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Teaching Faculty

FACULTY AND SELECTED PUBLICATIONS
ANATOMIC PATHOLOGY


Matthew Anderson, MD, PhD, Director of Neuropathology; Assistant Professor of Neurology and Pathology, Harvard Medical School

Anderson MP, Hooker BS, Herbert MR (2008). Bridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and Plasticity. Am. J. Biochem. Biotech. 4:167-176.

Herbert MR, Anderson MP (2008). An Expanding Spectrum of Autism Models: From Fixed Developmental Defects to Reversible Functional Impairments. In "Autism: Current Theories and Evidence," Edited by A. W. Zimmerman, Humana Press, Totowa, NJ.

Zhou Y-D, Lee S, Jin Z, Wright M, Anderson MP (2008). Arrested Development down-regulation of excitatory synapses in ADLTE. Soc. Neurosci. Abstr. 2008: 147.12. Free online at www.sfn.org.

Kasten MR, Anderson MP (2008). Epilepsy impairs in vitro thalamic signal processing. Soc. Neurosci. Abstr. 2008: 448.14. Free online at www.sfn.org.

Zhou YD, Lee S, Jin Z, Wright M, Smith SE, Anderson MP. Arrested maturation of excitatory synapses in autosomal dominant lateral temporal lobe epilepsy. Nat Med. 2009 Aug 23.

Anderson MP. Arrested Glutamatergic Synapse Development in Human Partial Epilepsy. Epilepsy Currents 2010;10:153-158.

Smith SEP, Zhou Y-D, Zhang G, Jin Z, Stoppel DC, Anderson MP. Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice. Science Translational Medicine 2011; 3:42-53.

Czupryn A*, Zhou Y-D*, Chen X*, McNay D, Anderson MP†, Flier JS†, Macklis JD†. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science. 2011; 334:1133-1137. *co-first authors; † co-senior authors

Smith SE, Xu L, Kasten MR, Anderson MP. Mutant LGI1 Inhibits Seizure-Induced Trafficking of Kv4.2 Potassium Channels. J Neurochem. 2012; 120:611-621.

Zhou YD, Zhang D, Wang X, Kasper EM, Leguern E, Baulac S, Anderson MP. Epilepsy gene LGI1 regulates postnatal developmental remodeling of retinogeniculate synapses. J Neurosci. 2012; 32:903-910.

Gamze Ayata, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

A. Ciampa, B. Xu, G. Ayata, D. Baiyee, J. Wallace, M. Wertheimer, K. Edmiston, A. Khan.Her-2 Status in Breast Cancer: Correlation of Gene Amplification by FISH with Immunohistochemistry expression using advanced Cellular Imaging System. Applied Immunohistochemistry and Molecular Morphology, 14(2):132-137,2006.

M. Piperdi, G. Ayata, J. Simons, V. Velagapudi, J. F. Tseng, B. Piperdi.Rectal prognostic index predicts outcome of patients with locally advanced rectal cancer treated with preoperative chemoradiation ASCO GI, Jan 2009.

Karoly Balogh, MD, Staff Pathologist, Associate Professor of Pathology, Harvard Medical School 

Nagy P, Szabo, Z, Balogh, K. Wegener's granulomatosis masquerading as chronic mastoiditis. Lege Artis Medicinae 2006.

Patologia. Ed. by L. Kopper and Z. Schaff. Chapter 14. Pathology of the Head and Neck Region. (pp. 681-714). Budapest, Medicine Pub. Co. (Hungarian textbook), 2nd edition, 2006.

Histology for Pathologists. Ed. by S. S. Sternberg. Chapter 15. Mouth, Nose and Paranasal Sinuses. New York, Raven Press, 3rd edition, 2007.

Essential Pathology. Ed. by E. Rubin and H.M. Reisner, Chapter 25. The Head and Neck. (pp. 658-666) 5th edition, 2008

Histology for Pathologists. Ed. by S.E. Mills, Chapter 15. Mouth, Nose, and Paranasal Sinuses. (in print) New York, Raven Press, 4th edition, 2012.

Lawrence F. Brown, MD, Staff Pathologist, Associate Professor of Pathology, Harvard Medical School 

Hirakawa S, Brown LF, Kodama S, Paavonen K, Alitalo K, Detmar M. Vascular endothelial growth factor C induced lymphangiogenesis in the sentinal lymph node promotes metastasis to distant sites. Blood, 2007; 109: 1010-7.

Rosenberger C, Solovan C, Rosenberger AD, Li J, Treudler R, Frei U, Eckardt K, Brown LF. Upregulation of hypoxia-inducible factors in normal and psoriatic skin. J Invest Dermatol, 2007; 127: 2445-52.

Halin C, Tobler NE, Vigl B, Brown LF, Detmar M. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood, 2007; 110: 3158-67.

Rahbar R, Brown LF, Folkman J, McGill T, Healy GB, Liu G, Vargas SO. The role of vascular endothelial growth factor in acquired airway stenosis. Ann Otol, Rhinol, and Laryngol, 2007; 116: 430-5.

Shih S, Zukuaskas A, Li D, Liu G, Ang L, Nagy JA, Brown LF, Dvorak HF. The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Cancer Res, 2009; 69: 3272-7.

Kane SE, Liu FW, Brown LF, Awtrey CS, Hecht JL. Papillary Serous Borderline tumor of the ovary with significant ascites and Vascular Endothelial Growth Factor expression. submitted.

Fu Y, Nagy JA, Brown LF, Dvorak HF, Wight TN. Proteolytic Cleavage of Versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced Pathological Angiogenesis. J Histochem Cytochem. 2011 May;59(5):463-73.

Kunstfeld R, Hawighorst T, Streit M, Hong Y-K, Nguyen L, Brown LF, Detmar. Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically-induced multistep skin carcinogenesis. Submitted.

Adini A, Doucette S, Brown LF, Benjamin LE. Prominin/CD133 is not just a marker, but regulates cancer cell survival. Submitted.

Li J, Wang E, Lau J, Schroeder MA, Rinaldo F, Brown LF, Mukhopadhyay D, O'Neill BP, Datta K. Factor inhibiting HIF (FIH) is essential for inhibiting HIF mediated gene transcription in glioblastoma multiforme. Submitted.

Kazerounian S, Huang M, Gerald D, Chin Y, O'Donnell R, Zheng N, Udayakumar D, Shechter S, McNamara S, Perruzzi C, Nuevo A, Kocher O, Brown LF, DuHadaway J, Toker A, Prendergast G, Benjamin L. RhoB differentially modifies early and late stages of breast cancer progression Cancer Discovery, 2011 submitted.

Tracy Challies, MD, Staff Pathologist, GI and Liver Pathology, Instructor in Pathology, Harvard Medical School

Byrnes V, Afdhal N, Challies T, Greenstein PE. Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis. Ann Hepatol. 2006 Jan-Mar;5(1):56-9

Lai M, Afdhal N, and Challies T. Liver Masses and Eosinophilia. Liver International. 2008 Jan; 28(1):150.

Solumedrol induced hepatitis. *Pending publication 2010*

Malik, R., Lai M., Sadiq A., Farnan R, Mehta S, Nasser I, Challies T, Schuppan D, Afdhal N. Comparison of transient elastography, serum markers and clinical signs for the diagnosis of compensated cirrhosis. J Gastroenterol Hepatol. 2010 Sept; 25(9):1562-8.

Klibansky DA, Mehta S, Curry M, Nasser I, Challies T, and Afdhal NH. Transient elastography for predicting clinical outcomes inpatients with chronic liver disease. J Viral Hepatitis. Article first published on line: 1 JUL 2011/ DOI:10.1111/j.1365-2893.2011.01493.x

Sensitivity of Ultrasound for Hepatic Steatosis Detection Based on Histological and Digital Scores in Nonalcoholic Fatty Liver Disease; abstract - Digestive Diseases Week 2010.

Laura Collins, MD, Associate Director of Anatomic Pathology; Associate Professor of Pathology, Harvard Medical School

Schnitt SJ and Collins LC. Pathology of Benign Breast Disorders. In: Diseases of the Breast. Philadelphia : Lippincott Williams & Wilkins;2009. p. 69-85.

Tung N, Wang Y, Collins LC, Kaplan J, Li H, Gelman R, Comander AH, Gallagher B, Fetten K, Krag K, Stoeckert KA, Legare RD, Sgroi D, Ryan PD, Garber JE, Schnitt SJ. Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features. Breast Cancer Res. 2010;12(1):R12.

Su X, Tamimi RM, Collins LC, Baer HJ, Cho E, Sampson L, Willett WC, Schnitt SJ, Connolly JL, Rosner BA, Colditz GA. Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease. Cancer Causes Control. 2010.

Haque R, Achacoso NS, Fletcher SW, Nekhlyudov L, Collins LC, Schnitt SJ, Quesenberry CP, Habel LA. Treatment of ductal carcinoma in situ among patients cared for in large integrated health plans. Am J Manag Care. 2010;16(5):351-60.

Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations in myoepithelial cells associated with benign sclerosing lesions of the breast. Am J Surg Pathol. 2010;34(6):896-900.

Aroner SA, Collins LC, Schnitt SJ, Connolly JL, Colditz GA, Tamimi RM. Columnar cell lesions and subsequent breast cancer risk: a nested case-control study. Breast Cancer Res. 2010;12(4):R61.

Dawood S, Hu R, Homes MD, Collins LC, Schnitt SJ, Connolly J, Colditz GA, Tamimi RM. Defining breast cancer prognosis based on molecular phenotypes: results from a large cohort study. Breast Cancer Res Treat. 2010.

Tung N, Miron A, Schnitt SJ, Gautam S, Fetten K, Kaplan J, Yassin Y, Buraimoh A, Kim JY, Szasz AM, Tian R, Wang ZC, Collins LC, Brock J, Krag K, Legare RD, Sgroi D, Ryan PD, Silver D, Garber JE, Richardson AL. Prevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers. Breast Cancer Res. 2010;12(6):R95.

Collins LC, Cole K, Marotti J, Hu R, Schnitt SJ, Tamimi RM. Androgen Receptor Expression in Breast Cancer in Relation to Molecular Phenotype: Results from the Nurses' Health Study. Mod Pathol. 2011;24(7):924-31.

Alexander BM, Sprott K, Farrow DA, Wang X, D'Andrea AD, Schnitt SJ, Collins LC, Weaver DT, Garber JE. DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer. Clin Cancer Res. 2010;16(23):5796-804.

Hu R, Dawood S, Holmes MD, Collins LC, Schnitt SJ, Cole K, Marotti JD, Hankinson SE, Colditz GA, Tamimi RM. Androgen Receptor Expression and Breast Cancer Survival in Postmenopausal Women. Clin Cancer Res. 2011;17(7):1867-74.

Tamimi RM, Colditz GA, Wang Y, Collins LC, Hu R, Rosner B, Irie HY, Connolly JL, Schnitt SJ. Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer. Breast Cancer Res Treat. 2011;128(1):243-50.

Liu Y, Tamimi RM, Collins LC, Schnitt SJ, Gilmore HL, Connolly JL, Colditz GA. The association between vascular endothelial growth factor expression in invasive breast cancer and survival varies with intrinsic subtypes and use of adjuvant systemic therapy: results from the Nurses' Health Study. Breast Cancer Res Treat. 2011;129(1):175-84.

Pantanowitz L, Valenstein PN, Evans AJ, Kaplan KJ, Pfeifer JD, Wilbur DC, Collins LC, Colgan TJ. Review of the current state of whole slide imaging in pathology. J Pathol Inform. 2011;2:36.

Yaghjyan L, Colditz GA, Collins LC, Schnitt SJ, Rosner B, Vachon C, Tamimi RM. Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to tumor characteristics. J Natl Cancer Inst. 2011;103(15):1179-89.

Tamimi RM, Colditz GA, Hazra A, Baer HJ, Hankinson SE, Rosner B, Marotti J, Connolly JL, Schnitt SJ, Collins LC. Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer. Breast Cancer Res Treat. 2011.

Collins, LC, Laronga, C and Wong J. Microinvasive Breast Carcinoma. In: UptoDate, 2011

Collins, LC, Laronga, C and Wong J. Breast DCIS: Epidemiology, Diagnosis, and Prognosis. In: UptoDate, 2011.

Collins, LC, Laronga, C and Wong J. Treatment of DCIS. In: UptoDate, 2011.

James L Connolly, MD, Residency Training Program Director, Staff Pathologist, Professor of Pathology, Harvard Medical School

Lester SC, Bose S, Chen YY, Connolly JL, de Baca ME, Fitzgibbons PL, Hayes DF, Kleer C, O'Malley FP, Page DL, Smith BL, Weaver DL, Winer E; Members of the Cancer Committee, College of American Pathologists. Protocol for the examination of specimens from patients with ductal carcinoma in situ of the breast. Arch Pathol Lab Med. 2009 Jan;133(1):15-25.

Lester SC, Connolly JL, Amin MB. College of American Pathologists protocol for the reporting of ductal carcinoma in situ. Arch Pathol Lab Med. 2009 Jan;133(1):13-4.

Goldfarb M, O'Neal P, Shih JL, Hartzband P, Connolly J, Hasselgren PO. Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. Endocr Pract. 2009 Jul-Aug;15(5):463-8.

Baer HJ, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, Tamimi RM. Lobule type and subsequent breast cancer risk: results from the Nurses' Health Studies. Cancer. 2009 Apr 1;115(7):1404-11.

Collins LC, Wang Y, Connolly JL, Baer HJ, Hu R, Schnitt SJ, Colditz GA, Tamimi RM. Potential role of tissue microarrays for the study of biomarker expression in benign breast disease and normal breast tissue. Appl Immunohistochem Mol Morphol. 2009 Oct;17(5):438-41.

Su X, Colditz GA, Willett WC, Collins LC, Schnitt SJ, Connolly JL, Pollak MN, Rosner B, Tamimi RM. Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease. Int J Cancer. 2010 Jan 1;126(1):180-90.

Zhou C, Wang Y, Aguirre AD, Tsai TH, Cohen DW, Connolly JL, Fujimoto JG. Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy. J Biomed Opt. 2010 Jan-Feb;15(1):016001.

Su X, Tamimi RM, Collins LC, Baer HJ, Cho E, Sampson L, Willett WC, Schnitt SJ, Connolly JL, Rosner BA, Colditz GA. Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease. Cancer Causes Control. 2010 Jul;21(7):1033-46. Epub 2010 Mar 14.

Aroner SA, Collins LC, Schnitt SJ, Connolly JL, Colditz GA, Tamimi RM. Columnar cell lesions and subsequent breast cancer risk: a nested case-control study. Breast Cancer Res. 2010 Aug 6;12(4):R61.

Beverly Faulkner-Jones, MD, PhD, Staff Pathologist, Dermatopathology and Surgical Pathology, Instructor in Pathology, Harvard Medical School 

Graves JE, Jones B, Lind AC and Heffernan MP. Non-scarring alopecia associated with the epidermal growth factor inhibitor Gefitinib. Journal of the American Academy of Dermatology 2006;55:349-353.

Klekotka PA, Faulkner-Jones BE and Heffernan MP. A Case of Mycosis Fungoides Cytotoxic Immunophenotype Variant (CD56+ Mycosis Fungoides) - Archives of Dermatology 2006;142(Pt10):1370-1372.

Gardiner DL, Pettit M, Palmer CH and Faulkner-Jones BE. CD10 immunoexpression in cutaneous spindle cell neoplasms. (2007). United States and Canadian Academy of Pathology 96th Meeting; San Diago, CA.

Faulkner-Jones, BE, Foster, W, Harbor, JM, Davila, RN and Smith, ME Fine Needle Aspiration Biopsy with Adjunct Immunohistochemistry in Intraocular Tumor management. (2005) Acta Cytologica 49(3):297-308.

Chan, M.P, Reynolds, R.V and Faulkner-Jones, B.E. Case 7: Focal squamous cell carcinoma in-situ, present in a background of squamous dysplasia: Patient with a history of psoriasis and a changing pigmented lesion on the medial thigh. In: Cases in Dermatopathology: The Suboptimal Biopsy in Dermatopathology. Knowledge Books and Software, Brisbane, Queensland, Australia, 2009. pp. 55-61

Chan, M.P. and Faulkner-Jones, B.E. Case 10: Melanoma with senescence-like changes versus nevus with senescent change. In: Cases in Dermatopathology: Mimicry in melanocytic lesions. Knowledge Books and Software, Brisbane, Queensland, Australia, 2010. pp.

Jeong, WK, Schneider, J, Turney, S, Faulkner-Jones, BE, Meyer, D, Westermann, R, Reid, RC, Lichtman, J and Pfister, H "Interactive Histology of Large-Scale Biomedical Image Stacks," IEEE Transactions on Visualization and Computer Graphics, vol. 16, no. 6, pp. 1386-1395, Nov./Dec. 2010, doi:10.1109/TVCG.2010.168

Harris, A., Faulkner-Jones, B.E and Zimarowski, M.J. Epidermal panfolliculoma: A report of two cases. Am J Dermatopathol. 2011 Feb;33(1):e7-10.

Jeffrey Goldsmith, MD, Staff Pathologist, Director of Surgical Pathology Laboratory and GI Pathology Fellowship, Assistant Professor of Pathology, Harvard Medical School

Pedrosa I, Lafornara M, Pandharipande P, Goldsmith JD, Rofsky NM. MRI for Pregnant Patients with Suspected Acute Appendicitis: Impact on Negative Appendectomy and Appendical Perforation Rates. Radiology. 2009 250:749-757.

Chen X, Fruehauf J, Goldsmith JD, Xu H, Katchar KK, Koon HW, Zhao D, Kokkotou E, Pothoulakis C, Kelly CP. Saccharomyces boulardii Inhibits EGF Receptor Signaling and Intestinal Tumor Growth in APCmin Mice. Gastroenterology. 2009 137:914-923.

Konstantinopoulos PA, Fountzilas H, Goldsmith JD, Bhasin M, Pillay K, Libermann TA, Gebhardt M, Spentzos D. Integrated analysis of multiple sarcoma expression datasets: implications for classification, oncogenic pathway activation and chemotherapy resistance. PloS One. 2010 5:e9747.

Fox VL, Perros S, Jiang H, Goldsmith JD. Juvenile Polyps Recur Frequently in Patients with Multiple and Solitary Polyps. Clin Gastroenterol Hepatol. 2010 8:795-799.

Kung JW, Brown A, Kruskal JB, Goldsmith JD, Pedrosa I. Heterotopic pancreas: typical and atypical imaging findings. Clin Radiol. 2010 65:403-407.

Turner MS, Goldsmith JD, Best Practices in Diagnostic Immunohistochemistry -- Spindle Cell Neoplasms of the Gastrointestinal Tract. Arch Pathol Lab Med. 2009 133:1370-1374.

Krasinskas A, Goldsmith JD, Immunohistology of the Gastrointestinal Tract. In: Dabbs DJ editor. Diagnostic Immunohistochemistry Theranostic and Genomic Applications. Third Edition. Philadelphia, PA: Churchill Livingstone Elsevier; 2010. pp. 500-540.

Bousvaros A, Goldsmith JD, Strople J. A Case-Based Monograph Focusing on Pediatric Idiopathic Inflammatory Bowel Disease. North American Society for Pediatric Gastroenterology, Physiology and Nutrition. May 2009.

Najarian RM, Bousvaros A, Ashworth L, Goldsmith JD. A Histopathologic Analysis of Ileitis in Pediatric Ulcerative Colitis. USCAP Abstracts; Washington DC 2010. Mod Pathol 2010; 23: 158A(#698).

Roshnan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R, Goldsmith J, Tariq S, Schuppan D, Kelly D. The Incidence and Clinical Spectrum of Refractory Celiac Disease in a North American Referral Center. Am J Gastro. 2011 106:923-928.

Kelly AD, Breitkopf SB, Yuan M, Goldsmith J, Spentzos D. Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: Application in sarcoma. PLoS One. 2011. In Press.

Lin MM, Goldsmith JD, Resch SC, DeAngelis JP, Ramappa AJ. Histologic Examinations of Arthroplasty Specimens are not Cost-effective: A Retrospective Cohort Study. Clin Orthop and Relat Res. 2011. In Press.

Hardy L, Fitzgibbons P, Goldsmith JD, Eisen R, Beasley M, Souers R, Nakleh R. Immunohistochemistry validation procedures and practices: A College of American Pathologists survey of 727 laboratories. Arch Pathol Lab Med. 2012. In Press.

Carbo AR, Blanco PG, Graeme-Cook F, Misdraji J, Kappler S, Shaffer K, Goldsmith JD, Berzin T, Leffler D, Najarian R, Sepe P, Kaplan J, Pitman M, Goldman H, Pelletier S, Hayward JN, Shields H. Revitalizing Pathology Laboratores in a Gastrointestinal Pathophysiology Course Using Multimedia and Team-based Learning Techniques. Pathology-Research and Practice. 2012. In Press.

Anderson ME, Spentzos D, Stevenson MA, Tawa NE, Goldsmith JD, Gebhardt, MC. Local Control with Preoperative Low Dose Continuous Infusion Doxorubicin and Concomitant Radiation Therapy for Patients with High Risk Soft Tissue Sarcomas. Connective Tissue Oncology Society / Musculoskeletal Tumor Society Annual Meeting; Chicago, IL 2011.

Pyatibrat SM, Najarian RM, Goldsmith JD. Lymphocytic colitis: Effect of Therapy on Histologic Findings. USCAP Abstracts; Vancouver BC 2012.

Hardy L, Fitzgibbons P, Goldsmith JD, Eisen R, Beasley M, Souers R, Nakhleh R. Immunohistochemistry validation procedures and practices: A College of American Pathologists Survey of 727 laboratories. USCAP Abstracts; Vancouver BC 2012.

Mamta Gupta, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Gupta M, Selig MK, Oliva E, Nielsen GP. Uterine tumors resembling ovarian sex cord stromal tumors: an ultrastructural analysis of 13 cases. Ultrastruct Pathol 2010; 34:16-24.

Gupta M, Lloyd RV, Fischer-Colbrie R, Tischler AS, Dayal Y. Immunohistochemical expression of neuroendocrine secretory protein-55 (NESP-55) in pituitary adenomas. Endocr Pathol 2011, 22:150-154.

Lefferts JA, Bentley HA, Le Corre D, Laurent-Puig P, Gupta M, Suriawinata AA, Tsongalis GJ. KRAS Mutation Detection by a PCR-based TaqMan Assay Compared to Traditional DNA Sequencing. USCAP, Boston, MA. March 2009.

Gupta M, Nucci MR, Quade B. Predictors of adverse outcome in smooth muscle tumors of uncertain malignant potential (STUMP): a clinico-pathological series of 20 cases. USCAP, Washington DC March 2010.

Gupta M, Gill K, Dal Cin P, Hirsch MS. Cytogenetic analysis demonstrates relatively conserved karyotype when taken from multiple areas of individual renal cell carcinoma. USCAP, Washington DC March 2010.

Gupta M, Wu L, Yemelyanova A, Vang R, Kurman R, Ronnett B. Diagnostic reproducibility of hydatidiform moles: molecular genotyping significantly improves morphologic assessment. USCAP, San Antonio, Feb 2011.

Li F, Gupta M, Ronnett B. Uterine/cervical embryonal rhabdomyosarcomas in adult women. USCAP, San Antonio, Feb 2011.

Cynthia Hayne, MD, PhD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Hayne C, Winer E, Williams T, Chaves F, Khorsand J, Mark HFL. Acute lymphoblastic leukemia with 4;11 translocation analyzed by a multi-modal strategy of conventional cytogenetics, FISH, morphology, flow cytometry and molecular genetics, and review of the literature. Experimental and Molecular Pathology, 81(1):62-71, 2006.

Hussain G, Tapper E, Mavrakis A, Krajewski K, Hayne C, Yagi Y, Lai M, Holder S, Challies T, Kane R, Afdhal N, Lau D. "Sensitivity of Ultrasound for Hepatic Steatosis Detection Based on Histological and Digital Scores in Nonalcoholic Fatty Liver Disease." Presented at Digestive Disease Week 2010.

Jonathan Hecht, MD, Medical Director of Autopsy Service, Associate Professor of Pathology, Harvard Medical School

Leviton A, Allred EN, Kuban KC, Hecht, JL, Onderdonk AB, O'shea TM, Paneth N. Microbiologic and Histologic Characteristics of the Extremely Preterm Infant's Placenta Predict White Matter Damage and Later Cerebral Palsy. The ELGAN Study. Pediatric Research 2010;67:95-101.

Gates MA, Rosner BA, Hecht JL, Tworoger SS. Risk factors for epithelial ovarian cancer by histologic subtype. Am J Epidemiol 2010;171:45-53.

Kotsopoulos J, Hecht JL, Marotti JD, Kelemen LE, Tworoger SS. Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors. Int J Cancer. 2010 May 1;126(9):2191-8.

Levine D, Brown DL, Andreotti RF, Benacerraf B, Benson CB, Brewster WR, Coleman B, Depriest P, Doubilet PM, Goldstein SR, Hamper UM, Hecht JL, Horrow M, Hur HC, Marnach M, Patel MD, Platt LD, Puscheck E, Smith-Bindman R. Management of Asymptomatic Ovarian and Other Adnexal Cysts Imaged at US: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology. 2010 May 26.

Chan MP, Hecht JL, Kane SE. Incidence and clinicopathologic correlation of fetal vessel thrombosis in mono- and dichorionic twin placentas. J Perinatol. 2010 Mar 4.

McElrath TF, Allred EN, Kuban K, Hecht JL, Onderdonk A, O'Shea TM, Paneth N, Leviton A; ELGAN Study Investigators. Factors associated with small head circumference at birth among infants born before the 28th week. Am J Obstet Gynecol. 2010 Jun 11.

Leviton A, Kuban K, Allred EN, Hecht JL, Onderdonk A, O'Shea TM, McElrath TF, Paneth N, Antenatal antecedents of a small head circumference at age 24-months post-term equivalent in a sample of infants born before the 28th post-menstrual week. Early Human Development (2010)

Fichorova R, Yamamoto Y, Allred EN, Dammann O, Hecht JL, Kuban K, McElrath T, O'Shea TM, Paneth N, Leviton, A. Inflammation-related proteins in the blood of extremely low gestational age newborns. The contribution of inflammation to the appearance of developmental regulation. Cytokine, 53 (2011) 66-73.

Hecht JL, Fichorova R, Allred EN, Leviton, A. The relationship between neonatal blood protein profiles and placenta histologic characteristics in ELGANs Pediatric Research, 2011;69:68-73.

McElrath TF, Fichorova RN, Allred EN, Hecht JL, Ismail MA, Yuan H, Leviton A. Blood protein profiles of infants born before 28th weeks differ by pregnancy complication. Am J Obstet Gynecol 2011;204, ePub.

Marotti, JD, Glatz K, Parkash V, Hecht, JL. International Internet-Based Assessment of Observer Variability for Diagnostically Challenging Endometrial Biopsies. Arch Pathol Lab Med. 2011;135(4):464-70.

Lu J, Esposito G, Scuderi C, Steardo L, Delli-Bovi LC, Hecht JL, Dickinson BC, Chang CJ, Mori T, Sheen V. S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors. PLoS ONE 6(7): e22126.

Karst AM, Levanon K, Duraisamy S, Liu JF, Hecht JL, Hirsch MS, Drapkin RI. Stathmin 1, a Marker of PI3K Pathway Activation and Regulator of Microtubule Dynamics, is Expressed in Early Pelvic Serous Carcinomas. Gynecol Oncol. 2011 Oct;123(1):5-12.

Faupel-Badger JM, Fichorova RN, Allred EN, Hecht JL, Dammann O, Leviton A, McElrath TF. Cluster Analysis of Placental Inflammatory Proteins can Distinguish Preeclampsia from Preterm Labor and Premature Membrane Rupture in Singleton Deliveries Less Than 28 Weeks of Gestation. Am J Reprod Immunol. 2011 Dec;66(6):488-94.

Leviton A, Hecht JL, Allred EN, Yamamoto H, Fichorova RN, Dammann O, Persistence after birth of systemic inflammation associated with umbilical cord inflammation. J Reprod Immunol. 2011 Aug;90(2):235-43.

Chen ML, Allred EN, Hecht JL, Onderdonk A, VanderVeen D, Wallace DK, Leviton A, Dammann O; ELGAN Study. Placenta microbiology and histology and the risk for severe retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2011 Sep 1;52(10):7052-8.

Konstantinopoulos PA, Spentzos D, Fountzilas E, Francoeur N, Sanisetty S, Grammatikos AP, Hecht JL, Cannistra SA. Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer. Cancer Res. 2011 Aug 1;71(15):5081-9.

Hecht JL. Chapter 6: Techniques for Fetal and Placental Examination and Chapter 9: Pre-viable Terminations for Anomalies (with TK Boyd and R Padera). In Pathology of Fetal Death: Principles and Practical Evaluation. Theonia K. Boyd, ed. Springer, 2012.

Nicole Belsley Johnson, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Jones SE, Belsley NA, McLoud TC, Mullins ME. Rheumatoid meningitis: radiologic and pathologic correlation. AJR Am J Roentgenol. 2006 Apr;186(4):1181-3.

Roth SI, Belsley NA, Abu-Jawdeh, G. Parathyroid Glands. In: Mills, SE editor. Histology for Pathologists. 3rd ed., Lippincott Williams & Wilkins, 2006.

Belsley NA, Mino-Kenudson M, Ban S, Park DY, Ochiai A, Kato Y, Muzikansky A, Deshpande V, Shimizu M, Vieth M, Lauwers GY. Endoscopic Mucosal Resection Does Not Improve Lingering Differences in the Evaluation of Gastric Neoplasia Between Eastern and Western Pathologists. Modern Pathology, Volume 19, Supplement 1, January 2006, p 102A.

Belsley NA, Lauwers GY, Pitman MB, Deshpande V. Serous Cystadenomas of the Pancreas: Diagnostic Performance of Imaging and Fine Needle Aspiration Biopsy. Modern Pathology, Volume 20, Supplement 2, March 2007, p 64A

Belsley NA, Pitman MB, Lauwers GY and Deshpande V. Serous cystadenoma of the pancreas: Limitations and pitfalls of EUS guided fine needle aspiration biopsy. Cancer Cytopathology, 2008 Feb 7.

Belsley NA, Tambouret RH, Misdraji J, Muzikansky A, Russell DK, and Wilbur DC. Cytologic features of Endocervical Glandular Lesions: Comparison of SurePath, ThinPrep, and Conventional Smear Specimen Preparations. Diagnostic Cytopathology, 2008; 36(4): 232-7.

Belsley NA, Collins LC, Rice MS, Walker S, Tworoger S, Frank DA. Expression of Phospho(p)STAT3 and Phospho(p)STAT5 in Breast Cancer and Correlation with Plasma Prolactin Levels. Modern Pathology, Volume 22, Supplement 1, January 2009, p. 30A.

Johnson NB, Collins LC. Update onpercutaneous needle biopsy of nonmalignant breast lesions. Adv Anat Pathol. 2009 Jul;16(4):183-95.

Johnson MM, Dialani V, Johnson NB. Histologic Characteristics of Benign Breast Lesions Identified for Biopsy by Magnetic Resonance Imaging. Modern Pathology, Volume 23, Supplement 1, January 2010, p. 54A.

Gupta RK, Genevay M, Johnson NB, Lauwers GY, Deshpande V. Is Autoimmune Pancreatitis associated with an Increased Risk of Malignancy? A Retrospective and Comparative Study. Modern Pathology, Volume 23, Supplement 1, January 2010, p.356A.

Johnson MM, Dialani V and Johnson NB. Histologic Characteristics of Benign Breast Lesions Identified for Biopsy by Magnetic Resonance Imaging; United States and Canadian Academy of Pathology National Conference; 2010, Washington, DC.

Johnson NB, Johnson MM, Selig MK and Nielsen GP. Use of Electron Microscopy in Core Biopsy Diagnosis of Oncocytic Renal Tumors. Ultrastructural Pathology, 2010; 34(4): 189-94.

Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, and Overholtzer M. A Non-genetic Route to Aneuploidy in Human Cancers. Nature Cell Biology, 2011; 13(3): 324-30.

Johnson NB, Collins LC. Less common variants and mimics of ductal carcinoma in-situ. Surgical Pathology Clinics, Breast Pathology, in press.

Olivier Kocher, MD, PhD, Staff Pathologist, Pulmonary Pathology, Associate Professor of Pathology, Harvard Medical School

Kocher O, Yesilaltay A, Shen C, Zhang S, Daniels K, Pal R, Chen J and Krieger M. Influence of PDZK1 on Lipoprotein Metabolism and Atherosclerosis. Biochim Biophys Acta., 2008.

Fenske SA, Yesilaltay A, Pal R, Daniels K, Rigotti A, Krieger M and Kocher O. Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I (SR-BI) by altering its abundance and cellular localization. J Biol Chem. 2008, 283:22097-22104.

Fenske SA, Yesilaltay A, Pal R, Daniels K, Barker C, Quiñones V, Rigotti A., Krieger M. and Kocher O. Normal hepatic cell-surface localization of the high-density lipoprotein receptor, SR-BI, depends on all four PDZ domains of PDZK1. J Biol Chem. 2009, 284:5797-5806.

Kocher O and Krieger M. Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI. Curr Opin Lipidol, 20:236-241, 2009.

Yesilaltay A, Daniels K, Pal R, Krieger M and Kocher O. Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient mice. PloS ONE, 2009, 4 (12): e8103.

Singh AK, Riederer B, Krabbenhoft A, Rausch B, Bonhagen J, Lehmann- Muhlenberg U, de Jonge HR, Donovitz M, Yun C, Weinman EJ, Kocher O, Hogema BM and Seidler U. Differential role for the PDZ proteins NHERF1, NHERF2 and PDZK1 in the regulation of CFTR-mediated intestinal anion secretion in vivo. J Clin Invest., 2009, 119:540-550.

Cheng J, Ke Q, Jin Z, Wang H, Kocher O, Morgan JP, Zhang J and Crumpacker CS. Cytomegalovirus infection causes an increase of arterial blood pressure. PLoS Pathog. 2009 May;5(5):e1000427

O'Brien K, Alberich-Jorda M, Yadav N, Kocher O, DiRuscio A, Ebralidze A, Levantini E, Sng NJL, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG and Kobayashi S. CARM1 (PRMT4) is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development, 2010, 137(13):2147-56.

Kocher O, Birrane G, Tsukamoto K, Fenske S, Yesilaltay A, Pal R, Daniels K, Ladias JAA and Krieger M. In vitro and in vivo Analysis of the binding of the C-terminus of the HDL Receptor SR-BI to the PDZ1 domain of its Adaptor Protein PDZK1. J Biol Chem, 2010, 285:34999-35010.

Shrikhande GV, Scali ST, da Silva CG, Damrauer SM, Csizmadia E, Putheti P, Matthey M, Arjoon R, Patel R, Siracuse JJ, Maccariello ER, Andersen ND, Monahan T, Peterson C, Essayagh S, Studer P, Guedes RP, Kocher O, Usheva A, Veves A, Kaczmarek E and Ferran C. O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-null Mice. PloS ONE, 2010, 5 (12): e14240.

Kocher O, Birrane G, Yesilaltay A, Shechter S, Pal R, Daniels K and Krieger M. Identification of the PDZ3 domain of the adaptor protein PDZK1 as a second, physiologically functional, binding site for the C-terminus of the HDL Receptor SR-BI. J Biol Chem, 2011,286:25171-25186.

Yael Kushner, MD, Staff Pathologist, Director, Quality Assurance and Quality Improvement, Instructor in Pathology, Harvard Medical School

Al-Thihli K, Palma L, Marcus V, Cesari M, Kushner YB, Barkun A, Foulkes WD. Cowden syndrome presenting with synchronous gastric carcinomas in a setting of gastrointestinal polyposis. Nat Clin Pract Gastroenterol Hepatol; 2009 Mar; 6(3):184-189.

Huang F, Kushner YB, Langleben A, Foulkes WD. Eleven years disease free: the likely role of chemotherapy in diffusely metastatic BRCA2-related breast cancer. Nat Rev Clin Oncol 2009 Aug; 6(8):488-492.

Geyer FG, Kushner YB, Lambros M, Natrajan R, Mackay A, Tamber N, Fenwick K, Purnell D, Ashworth A, Walker RA, Reis-Filho JS. Microglandular adenosis or microglandular adenoma? A molecular genetic study. Histopathology 2009 Dec; 55(6):732-743.

Kushner YB, Brimo F, Schwartzman K, Auger M. A rare case of cryptococcal pulmonary inflammatory myofibroblastic tumour diagnosed by fine needle aspiration cytology. Diagnostic Cytopathology 2010; 38:447-451.

Rio Frio T, Lavoie J, Hamel N, Geyer FC, Kushner YB, Novak DJ, Wark L, Capelli C, Reis-Filho JS, Mai S, Pastinen T, Tischkowitz MD, Marcus VA, Foulkes WD. Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia. N Engl J Med. 2010 Dec 30;363(27):2628-37.

Varma MC, Kushner YB, Ko DSC, Kawai T, Martins PN, Kaur P, Markmann JF, Kotton CN. Early Onset Adenovirus Infection after Simultaneous Kidney-Pancreas Transplant: Report of a Case. Am J Transplant 2011 Mar;11(3):623-7

Osher D, Kushner YB, Arseneau J, Foulkes WD. Melphalan as a Treatment for BRCA1-related Ovarian Carcinoma: can you teach an old drug new tricks? Journal of Clinical Pathology 2011 Oct;64(10):924-6.

Bazari H, Kushner YB, Guimaraes AR et al. Case Records of the Massachusetts General Hospital: A 77 year old man with leg edema, hematuria, and acute renal failure. N Eng J Med (in press)

Glassock RJ, Kushner YB, Khorashadi L et al. Case Records of the Massachusetts General Hospital: A 34 year old man with dyspnea, anemia, and renal failure. N Eng J Med (in press)

Randhawa P, Chanl S, Climenhaga J, Zeng G, Regele H, Kushner YB, Colvin RB, Mengel M. The Banff Initiative on Quality Assurance in Transplantation (BIFQUIT): Proficiency Testing of Immunohistochemistry for Polyomavirus BK Antigens in Renal Allograft Tissue. (in progress)

Salem SB, Kushner YB, Marcus V, Mayrand S, Fallone CA, Barkun, A. The potential impact of contemporary developments in the management of patients with gastroesophageal reflux disease undergoing an initial gastroscopy. Can J Gastroenterol 2009 Feb; 23(2):99-104.

Kushner YB, Malik FA, Holmes RK, Collins AB, Smith RN, Colvin RB. Glomerular Endothelial Injury in Patients with Non-Renal Transplants: Are We Missing Subclinical Thrombotic Microangiopathy? Modern Pathology Feb 2011; 24(Suppl 1):347A.

Kushner YB, Colvin RB. Pathology of Chronic Rejection, in Organ Transplantation: A Clinical Guide, Klein A, Lewis C and Madsen J, Eds, Cambridge University Press. (in press)

Robert Najarian, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Fang D, Das KM, Cao W, Malhotra U, Triadafilopoulos G, Najarian RM et al. Barrett's esophagus: progression to adenocarcinoma and markers. Ann NY Acad Sci 2011 Sep; 1232(1): 210-229.

Roshan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R, Goldsmith J, Tariq S, Schuppan D, Kelly CP. The incidence and clinical spectrum of refractory celiac disease in a North American referral center. Am J Gastroenterol 2011 May; 106(5):923-8.

Jamma S, Leffler DA, Dennis M, Najarian RM, Schuppan DB, Sheth S, Kelly CP. Small intestinal release mesalamine for treatment of refractory celiac disease type 1. J Clin Gastroenterol 2011 Jan; 45(1):30-3.

Genega EM, Ghebremichael M, Najarian R. et al. Carbonic Anhydrase IX expression in renal neoplasms: Correlation with tumor type and grade. Am J Clin Pathol 2010:134 (6): 873-879.

Warner J, Najarian R, Tierney L. Uses and misuses of thresholds in diagnostic decision making. Academic Medicine 2010;85(3):556-563.

Jamma S, Rubio-Tapia A, Kelly CP, Murray J, Sheth S, Schuppan D, Dennis M, Najarian RM, Leffler DA. Celiac crisis is a rare but serious complication of celiac disease in adults. Clin Gastroenterol Hepatol 2010; 8(7):587-90.

Najarian RM, Hait EJ, Leichtner AM, Glickman JN, Antonioli DA, Goldsmith JD. Clinical significance of colonic intraepithelial lymphocytosis in the pediatric population. Modern Pathology 2009; 22: 13-20.

Brook OR, Thornton E, Mendiratta-Lala M, Mahadevan A, Raptopoulos VD, Brook A, Najarian R, Siewert B. Spectrum of CT findings after stereotactic radiotherapy for liver tumors. Radiological Society of North America National Meeting, Chicago, IL, November 27- December 2, 2011.

Leffler D, Pallav K, Najarian RM, Kelly CA. Not all that flattens is celiac disease: mimics of celiac enteropathy in contemporary clinical practice. Presented at Digestive Disease Week 2011, Chicago, IL, May 7- May 10, 2011.

Ziogas D, Najarian RM, Kokkotou E. Colitis development in IL-10 deficient mice reveals a direct role of MCH in regulating IL-10 expression by monocytes. Presented at Digestive Disease Week 2011, Chicago, IL, May 7- May 10, 2011.

Hagen CE, Najarian RM, Levy LC, Siegel C, Wang HH, Odze RD, Srivastava A. Histological outcome after treatment in collagenous colitis: A long term follow-up study of 50 patients. Presented at the United States Canadian Academy of Pathology Annual Meeting, San Antonio, TX, February 28-March 3, 2011.

Carbo A, Blanco P, Graeme-Cook F, Misdraji J, Kappler S, Shaffer K, Goldsmith J, Berzin T, Leffler D, Najarian R, Sepe P, Kaplan J, Pitman M, Goldman H, Pelletier S, Shields H. Revitalization of pathology laboratories in a gastrointestinal pathophysiology course using modified team-based learning techniques and multimedia presentations. Presented at the American Association of Medical Colleges Annual Meeting, November 5-10, 2010.

Najarian RM, Bousvaros A, Ashworth L, Goldsmith JD. Ileitis in pediatric ulcerative colitis: histopathology and its clinical implications. Presented at the United States and Canadian Academy of Pathology Annual Meeting, Washington, DC, March 20-26, 2010.

Imad Nasser, MD, BS, Staff Pathologist Surgical Pathology, Liver Pathology and Cytopathology; Assistant Professor of Pathology, Harvard Medical School

Banff Working Group, Demetris AJ, Adeyi O, Bellamy CO, Clouston A, Charlotte F, Czaja A, Daskal I, El-Monayeri MS, Fontes P, Fung J, Gridelli B, Guido M, Haga H, Hart J, Honsova E, Hubscher S, Itoh T, Jhala N, Jungmann P, Khettry U, Lassman C, Ligato S, Lunz JG 3rd, Marcos A, Minervini MI, Molne J, Nalesnik M, Nasser I, Neil D, Ochoa E, Pappo O, Randhawa P, Reinholt FP, Ruiz P, Sebagh M, Spada M, Sonzogni A, Tsamandas AC, Wernerson A, Wu T, Yilmaz F. Liver biopsy interpretation for causes of late liver allograft dysfunction. Hepatology. 2006 Aug;44(2):489-501. Review.

Lai M, Hyatt BJ, Nasser I, Curry M, Afdhal NH. The clinical significance of persistently normal ALT in chronic hepatitis B infection. J Hepatol. 2007 Dec;47(6):760-7.

Becker L, Salameh W, Sferruzza A, Zhang K, Chen R, Malik R, Reitz R, Nasser I, Afdhal NH. Validation of Hepascore, compared to simple indices of fibrosis, in US patients with chronic hepatitis C virus infection. Clin Gastroenterol Hepatol. 2009 Jan 24.

Pihlajamäki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME. Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab. 2009 Sep;94(9):3521-9. Epub 2009 Jun 23.

Becker L, Salameh W, Sferruzza A, Zhang K, ng Chen R, Malik R, Reitz R, Nasser I, Afdhal NH. Validation of hepascore, compared with simple indices of with chronic hepatitis C virus infection in United States.fibrosis, in patients. Clin Gastroenterol Hepatol. 2009 Jun;7(6):696-701.

Malik R, Chang M, Bhaskar K, Nasser I, Curry M, Schuppan D, Byrnes V, Afdhal N. The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN liver biopsy scoring system in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2009 Apr;24(4):564-8.

Malik R, Lai M, Sadiq A, Farnan R, Mehta S, Nasser I, Challies T, Schuppan D, Afdhal N. Comparison of transient elastography, serum markers and clinical signs for the diagnosis of compensated cirrhosis.J Gastroenterol Hepatol. 2010 Sep;25(9):1562-8.

Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME. Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metab. 2011 Aug 3;14(2):208-18.

Shaoyong L, Vriend LM, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley M, Alatrakchi. A Hepatitis C Virus-Specific T cell-Derived Transforming Growth Factor beta is Associated with Slow Hepatic. Submitted for publication.

Chui PC, Nasser IA, Fisher fM Popov Y, Kharitonenkov A, Schuppan D, Flier JS, Maratos-Flier E. Fibroblast growth factor 21 plays a critical and protective role in the development of steatohepatitis in mice. Submitted for publication.

Nandy N, Rogers C, Nasser I, Challies TL, Karp S, Johnson S, Hanto D, Curry MP. Impact Of Sirolimus Based Immunosuppression On Fibrosis Progression In Hcv Liver Transplant Recipients Hepatology, Volume 52, Number 4 (Suppl) AASLD Abstracts 395A, 2010.

Rolf Pfannl, MD, Staff Neuropathologist, Instructor in Pathology, Harvard Medical School

Hwang SW, Pfannl RM, Wu JK. Convexity dural cavernous malformation with intradural and extradural extension mimicking a meningioma: a case report. Acta Neurochir (Wien). 2009 Jan;151(1):79-83. Epub 2008 Dec 19.

Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 106(8):2712-6, 2009 Feb 24. Epub 2009 Feb 5.

Chaux A, Torres J, Pfannl R, Barreto J, Rodriguez I, Velazquez EF, Cubilla AL. Histologic Grade in Penile Squamous Cell Carcinoma: Visual Estimation Versus Digital Measurement of Proportions of Grades, Adverse Prognosis With any Proportion of Grade 3 and Correlation of a Gleason-like System With Nodal Metastasis. American Journal of Surgical Pathology. 33(7):1042-8, 2009 Jul.

Bagci T, Wu JK, Pfannl R, Ilag LL, Jay DG. Autocrine semaphorin 3A signaling promotes glioblastoma dispersal. Oncogene. 28(40):3537-50, 2009 Oct 8. Epub 2009 Aug 17.

Hwang SW, Abozed MM, Hale A, Eisenberg RL, Dvorak T, Yao K, Pfannl R, Mignano J, Zhu JJ, Price LL, Strauss GM, Wu JK. Adjuvant Gamma Knife radiosurgery following surgical resection of brain metastases: a 9-year retrospective cohort study. J Neurooncol. 2010 May;98(1):77-82. Epub 2009 Nov 12.

Lang T, Laver N, Strominger MB, Witking A, Pfannl R, Alroy J. Morphological findings of extraocular myopathy with chronic progressive external ophthalmoplegia. Ultrastruct Pathol. 34(2):78-81, 2010 Apr.

Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL. Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature. American Journal of Surgical Pathology. 34(3):385-92, 2010 Mar.

Joseph Alroy, Rolf Pfannl. Electron Microscopic Finding in Skin Biopsies from Patients with Danon Disease. Ultrastruct Pathol. 2010 Dec;34(6):333-6.

Aurelio Hernandez Lain, Andrew P. Lieberman, Rolf Pfannl and E. Tessa Hedley-Whyte. Nodular bilateral amygdala degeneration in demented individuals. Acta Neuropathol. 2010 Nov;120(5):683-8. Epub 2010 Sep 14.

Hirano Body-like Structures in Alpaca. Veterinary Pathology, 2011

William R. Miele, Rolf. Pfannl, James T. Kryzanski. Primary Holocord Ganglio-neuroblastoma. Journal of Neurosurgery: Spine, 2011.

Jaime Acquaviva, Hyun Jung Jun, Rolando Ruiz, Julie Lessard, Haihao Zhu, Melissa Donovan, Steve Woolfenden, Abraham Boskovitz, Ami Raval, Roderick T. Bronson, Rolf Pfannl, Charles A. Whittaker, David E. Housman and Al Charest. Chronic Activation of Wild Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation. Cancer Research, 2011

Seymour Rosen, MD, Staff Pathologist, Director of Surgical, Renal, and Genitourinary Pathology, Professor of Pathology, Harvard Medical School

Rosen S Peters CA Chevalier RL Huang WY The kidney in congenital ureteropelvic junction obstruction: a spectrum from normal to nephrectomy. J Urol (2008 Apr) 179(4):1257-63.

Rosenberger C Khamaisi M Abassi Z Shilo V Weksler-Zangen S Goldfarb M Shina A Zibertrest F Eckardt KU Rosen S Heyman SN Adaptation to hypoxia in the diabetic rat kidney. Kidney Int (2008 Jan) 73(1):34-42.

Heyman SN Khamaisi M Rosen S Rosenberger C Renal parenchymal hypoxia, hypoxia response and the progression of chronic kidney disease. Am J Nephrol (2008) 28(6):998-1006.

Rosenberger C Khamaisi M Goldfarb M Shina A Shilo V Zilbertrest F Rosen S Heyman SN. Acute kidney injury in the diabetic rat: studies in the isolated perfused and intact kidney. Am J Nephrol(2008)28(5):831-9.

Ho J Ng KH Rosen S Dostal A Gregory RI Kreidberg JA Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol (2008 Nov) 19(11):2069-75.

Rosen S Stillman IE. Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation. J Am Soc Nephrol (2008 May) 19(5):871-5.

Rosenberger C Rosen S Shina A Frei U Eckardt KU Flippin LA Arend M Klaus SJ Heyman SN. Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Nephrol Dial Transplant (2008 Nov) 23(11):3472-8.

Rosenberger C Goldfarb M Shina A Bachmann S Frei U Eckardt KU Schrader T Rosen S Heyman SN. Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant (2008 Apr) 23(4):1135-43.

Heyman SN, Rosen S, Rosenberger C. Renal parenchymal hypoxia, hypoxia adaptation, and the pathogenesis of radiocontrast nephropathy. Clin J Am Soc Nephrol (2008 Jan) 3(1):288-96.

Rosenberger C Rosen S Paliege A Heyman SN Pimonidazole adduct immunohistochemistry in the rat kidney: detection of tissue hypoxia. Methods Mol Biol (2009) 466:161-74.

Heyman SN, Rosenberger C, Rosen S. Experimental ischemia-reperfusion: biases and myths-the proximal vs.distal hypoxic tubular injury debate revisited. Kidney Int (2010 Jan) 77(1):9-16.

Heyman SN, Rosen S, Khamaisi M Idee JM Rosenberger C Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy.Invest Radiol (2010 Apr) 45(4):188-95.

Nicksa GA, O'Neil E, Yu DC, Curatolo AS, McNeish BL, Barnewolt CE, Zurakowski D, Buchmiller TL, Moses MA, Rosen S, Fauza DO. Correlation between prenatal urinary matrix metalloproteinase activity and the degree of kidney damage in a large animal model of congenital obstructive uropathy. J Pediatr Surg (2010 Jun) 45(6):1120-5.

O'Neill EB, Nicksa GA, Yu, DC, Curatolo AS, McNeish BL, Barnewolt CE, Buchmiller TL, Zurakowski D, Moses MA, Rosen S, Fauza D. Fetal ovine congenital obstructive uropathy: Morphological observations and correlation with metalloproteinase activity. USCAP 2010.

Jeffrey E. Saffitz, MD, PhD, Chief of Pathology, Mallinckrodt Distinguished Professor of Pathology, Harvard Medical School

Asimaki A, Tandri H, Huang H, Halushka MK, Gautam S, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, WcKenna WJ, Calkins H, Saffitz JE: A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Eng J Med, 2009, 360:1075-1084.

van Tintelen JP, van Gelder IC, Asimaki A, Suurmeijer AJH, Wiesfeld ACP, Jongbloed JDH, van den Wijngaard A, Kuks JBM, van Spaendonck-Zwarts KY, Notermans N, Boven L, van den Heuvel F, Veenstra-Knol HE, Saffitz JE, Hofstra RMW, van den Berg MP: Severe cardiac phenotypes with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene. Heart Rhythm, 2009; 6:1574-1583 (featured in an Editorial Commentary).

Xu T, Yang Z, Vatta M, Rampazzo A, Beffagna G, Pillichou K, Scherer SE, Saffitz J, Kravits J, Zareba W, Danielli GA, Lorenzon A, Nava A, Bauce B, Thiene G, Basso C, Calkins H, Gear K, Marcus F, Towbin JA: Compound and digenic heterozygosity contributes to arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol, 55:587-597, 2010.

Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA. Calkins H, Corrado DA, Cox MG, Daubert J, Fontaine G, Gear K, Hauer RN, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri HM, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D); proposed modification of the Task Force criteria. Circulation, 2010; 121:1533-1541.

Otten E, Asimaki A, Maass A, van Langen IM, van der Wal A, de Jonge N, van den Berg MP, Saffitz JE, Wilde AA, Jongbloed JD, van Tintelen P. Desmin mutations as a cause of right ventricular heart failure affect the intercalated disks. Heart Rhythm, 2010; 7:1058-1064.

Gehmlich K, Asimaki A, Cahill T, Ehler E, Syrris P, Zachara E, Re F, Avella A, Monserrat, L, Saffitz JE, McKenna WJ: Novel missense mutations in desmoglein 2 - a role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy? Heart Rhythm, 2010 7:1446-1453.

Gehmlich K, Syrris P, Peskett E, Evans A, Ehler E, Asimaki A, Anastasakis A, Tsatsopoulou A, Vouliotis AI, Stefanadis C, Saffitz JE, Protonotarios N, McKenna WJ: Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. Cardiovasc Res, 2011, 90:77-87.

Gehmlick K, Lambiase PD, Asimaki A, Ciaccio EJ, Ehler E, Syrris P, Saffitz JE, McKenna WJ: A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions. Heart Rhythm, 2011; 8:711-718.

Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Bodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW, Nichols CG, Semenkovich CF: Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem, 2011; 286:30949-30961

Asimaki A, Tandri H, Duffy ER, Winterfield JR, Mackey-Bojack S, Picken MM, Cooper LT, Wilber DJ, Marcus FI, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, Stevenson WG, McKenna WJ, Gautam S, Remick DG, Calkins H, Saffitz JE: Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy. Circ Arrhythm Electrophysiol, 2011; 4:743-752.

Saffitz JE, Asimaki A, Huang H: Arrhythmogenic right ventricular cardiomyopathy: New insights into disease mechanisms and diagnosis. J Invest Med, 57:861-864, 2009.

Asimaki A, Saffitz JE: The role of endomyocardial biopsy in ARVC: Looking beyond histology in search of new diagnostic markers. J Cardiovasc Electrophysiol, 22:111-117, 2011.

Saffitz JE: The pathobiology of arrhythmogenic cardiomyopathy. Annu Rev Pathol, 6:299-321, 2011.

Saffitz JE: "The Heart" in: Rubin's Pathology, Rubin R and Strayer DS (eds), 6th Edition, Lippincott, Williams and Wilkins, Philadelphia, 2011; pp 479-536.

Asimaki A, Saffitz JE: Gap junctions and arrhythmogenic cardiomyopathy. Heart Rhythm, 2011; in press.

Huang H, Asimaki A, Marcus F, Saffitz JE: Mechano-electrical coupling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. in: Cardiac Mechano-Electrical Coupling and Arrhythmias, 2nd Ed, P. Kohl, F. Sachs, M.R. Franz, Eds, Oxford Univ Press, Oxford, UK, 2011, pp 407-411.

Tonellato PJ, Crawford JM, Boguski MS, Saffitz JE: A national agenda for the future of pathology in personalized medicine. Report of the proceedings of a meeting at the Banbury Conference Center: Genome-Era pathology, precision diagnostics and pre-emptive care: A stakeholder summit. Am J Clin Path, 2011; 135:668-672.

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE: A call to action: Training pathology residents in genomics and personalized medicine. Am J Clin Path, 133:832-834, 2010.

Van Norstrand DW, Asimaki A, Rubinos C, Dolmatova E, Srinivas M, Tester DJ, Saffitz JE, Duffy HS, Ackerman MJ: Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death. Circulation, 2012; 125:474-481.

Leone O, Veinot JP, Angelini A, Baandrup UT, Basso C, Berry G, Bruneval P, Burke M, Butany J, Calabrese F, d'Amati G, Edwards WD, Fallon JT, Fishbein MC, Gallagher PJ, Halushka MK, McManus B, Pucci A, Rodriguez ER, Saffitz JE, Sheppard MN, Steenbergen C, Stone JR, Tan C, Thiene G, van der Wal AC, Winters GL: 2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol, 2012, in press

Saffitz JE: Genomic pathology: a disruptive innovation. Personalized Medicine, 2012, in press

Stuart J. Schnitt, MD, Director, Division of Anatomic Pathology; Professor of Pathology, Harvard Medical School

Schnitt SJ, Collins LC. Biopsy Interpretation of the Breast, Lippincott Williams & Wilkins, 2008.

Turner RR, Weaver DL, Cserni G, Lester SC, Hirsch K, Elsahoff D, Fitzgibbons PL, Viale G, Mazzarol G, Ibarra JA, Schnitt SJ, Giuliano AE. Nodal stage classification for breast carcinoma: Improving interobserver reproducibility through standardized histologic criteria and image-based training. J Clin Oncol 2008;26:258-263.

Tamimi RM, Baer HJ, Marotti J, Galan M, Galaburda L, Fu Y, Deitz A, Connolly JL, Schnitt SJ, Colditz GA, Collins LC. Comparison of molecular phenotypes of ductal carcinoma in situ and invasive breast cancer. Breast Cancer Res 2008;10:R67.

Kleer CG, Bloushtain-Qimron N, Chen Y-H, Carrasco D, Hu M, Yao J, Kraeft S-K, Collins LC, Sabel MS, Argani P, Gelman R, Schnitt SJ, Krop IE, Polyak K. Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res 2008;14:5357-5367.

Jensen KC, Schaeffer DF, Nielsen TO, Cheang M, Montgomery K, West RB, Gilks CB, Ross D, Gulisa T, Schnitt S, van de Rijn M. Characterization of a novel anti-fatty acid synthase (FASN) antiserum in breast tissue. Mod Pathol 2008;21:1413-1420.

Hu M, Yao J, CarrollDK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred DC, Bissell MJ, Schnitt S, Polyak K. Regulation of in situ to invasive breast carcinoma transition. Cancer Cell 2008;13:394-406.

Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: Biological and diagnostic implications. Am J Surg Pathol 2009;33:227-232.

Baer HJ, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, Tamimi RM. Lobule type and subsequent breast cancer risk: Results from the Nurses' Health Studies. Cancer 2009;115:1404-1411.

Hu M, Peluffo G, Chen H, Gelman R, Schnitt S, Polyak K. The role of COX-2 in epithelial-stromal cell interactions and the progression of ductal carcinoma in situ (DCIS) of the breast. Proc Nat Acad Sci 2009;106:3372-3377.

Collins LC, Martyniak AJ, Kandel MJ, Stadler ZK, Masciari S, Miron A, Richardson AL, Schnitt SJ, Garber JG. Basal cytokeratin and epidermal growth factor receptor expression are not predictive of BRCA1 mutation status in women with triple negative breast cancers. Am J Surg Pathol 2009;33:1093-1097.

Nekhlyudov L, Habel LA, Achacoso NS, Jung I, Haque R, Collins LC, Schnitt SJ, Quesenberry Jr CP, Fletcher SW. Adherence to long-term surveillance mammography among women with ductal carcinoma in situ treated with breast conserving surgery. J Clin Oncol 2009;27:3211-3216.

Collins LC, Wang Y, Connolly JL, Baer HJ, Hu R, Schnitt SJ, Colditz GA, Tamimi RM. Potential role of tissue microarrays for the study of biomarker expression in benign breast disease and normal breast tissue. Appl Immunohistochem Mol Morphol 2009;17:438-441.

Chen Y-Y, Hwang ES, Roy R, DeVries S, Anderson J, Wa C, Fitzgibbons PL, Jacobs TW, MacGrogan G, Peterse H, Vincent-Salomon A, Tokuyasu T, Schnitt SJ, Waldman FM. Genetic and phenotypic characteristics of pleomorphic lobular carcinoma in situ. Am J Surg Pathol 2009;33:1683-1694.

Habel LA, Achacoso NS, Haque R, Nekhlyudov L, Fletcher SW, Schnitt SJ, Collins LC, Geiger AM, Puligandla B, Acton L, Quesenberry Jr, CP. Declining recurrence among ductal carcinoma in situ patients treated with breast-conserving surgery in the community setting. Breast Cancer Res 2009;11:R85.

Collins LC, Achacoso N, Nekhlyudov L, Fletcher SW, Haque R, Quesenberry CP, Puligandla B, Alshak NS, Goldstein LC, Gown AM, Schnitt SJ, Habel LA. Relationship between clinical and pathologic features of ductal carcinoma in situ and patient age: An analysis of 657 patients. Am J Surg Pathol 2009;33:1802-1808.

Su X, Colditz GA, Willett WC, Collins LC, Schnitt SJ, Connolly JL, Pollak MN, Rosner B, Tamimi RM. Genetic variation and circulating levels of IGF-1 and IGFBP-3 in relation to risk of proliferative benign breast disease. In J Cancer 2010;126:180-190.

Tung N, Wang Y, Collins LC, Kaplan J, Li H, Gelman R, Comander A, Gallagher B, Fetten K, Krag K, Stoeckert K, Legare RD, Sgroi D, Garber JE, Schnitt SJ. Estrogen receptor positive breast cancers in BRCA1 mutation carriers: Clinical risk factors and pathologic features. Breast Cancer Res 2010;12:R12.

Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations myoepithelial cells associated with benign sclerosing lesions of the breast. Am J Surg Pathol 2010;34:896-900.

Haque R, Achacoso NS, Fletcher SW, Nekhlyudov L, Collins LC, Schnitt SJ, Quesenberry CP, Habel LA. Treatment of ductal carcinoma in situ among patients in large integrated health plans. Am J Manag Care. 2010 May;16(5):351-60.

Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA.High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18378-83. Epub 2011 Oct 31.

Robens J, Goldstein L, Gown AM, Schnitt SJ. Thyroid transcription factor-1 expression in breast carcinomas. Am J Surg Pathol. 2010 Dec;34(12):1881-5.

Su X, Colditz GA, Collins LC, Baer HJ, Sampson LA, Willett WC, Berkey CS, Schnitt SJ, Connolly JL, Rosner BA, Tamimi RM. Adolescent intakes of vitamin D and calcium and incidence of proliferative benign breast disease.. Breast Cancer Res Treat. 2012 Jul;134(2):783-91. Epub 2012 May 24.

Aroner SA, Collins LC, Schnitt SJ, Connolly JL, Colditz GA, Tamimi RM. Columnar cell lesions and subsequent breast cancer risk: A nested case-control study. Breast Cancer Research (in press).

Kaplan JS, Schnitt SJ, Collins LC, Wang Y, Garber JE, Montgomery K, West RB, Krag K, Fetten K, Lincoln A, Tung NM. Pathologic Features and Immunophenotype of Estrogen Receptor-positive Breast Cancers in BRCA1 Mutation Carriers. Am J Surg Pathol. 2012 Oct;36(10):1483-8.

Liu Y, Tamimi RM, Berkey CS, Willett WC, Collins LC, Schnitt SJ, Connolly JL, Colditz GA. Intakes of alcohol and folate during adolescence and risk of proliferative benign breast disease. Pediatrics. 2012 May;129(5):e1192-8. Epub 2012 Apr 9.

Alireza Sepehr, MD, Staff Dermatopathologist, Instructor in Pathology, Harvard Medical School 

Avram MM, Gobel V, and Sepehr A. Case Records of the Massachusetts General Hospital. Case 30-2007: A newborn girl with skin lesions. N Engl J Med. 2007;27;357:1327-35.

Sepehr A and Mihm, J., MC. Dermatitis Herpetiformis. In: Zembowicz A et al., editors: Critical Diagnoses in Dermatopathology. Brisbane: KBS; 2007.

Sepehr A, Lauwers GY. Gastrointestinal evidence of autoimmune pancreatitis: a rare manifestation. Histopathology. 2008;53:358-9.

Sepehr A, Mino-Kenudson M, Ogawa F, Brugge WR, Deshpande V, Lauwers GY. IgG4+ to IgG+ plasma cells ratio of ampulla can help differentiate autoimmune pancreatitis from other "mass forming" pancreatic lesions. Am J Surg Pathol. 2008;32:1770-9.

Sepehr A, Kroshinsky D, and Mihm, J., MC. Necrotizing fasciitis. In: Hoang MP et al., editors: Diagnostic Pitfalls in Dermatopathology. Brisbane: KBS; 2008.

Islami F, Kamangar F, Nasrollahzadeh D, Aghcheli K, Sotoudeh M, Abedi-Ardekani B, Merat S, Nasseri-Moghaddam S, Semnani S, Sepehr A, Wakefield J, Møller H, Abnet CC, Dawsey SM, Boffetta P, and Malekzadeh R. Socioeconomic status and esophageal cancer: results from a population-based case-control study in a high-risk area. Int J Epidemiology. 2009;38 (4):978-88.

Kroshinsky D, Stone JH, Bloch DB, and Sepehr A. Case records of the Massachusetts General Hospital. Case 5-2009. A 47-year-old woman with a rash and numbness and pain in the legs. N Engl J Med. 2009;12;360:711-20.

Harris A, Bigby M, and Sepehr A. Pemphigus foliaceus with negative direct immunofluorescence (DIF) studies. In Hoang MP et al., editors: Suboptimal biopsies in dermatopathology. Brisbane: KBS; 2009.

Ibrahimi OA, Gunawardane N, Sepehr A, and Reynolds R. Terbinafine-induced acute generalized exanthematous pustulosis (AGEP) responsive to high dose intravenous corticosteroid. Dermatology Online Journal. 2009 Sep 15;15(9):8.

Sepehr A, Wenson S, and Tahan S. Histopathologic Manifestations of Systemic Diseases: The Example of Lupus Erythematosus. J Cutan Pathol 2010;37:112-124

Harris A, Mihm, J., MC, and Sepehr A. Spitz nevus versus Spitzoid melanoma. In: Hoang MP et al., editors: Mimicry in Melanocytic Lesions. Brisbane: KBS; 2010.

Harris A and Sepehr A. Sclerosing nevus versus desmoplastic melanoma. In: Hoang MP et al., editors: Mimicry in Melanocytic Lesions. Brisbane: KBS; 2010.

Frieling GW and Sepehr A. Cutaneous Mycobacterium chelonae in an Immunocompetent Individual. In: Hoang MP, Duncan LM, Mihm, Jr MC, Murphy GF, and Tahan SR, editors: Cutaneous Infections and Infestations. Brisbane: KBS; 2011.

Kraft S, Gee SN, Velez NF, Burgin S, and Sepehr A. Kaposi's varicelliform eruption. In: Hoang MP, Duncan LM, Mihm, Jr MC, Murphy GF, and Tahan SR, editors: Cutaneous Infections and Infestations. Brisbane: KBS; 2011.

Wenson SF, Jan F, and Sepehr A. Unilateral Nevoid Telangiectasia Syndrome: A Case Report and Review of the Literature. Dermatology Online J. 2011;17(5): 2.

Kaplan J, Burgin S, and Sepehr A. Granulomatous Pigmented Purpuric Dermatosis: Report of a Case in the Caucasian Population and Review of the Literature. J Cut Pathol 2011; 38(12):984-9.

Lu S, Sepehr A, and Tsao H. Spitz nevi and other Spitzoid lesions. J Am Acad Dermatol. 2011;65(6):1087-92.

Sepehr A, Chao A, Trefrey B, Blackford A, Duncan LM, Flotte TJ, Sober A, Mihm Jr. MC, and Tsao H. Long-term Outcome of Spitz-type Melanocytic Tumors. Arch Dermatol. 2011;147(10):1173-9.

Sepehr A, Seeley E, Harris A, Tahan S, and Caprioli R. Discrimination of benign versus malignant melanocytic skin tumors by MALDI-imaging mass spectrometry (MALDI-IMS). Human Proteome Organization (HUPO), 2011 September, Geneva, Switzerland. Juried poster presentation.

Sepehr A, and Tahan S. Nevus/Melanocytome/Melanoma": That Which We Call a Rose by any other Name Would Smell as Sweet. Arch Pathol Lab Med. 2012;136(2):135.

Kroshinsky D, Alloo A, Rothschild B, Cummins B, Tan B, Montecino R, Hoang MP, Duncan L, Mihm M, and Sepehr A. Necrotizing Sweet Syndrome: A New Variant of Neutrophilic Dermatosis Mimicking Necrotizing Fasciitis. J Am Acad Dermatol. 2012 March 23 [Epub ahead of print].

Isaac E. Stillman, MD, Staff Pathologist, Renal Pathology, Director, Clinical Electron Microscopy, Assistant Professor of Pathology, Harvard Medical School

Cohen, R.A., et al., T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin Immunol, 2008. 128(1): p. 1-7.

Crispin, J.C., et al., Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol, 2008. 181(12): p. 8761-6.

Magee, C.C., et al., Case 2-2008 -- A 38-Year-Old Woman with Postpartum Visual Loss, Shortness of Breath, and Renal Failure. N Engl J Med, 2008. 358(3): p. 275-289.

Maki, T., et al., SV40 infection associated with rituximab treatment after kidney transplantation in nonhuman primates. Transplantation, 2008. 85(6): p. 893-902.

Rosen, S. and I.E. Stillman, Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation. J Am Soc Nephrol, 2008. 19(5): p. 871-5.

Shan, H.Y., et al., Use of circulating antiangiogenic factors to differentiate other hypertensive disorders from preeclampsia in a pregnant woman on dialysis. Am J Kidney Dis, 2008. 51(6): p. 1029-32.

Stillman, I.E., E.Q. Lima, and E.A. Burdmann, Renal biopsies in acute kidney injury: who are we missing? Clin J Am Soc Nephrol, 2008. 3(3): p. 647-8.

Mutter, W.P., I.E. Stillman, and N.K. Dahl, Thrombotic Microangiopathy and Renal Failure Exacerbated by [epsilon]-Aminocaproic Acid. American Journal of Kidney Diseases, 2009. 53(2): p. 346-350.

Xu Y, Zhang Z, Hu J, Stillman IE, Leopold JA, Handy DE, Loscalzo J, Stanton RC. Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J 2009 Oct 5.

Kanter D, Lindheimer MD, Wang E, Borromeo RG, Bousfield E, Karumanchi SA, Stillman, IE. Angiogenic dysfunction in molar pregnancy. Am J Obstet Gynecol
2009 Nov 16.

Stillman IE, Pavlakis M. Allograft biopsies: studying them for all they're worth J Am Soc Nephrol. 2009 Nov;20(11):2282-4.

Xu Y, Zhang Z, Hu J, Stillman IE, Leopold JA, Handy DE, Loscalzo J, Stanton RC.Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J 2010 Feb;24(2):609-16. Epub 2009 Oct 5

Kanter D, Lindheimer MD, Wang E, Borromeo RG, Bousfield E, Karumanchi SA, Stillman, IE. Angiogenic dysfunction in molar pregnancy. Am J Obstet Gynecol
2010 Feb;202(2):184.e1-5

Rovin BH, Stillman IE. The Kidney in Systemic Lupus Erythematosus in Systemic Lupus Erythematosus, 5TH Edition, Elsevier. Edited by R Lahita, 2011.

Silasi, M. Rana, S. Powe, C. Cohen, B. Lim, K. H. Zsengeller, Z. K. Karumanchi, S. A. Stillman, IE. Placental expression of angiogenic factors in Trisomy 13. Am J Obstet Gynecol 2011 Jun;204(6):546.e1-4. Epub 2011 Apr 20.

Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM. PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest (2011 Oct) 121(10):4003-14.

Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G; Holovac, E; Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P. Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radical Biology & Medicine. 2012 Jan 15;52(2):497-506. Epub 2011 Nov 10.

Hasnain W, Stillman IE, Bayliss GP. Minimal-change renal disease and Graves' disease: a case report and literature review. NDT Plus 2011 4:2 96-98.

Bixel K, Silasi M, Zelop CM, Lim K, Zsengeller Z, Stillman IE, Rana S. Placental Origins of Angiogenic Dysfunction in Mirror Syndrome. Hypertension in Pregnancy, Early Online:1-7, 2011

Stillman IE, Karumanchi SA. Vasculitis is an antiangiogenic state. J Am Soc Nephrol 2012 Jan; 23(1):8-10. Epub 2011 Dec 15.

Rajakumar A, Cerdeira A, Hubel CA, Jeyabalan A, Rana S, Zsengellér Z, Stillman IE, Parikh SM, Karumanchi, S. A. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating sFlt1 in preeclampsia. Hypertension. 2012 Feb;59(2):256-64. Epub 2012 Jan 3.

Zsengellér Z, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, and Pacher P. Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. J Histochem Cytochem, 2012 Jul;60(7):521-9. Epub 2012 Apr 17.

Mukhopadhyay P, Horvath B, Zsengeller Z, Batkai S, Cao Z, Kechrid M, Holovac E, Erdelyi K, Tanchian G, Liaudet L, Stillman IE, Joseph J, Kalyanaraman B, Pacher P. Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially-targeted antioxidants. Free Radical Biology & Medicine, 2012 Jun 6. [Epub ahead of print]

McMahon G, Datta D, Bruneau S, Kann M, Khalid M, Ho J, Seto T, Kreidberg JA, Stillman IE, Briscoe DM. Constitutive activation of the mTOR signaling pathway within the normal glomerulus. Biochem Biophys Res Commun. 2012 Jul 22. [Epub ahead of print]

Steven R. Tahan, MD, Director of Dermatopathology, Associate Professor of Pathology, Harvard Medical School

Zembowicz A, Duncan LM, Mihm MC, Murphy GF, and Tahan SR. Cases in Dermatopathology: Critical Diagnoses in Dermatopathology. Brisbane: Knowledge Books and Software Publishing, 2007.

Negin B, Panka D, Wang W, Saddiqi M, Tawa N, Mullen J, Tahan SR, Mandato L, Polivy A, Mier J, and Atkins M: Effect of Melanoma on Immune Function of the Local Lymph Node Basin. Clin Cancer Res. 2008 Feb 1;14(3): 654-9.

Krause PJ, Grant-Kels JM, Tahan SR, Dardick KR, Alarcon-Chaidez F, Bouchard K, Visini C, Deriso C, Foppa IM, Wikel S. Dermatologic changes induced by repeated Ixodes scapularis bites and implications for prevention of tick-borne infection. Vector Borne Zoonotic Dis. 2009 Dec; 9(6):603-10.

Hoang MP, Duncan LM, Mihm MC, Murphy GF, Tahan SR. Cases in Dermatopathology: Suboptimal Biopsies in Dermatopathology. Brisbane: Knowledge Books and Software Publishing, 2009.

Chan MM, Tahan SR. Low Affinity Nerve Growth Factor Receptor (P75 NGFR) as a Marker of Perineural Invasion in Malignant Melanomas. J Cutan Pathol. 2010 Mar; 37(3):336-43.

Chan MP, Chan MM, Tahan SR. Melanocytic nevi in pregnancy: Histologic features and Ki-67 proliferation index. J Cutan Pathol. 2010 Aug;37(8):843-51.

Sepehr A, Wenson S, Tahan SR. Histopathologic manifestations of systemic diseases: the example of cutaneous lupus erythematosus. Journal of Cutaneous Pathology 2010, 37: 112-124.

Haws AL, Rafael Rojano, Tahan SR, Phung TL: Accuracy of Biopsy Sampling for Subtyping Basal Cell Carcinoma. J Am Acad Dermatol. 2012 Jan;66(1):106-11. Epub 2011 Jul 28.

Hsu SW, Tahan SR, and Kim, CC. Follicular Malignant Melanoma: A Case Report of a Metastatic Variant and Review of the Literature. J Am Acad Dermatol 64 (2011), pp. 1007-1010.

Fox M, Tahan SR, and Kim CC. Livedo Reticularis: A Side Effect of Interferon Therapy in a Pediatric Melanoma Patient. Pediatric Dermatol 2011 May 16.

Hoang MP, Duncan LM, Mihm MC, Murphy GF, Tahan SR. Mimicry in Melanocytic Lesions. Brisbane: Knowledge Books and Software Publishing, 2010.

Hoang MP, Duncan LM, Mihm MC, Murphy GF, Tahan SR. Cutaneous Infections and Infestations. Brisbane: Knowledge Books and Software Publishing, 2011.

Harris AC, Nagle D, and Tahan SR. Anal Skin Tags with Granulomatous Inflammation: Association with Inflammatory Bowel Disease and Symptoms. Poster presented at USCAP meeting March 2011.

Shalin S, Ward A, Patel R, Misialek M, Tahan SR, Sepehr A. Aggressive Digital Papillary Adenocarcinoma: ASDP October 2011.

Kaplan J and Tahan SR. Nevi with Epithelioid Cytomorphology and Architectural Disorder (NECAD). USCAP 2012.

Freiling G, Ahern T, and Tahan SR. Accuracy of the Measured Depth of Histologic Sections Compared to the Gross Specimen Measurement. USCAP 2012.

Varmeh S, Egia A, McGrouther D, Tahan SR, Bayat A, and Pandolfi PP. Cellular Senescence as a Possible Mechanism for Halting Progression of Keloid Lesions. Genes and Cancer 2012 (accepted for publication).

Paul A. VanderLaan, MD, PhD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

VanderLaan PA, Reardon CA, Thisted RA, Getz GS. VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice. J Lipid Res. 2009;50:376-385.

Fairweather M, Burt BM, VanderLaan PA, Brunker PA, Bafford AC, Ashley SW. Acute hemorrhage from small bowel diverticula harboring strongyloidiasis and schistosomiasis. Am Surg. 2010;76:539-341.

VanderLaan PA, Marqusee E, Krane JF. Clinical outcome for atypia of undetermined significance in thyroid fine-needle aspirations: Should repeat FNA be the preferred initial approach? Am J Clin Pathol. 2011;135:770-775.

VanderLaan PA, Marqusee E, Krane JF. Usefulness of diagnostic qualifiers for thyroid fine-needle aspirations with atypia of undetermined significance. Am J Clin Pathol. 2011;136:572-557.

VanderLaan PA, Krane JF, Cibas ES. The Frequency of "Atypia of Undetermined Significance" Interpretations for Thyroid FNAs is Negatively Correlated with Histologically Proven Malignant Outcome. Acta Cytol. 2011;55:512-517.

Jo VY, VanderLaan PA, Marqusee E, Krane JF. Repeatedly Nondiagnostic Thyroid Needle Aspirations Do Not Modify Malignancy Risk. Acta Cytol. 2011;55:539-543.

Getz GS, VanderLaan PA, Reardon CA. Natural killer T cells in lipoprotein metabolism and atherosclerosis. Thromb Haemost. 2011;106:814-819.

Krane JF, VanderLaan PA, Faquin WC, Renshaw AA. The atypia of undetermined significance/follicular lesion of undetermined significance: Malignant ratio: A Proposed Performance Measure for Reporting in The Bethesda System for Thyroid Cytopathology. Cancer Cytopathol. 2012;120:111-116

VanderLaan PA, Renshaw AA, Krane JF. Atypia of Undetermined Significance and Nondiagnostic Rates in the Bethesda System for Reporting Thyroid Cytopathology are Inversely Related. Am J Clin Pathol. 2012;137:462-465.

Vanderlaan PA, Marqusee E, Krane JF. Features associated with locoregional spread of papillary carcinoma correlate with diagnostic category in the Bethesda System for reporting thyroid cytopathology. Cancer Cytopathol. 2012: in press.

VanderLaan PA, Padera RF, Schoen FJ. Practical approach to the evaluation of prosthetic mechanical and tissue replacement heart valves. In: Current Concepts in Cardiovascular Pathology. Surgical Pathology Clinics Volume 5, Number 2, June 2012: pages 353-369.

VanderLaan PA, Krane JF, Winters GW. "Utility of Rapid Cytologic Techniques in the Autopsy Setting." 101st Annual Meeting of the United States and Canadian Academy of Pathology 2012, March 19 in Vancouver, CA. Mod Pathol. 2012;25:7A - 14.

Helen H. Wang, MD, MPH, DrPH, Medical Director of Cytology, Associate Professor of Pathology, Harvard Medical School

Peng Y, Wang HH. A meta-analysis of comparing fine needle aspiration and frozen section for evaluating thyroid nodules. Diagn Cytopathol 2008;36:916-20.

Shields HM, Recht A, Wang HH. Exposure to both radiation and chemotherapy increases the risk of Barrett's and multilayered epithelium. Dig Dis Sci 2009;54:2143-9.

Azabdaftari G, Goldberg SN, Wang HH. Efficacy of on-site specimen adequacy evaluation of image-guided fine and core needle biopsies. Acta Cytol 2010;54:132-137.

Jain N, Wang HH. Core-biopsies are replacing FNAs in most organs. Mod Pathol 2008;21(Supplement 1):75A.

Schmidt JF, Joo M, Greenberg JA, Cerda S, Dendrinos K, Farraye F, Wang HH, Odze RD. Clinical and histologic predictors of outcome in patients with colonic Crohn's disease. Mod Pathol 2008;21(Supplement 1):135A.

Turner MS, Wang HH, Beasley MB, Collins LC, Folpe AL, Hecht JL, Hunt JL, van de Rijn M, Goldsmith JD. Non-gastrointestinal pathologists are highly reproducible in their diagnosis of serrated polyps of the colorectum following tutorial instruction. Mod Pathol 2008;21(Supplement 1):138A.

Soucy G, Schmidt JF, Greenberg JA, Cerda S, Dendrinos K, Farraye F, Farris AB, Lauwers GY, Wang HH, Odze RD. Colonic Crohn's disease: a clinical/pathologic and outcome study of 120 patients. Mod Pathol 2009; 22 (Supplement 1):149A.

Soucy G, Schmidt J, Greenberg J, Cerda SR, Agarwal S, Dendrinos K, Farraye FA, Farris AB, Lauwers GY, Wang HH, Odze RD. Ulcerative colitis-like Crohn's disease: A clinical/pathologic and outcome study. Gastroenterology 2009;136 (supplement 1):A216-7.

Coco D, Goldblum JR, Hornick JL, Lauwers GY, Montgomery EA, Srivastava A, Wang HH, Odze RD. Interobserver variability in the diagnosis of crypt dysplasia in Barrett's esophagus. Gastroenterology 2009;136(supplement 1):A-593.

White SR, Hecht J, Kane SE, Fu Y, Cohen DW, Wang HH. Bile duct brush cytology: indeterminate diagnosis is essential. Arch Pathol Lab Med 2009;133:1689.

Singh RS, Hecht JL, Wang HH. Utility of repeat thyroid FNA in the management of patients with thyroid nodules. Mod Pathol 2010;23(supplement 1):105A.

Coco, DP, Goldblum JR, Hornick JL, Lauwers GY, Montgomery E, Srivastava A, Wang HH, and Odze RD. Interobserver variability in the diagnosis of crypt dysplasia in Barrett's esophagus. Am J Surg Pathol, 2011;35:45-54.

Gupta NJ and Wang HH. Increase of core biopsies in visceral organs - experience at one institution. Diagn Cytopathol, in print.

Soucy G, Wang HH, Farraye FA, Schmidt J, Farris AB, Lauwers G, Cerda S, Dendrinos K, Odze RD. Clinical and pathological analysis of colonic Crohn's disease, including a subgroup with ulcerative colitis-like features. Mod Pathol, in print.

Singh SR, Wang HH. Eliminating the "Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance" category from the Bethesda System for Reporting Thyroid Cytopathology. Am J Clin Pathol, in print.

Kindelberger DW, Wang HH. Gastrointestinal tract. In: Cibas ES and Ducatman BS, eds. Cytology. Diagnostic Principles and Clinical Correlates, 3rd Edition. Philadelphia: Saunders-Elsevier; 2009.p.197-220. June 1, 2011 25.

Ducatman BS, Wang HH. Breast. In: Cibas ES and Ducatman BS, eds. Cytology. Diagnostic Principles and Clinical Correlates, 3rd Edition. Philadelphia: Saunders-Elsevier; 2009.p.221-254.

Wang HH. Diagnostic cytology of the GI tract. In: Odze RD, Goldblum JR, eds. Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas, 2nd Edition. Philadelphia: Saunders; 2009.p.39-50.

Wang HH, Filie AC, Clark DP, Powers CN. Suspicious for malignancy. In: Ali SZ, Cibas ES, eds. The Bethesda System for Reporting Thyroid Cytopathology. Definitions, Criteria and Explanatory Notes. New York: Spinger; 2010.p.75-89.

Samedi V, White S, Zimarowski MJ, Harris A, Saffitz J, Wang HH. Metastatic peritoneal mesothelioma in the setting of recurrent ascites: A Case Report. Diagn Cytopathol 2010;38:675-81.

Singh RS, Wang HH. Timing of repeat thyroid FNA in the management of thyroid nodules. Mod Pathol 2011;24(supplement 1): 105A.

Hagen C, Najarian R, Wang H, Levine J, Siegel C, Levy C, Burakoff, R, Odze R, and Srivastava A. Histologic outcome after treatment in collagenous colitis: A long tem outcome study of 50 patients. Mod Pathol 2011;24(supplement 1):151A.

Huihui Ye, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Ye H, Yoon GS, Epstein J. Intrarenal ectopic adrenal tissue and renal-adrenal fusion: a report of 9 cases. Mod Path. 2009 Feb;22(2):175-81.

Ye H, Li Y, Melamed J, Zou X, Pearce P, Wei JJ, Chiriboga L, Yi P, Garabedian MJ, Wang, Osman I, Lee P. Stromal anti-apoptotic androgen receptor target gene c-FLIP in prostate cancer. J Urol. 2009 Feb;181(2):872-7.

Lotan TL, Ye H, Melamed J, Wu XR, Shih IM, Epstein JI. Immunohistochemical Panel to Identify the Primary Site of Invasive Micropapillary Carcinoma. Am J Surg Pathol. 2009 Feb 20.

Miller J, Chen YB, Ye H, Robinson B, Brimo F. Epstein JI. Extraprostatic Extension of Prostatic Adenocarcinoma on Needle Core Biopsy: Report of 72 Cases with Clinical Follow-up. BJU Int. 2010 Aug;106(3):330-3.

Miyamoto H, Brimo F, Schultz L, Ye H, Miller J, Fajardo D, Lee T, Epstein JI, Netto G. Low-Grade Papillary Urothelial Carcinoma of the Urinary Bladder: A Clinicopathologic Analysis of a Post-WHO/ISUP Classification Cohort from a Single Academic Center. Arch Pathol Lab Med. 2010 Aug;134(8):1160-3.

Zavadil J*, Ye H*, Liu Z, Wu J, Lee P, Hernando E, Soteropoulos P, Toruner GA, Wei JJ. Profiling and Functional Analyses of MicroRNAs and Their Target Gene Products in Human Uterine Leiomyomas. PLoS One. 2010 Aug 24;5(8). pii: e12362. (* Co-first Authorship)

Ye H, Montgomery E, Epstein JI. Incidental anorectal pathological findings in prostatic needle core biopsies: a 13-year experience from a genitourinary pathology consult service. Hum Pathol. 2010 Dec;41(12):1674-81.

Ye H, Walsh PC, Epstein JI. Skeletal muscle involvement by limited Gleason score 6 adenocarcinoma of the prostate on needle biopsy is not associated with adverse findings at radical prostatectomy. J Urol. 2010 Dec;184(6):2308-12.

Ye H, Epstein JI. Skeletal muscle involvement by limited Gleason score 3+3=6 cancer on needle biopsy is not associated with adverse findings at radical prostatectomy. (2010) United States and Canadian Academy of Pathology Annual Meeting, Washington DC

Ye H, Kong T, He TW, Jolis T, Lepor H, Melamed J. Intraoperative frozen section analysis of apical margin biopsies during radical prostatectomy: ten year experience from a single institution. Urology. 2011 Aug;78(2):399-404. Epub 2011 May 31.

Ye H, Ulbright TM. Difficult Differential Diagnoses in Testicular Pathology. Arch of Path & Lab. (accepted)

Sheikine Y, Melamed J, Lee P, Ye H. Molecular Genetics of Testicular Germ Cell Tumors. (in preparation)

Eric Yee, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Yee, E; Zaino, R; Torkko, K; Shroyer, K. "B7-H4 expression in Brenner Tumors, a Descriptive and Comparative Study." Histopathology, Apr 2010; 56(5): 652-4.

Klempner, S; Choueiri, T; Yee, E; Doyle, L; Schuppan, D; Atkins, M. "Severe Pazopanib-Induced Hepatotoxicity: Clinical and Histologic Course in 2 Patients." Journal of Clinical Oncology. Vol. 30. July 2012.

Yee, E; Berg, A. "Can 2,3-butanediol levels help distinguish chronic alcoholics from occasional drinkers?" Clinical Chemistry, July 2011 Abstract and Poster Presentation.

Mary Jane Zimarowski, MD, Staff Pathologist, Dermatopathology and Surgical Pathology, Instructor in Pathology, Harvard Medical School

Chan M, Zimarowski MJ #298, "Lupus erythematosus-like reaction in imiquimod-treated skin", poster presentation at the 46th Annual Meeting of The American Society of Dermatopathology (ASDP), 2009.

Harris A, Faulkner-Jones B, Zimarowski MJ #87, "Epidermal Panfolliculoma", poster presentation at the 46th Annual Meeting of The American Society of Dermatopathology (ASDP), 2009.

Marsee D, Williams G, Lee J, Shofner J, Farhana J, Sepehr A, Zimarowski, MJ #377, "Multinucleate Cell Angiohistiocytoma", poster presentation at the 46th Annual Meeting of The American Society of Dermatopathology (ASDP), 2009.

Samedi, V., White, S., Zimarowski, M., Harris, A., Saffitz, J., Wang, H. Metastatic Peritoneal Mesothelioma in the Setting of Recurrent Ascites: A Case Report, Diagn Cytopathol. 2010 Sep;38(9):675-81.

Harris A, Faulkner-Jones BF, Zimarowski MJ. Epidermal Panfolliculoma: A report of two cases. Am J Dermatopathol. 2011 Feb;33(1):e7-10.

Chan MP, Zimarowski MJ. Lupus erythematosus-like reaction in imiquimod-treated skin: a report of two cases. Am J Dermatopathol. 2011 Jul;33(5):523-7.

Frieling G, Zimarowski MJ, Pihan GA. Life-Threatening Leukocytoclastic Vasculitis (LCV) Precipitated by Rituxan Therapy in a Patient with Hepatitis C and Lymphoplasmacytic Lymphoma (LPL): A Type I-II Cryoglobulinemia? Accepted for presentation at the 2011 American Society of Dermatopathology Conference (ASDP)

Sheikine Y, Hawryluk EB, Burgin S, Zimarowski MJ. Histopathology of measles exanthem: a case with characteristic features and eosinophils. Accepted for publication, J Cutan Pathol.

Gee SN, Harris AC, Zimarowski MJ. Churg-Strauss syndrome presenting as scar reactivation: histopathologic features and an illustration of "locus minoris resistentiae". Accepted for publication, J Cutan Pathol.

Shalin SC, Cukras A, Zimarowski MJ. Granular Parakeratosis Mimicking Pustular Psoriasis: An Unusual Presentation. Poster presentation at the 48th Annual Meeting of The American Society of Dermatopathology (ASDP), 2011.

Chan MP, Zimarowski MJ. Non-Infectious Vulvitis: A Histopathologic Review and Classification of 183 Cases. Platform presentation at the 101st Annual Meeting of the United States and Canadian Academy of Pathology (USCAP), 2012.



FACULTY AND SELECTED PUBLICATIONS
CLINICAL PATHOLOGY


Ramy A. Arnaout, MD, PhD, Associate Director, Clinical Microbiology, Instructor in Pathology, Harvard Medical School

Dostie J, Richmond TA, Arnaout RA, Selzer RR, Lee WL, Honan TA, Rubio ED, Krumm A, Lamb J, Nusbaum C, Green RD, Dekker J. Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res. 2006 Oct;16(10):1299-309. Epub 2006 Sep 5.

Sällström B, Arnaout RA, Davids W, Bjelkmar P, Andersson SG. Protein evolutionary rates correlate with expression independently of synonymous substitutions in Helicobacter pylori. J Mol Evol. 2006 May;62(5):600-14. Epub 2006 Apr 1.

Arnaout RA. Specificity and overlap in gene segment-defined antibody repertoires. BMC Genomics. 2005 Oct 28;6:148.

Tsibris, Athe M.N., Korber, B.*, Arnaout, R.*, Russ, C., Lo, C-C., Leitner, T., Gaschen, B., Theiler, J., Paredes, R., Su, Z., Hughes, M.D., Gulick, R.M., Greaves, W., Coakley, E., Flexner, C., Nusbaum, C., and Kuritzkes, D.R. Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo. PLoS ONE 4, e5683 (2009) *These authors contributed equally to this work

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE. A curriculum in genomics and personalized medicine for pathology residents. Am J Clin Pathol. 2010; 133: online supplement.

Patil P, Heus H, Arnaout R, and Tonellato PJ. Refining a method for processing an individual's whole genome to clinical utility. CSHL Personal Genomes Meeting, Sept. 2010. (abstract)

Buck TP, Connor IM, Horowitz GL, Arnaout RA. CallWall: tracking resident calls to improve clinical utilization of pathology laboratories. Arch Pathol Lab Med. 2011;135(7):920-4.

Arnaout R, Lee W, Cahill P, Honan T, Sparrow T, Weiand M, et al. High-resolution description of antibody heavy-chain repertoires in humans. PLoS One. 2011;6(8):e22365. PMCID: 3150326.

Arnaout RA. Big data in clinical pathology. Critical Values. 2011;4(2):15-9.

Arnaout RA, Demetri GM. Pharmacology of Hematopoietic and Immune Stimulation. In: Golan DE, Tashjian AH, Armstrong EJ, Armstrong AW, editors. In Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Third ed. New York: Lippincott, Williams, and Wilkins; 2012.

Arnaout RA, Kasmar AG, Hooper D. Pharmacology of Bacterial Infections: Cell Wall Synthesis. In: Golan DE, Tashjian AH, Armstrong EJ, Armstrong AW, editors. In Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Third ed. New York: Lippincott, Williams, and Wilkins; 2012.

Arnaout, R. Elementary, My Dear Doctor Watson. Clinical Chemistry. 2012. 58(6):986-988

Anders Berg, MD, PhD, Assistant Director, Clinical Chemistry, Instructor in Pathology, Harvard Medical School 

Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, Scherer PE, Bernlohr DA. Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. Am J Physiol Endocrinol Metab. 2006;290(5):E814-23.

Darabi K, Berg AH. Rituximab can be combined with daily plasma exchange to achieve effective B-cell depletion and clinical improvement in acute autoimmune TTP. Am J Clin Pathol. 2006 Apr;125(4):592-7.

Berg AH, Sacks DB. Haemoglobin A1c analysis in the management of patients with diabetes: from chaos to harmony. J Clin Pathol. 2008 Sep;61(9):983-7. Review.

Berg AH, Sacks DB. Diabetes. In: Mitchell G, Gronowski AM, Eby CS, eds. Tietz's Applied Laboratory Medicine, 2nd Edition. 2006. John Wiley & Sons, Hoboken, NJ, 2006, Cases 26-28.

Melanson SE, Berg A, Jarolim P, Tanasijevic MJ, McElrath TF. Validaiton of a formula that calculates the estimated risk of respiratory distress syndrome. Obstet Gynecol. 2006;108(6):1471-6.

Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10;39(5):797-808.

Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, Wenger J, Karumanchi SA, Thadhani R, Bhan I. Vitamin D binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011 Jul;26(7):1609-16. PMID: 21416506

Berg AH. Abstract Title: Vitamin D Binding Protein Modifies the Vitamin D-Bone Mineral Density Relationship. Presented at AACC Annual Conference in 2011. Received Distinguished Abstract award from the National Academy of Clinical Biochemistry, and the Best Abstract Award from the Nutrition Division of the American Academy of Clinical Chemistry.

Parul Bhargava, MD, Medical Director, Hematology, Assistant Professor of Pathology, Harvard Medical School

Bhargava P, Rushin JM, Rusnock EJ, Hefter LJ, Franks TJ, Sabnis S, Travis WD. Pulmonary light chain deposition disease. Report of five cases and review of literature. Am J Surg Pathol 2007 Feb;31(2):267-76.

Bhargava P and Longhi L. Peripheral smear with Malassezia Furfur. Images in clinical Medicine. N Eng J Med 2007 Jun14; 356(24):e25.

Bhargava P, Kallakury BVS, Ross JS, Azumi N, and Bagg A. CD79a is heterogeneously expressed in neoplastic and normal myeloid precursors and megakaryocytes in an antibody clone dependent manner. Am J Clin Pathol 2007 Aug; 128(2):306-13.

Braza JM, Sullivan RJ, Bhargava P, Pantanowitz L, Dezube BJ. Pericardial Primary Effusion Lymphoma. AIDS Reader. 2007;17:250-2.

Marotti J, Bryan B, Bhargava P. Mild anemia, microcytosis and target cells in a man from Thailand. Lab Medicine 2007 Sept; 38(9):539-42.

Bhargava P, Anthony J Parker, Bruce Dezube. Pitfalls in Flow cytometry and FDG-PET scan evaluation in an HIV positive male. Clin Lymphoma Myeloma 2008; 8(2):117-20.

Marzocchetti A, Wuthrich C, Tan CS, Tompkins T, Bernal-Cano F, Bhargava P, Ropper AH, Koralnik IJ. Rearrangement of the JCV regulatory region sequence in the bone marrow of a patient with Rheumatoid Arthritis and Progressive Multifocal Leukoencephalopathy. J NeuroVirol 2008; Nov 6:1-4.

Braza J, Bhargava P. A 71 Year-Old-Male Presented to the Emergency Department with Dizziness, Progressive Lethargy and Confusion for 5 Days. Images in clinical Medicine. N Eng J Med 2008; Oct 30:1941.

Braza J, Bhargava P. Medical Mystery: A 71-year-old-man with pancytopenia- The answer. N Eng J Med 2008; Dec 25:2845-46.

Tan CS, Dezube BJ, Bhargava P, Autissier P, Wuthrich C, Miller J, Koralnik IJ. Detection of JC virus DNA and proteins in bone marrow of HIV-positive and HIVnegative patients: implications for viral latency and neurotropic transformation. Journal of Infectious Diseases 2009 Feb 1 Mar 15; 199(6):881-8.

Bhargava P, and Pantanowitz L, Pinkus GS, Pinkus JL, Paessler ME, Roullet M, Gautam S, Bagg A, Kadin ME. Utility of Fascin and JunB in Distinguishing Nodular Lymphocyte Predominant from Classical Lymphocyte Rich Hodgkin Lymphoma. Applied Immunohistochemistry & Molecular Morphology 2010 Jan 18(1):16-23.

Bhargava P and Kadin ME; Chapter 5; Immunohistology of Hodgkin Lymphoma. Diagnostic Immunohistochemistry by Dabbs, 3nd edition 2010.

Bhargava P. Hemoglobinopathies. Chapter 5. Non-Neoplastic Hematopathology and Infections (in press).

Bhargava P, Sandin R, Cualing H; editor for book entitled 'Non-Neoplastic Hematopathology and Infections'. Publisher: Wiley-Blackwell, Hoboken, NJ (in press).

Rajan Dewar, MD, PhD, Assistant Director, Hematopathology; Instructor in Pathology, Harvard Medical School (Note: name prior to 2009: MR Mariappan)

Jensen KC, Mariappan MR, Putcha GV, Hussain A, Chun N, Ford JG, Schrijver I, Longacre TA. Microsatellite Instability and Mismatch Repair Protein Defects in Ovarian Epithelial Neoplasms in Patients 50 Years of Age and Younger. American Journal of Surg. Pathol. 2008 Jul;32(7):1029-37.

Fadare O and Mariappan MR. Mucocele-like tumor and columnar cell hyperplasia of the breast occurring in a morphologic continuum. J Med Case Reports. 2008 Apr; 2:138.

Salama ME, Mariappan MR, Inamdar K, Tripp SR, Perkins SL. The Value of CD23 Expression as an Additional Marker in Distinguishing Mediastinal (Thymic) Large B-Cell Lymphoma From Hodgkin Lymphoma. Int J Surg Pathol 2009 Feb.

Fadare O, Orejudos MP, Jain R, Mariappan MR, Hecht JL, Renshaw IL, Hileeto D, Wang SA, Ghofrani M, Liang SX. A comparative analysis of lymphatic vessel density in ovarian serous tumors of low malignant potential (borderline tumors) with and without lymph node involvement. Int J Gynecol Pathol. 2008 Oct;27(4):483-90.

Song K, Mariappan R, Khosravi-Far R. Analysis of TNF-related apoptosis-inducing ligand in vivo through bone marrow transduction and transplantation. Methods Enzymol. 2008;446:315-31.

Zainab Jagani, Keli Song, Jeffery Kutok, Rajan Dewar, Armelle Melet, Tanya Santos, Alexandra Grassian, Saghi Ghaffari, Catherine J. Wu, Ruibao Ren, Kenneth Miller, and Roya Khosravi-Far. Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL-Induced Evasion of Apoptosis in Part Through Regulation of Forkhead Tumor Suppressors. Cancer Research. 2009. 69, 6546-55.

Francisco A, Dewar R, Kieran M, Kalluri R. Contribution of bone Microenvironment and acute leukemia progression. Leukemia Research., 2009. 23: 2233-2241(PMID: 19727127)

Dewar R, Chen ST, Yeckes-Rodin H, Miller K, Khosravi-Far R. Bortezomib treatment causes remission in a Ph+ ALL patient and reveals FoxO as a theranostic marker. Cancer Biol Ther. 2011 Mar 15;11(6). (Editorial Commentary & COVER PAGE ILLUSTRATION)

Dewar R, Fadare O, Gilmore H, Gown A. Best practices in diagnostic immunohistochemistry: Myoepithelial markers in breast pathology. Arch Pathol Lab Med., 2011. 135 (4): page 422-429. (COVER PAGE ILLUSTRATION)

Gilmore LC, Dewar R. Caution in Metastatic Renal Cell Carcinoma Within Lymph Nodes: PAX-2 Expression Is Also Seen in Nodal Lymphocytes. Arch Pathol Lab Med, 2011. 135 (4): page 414. (in print; April 2011).

Dewar R and Khosravi-Far R. Inhibition of apoptosis in Leukemia: BCR-ABL induced leukemogenesis. In Modern Insights Into Disease From Molecules to Man: Apoptosis. Editor. Professor Victor R Preedy. 2010.

Shu-Ling (Liang) Fan, PhD, Assistant Director, Clinical Chemistry; Instructor in Pathology, Harvard Medical School

Liang S, and Clarke W., *Urinalysis,* in Dufour R, and Clarke W. (Eds.), Contemporary Practice in Clinical Chemistry (p339-p350). Washington DC: AACC Press, 2006.

Liang SL, Liu H, Zhou A. Lovastatin-induced apoptosis in macrophages through the Rac1/Cdc42/JNK pathway. J Immunol. 2006 Jul 1;177(1):651-6.

Liang SL, Quirk D, Zhou A. RNase L: its biological roles and regulation. IUBMB Life. 2006 Sep;58(9):508-14.

Liu W, Liang SL, Liu H, Silverman R, Zhou A. Tumour suppressor function of RNase L in a mouse model. Eur J Cancer. 2007 Jan;43(1):202-9.

Liang SL, Chan DW. Enzymes and related proteins as cancer biomarkers: A proteomic approach. Clin Chim Acta. 2007 Feb 20.

Liang SL, Lin MT, Hafez MJ, Gocke CD, Murphy KM, Sokoll LJ, Eshleman JR. Application of traditional clinical pathology quality control techniques to molecular pathology. J. of Molecular Diagnostics 2008;10:142-6.

Liang SL, Breaud A, Dunn W, and Clarke W., "Comparison of the CEDIA((R)) and MEIA((R)) Assays for Measurement of Tacrolimus in Organ Transplant
Recipients," Clin Chim Acta, 2008;396(1-2):1-6.

Liang S, Schmith E, Hunsley B, Sornson H, and Clarke W., "Use of Stabilized Whole Blood for Glucose Proficiency Testing at Point-of-Care Sites," Point of Care,
2008;7(2):64-68.

Liu H, Liang SL, Kumar S, Weyman CM, Liu W, and Zhou A. "Statins Induce Apoptosis in Ovarian Cancer Cells through Activation of JNK and Enhancement of Bim Expression," Cancer Chemother Pharmacol. 2009;63:997-1005.

McGillicuddy D, Volz K, Horowitz G, Fan S, Joyce N and Sanchez L, "Effect of two different FDA approved D-dimer assays on resource utilization in the Emergency
Department," Academic Emergency Medicine. 2010.

Fan S, Hardy L. "Urinalysis," in Clarke W. (Ed.), Contemporary Practice in Clinical Chemistry (Ch32). Washington DC: AACC Press, 2010.

Saxena AR, Karumanchi AS, Fan SL, Horowitz GL, Hollenberg NK, Graves SW, and Seely EW., "Correlation of Cystatin-C with Glomerular Filtration Rate by
Inulin Clearance in Pregnancy," Hypertension in Pregnancy. Hypertens Pregnancy. 2012;31(1):22-30. Epub 2011 Oct 18.

Richard Haspel, MD, PhD, Associate Residency Training Program Director; Medical Director, Stem Cell Processing Laboratory; Assistant Professor of Pathology, Harvard Medical School 

Haspel RL, Kao G, Yeap BY, Cutler C, Soiffer RJ, Alyea EP, Ho VT, Koreth J, Dey BR, McAfee SL, Attar EC, Spitzer T, Antin JH, Ballen KK. Preinfusion variables predict the predominant unit in the setting of reduced-intensity double cord blood transplantation. Bone Marrow Transplant. 2008;41:523-9.

Delaney M, Haspel RL. Thawing and Infusing Cellular Therapy Products. In: Areman EM, Loper K, eds. Cellular Therapy: Principles, Methods and Regulations, 1st edition. Bethesda, MD: AABB; 2009: 375-383. 2009.

Haspel RL, Ballen KK. Cord blood transplants: perinatal stem cells in clinical practice. In: Cetrulo CL, Cetrulo KJ and Cetrulo CL, Jr, eds. Perinatal Stem Cells, 1st edition. Hoboken, NJ: John Wiley and Sons; 2009: 1-14.

O'Neill E, Richardson-Weber L, McCormack G, Uhl L, Haspel RL. Strict adherence to a blood bank specimen labeling policy by all clinical laboratories significantly reduces the incidence of "wrong blood in tube." Am J Clin Pathol. 2009;132:164-8.

Haspel RL, Lamontagne D. Pre-thaw predictors of cord blood unit quality. Transfusion. 2010; 50: 265.

Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Brock J, Campbell S, Crookston K, Fitzgerald R, Fung M, Haspel R, et al. Educating medical students in laboratory medicine: A proposed curriculum. Am J Clin Pathol. 2010; 133: 525-8.

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE. A Call to Action: Training pathology residents in genomics and personalized medicine. Am J Clin Pathol. 2010; 133: 832-4.

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE. A curriculum in genomics and personalized medicine for pathology residents. Am J Clin Pathol. 2010; 133: online supplement.

Haspel RL. Implementation and assessment of a resident curriculum in evidence-based transfusion medicine. Arch Path Lab Med. 2010; 134: 1054-9

Perry J, Haspel R, Mohammed M, Gingerich AM, Powers A. A curious case of blue blood. Transfusion 2010; 50: 1179-80.

Delaney M, Meyer E, Cserti-Gaxdewich C, Haspel RL, Lin Y, Morris A, Pavenski K, Dzik WH, Murphy M, Slichter S, Wang G, Dumont LJ, Heddle N. A systematic assessment of the quality of reporting for platelet transfusion studies. Transfusion. 2010; 50: 2135-44.

Haspel RL. Implementation and Assessment of a Resident Curriculum in Evidence-Based Transfusion Medicine. Arch Pathol Lab Med. 2010; 134: 1054-9.

Haspel RL, Bhargava P, Gilmore H, Kane S, Powers A, Sepehr A, Weinstein AR, Schwartzstein, Roberts DH. Successful implementation of a longitudinal, integrated pathology curriculum during the third-year of medical school. Arch Path Lab Med (in press).

Gary L. Horowitz, MD, Medical Director, Clinical Chemistry; Associate Professor of Pathology, Harvard Medical School

Horowitz GL. Reference Intervals: Practical Aspects. Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (eJIFCC) 2008;19:2 [http://www.ifcc.org/ejifcc/vol19no2/190201200802.htm]

Mocarelli P, Horowitz GL, Cecere R, Imdahl R, Ruinemans-Koerts J, Luthe H, Calatayud SP, Salve ML, Kunst A, McGovern M, Ng K, Stockmann W. Increasing efficiency and quality by consolidation of clinical chemistry and immunochemistry systems with MODULAR ANALYTICS SWA. Journal of Automated Methods and Management in Chemistry 2008. Article ID 498921.

Liang S, Bae H, Horowitz GL. Falsely elevated acetaminophen results in icteric and hemolyzed specimens. Clin Chem 2008;54;A223.

Horowitz GL, Altaie S, Boyd JC, Ceriotti F, Garg U, Horn P, Pesce A, Sine HE, Zakowski J. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory - Third Edition. CLSI document C28-A3. Wayne, PA: Clinical Laboratory and Standards Institute, 2008.

Levine R, Horowitz G, Qian C, Yai Y, Epstein F, Vatten L, Kaumanchi SA (for the CPEP Study Group). Soluble sFlt1 (sFlt1), preeclampsia and hypothyproidism. 2009 Annual Meeting Society for Maternal Fetal Medicine.

Nardin RA, Zarrin AR, Horowitz GL, Tarulli AW. Effect of newly proposed CK reference limits on neuromuscular diagnosis.Muscle Nerve2009Apr;39(4):494-7.

O'Neal PB, Poylin V, Mowschenson P, Parengi A, Horowitz G, Pant P, Hasselgren PO. When initial postexcision PTH level does not fall appropriately during parathyroidectomy - what to do next? World Journal of Surgery. 2009.

Elliott RM, Horowitz GL, Fan SL. Comparison of anti-tissue transglutaminase, anti-gliadin, and antideamidated gliadin peptide serologic testing in the detection of celiac disease. Clin Chem 2009; 55:A126.

Kaplan J, Horowitz G. 24-hour Bence-Jones protein determinations: can we ensure accuracy? Clin Chem 2009; 55:A161.

Hardy LB, Fan SL, Pistorino AM, Juenke JM, McMillin GA, Horowitz GL. Ethylene glycol screening: adapting the CATACHEM enzymatic assay to minimize false positives. Clin Chem 2010; 6(Supplement):A230

Shapiro NI, Fisher C, Donnino M, Cataldo L, Tang A, Trzeciak S, Horowitz G, Wolfe RE. The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infection. J Emerg Med 2010; 39:89-94.

Horowitz GL. Estimating reference intervals.Am J Clin Pathol.2010;133;175-177.

Saxena AR, Karumanchi AS, Fan SL, Horowitz GL, Hollenberg NK, Graves SW, and Seely EW., "Correlation of Cystatin-C with Glomerular Filtration Rate by
Inulin Clearance in Pregnancy," Hypertension in Pregnancy. Hypertens Pregnancy. 2012;31(1):22-30. Epub 2011 Oct 18.

James E. Kirby, MD, Medical Director, Clinical Microbiology; Assistant Professor of Pathology, Harvard Medical School

Chiaraviglio, L and Kirby JE. Infection of Cultured Human Endothelial Cells by Legionella pneumophila. PLoS-One. 2008 Apr 23;3(4):e2012.

Kirby JE, Delaney M, Qian Q, and Gold HS. Optimal Use of Myco/F Lytic and Standard BACTEC Blood Culture Bottles for Detection of Yeast and Mycobacteria. Archives of Pathology and Laboratory Medicine. 2009 Jan;133(1):93-6.

Duong S, Dezube, BJ, Desai G, Eichelberger K, Qian Q and Kirby JE. Limited Utility of Bone Marrow Culture: A Ten Year Retrospective Analysis. Laboratory Medicine. 2009. Jan 40, 37-38.

Wang Y, Kirby JE, Qian Q. Effective use of JC virus PCR for diagnosis of progressive multifocal leukoencephalopathy. J Med Microbiol. 2009 Feb;58(Pt 2):253-5.

Pollock, N., Duong, S, Cheng A; Han L, Smole, S, and Kirby, JE. Ruling out novel H1N1 influenza with direct fluorescent antigen testing. Clin Infect Dis.2009 Sep 15;49(6):e66-8.

Qian Q, Venkatamarman, L, Kirby JE, Gold HS, and Yamazumi T. Direct Detection of Methicillin Resistance in Staphylococcus aureus in Blood Culture Broth Using a Penicillin Binding Protein 2a Latex Agglutination Test. J Clin Microbiol. 2010 Apr;48(4):1420-1.

Chiaraviglio L, Duong S, Brown D, Birtles R, and Kirby, JE. 2010. An immunocompromised murine model of Bartonella infection. Am J Pathol. 2010 Apr 15. [Epub ahead of print] PubMed PMID: 20395436.

Socia SJ, Kirby JE, Washicosky KJ, Tucker SM, Burton, MA, Goldstein LE, Duong S, Tanzi RE and Moir RD. 2010.. The Alzheimer 's disease-associated amyloid -protein is an antimicrobial peptide. PLoS ONE 5(3): e9505.

Cheng A, Qian Q, Kirby JE. Evaluation of the Abbott RealTime™ CT/NG assay in comparison to the Roche COBAS AMPLICOR CT/NG assay. J Clin Microbiol. 2011. Apr;49(4):1294-300. Epub 2011 Feb 16.

Bieniek R, Kirby JE, Cheng A, Eichelberger K, and Qian Q Effective Use of PCR for the Detection of Cytomegalovirus Viremia and Monitoring Therapy in Immunocompromised Patients. (2011) LabMedicine, 42, 339-343.

Kerry O'Brien, MD, Staff Pathologist; Instructor in Pathology, Harvard Medical School

O'Brien KL, Champeaux AL, Sundell ZE, Short MW, Roth BJ. Transfusion medicine knowledge in postgraduate year-1 residents. Transfusion 2010;50:1649-53.

Makowski RL, Peterson DJ, O'Brien KL, Harsha WJ. Sarcoidosis of the thyroid: A case report and review of the literature. The Laryngoscope 2010;120:S41.

Champeaux AL, O'Brien KL, Short MW, Roth BJ. Blood transfusion consent. In: Stevens N, editor. The objective structured clinical examination for the resident physician: an instructional manual for program directors. Scotts Valley (CA): CreateSpace; 2010. p. 47-55.

O'Brien KL, Pereira SE. Wagner J, Shadman M, Hendrie P, Nelson K, Gernsheimer TB, Price T, Reyes JD, Nester T. Transfusion-associated graft-versus-host disease in a liver transplant recipient: an unusual case presentation and review of the literature. Transfusion 2012 (accepted for publication/forthcoming in print).

German Pihan, MD, Director, Hematopathology; Assistant Professor of Pathology, Harvard Medical School 

Ke Y, Zhou Y, Chen Y, Dezube B, Pihan G. A pan-HPV assay in the era of oligovalet vaccines: An opportunity to define the impact of prevention, vaccination and therapeutic interventions in the burden of HPV-induced diseases in diverse communities (2008).

Zhou Y, Fundyler O, Miller K, Pihan G. A highly multiplexed bead microarray assay for World Health Organization disease-defining chromosomal translocations/inversions in acute myeloid leukemia (2008).

Zhou Y, Chen Y, Miller K, Pihan G. Ultrafast, High-Throughput Sequencing-by-hybridization Assay For Insertion Mutations In The Nucleophosmin 1 Gene. Leukemia (in preparation). Miller K, and Pihan G. Treatment and Evaluation of High-risk Myelodysplastic Syndrome. Clin Adv Hematology Oncology 2008, 3(6):6.

Pantanowitz L, Doweiko JP, Braza J, Pihan G, Dezube BJ, HIV-Associated Plasmablastic Lymphoma Following HAART Related Immune Reconstitution hiv & aids review. 2007, 7:31-4.

Maithel SK, Pratt W, Kelleher T, Avigan D, Goldman H, Pfeifer W, Pihan GA, Vollmer CM. Autoimmune pancreatitis in the setting of Castleman disease. Pancreas. 2007, 35:384-7.

Miller K and Pihan G. CHAPTER 60: Clinical Manifestations of Acute Myeloid Leukemia. In: Hoffman et al. Hematology: Basic Principles and Practice. 5th Edition, 2008.

Miller K, and Pihan G. Treatment and Evaluation of High-risk Myelodysplastic Syndrome. Clin Adv Hematology Oncology 2008, 3(6):6.

Zota V, Braza J, Pantanowitz L, Dezube BJ, Pihan G. A 57-year-old HIV-positive man with persistent fever, weight loss, and pancytopenia. Am J Hematol. 2009 Jul;84(7):443-6.

Li L, Wang H, Kim JS, Pihan G, Boussiotis VA. The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell Cycle. 2009 Jun 1;8(11):1794-802.

Pantanowitz L, Pihan G, Carbone A, Dezube BJ. Differentiating HIV-associated non-Hodgkin lymphomas with plasmacellular differentiation. Journal HIV Therapy 2009; 14:24-33.

Qianfang Qian, MD, PhD, Assistant Director, Clinical Microbiology; Instructor in Pathology, Harvard Medical School 

Qian Q, Eichelberger K, and Kirby JE. Rapid identification of Staphylococcus aureus in blood cultures by use of the direct tube coagulase testClin Microbiol. 2007 Jul;45(7):2267-9.

Wang Y, Doucette S, Qian Q, Kirby JE. Yield of primary and repeat induced sputum testing for Pneumocystis jiroveci in human immunodeficiency virus positive and negative patients. Arch. Pathol. Lab. Med. 2007; 131:1582-1584.

Wang, Y., J. E. Kirby and Q. Qian. Effective use of JC virus PCR for diagnosis of progressive multifocal leucoencephalopathy. J. Med. Micro. 2009. 58:253-255.

Kirby, J.E., M. Delaney, Q. Qian, and H. Gold. Optimal Use of the Myco/F Lytic and Standard BACTECTM Blood Culture Bottles for Detection of Yeast and Mycobacteria. Arch. Path. Lab. Med. 2009. 133:93-96.

Duong S, Dezube BJ, Desai G, Eichelberger K, Qian Q, Kirby JE. Limited Utility of Bone Marrow Culture: A Ten Year Retrospective Analysis. LabMedicine. 2009; 40: 37-38.

Qian Q, Venkataraman L, Kirby JE, Gold HS, Yamazumi T. Direct detection of methicillin resistance in Staphylococcus aureus in blood culture broth using a penicillin binding protein 2a latex agglutination test. J. Clin. Micro. 2010; 48: 1420-1421.

Qian Q, Kirby JE. Technical advances in laboratory diagnosis of fungal infection. (Review). J. Microbes Infect. 2010; 5(1): 2-25.

Bieniek R, Kirby JE, Cheng A, Eichelberger K, Qian Q. Effective use of PCR for the detection of cytomegalovirus viremia and monitoring therapy in immunocompromised patients. LabMedicine. 2011; 42:339-342

Cheng A, Qian Q, Kirby JE. Evaluation of the Abbott RealTimeTM CT/NG assay in comparison to the Roche COBAS AMPLICOR CT/NG assay. J. Clin. Micro. 2011; 49:1294-1300

Lynne Uhl, MD, Director, Division of Clinical Pathology; Medical Director, Transfusion Medicine; Associate Professor of Pathology, Harvard Medical School

Chan M, Malynn E, Shaz B, Uhl L. Utility of consecutive repeat HIT ELISA testing for heparin-induced thrombocytopenia. Am J Hematol. 2008;83:212-7.

Shaulov A, Yue S, Wang R, Joyce RM, Balk SP, Kim HT, Avigan DE, Uhl L, Sackstein R, Exley MA.. Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: Implications for posttransplant survival.Exp Hematol. 2008;36:464-72.

Gaines AR, Lee-Stroka H, Byrn K, Scott DE, Uhl L, Lazarus E, Stroncek DF. Investigation of whether the acute hemolysis associated with Rho(D) immune globulin intravenous (human) administration for treatment of immune thrombocytopenic purpura is consistent with the acute hemolytic transfusion reaction model. Transfusion 2009; 49: 1050-1058.

O'Neill E, Richardson-Weber L, McCormack G, Uhl L, and Haspel RL. Strict Adherence to a Blood Bank Specimen Labeling Policy by All Clinical Laboratories Significantly Reduces the Incidence of "Wrong Blood in Tube". Am J Clin Pathol 2009;132:164-168

Powers A, Chandrashekar S, Mohammed M, Uhl L. Identification and evaluation of false-negative antibody screens. Transfusion. 2010 Mar;50(3):617-21. Epub 2009 Nov 23.

Goodell PP, Uhl L, Mohammed M, Powers AA. Risk of hemolytic transfusion reactions following emergency-release RBC transfusion.Am J Clin Pathol. 2010 Aug;134(2):202-6.

Slichter SJ, Kaufman RM, Assmann SF, McCullough J, Triulzi DJ, Strauss RG, Gernsheimer TB, Ness PM, Brecher ME, Josephson CD, Konkle BA, Woodson RD, Ortel TL, Hillyer CD, Skerrett DL, McCrae KR, Sloan SR, Uhl L, George JN, Aquino VM, Manno CS, McFarland JG, Hess JR, Leissinger C, Granger S. Dose of prophylactic platelet transfusions and prevention of hemorrhage. N Engl J Med 2010; 362:600-13.

Wahl PM, Terrell DR, George JN, Rodgers JK, Uhl L, Cataland S, Bohn RL. Validation of claims-based diagnostic codes for idiopathic thrombotic thrombocytopenic purpura in a commercially-insured population. Thromb Haemost 2010 Mar 29;103(6).

Uhl L. Alternatives to transfusion: perioperative blood management. In: Simon TL,ed. Rossi's Principles of Transfusion Medicine, 4th Edition. Oxford UK: Wiley-Blackwell, 2009. p 566-574.



FACULTY AND SELECTED PUBLICATIONS
EXPERIMENTAL PATHOLOGY


Ramy A. Arnaout, MD, PhD, see Clinical Pathology

Andrew Beck, MD, Director of Breast Cancer Molecular Pathology Laboratory; Assistant Professor of Pathology, Harvard Medical School

Beck AH, Espinosa I, Gilks CB, van de Rijn M, West RB. The fibromatosis signature defines a robust stromal response in breast carcinoma. Lab Invest 2008; 88:591. (2008 Jun).

Beck AH, Espinosa I, Edris B, Li R, Montgomery K, Zhu S, Varma S, Marinelli RJ, van de Rijn M, West RB. The macrophage colony-stimulating factor 1 response signature in breast carcinoma. Clin Cancer Res 2009; 15:778. (2009 Feb).

Weinberg OK, Ma L, Seo K, Beck AH, Pai RK, Morales A, Kim Y, Sundram U, Tan D, Horning SJ, Hoppe RT, Natkunam Y, Arber DA. Low stage follicular lymphoma: biologic and clinical characterization according to nodal or extranodal primary origin. Am J Surg Pathol 2009; 33:591. (2009 Apr).

Sangoi AR, Dulai MS, Beck AH, Brat DJ, Vogel H. Distinguishing chordoid meningiomas from their histologic mimics: an immunohistochemical evaluation. Am J Surg Pathol 2009; 33:669. (2009 May).

Espinosa I, Beck AH, Lee CH, Zhu S, Montgomery KD, Marinelli RJ, Ganjoo KN, Nielsen TO, Gilks CB, West RB, van de Rijn M. Coordinate expression of colony-stimulating factor-1 and colony-stimulating factor-1-related proteins is associated with poor prognosis in gynecological and nongynecological leiomyosarcoma. Am J Pathol 2009; 174: 2347. (2009 Jun).

Natkunam Y, Tedoldi S, Paterson JC, Zhao S, Rodriguez-Justo M, Beck AH, Siebert R, Mason DY, Marafioti T. Characterization of c-Maf transcription factor in normal and neoplastic hematolymphoid tissue and its relevance in plasma cell neoplasia. Am J Clin Pathol 2009; 132:361. (2009 Sep).

Pai RK, Beck AH, Norton JA, Longacre TA. Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence. Am J Surg Pathol 2009; 33:1425. (2009 Oct).

Lee CH, Subramanian S, Beck AH, Espinosa I, Senz J, Zhu SX, Huntsman D, van de Rijn M, Gilks CB. MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovary. PLoS One 2009; 4:e7314. (2009 Oct).

Sharma M, Beck AH, Webster JA, Espinosa I, Montgomery K, Varma S, van de Rijn M, Jensen KC, West RB. Analysis of stromal signatures in the tumor microenvironment of ductal carcinoma in situ. Breast Cancer Res Treat 2010; 123:397. (2009 Dec).

Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, Zhu S, Downs-Kelly E, Montgomery K, Goldblum JR, Hogendoorn PC, Corless CL, Oliveira AM, Dry SM, Nielsen TO, Rubin BP, Fletcher JA, Fletcher CD, van de Rijn M. Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J Pathol 2010; 220:58. (2010 Jan).

Beck AH, Weng Z, Witten DM, Zhu S, Foley JW, Lacroute P, Smith CL, Tibshirani R, van de Rijn M, Sidow A, West RB. 3'-end sequencing for expression quantification (3SEQ) from archival tumor samples. PLoS One 2010; 5:e8768. (2010 Jan).

Beck AH, Lee CH, Witten DM, Gleason BC, Edris B, Espinosa I, Zhu S, Li R, Montgomery KD, Marinelli RJ, Tibshirani R, Hastie T, Jablons DM, Rubin BP, Fletcher CD, West RB, van de Rijn M. Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling. Oncogene 2010; 29:845. (2010 Feb).

Zhang B, Beck AH, Taube JM, Kohler S, Seo K, Zwerner J, Viakhereva N, Sundram U, Kim YH, Schrijver I, Arber DA, Zehnder JL. Combined use of PCR-based TCRG and TCRB clonality tests on paraffin-embedded skin tissue in the differential diagnosis of mycosis fungoides and inflammatory dermatoses. J Mol Diagn 2010; 12: 320. (2010 May).

Kong CS, Beck AH, Longacre TA. A panel of 3 markers including p16, ProExC, or HPV ISH is optimal for distinguishing between primary endometrial and endocervical adenocarcinomas. Am J Surg Pathol 2010; 34:915. (2010 Jul).

Sangoi AR, Beck AH, Amin MB, Cheng L, Epstein JI, Hansel DE, Iczkowski KA, Lopez-Beltran A, Oliva E, Paner GP, Reuter VE, Ro JY, Shah RB, Shen SS, Tamboli P, McKenney JK. Interobserver Reproducibility in the Diagnosis of Invasive Micropapillary Carcinoma of the Urinary Tract Among Urologic Pathologists. Am J Surg Pathol 2010; 34: 1367. (2010 Sep).

Younes SF, Beck AH, Lossos IS, Levy R, Warnke RA, Natkunam Y. Immunoarchitectural Patterns in Follicular Lymphoma: Efficacy of HGAL and LMO2 in the Detection of the Interfollicular and Diffuse Components. Am J Surg Pathol 2010; 34:1266. (2010 Sep)

Webster JA, Beck AH, Sharma M, Espinosa I, Weigelt B, Schreuder M, Montgomery KD, Jensen KC, van de Rijn M, West R. Variations in stromal signatures in breast and colorectal cancer metastases. J Pathol 2010; 222:158. (2010 Oct).

Wu JM, Beck AH, Pate LL, Witten D, Zhu S, Montgomery KD, Allison KH, van de Rijn M, West RB. Endogenous versus tumor-specific host response to breast carcinoma: a study of stromal response in synchronous breast primaries and biopsy site changes. Clin Cancer Res 2011; 17: 437. (2011 Feb).

Pai RK, Beck AH, Mitchem J, Linehan DC, Chang DT, Norton JA, Pai RK. Pattern of lymph node involvement and prognosis in pancreatic adenocarcinoma: direct lymph node invasion has similar survival to node-negative disease. Am J Surg Pathol 2011; 35: 228. (2011 Feb).

Sangoi AR, Ohgami RS, Pai RK, Beck AH, McKenney JK, Pai RK. PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma. Mod Pathol 2011; 24: 412. (2011 Mar).

Mills AM, Beck AH, Montgomery KD, Zhu SX, Espinosa I, Lee CH, Subramanian S, Fletcher CD, van de Rijn M, West RB. Expression of subtype-specific group 1 leiomyosarcoma markers in a wide variety of sarcomas by gene expression analysis and immunohistochemistry. Am J Surg Pathol 2011; 35: 583 (2011 Apr).

Younes SF, Beck AH, Ohgami RS, Lossos IS, Levy R, Warnke RA, Natkunam Y. The Efficacy of HGAL and LMO2 in the Separation of Lymphomas Derived From Small B Cells in Nodal and Extranodal Sites, Including the Bone Marrow. Am J Clin Pathol 2011; 135: 697. (2011 May).

Wu K, Liu JJ, Adams W, Sonn GA, Mach KE, Pan Y, Beck AH, Jensen KC, Liao JC. Dynamic Real-time Microscopy of the Urinary Tract Using Confocal Laser Endomicroscopy. Urology 2011. (2011 May 19).

Beck AH, Rodriguez-Paris J, Zehnder J, Schrijver I. Evaluation of a Gene Expression Microarray-Based Assay to Determine Tissue Type of Origin on a Diverse Set of 49 Malignancies. Am J Surg Pathol 2011. (2011 May 19).

Espinosa I, Edris B, Lee CH, Wei Cheng H, Gilks CB, Wang Y, Montgomery KD, Varma S, Li R, Marinelli RJ, West RB, Nielsen T, Beck AH, van de Rijn M. CSF1 Expression in Nongynecological Leiomyosarcoma Is Associated with Increased Tumor Angiogenesis. Am J Pathol 2011; 179: 2100. (2011 Aug).

Beck AH, Sangoi AR, Leung S, Marinelli RJ, Nielsen TO, van de Vijver MJ, West RB, van de Rijn M, Koller D. Systematic analysis of breast cancer morphology uncovers stromal features associated with survival. Sci Transl Med 2011; 3: 108ra113. (2011 Nov).

Anders Berg, MD, PhD, see Clinical Pathology

Mark S. Boguski, MD, PhD, Associate Professor of Pathology, Harvard Medical School

Voshol, H. Cho, C.R., Vachon, T., Boguski MS, van Oostrum, J. and Peitsch, M.C. (2006), Systems Biology: Integrating in silico approached and experimental approaches to study signaling networks in Systems Biology: a User's Guide, a Focus issue of Nature Cell Biology and Nature Reviews Molecular Cell Biology. 8(11).

Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski MS, et al (2007) "Genome-wide atlas of gene expression in the adult mouse brain." Nature 455:168-176.

Boguski MS. (2008) Translational Research in Genetics and Genomics. New England Journal of Medicine 359:1969-1970

Boguski, MS (2008) Reviews of Genomics and Clinical Medicine (Edited by D. Kumar) and Translational Research in Genetics and Genomics (By M. Smith). New Engl. J. Med. 359:1969.

Boguski, MS (2009) Health information retrieval by consumers and the challenge of personal genomics. Chapter 21 in Genomics and Personalized Medicine: Principles, Methodology and Translational Approaches, H.F Willard and G. Ginsberg, eds. Elsevier Inc. and Academic Press.

Boguski MS, (2009) Health information retrieval by consumers and the challenge of personal genomics. Chapter 21 in Genomics and Personalized Medicine, H.F Willard and G. Ginsberg, eds., Academic Press.

Boguski MS, Mandl, K.D. and Sukhatme, V.P. (2009) Drug discovery: Repurposing with a difference. Science 324(5933): 1394-1395.

Boguski MS, Arnaout, R. and Hill, C. (2009) Customized care 2020: How medical sequencing and network biology will enable personalized medicine. Faculty of 1000 (invited commentary).

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE: A call to action: Training pathology residents in genomics and personalized medicine. Am J Clin Path, 133:832-834, 2010.

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE. A curriculum in genomics and personalized medicine for pathology residents. Am J Clin Pathol. 2010; 133: online supplement.

Tonellato, PJ, Crawford, J, Boguski, MS and Saffitz, JE (2011) A National Agenda for the Future of Pathology in Personalized Medicine: Report of the proceedings of a meeting at the Banbury Conference Center: Genome-Era Pathology, Precision Diagnostics and Pre-emptive Care: A Stakeholder Summit, Amer J Clin Path, in press.

Lawrence Brown, MD, see Anatomic Pathology

Ann M. Dvorak, MD, Professor of Pathology, Harvard Medical School

Melo RCN, Dvorak AM, Weller PF. New aspects of piecemeal degranulation in human eosinophils. Chap 16 In: New Research in Innate Immunity, Durand M, Morel CV (eds) Hauppauge NY Nova Science 2008; 351-370.

Nagy JA, Chang S-H, Dvorak AM, Dvorak HF. Why are tumor blood vessels abnormal and why is it important to know? Brit J Ca 100:865-869, 2009.

Radke AL, Spencer LA, Reynolds LE, Melo RCN, Dvorak AM, Weller PF. Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation. Blood 113:3092-3101, 2009.

Melo RCN, Spencer LA, Perez SAC, Neves JS, Bafford SP, Morgan ES, Dvorak AM, Weller PF. Vesicle-mediated secretion of human eosinophil granule-derived major basic protein (MBP). Lab Invest 88:769-781, 2009.

Chang S-H, Feng D, Nagy JA, Sciuto TE, Dvorak AM, Dvorak HF. Vascular permeability and pathological angiogenesis in caveolin-1 null mice. Am J Pathol 175:1768-1776, 2009.

Nagy JA, Chang S-H, Shih S-C, Dvorak AM, Dvorak HF. Heterogeneity of tumor vascularture. Semin Throb Hemost 36:321-331, 2010.

Connolly JL, Goldsmith JD, Wang HH, Longtine JA, Dvorak AM, Dvorak HF, Hamilton SR. Cancer Pathology. In: Hong WK, Bast Jr RC, Hait WN, Kufe DW, Pollock RE, Weichselbaum RR , Holland JF, Frei IIIrd E, eds. Cancer Medicine, 8th Edition. BC Decker Inc, Hamilton, Ontario, 2010, 484-485.

Galli SJ, Metcalf DD, Arber DA, Dvorak AM. Basophils and mast cells and their disorders. 8th ed. Williams Hematology eds Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Prchal JT. McGraw-Hill, NY 2010, pp 915-932.

Harold F. Dvorak, MD, Director, Vascular Biology Research Center; Mallinckrodt Distinguished Professor of Pathology, Harvard Medical School

Sung-Hee Chang, Keizo Kanasaki, Vasilena Gocheva, Galia Blum, Jay Harper, Marsha A. Moses, Shou-Ching Shih, Janice A. Nagy, Johanna Joyce,
Matthew Bogyo, Raghu Kalluri, and Harold F. Dvorak. VEGF-A Induces Angiogenesis by Perturbing the Cathepsin-Cysteine Protease Inhibitor Balance in Venules, Causing Basement Membrane Degradation and Mother Vessel Formation. www.aacrjournals.org Cancer Res 2009; 69: (10). May 15, 2009.

JA Nagy, S-H Chang, AM Dvorak and HF Dvorak.Why are tumour blood vessels abnormal and why is it important to know? British Journal of Cancer (2009).

Shou-Ching Shih, Andrew Zukauskas, Dan Li, Guanmei Liu, Lay-Hong Ang, Janice A. Nagy, Lawrence F. Brown, and Harold F. Dvorak. The L6 Protein TM4SF1 Is Critical for Endothelial Cell Function and Tumor Angiogenesis. www.aacrjournals.org Cancer Res 2009; 69: (8). April 15, 2009.

Xue, Q., Nagy, JA, Manseau, EJ, Phung, TL, Dvorak, HF, Benjamin, LE. (2009) Rapamycin Inhibition of the Akt/mTOR Pathway Blocks Select Stages of VEGF-A 164 Driven Angiogenesis, in Part by Blocking S6Kinase. Arterioslerosis, Thrombosis, and Vascular Biology. 29: 1172-1178. PMCID: PMC2756965

Zhang, X., Kazerounian, S., Duquette, M., Perruzzi, C., Nagy, JA, Dvorak, HF, Parangi, S., Lawler, J. (2009) Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. The FASEB Journal. Vol. 23, 3368-3376.

Marie-Helene Jouvin, MD, Instructor in Pathology, Harvard Medical School

Hartman ML, Lin SY, Jouvin MH, Kinet JP. Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the
high affinity receptor for IgE Fc epsilon RI. Mol Immunol. 2008 Apr;45(8):2307-11. Epub 2008 Jan 7.

Vig M, DeHaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol. 2008 Jan;9(1):89-96. Epub 2007 Dec 2.

Kraft S, Fleming T, Billingsley JM, Lin SY, Jouvin MH, Storz P, and Kinet JP. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J Exp Med 201:385-96 2005.

Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FceRI controls the formation of functional IgE-binding receptors. J Exp Med 201:267-77 2005.

Antoine E. Karnoub, PhD, Assistant Professor of Pathology, Harvard Medical School

Karnoub AE, Weinberg RA. Ras oncogenes: split personalities. Nat Rev Mol Cell Biol. 2008 Jul;9(7):517-31.

Scheel C, Onder T, Karnoub A, Weinberg RA. Adaptation versus selection: the origins of metastatic behavior. Cancer Res. 2007 Dec 15;67(24):11476-9; discussion 11479-80. Review. No abstract available.

Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007 Oct 4;449(7162):557-63.

Ince TA, Richardson AL, Bell GW, Saitoh M, Godar S, Karnoub AE, Iglehart JD, Weinberg RA. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell. 2007 Aug;12(2):160-70.

Karnoub AE, Weinberg RA. Chemokine networks and breast cancer metastasis. Breast Dis. 2006-2007;26:75-85.

Yohe ME, Rossman KL, Gardner OS, Karnoub AE, Snyder JT, Gershburg S, Graves LM, Der CJ, Sondek J. Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif. J Biol Chem. 2007 May 4;282(18):13813-23.

El-Haibi C and Karnoub AE. Mesenchymal stem cells in the initiation and progression. J Mammary Gland Biol Neoplasia 2010;15(4): 399-409.

Roya Khosravi-Far, PhD, Associate Professor of Pathology, Harvard Medical School

Chalah, A., Khosravi-Far, R. 2008. The mitochondrial death pathway. Adv Exp Med Biol 615:25-45.

Jagani, Z., Khosravi-Far, R. 2008. Cancer stem cells and impaired apoptosis. Adv Exp Med Biol 615:331-344.

Jagani, Z., Singh, A., Khosravi-Far, R. 2008. FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis. Biochim Biophys Acta 1785:63-84.

Khosravi-Far, R., Zakeri, Z., Lockshin, R.A., and Piacentini, M. 2008. Methods in enzymolology book on cell death. Methods Enzymol 446:xxi-xxii.

Matarrese, P., Manganelli, V., Garofalo, T., Tinari, A., Gambardella, L., Ndebele, K., Khosravi-Far, R., Sorice, M., Esposti, M.D., and Malorni, W. 2008. Endosomal compartment contributes to the propagation of CD95/Fas-mediated signals in type II cells. Biochem J 413:467-478.

Melet, A., Song, K., Bucur, O., Jagani, Z., Grassian, A.R., Khosravi-Far, R. 2008. Apoptotic pathways in tumor progression and therapy. Adv Exp Med Biol 615:47-79.

Ndebele, K., Gona, P., Jin, T.G., Benhaga, N., Chalah, A., Degli-Esposti, M., Khosravi-Far, R. 2008. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3. Apoptosis 13:845-856.

Plati, J., Bucur, O., Khosravi-Far, R. 2008. Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities. J Cell Biochem 104:1124-1149.

Song, K., Mariappan, R., Khosravi-Far, R. 2008. Analysis of TNF-related apoptosis-inducing ligand in vivo through bone marrow transduction and transplantation. Methods Enzymol 446:315-331.

Degli Esposti, M., Tour, J., Ouasti, S., Ivanova, S., Matarrese, P., Malorni, W., Khosravi-Far, R. 2009. Fas death receptor enhances endocytic membrane traffic converging into the Golgi region. Mol Biol Cell 20:600-615.

Jagani, Z., Song, K., Kutok, J.L., Dewar, M.R., Melet, A., Santos, T., Grassian, A., Ghaffari, S., Wu, C., Ren, R., Rodin, H.Y., Miller, K., Khosravi-Far, R. 2009. Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL-Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor Suppressors. Cancer Res.

Ren, B., Song, K., Parangi, S., Jin, T., Ye, M., Humphreys, R., Duquette, M., Zhang, X., Benhaga, N., Lawler, J., Khosravi-Far, R. 2009. A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. Cancer Res 69:3856-3865.

Weisberg E, Choi HG, Ray A, Barrett R, Zhang J, Sim T, Zhou W, Seeliger M, Cameron M, Azam M, Fletcher JA, Debiec-Rychter M, Mayeda M, Moreno D, Kung AL, Janne PA, Khosravi-Far R, Melo JV, Manley PW, Adamia S, Wu C, Gray N, Griffin JD. Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants. Blood. 2010 May 27;115(21):4206-16.

Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell. 2010 Mar;21(6):1140-52.

Jagani Z, Song K, Kutok JL, Dewar MR, Melet A, Santos T, Grassian A, Ghaffari S, Wu C, Yeckes-Rodin H, Ren R, Miller K, Khosravi-Far R. Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors. Cancer Res. 2009 Aug 15;69(16):6546-55.

Jean-Pierre Kinet, MD, Professor of Pathology, Harvard Medical School

Kinet JP. A new strategy to counter allergy. N Engl J Med. 2005 Jul 21;353(3):310-2.

Kraft S, Fleming T, Billingsley JM, Lin, SY, Jouvin MH, Storz, P, and Kinet JP. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J. Exp. Med. 201:385-396, 2005.

Peinelt C, Vig M, Koomoa DL, Beck A, Nadler MJ, Koblan-Huberson M, Lis A, Fleig A, Penner R, Kinet JP. Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat Cell Biol. 2006 Jul;8(7):771-3. Epub 2006 May 30.

Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science. 2006 May 26;312(5777):1220-3. Epub 2006 Apr 27.

Vig M, Kinet JP. The long and arduous road to CRAC. Cell Calcium. 2007 Aug;42(2):157-62. Epub 2007 May 22.

Kinet JP. The essential role of mast cells in orchestrating inflammation. Immunol Rev. 2007 Jun;217:5-7. Review.

Kraft S, Kinet JP. New developments in FcepsilonRI regulation, function and inhibition. Nat Rev Immunol. 2007 May;7(5):365-78.

Hartman ML, Lin SY, Jouvin MH, Kinet JP. Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI. Mol Immunol. 2008 Apr;45(8):2307-11. Epub 2008 Jan 7.

Vig M, DeHaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol. 2008 Jan;9(1):89-96. Epub 2007 Dec 2.

Calloway N, Vig M, Kinet JP, Holowka D, Baird B. Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions. Mol Biol Cell. 2009 Jan;20(1):389-99. Epub 2008 Nov 5.

Vig M, Kinet JP. Calcium signaling in immune cells. Nat Immunol. 2009 Jan;10(1):21-7. Review. Erratum in: Nat Immunol. 2009 Feb;10(2):223.

James Kirby, MD, see Clinical Pathology

Olivier Kocher, MD, PhD, see Anatomic Pathology

Jack Lawler, PhD, Director, Division of Experimental Pathology; Professor of Pathology, Harvard Medical School

Tan K, Duqutte M, Liu JH, Lawler J, Wang JH. The crystal structure of the Heparin-Binding Reelin-N Domain of F-Spondin. J Mol Biol 2008.

Tan K, Duquette M, Liu JH, Shanmugasundaram K, Joachimial A, Gallaher JT, Rigby AC, Wang JH, Lawler J. Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 Nterminal domain. J Biol Chem. 2008; 283(7): 3932-41.

Punekar S, Zak S, Kalter VG, Dobransky L, Punekar I, Lawler JW, Gutierrez LS. Thrombospondin 1 and its mimetic peptide ABT-510 decrease angiogenesis and
inflammation in a murine model of inflammatory bowel disease. Pathobiology 2008; 75 (1): 9-21.

Yee KO, Conolly CM, Duquette M, Kazerounian S, Washington R, Lawler J. The effect of throbmospondin-1 on breast cancer metastasis. Breast Cancer ResTreat.2008 Apr 13.

Olerud J, Johansson M, Lawler J, Welsh N, Carlsson PO. Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes 2008; 57(7): 1870-7.

Kazerounian S, Yee KO, Lawler J. Thrombospondins in cancer. Cell Mol Life Science 2008, 65(5): 700-12.

Sun J, Hopkins BD, Tsujikawa K, Perruzzi C, Adini I, Swerlick R, Bornstein P, Lawler J, Benjamin LE. Thrombospondin-1 modulates VEGF-A mediated AKT signaling and capillary survival in the developing retina. Am. J. Physiol Heart Cir Physiol, 2009,296 (5): H 1344-51.

Ren B, Song K, Jin T, Parangi S, Duquette M, Zhang X, Lawler J, Khosravi-Far R. A double hit to kill tumor and endothelial cells by TRAIL and anti-angiogenic 3TSR. Cancer Res. 69 (9): 3856-3865.

Tan K, Duquette M, Joachimiak A, Lawler J. The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. FASEB J. 2009, 23(8): 2490-501.

Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J.Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 2009 Oct;23(10):3368-76.

Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10649-54.

Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell. 2009 Oct 16;139(2):380-92.

Janice A. Nagy, PhD, Principal Associate in Pathology, Harvard Medical School

SC Shih, A Zukauskas, D Li, G Liu, L-H Ang, JA Nagy, LF Brown, and HF Dvorak. The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Cancer Res. 69:3272-7, 2009.

Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Nagy JA, Joyce J, Bogyo M, Kalluri R, Dvorak HF.VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res. 69:4537-44, 2009.

Xue Q, Nagy JA, Manseau EJ, Phung TL, Dvorak HF, Benjamin LE. Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase. Arterioscler Thromb Vasc Biol. 29:1172-8, 2009.

Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J.Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 23:3368-3375, 2009.

Chang SH, Feng D, Nagy JA, Sciuto TE, Dvorak AM, Dvorak HF. Vascular Permeability and Pathological Angiogenesis in Caveolin-1-Null Mice. Am J Pathol. 175: 1768-1776, 2009.

Nagy JA, Chang SH, Dvorak AM, Dvorak HF. Why are tumour blood vessels abnormal and why is it important to know? Br J Cancer. 100:865-9, 2009.

Nagy JA, Chang SH, Shih SC, Dvorak AM, Dvorak HF. Heterogeneity of the tumor vasculature. Semin Thromb Hemost. 36:321-331, 2010.

Hoang MV, Nagy JA, Fox JB, Senger DR, Moderation of Calpain Activity Promotes Neovascular Integration and Lumen Formation During VEGF-induced Pathological Angiogenesis. PLOS One 5:e13612, 2010.

Hoang MV, Nagy JA, Senger DR. Active Rac1 improves pathological VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1. Blood 117:1751-60, 2011.

Fu Y, Nagy JA, Brown LF, Shih SC, Johnson PY, Chan CK, Dvorak HF, and Wight TN. Proteolytic Cleavage of Versican and Involvement of ADAMTS-1 in VEGF-A/VPF-Induced Pathological Angiogenesis. J Histochem Cytochem. 59:463-73, 2011.

Hoang MV, Nagy JA, Senger DR. Cdc42-mediated inhibition of GSK-3b improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis. Microvas Res. 81:34-43, 2011.

Yuan L, Sacharidou A, Stratman AN, Le Bras A, Zwiers PJ, Spokes K, Bhasin M, Shih SC, Nagy JA, Molema G, Aird WC, Davis GE, Oettgen P. RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG. Blood. 118:1145-53, 2011.

Sitohy B, Nagy JA, Jaminet SC, Dvorak HF. Tumor surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy.Cancer Res. 2011 Sep 21. [Epub ahead of print]

Gerald D, Adini I, Shechter S, Perruzzi C, Varnau J, Hopkins B, Kazerounian S, Kurschat P, Blachon S, Klagsbrun M, Stuhlmann H, Rigby AC, Nagy JA, and Benjamin LE. RhoB coordinates the angiogenic and lymphangiogenic response to pathological challenge through regulation of VEZF1-mediated transcription. Nature Communications (manuscript under review).

B Sitohy, JA Nagy, HF Dvorak Anti-VEGF/VEGFR therapy for cancer: Reassessing the target, Cancer Res 2011 (in press)

Trista E. North, PhD, Assistant Professor of Pathology, Harvard Medical School

Goessling W, North TE, and Zon LI Ultrasound biomicroscopy enables in vivo characterization of zebrafish tumorigenesis and therapeutic response. 2007. Nature Methods 4: 551-553.

North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord A, Weber G, Bowman T, Jang IH, Grosser T, FitzGerald GA, Daley GQ, and Zon LI. Prostaglandin E2 regulates zebrafish hematopoietic stem cell homeostasis. 2007. Nature 447: 1007-1011.

Goessling W, North TE, Weidinger G, Lord A, Haramis AP, Clevers H, Moon RT, and Zon LI. APC mutant zebrafish uncover a biphasic requirement for wnt signaling in liver development. 2007. Developmental Biology 320: 161-174.

Upadhyay G, Goessling W, North TE, Zon LI, Yajnik V. Molecular association between b-catenin degradation complex and guanine exchange factor DOCK4 is essential for Wnt signaling. 2008. Oncogene 27: 5845-5855.

Goessling W, North TE, Schmitt S, Lord AM, Lee S, Stoick-Cooper C, Puder M, Daley GQ, Moon RT, and Zon LI. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. 2009. Cell 136: 1136-1147.

Dovey M, Patton EE, Bowman T, North T, Goessling W, Zhou Y, Zon LI. Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. 2009. Molecular and Cellular Biology 29: 3746-3753.

North, TE, Goessling W, Peeters M, Li P, Ceol C, Lord AM, Weber GJ, Harris J, Cutting CC, Huang P, Dzierzak E, Zon LI. 2009. Cell 137: 736-748.

Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA. β-catenin determines developmental stage specific transformation to leukemia stem cells. 2010 Science 327: 1650-1653.

North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, and Goessling W. Prostaglandin E2-regulated wnt signaling and N-cetylcysteine act synergistically in zebrafish regeneration after acetaminophen liver injury. 2010. PNAS 107:17315-17320.

North TE and Goessling W. NOTCHing an arrow at cord blood: translating stem cell knowledge into clinical practice. 2010. Cell Stem Cell, 6: 186-187.

Pier Paolo Pandolfi, MD, PhD, Director, Cancer Genetics Program at BIDMC; Professor of Pathology and Medicine, Harvard Medical School

Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Sci Signal. 2009 Aug 18;2(84):ra44.

Cheng K, Sportoletti P, Ito K, Clohessy JG, Teruya-Feldstein J, Kutok JL, Pandolfi PP. The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model. Blood. 2009 Aug 7.

Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell. 2009 Aug 4;16(2):115-25.

Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8.

Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, Ahn Y, Dahlberg S, Neuberg D, Moreau LA, Winter SS, Larson R, Zhang J, Protopopov A, Chin L, Pandolfi PP, Silverman LB, Hunger SP, Sallan SE, Look AT. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood. 2009 Jul 16;114(3):647-50.

Clohessy JG, Pandolfi PP. beta-tting on p63 as a metastatic suppressor. Cell. 2009 Apr 3;137(1):28-30.

Ito K, Bernardi R, Pandolfi PP. A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell. Curr Opin Genet Dev. 2009 Feb;19(1):51-9. Review.

Carracedo A, Baselga J, Pandolfi PP. Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors. Cell Cycle. 2008 Dec 15;7(24):3805-9. Epub 2008 Dec 22. Review.

Bernardi R, Papa A, Pandolfi PP. Regulation of apoptosis by PML and the PML-NBs. Oncogene. 2008 Oct 20;27(48):6299-312. Review.

German Pihan, MD, see Clinical Pathology

Isaac Rabinovitz, MD, PhD, Assistant Professor of Medicine, Harvard Medical School

Rabinovitz I. and Mercurio, AM, M. Dynamic Functions of theα6β4 Integrin in Carcinoma. In: A. Wells (ed.), Cell Motility in Cancer Invasion and Metastasis, 1st edition, Vol. 8, pp. 29. New York, NY: Springer, 2006.

Germain EC, Santos TM, Rabinovitz I. Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly. Mol Biol Cell. 2009 Jan;20(1):56-67. Epub 2008 Nov 12.

Germain E.C., Santos T.M., and Rabinovitz I. Phosphorylation of a novel site on the β4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly. Molecular Biology of the Cell. 20:56-67, 2009

Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Molecular Biology of the Cell. 21(6):1140-52, 2010.

Kashyap, T., Germain E.C., Roche M., Lyle S., and Rabinovitz I. Role of integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration. Laboratory Investigation. 91(10):1414-26. 2011.

Deng X., Li Q, Novak N, Yang H, Hoff J, Xu F, Sharma C, Zhou P, Rabinovitz I, Sonnenberg A, Zhou P, Ni A, Brown M, Kaetzel K, Hemler ME and Yang X. CD151 Drives Mammary Tumor Onset and Metastasis by Coordinating Integrin 1- and  -dependent Cell Adhesion, Motility, Survival and Signaling. Submitted 2011

Sharma C, Rabinovitz I, and Hemler ME. Palmitoylation by DHHC3 is critical for the function expression and stability of integrin α6β4. Submitted EMBO J, 2011

Li Q, Yang XH, Xu F, Chandan C, Wang HX, Knoblich K, Rabinovitz I, Granter S, and Hemler ME.Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Submitted EMBO J. 2011

John L. Rinn, PhD, Assistant Professor of Pathology, Harvard Medical School

Pauli A, Valen E, Lin MF, Garber M, Vastenhouw NL, Levin JZ, Fan L, Sandelin A, Rinn JL, Regev A, Schier AF. Systematic identification of long non-coding RNAs expressed during zebrafish embryogenesis. Genome Res. 2011 Nov 22.

Mercer TR, Gerhardt DJ, Dinger ME, Crawford J, Trapnell C, Jeddeloh JA, Mattick JS, Rinn JL*. Targeted RNA sequencing reveals the deep complexity of the human transcriptome. Nature Biotechnology. 2011 Nov 13.

Cabili MN, Trapnell C, Goff L, Koziol M, Tazon-Vega B, Regev A, Rinn JL*. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev. 2011 Sep 2. 15;25(18):1915-27

Guttman M, Donaghey J, Carey BW, Garber M, Grenier JK, Munson G, Young G, Lucas AB, Ach R, Bruhn L, Yang X, Amit I, Meissner A, Regev A, Rinn JL, Root DE, Lander ES. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature. 2011 Aug 28. 477(7364):295-300

Broadbent KM, Park D, Wolf AR, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti PC, Rinn JL*. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol. 2011 Jun 20;12(6)

Roberts A, Trapnell C, Donaghey J, Rinn JL, Pachter L. Improving RNA-Seq expression estimates by correcting for fragment bias. Genome Biol (2011) Mar 16;12(3)

Loewer S, Guttman M, Loh,YH, Garber M, Thomas K, Park IH, Curran M, Agarwal S, Manos P, Datta S, Lander ES, Schlaeger T, Daley GQ and Rinn JL*. Large intergenic non-coding RNAs as novel regulators of induced pluripotent cell survival. Nature Genetics. (2010), Epub Nov 7.

Huarte M, Guttman M, Feldser D, Garber M, Khalil AM, Zuk O, Amit I, Regev A, Lander ES, Jacks T and Rinn JL*. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 transcriptional response. Cell. (2010), Aug 6;142(3):409-19.

Kertesz M, Wan Y, Mazor E, Rinn JL, Nutter RC, Chang HY, Segal E. Genome-wide measurement of RNA secondary structure in yeast Nature. 2010 Sep 2;467(7311):103-7.

Zhu H, Shah S, Shyh-Chang N, Shinoda G, Einhorn WS, Viswanathan SR, Takeuchi A, Grasemann C, Rinn JL, Lopez MF, Hirschhorn JN, Palmert MR & Daley GQ. Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies (2010). Nature Genetics. Jul;42(7):626-30. Epub 2010 May 30.

Guttman M, Garber M, Levin JZ, Donaghey J, Robinson J, Adiconis X, Fan L, Koziol M, Gnirke A, Nusbaum C, Rinn JL, Lander ES, and Regev A. Ab initio reconstruction of transcriptomes of pluripotent and lineage committed cells reveals gene structures of thousands of lincRNAs (2010). Nature Biotechnology. May;28(5):503-10.

Vastenhouw NL, Zhang Y, Woods IG, Imam F, Regev A, Liu XS, Rinn JL* and Schier AF. Chromatin signature of embryonic pluripotency is established during genome activation (2010). Nature. Apr 8;464(7290):922-6. Epub 2010 Mar 24.

Gupta RA, Shah N, Wang KC, Kim J, Horlings HN, Wong DJ, Tsai M, Hung T, Argani P, Rinn JL, Wang Y, Brzoska P, Kong B, Li R, West RB, van de Vijver MJ, Sukumar S and Chang HY. Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis (2010). Nature. Apr 15;464(7291):1071-6.

Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M, Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, Smith Z, Deering R, McDonald RC, Cabili M, Bernstein BE, Rinn JL, Meissner A, Root DE, Hacohen N, Regev A. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses (2009). Science. 2009 Oct 9;326(5950):257-63. Epub 2009 Sep 3.

Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Rivera D, Thomas K, Presser A, Bernstein BE, Oudenaarden A, Regev A, Lander ES and Rinn JL*. Many Mammalian Large Intergenic Non coding RNAs Associate with Chromatin Modifying Complexes (2009). PNAS. Jul 14;106(28):11667-72. Epub 2009 Jul 1.

Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Hurate M, Mikkelsen TS, Zuk O, Hacohen N, Bernstein BE, Kellis M, Regev A, Rinn JL*, E.S. Lander. Chromatin signature reveals more than a thousand highly conserved, large non-coding RNAs in mammals (2009) Nature. Mar 12;458(7235):223-7

Jeffrey Saffitz, MD, PhD, see Anatomic Pathology

Donald R. Senger, PhD, Principal Associate in Pathology, Harvard Medical School

Senger, DR. Vascular endothelial growth factor: Much more than an angiogenesis factor. Mol Biol Cell 2010, 21: 377-379

Hoang MV, Smith LEH, Senger DR. Moderate GSK-3b inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy. Angiogenesis 2010, 13: 269-277.

Hoang MV, Smith LEH, Senger DR. Calpain inhibitors reduce retinal hypoxia in ischemic retionopathy by improving neovascular architecture and functional perfusion. BBA - Molecular Basis of Disease 2010, Biochim Biophys Acta. 2011 Apr;1812(4):549-57. Epub 2010 Sep 8.

Senger DR, Davis GE. "Angiogenesis", in Extracellular Matrix Biology, R. O. Hynes and K. M. Yamada, editors; Cold Spring Harbor Laboratory Press, 2009.

Davis GE, Senger DR. Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression. Current Opinion in Hematology 2008; 15: 197-203.

Hoang MV, Nagy JA, Senger DR. Cdc42-mediated inhibition of GSK-3b improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis. Microvasc Res.2011 Jan;81(1):34-43.

Hoang MV, Nagy JA, Senger DR. Moderation of calpain activity promotes neovascular integration and lumen formation during VEGF-induced pathological angiogenesis. PLoS One. 2010 Oct 25;5(10):e13612.

Hoang MV, Nagy JA, Senger DR. Active Rac1 improves pathological VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1. Blood. 2011 Feb 3;117(5):1751-60. Epub 2010 Oct 28.

Shou-Ching Shih, PhD, Research Associate; Instructor in Pathology, Harvard Medical School

English SB, Shih SC, Ramoni MF, Smith LE, Butte AJ. Use of Bayesian networks to probabilistically model and improve the likelihood of validation of microarray findings by RT-PCR. J Biomed Inform 2008.

Dudley AC, Khan ZA, Shih SC, Kang SY, Zwaans BM, Bischoff J, Klagsbrun M. Calcification of multipotent prostate tumor endothelium. Cancer Cell 2008; 14(3):201-11

Shapiro, N.I., Yano, K., Sorasaki, M., Fischer, C., Shih, S.C., and Aird, W.C. 2009. Skin Biopsies Demonstrate Site-Specific Endothelial Activation in Mouse Models of Sepsis. J Vasc Res 46:495-502.

Liu, J., Kanki, Y., Okada, Y., Jin, E., Yano, K., Shih, S.C., Minami, T., and Aird, W.C. 2009. A +220 GATA motif mediates basal but not endotoxin-repressible expression of the von Willebrand factor promoter in Hprt-targeted transgenic mice. J Thromb Haemost 7:1384-1392.

Shih, S.C., Zukauskas, A., Li, D., Liu, G., Ang, L.H., Nagy, J.A., Brown, L.F., and Dvorak, H.F. 2009. The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis. Cancer Res 69:3272-3277.

Chang, S.H., Kanasaki, K., Gocheva, V., Blum, G., Harper, J., Moses, M.A., Shih, S.C., Nagy, J.A., Joyce, J., Bogyo, M., et al. 2009. VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res 69:4537-4544.

Nagy, J.A., Chang, S.H., Shih, S.C., Dvorak, A.M., and Dvorak, H.F. 2010. Heterogeneity of the Tumor Vasculature. Semin Thromb Hemost 36:321-331.

Dudley, A.C., Udagawa, T., Melero-Martin, J.M., Shih, S.C., Curatolo, A., Moses, M.A., and Klagsbrun, M. 2010. Bone marrow is a reservoir for pro-angiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors. Blood.

Matsuda, K., Ohga, N., Hida, Y., Muraki, C., Tsuchiya, K., Kurosu, T., Akino, T., Shih, S.C., Totsuka, Y., Klagsbrun, M., et al. 2010. Isolated tumor endothelial cells maintain specific character during long-term culture. Biochem Biophys Res Commun 394:947-954.

Shapiro, N.I., Khankin, E.V., Van Meurs, M., Shih, S.C., Lu, S., Yano, M., Castro, P.R., Maratos-Flier, E., Parikh, S.M., Karumanchi, S.A., et al. 2010. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol 185:517-524.

Ismail, N.S., Pravda, E.A., Li, D., Shih, S.C., and Dallabrida, S.M. 2010. Angiopoietin-1 reduces H(2)O(2)-induced increases in reactive oxygen species and oxidative damage to skin cells. J Invest Dermatol 130:1307-1317.

Steven Tahan, MD, see Anatomic pathology

Alex Toker, PhD, Associate Professor of Pathology, Harvard Medical School

Yoeli-Lerner, M., Chin, Y. R., Hansen, K. C. and Toker, A. The Akt/PKB and GSK-3 Signaling Pathway Regulates Cell Migration through the NFAT1 transcription factor. Molecular Cancer Research 2009; 7(3): 425-432.

Gao, D., Inuzuka, H., Tseng, A., Chin Y. R., Toker, A. and Wei, W. Akt Phosphorylates Skp2, Promotes its Cytoplasmic Localization, and Impairs its Destruction by APC/Cdh1. Nature Cell Biology 2009; 11 (4): 397-408.

Storz, P., Döppler, H., Copland, J. A., Simpson, K. J. and Toker, A. The FOXO3a Transcription Factor Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases. Molecular and Cellular Biology 2009; 29 (18): 4906-4917.

Maurer, M., Su, T., Saal, L. H., Koujak S., Hopkins B. D., Barkley C. R., Wu, J., Nandula S., Dutta, B., Xie Y., Chin Y. R., Kim, D.-I., Ferris, J. S., Gruvberger-Saal S. K., Laakso M., Wang X., Memeo L., Rojtman A., Matos T., Yu J. S., Cordon-Cardo C., Isola J., Terry M. B., Toker A., Mills G. B., Zhao J. J., Murty V. V. V. S., Hibshoosh H., and Parsons, R. 3-Phosphoinositide-Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma. Cancer Research 2009; 69 (15): 6299-6306

Chin, Y. R. and Toker, A. The actin bundling protein Palladin is an Akt1-specific substrate that regulates breast cancer cell migration. Molecular Cell 2010; 38: 333-344.

Nhek, S., Ngo, M., Yang, X., Ng, M., Field, S. J., Asara, J. M., Ridgeway, N. D. and Toker, A. Regulation of OSBP Golgi Localization Through Protein Kinase D-mediated Phosphorylation Molecular Biology of the Cell 2010; 21: 2327-2337.

Gao, D., Wan, L., Inuzuka, H., Berg, A. H., Tseng, A., Zhai, B., Shaik, S., Bennett, E., Tron, A. E., Gasser, J. A., Lau, A., Gygi S., Harper, J. W., DeCaprio, J. A., Toker, A. and Wei, W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Molecular Cell 2010; 39: 797-808.

Fry, J. S. and Toker, A. Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration. Cancer Research 2010; 70(20): 8187-8198.

Chin, Y. R. and Toker, A. Akt2 Regulates Expression of the Actin-Bundling Protein Palladin. FEBS Letters 2010; 584: 4769-4774.

Peter Tonellato, PhD, Senior Research Scientist at the Center for Biomedical Informatics, Harvard Medical School and Visiting Professor, Department of Pathology, Beth Israel Deaconess Medical Center

Haspel, RL, Arnaout, R, Briere, L, Kantarci,S, Marchand,K, Tonellato, PJ, Connolly, C, Boguski, MS,.Saffitz,JE, A Call to Action: Training Pathology Residents in Genomics and Personalized Medicine, American Journal of Clinical Pathology | AJCP-2010-02-0104.R1 (2010).

Wall, DP, Kudtarkar, P, Fusaro, V, Pivovarov, R, Patil, P and Tonellato, PJ. Cloud Computing for Comparative Genomics. BMC Bioinformatics (2010 accepted for publication)

Prasad, P and Tonellato, PJ. Individual Whole Genome Mapping: From NGS Reads to Clinical Variants, Proceedings of the 2010 AMIA Summit on Clinical Research Informatics, San Francisco, CA, March, 2010.[pdf available on request]

Fusaro, VA, Kos, P, Tector, M, Patil,P, Tonellato, PJ, Electronic Medical Record Analysis Using Cloud Computing, . Proceedings of the 2010 AMIA Summit on Clinical Research Informatics, San Francisco, CA, March, 2010.[pdf available on request]

Tonellato, PJ, Reede, J, Kos, P, Demas, K, Personalized Medicine and the Potential for Health Inequity. 2010 Annual Wisconsin Public health Association, Madison, WI, June, 2010

Dennis Wall, PhD, Assistant Professor of Pathology, Harvard Medical School, Center for Biomedical Informatics

Wall D.P., F.J. Esteban, T. F. DeLuca, M. Huyck, T. Monaghan, N. Velez de Mendizabal, J. Goni, I. S. Kohane. (2009). Comparative analysis of neurological disorders focuses genome-wide search for autism-linked genes. Genomics 93(2):120-9.

Cano, C. Cano, C., Monaghan, T. Blanco, A., Wall, D.P. Peshkin, L. (2009). Collaborative text-annotation resource for disease-centered relation extraction from biomedical text. Journal of Biomedical Informatics. Feb 14.

Peshkin L., Goni J., Loewer A., Kolluri R., Lahav G., and Wall D.P. 2009. Morphology from Texture in Cytometry. International Journal of Tomography & Statistics16: 56-67 (S10).

Esteban, P. and D. P. Wall. 2009. Game theory improves detection of genes involved in Autism Spectrum Disorder. TOP. (ISSN 1863-8279).

Wall D, Kudtarkar P, Fusaro V, Pivovarov R, Patil P, Tonellato P. Cloud computing for comparative genomics. BMC Bioinformatics 2010;11:259.

Wall, D.P. Pivavorov, R. and P.J. Tonellato. (2010). Genotator: A disease-agnostic tool for genetic annotation of disease. BMC Medical Genomics 3(1):50.

Goñi J, Arrondo G, Sepulcre J, Martincorena I, Vélez de Mendizábal N, Corominas-Murtra B, Bejarano B, Ardanza-Trevijano S, Peraita H, Wall DP, Villoslada P. The semantic organization of the animal category: evidence from semantic verbal fluency and network theory. 2010. Cognitive Processing Oct 12.

Kudtarkar P, DeLuca, TF, Fusaro V., Tonellato PJ, and Wall, D.P. 2010. Cost-effective cloud computing: A case study using the comparative genomics tool, Roundup. Evolutionary Bioinformatics.

Wall, D.P., Eran A., Vadarajan, B. In press. Haplotype structure enables prioritization of disease markers and candidate genes in autism spectrum disorder. PLoS ONE.

Banos, M. and Wall, D.P. In press. Genomic variation in autism pathways. PLoS ONE.

Jung, JY and Wall, D.P. In review. Cross-disease analysis between autism and autoimmune diseases. Molecular Autism.

Wall, D.P. and P. Kudtarkar. In preparation. Comparative genomics using the Roundup application. Evolutionary Bioinformatics.

Wenyi Wei, PhD, Assistant Professor of Pathology, Harvard Medical School

Wei, W.*, Ayad, N. G.*, Wan, Y., Zhang, G.-J., Kirschner, M. W. and Kaelin, W. G., Jr. (2004) Degradation of the SCF component Skp2 in cell cycle G1 by the anaphase promoting complex. Nature 428: 194-8.

Gao, D., Inuzuka, H., Tseng, A., Chin, R., Toker, A. and Wei, W. (2009) Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APC/Cdh1-medaited Skp2 destruction. Nature Cell Biology 11(4): 397-408.

Gao, D., Inuzuka H., Korenjak M., Tseng A., Wu T., Wan L., Kirschner M., Dyson N. and Wei, W. (2009) Cdh1 regulates cell cycle through modulating the Claspin/Chk1 and the Rb/E2F1 pathways. Molecular Biology of the Cell 20(14): 3305-16.

Inuzuka H., Tseng A., Gao D., Zhai B., Zhang Q., Shaik S., Wan L., Ang X.L., Mock C., Yin H., Stommel J.M.,Gygi S., Lahav L., Asara J., Xiao Z., Kaelin W. G., Jr., Harper J. W. and Wei, W. (2010) Phosphorylation by Caesin Kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFb-TRCP ubiquitin ligase. Cancer Cell 18(2): 147-159.

Gao D., Wan L., Inuzuka H., Berg A. H., Tseng, A., Zhai B., Shaik S., Bennet E., Tron A. E., Gasser J.A., Lau A., Gygi S., Harper J. W., DeCaprio J. A., Toker A. and Wei, W. (2010) Rictor forms a complex with Cullin-1 to promote SGK1 ubiqutination and destruction. Molecular Cell 39(5): 797-808.

Inuzuka, H., Shaik, S., Onoyama, I., Tseng, A., Gao, D., Maser, R., Zhai, B., Wan, L., Gurierrez, A., Lau, A., Xiao, Y., Christie, A., Aster, J., Settleman, J., Gygi, S, Kung, A. L., Look, T., Nakayama, K. I., DePinho, R. A. and Wei, W. SCFFbw7 regulates cellular apoptosis by targeting the Mcl-1 oncoprotein for ubiquitination and destruction. Nature 2011 Mar 3;471(7336):104-9.

Wei, W. and Kaelin, W.G., Jr. (2011) Good COP1 or Bad COP1? In Vivo Veritas. Journal of Clinical Investigation (in press).

Catherine T. Yan, PhD, Assistant Professor of Pathology, Harvard Medical School

Yan CT, Boboila C, Souza EK, Franco S, Hickernell T, Murphy M, Gumaste S, Geyer M, Zarrin A, Manis JP, Rajewsky K and Alt FW. IgH Class Switching and Translocations Employ a Robust Non-classical End-joining Pathway. Nature, 2007, 449 (7161):478-82.

Xie A, Harlterode A, Stucki M, Odate S, Puget N, Nagaraju G, Yan CT, Alt FW, Chen, J, Jackson SP, and Scully, R. Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair. Molecular Cell, 2007, 28:1045-57.

Wang, JH*, Gostissa M*, Yan CT*, Goff P, Hickernell, T, Hansen E, Difilippantonio S, Zarrin A, Rajewsky K, Nussenzweig A, and Alt, FW. (2009) Mechanistic factors that promote recurrent translocations in peripheral B lymphocytes. Nature 460: 231-6. (*equal contribution).

Gostissa M., Yan CT, Bianco JM, Cogne M, PInaud E and Alt, FW. (2009) Long-range Oncogenic Activation of IgH/c-myc Translocations by the IgH 3' Regulatory Region. Nature, 462:803-7. PMID 20010689

Rucci, F*, Notarangelo, LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley K, Detre C, Keszei M, Walter JE, Feldman L, Cheng H, Poliani PL, Wang JH, Balter B, Recher M, Andersson E-M, Zha S, Giliani S, Terhorst C, Alt FW, Yan, CT* (2010) Homozygous DNA Ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. PNAS, 107:3024-9. PMID: 20133615 (equal contribution).

Boboila C, Yan CT, Wesemann, DR, Jankovic M, Wang JH,, Manis J, Nussenzweig A, Nussenzweig M, At FW. (2010) Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA Ligase 4. Journal of Exp. Med, 207:417-27. PMID: 20142431

Boboila C*, Jankovic M, Yan CT*, Wang JH, Wesemann, DR, Zhang, T, Feldman L, Fazeli A, Nussenzweig A, Nussenzweig M, At FW. (2010) Alternative End-joining catalyzes robust IgH locus deletions and translocations in the absence of combined Ligase 4 and Ku70. PNAS, 107:3034-9. (equal contribution). PMID: 20133803 (equal contribution).

Eccleston, J, Yan, C, Yuan K, Alt FW, Selsing E. (2010). Mismatch repair proteins, MSH2, MLH1 and EXO1 are important for class switch recombination events occurring in B cells that lack non-homologous end joining. Journal of Immunology. 2011 Feb 15;186(4):2336-43. Epub 2011 Jan 17.