY, Fox CS, North TE, Goessling W. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. 2013. Disease Model Mech., 6(5):1271-1278. PMID: 23813869; PMCID: PMC3759346.

Cox AG, Saunders DC, Kelsey PB Jr, … North TE*, Goessling W*. S-Nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury. 2014. Cell Reports, in press. PMID: 24388745.

Nissim S, Sherwood RI, Wucherpfenning J, … North TE*, Goessling W*. Prostaglandin E2 regulates liver versus pancreas cell fate decisions and endodermal outgrowth. Developmental Cell, in press.

Pier Paolo Pandolfi, MD, PhD, Director, Cancer Genetics Program at BIDMC; Professor of Pathology and Medicine, Harvard Medical School

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, …Cantley L, Wei W. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24;508(7497):541-5.

Inuzuka H, Gao D, Finley LW, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 6;150(1):179-93.

Dipak Panigrahy, MD, Center for Vascular Biology Research; Assistant Professor of Pathology, Harvard Medical School

Panigrahy D, Edin ML, Lee CR, et al. Epoxy-eicosanoids stimulate multi-organ metastasis and tumor dormancy escape in mice. The Journal of Clinical Investigation 2012, 122(1):178-191. PMID:22182838 (Featured with related commentary in The Journal of Clinical Investigation: Wang D, Dubois RN. Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer 2012, 122(1):19-22.)

Zhang G, Panigrahy D, Mahakian L, et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proceedings of the National Academy of Sciences. 2013, April 3.

Panigrahy D*, Kalish BT, Huang S, et al. Epoxyeicosanoids Promote Organ and Tissue Regeneration. Proceedings of the National Academy of Sciences. 2013 Aug 13:110(33):13528-33.

German Pihan, MD, see Clinical Pathology

Isaac Rabinovitz, MD, PhD, Assistant Professor of Medicine, Harvard Medical School

Kashyap, T., Germain E.C., Roche M., Lyle S., and Rabinovitz I. Role of integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration. Laboratory Investigation. 91(10):1414-26. 2011.

Sharma C, Rabinovitz I, and Hemler ME. Palmitoylation by DHHC3 is critical for the function expression and stability of integrin α6β4. EMBO J, 2011

John L. Rinn, PhD, Assistant Professor of Pathology, Harvard Medical School

Ahfeldt T, Schinzel RT, Lee YK, … Rinn JL, Cowan CA. Programming human pluripotent stem cells into white and brown adipocytes. Nature Cell Biol 14:209-19 (2012).

Kretz M, Webster DE, Flockhart RJ, … Rinn JL, et al. Suppression of progenitor differentiation requires the long noncoding RNA ANCR. Genes Dev 26:338-43 (2012).

Trapnell C, Roberts A, Goff L, … Rinn JL, Pachter L. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nature Protoc 7:562-78 (2012).

Jeffrey Saffitz, MD, PhD, see Anatomic Pathology

Donald R. Senger, PhD, Principal Associate in Pathology, Harvard Medical School

Hoang MV, Nagy JA, Senger DR. Cdc42-mediated inhibition of GSK-3b improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis. Microvasc Res.2011 Jan;81(1):34-43.

Steven Tahan, MD, see Anatomic pathology

Alex Toker, PhD, Associate Professor of Pathology, Harvard Medical School

Chin YM, Yuan X, Balk SP, Toker A. Pten-deficient tumors depend on akt2 for maintenance and survival. Cancer Discov. 2014 May 16. pii: CD-13-0873. [Epub ahead of print] PubMed PMID: 24838891.

Toker A, Marmiroli S. Signaling specificity in the Akt pathway in biology and disease. Adv Biol Regul. 2014 May;55:28-38. doi: 10.1016/j.jbior.2014.04.001. Epub 2014 Apr 19. PubMed PMID: 24794538

White CD, Toker A. Using phospho-motif antibodies to determine kinase substrates. Curr Protoc Mol Biol. 2013Jan;Chap18:Unit 18.20. PMID: 23288461.

Wenyi Wei, PhD, Associate Professor of Pathology, Harvard Medical School

Wei, W., Lin, H.K. (2012) The key role of ubiquitination and sumoylation in signaling and cancer: a research topic. Frontiers in Molecular and Cellular Oncology 2:187. doi: 10.3389/fonc.2012.00187

Liu P, Begley M, Michowski W, … Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature.2014 Apr 4;508(7497):541-5.

Wang, Z. and Wei, W. (2014) Fbxo45 joins the “Par-4”ty in controlling apoptosis of cancer cells. Cell Death and Differentiation 21(10):1508-10.

Catherine T. Yan, PhD, Assistant Professor of Pathology, Harvard Medical School

Cheng, Z., Yan, CT, Dou Y, et al. (2013). The Role of the SET domaincontaining protein, SETD3, in oncogenesis. Hematologica. 98:739-43. PMID: 23065515 PMCID: PMC3640118.

Park JH, Welner RS, Chan MY, Troppito L, Staber PB, Tenen DG and Yan CT. Lig4 R278H mutation suppresses genomic instability in B cells by limiting alternative end-joining (Blood, submitted).