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Publications by Faculty

FACULTY AND SELECTED PUBLICATIONS
ANATOMIC PATHOLOGY

Matthew Anderson, MD, PhD, Director of Neuropathology; Associate Professor of Neurology and Pathology, Harvard Medical School

Anderson MP
. Arrested Glutamatergic Synapse Development in Human Partial Epilepsy. Epilepsy Currents 2010;10:153-158.

Smith SEP, Zhou Y-D, Zhang G, Jin Z, Stoppel DC, Anderson MP. Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice. Science Translational Medicine 2011; 3:42-53.

Czupryn A*, Zhou Y-D*, Chen X*, McNay D, Anderson MP†, Flier JS†, Macklis JD†. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science. 2011; 334:1133-1137. *co-first authors; † co-senior authors

Smith SE, Elliot RM, Anderson MP. Maternal immune activation increases neonatal mouse cortex thickness and cell density. J Neuroimmune Pharmacology. 2012, May 9.

Smith SE, Xu L, Kasten MR, Anderson MP. Mutant LGI1 Inhibits Seizure-Induced Trafficking of Kv4.2 Potassium Channels. J Neurochem. 2012; 120:611-621.

Zhou YD, Zhang D, Wang X, Kasper EM, Leguern E, Baulac S, Anderson MP. Epilepsy gene LGI1 regulates postnatal developmental remodeling of retinogeniculate synapses. J Neurosci. 2012; 32:903-910.

Krishnan V, Tarula E, Anderson MP, Hanafy KA, Herman ST. Postictal bradyarrhythmia following an isolated seizure in a patient with left hemisphere stroke. Seizure. 2013 Jul 10.

Gamze Ayata, MD, Staff Pathologist, Instructor in Pathology, HMS

A. Ciampa, B. Xu, G. Ayata, D. Baiyee, J. Wallace, M. Wertheimer, K. Edmiston, A. Khan.Her-2 Status in Breast Cancer: Correlation of Gene Amplification by FISH with Immunohistochemistry expression using advanced Cellular Imaging System. Applied Immunohistochemistry and Molecular Morphology, 14(2):132-137,2006.

M. Piperdi, G. Ayata, J. Simons, V. Velagapudi, J. F. Tseng, B. Piperdi.Rectal prognostic index predicts outcome of patients with locally advanced rectal cancer treated with preoperative chemoradiation ASCO GI, Jan 2009.

Karoly Balogh, MD, Staff Pathologist, Associate Professor of Pathology, HMS

Nagy P, Szabo, Z, Balogh, K. Wegener’s granulomatosis masquerading as chronic mastoiditis. Lege Artis Medicinae 2006.

Patologia. Ed. by L. Kopper and Z. Schaff. Chapter 14. Pathology of the Head and Neck Region. (pp. 681-714). Budapest, Medicine Pub. Co. (Hungarian textbook), 2nd edition, 2006.

Histology for Pathologists. Ed. by S. S. Sternberg. Chapter 15. Mouth, Nose and Paranasal Sinuses. New York, Raven Press, 3rd edition, 2007.

Essential Pathology. Ed. by E. Rubin and H.M. Reisner, Chapter 25. The Head and Neck. (pp. 658-666) 5th edition, 2008

Histology for Pathologists. Ed. by S.E. Mills, Chapter 15. Mouth, Nose, and Paranasal Sinuses. (in print) New York, Raven Press, 4th edition, 2012.

Lawrence F. Brown, MD, Staff Pathologist, Associate Professor of Pathology, HMS

Fu Y, Nagy JA, Brown LF, Dvorak HF, Wight TN. Proteolytic Cleavage of Versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced Pathological Angiogenesis. J Histochem Cytochem. 2011 May;59(5):463-73.

Kazerounian S, Gerald D, Huang M, Chin Y, Udayakumar D, Zheng N, O'Donnell R, Perruzzi C, Magiante L, Pourat J, Phung T, Bueva-Nuevo A, Shechter S, McNamara S, DuHadaway J, Kocher O, Brown L, Toker A, Prendergast G, Benjamin L. RhoB differentially controls AKT function in tumor cells and stromal endothelial cells during breast tumorogenesis. Cancer Research, 2012;73: 50-61.

Kunstfeld R, Hawighorst T, Streit M, Hong Y-K, Nguyen L, Brown LF, Detmar. Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically-induced multistep skin carcinogenesis. Submitted.

Adini A, Doucette S, Brown LF, Benjamin LE. Prominin/CD133 is not just a marker, but regulates cancer cell survival. Submitted.

Li J, Wang E, Lau J, Schroeder MA, Rinaldo F, Brown LF, Mukhopadhyay D, O’Neill BP, Datta K. Factor inhibiting HIF (FIH) is essential for inhibiting HIF mediated gene transcription in glioblastoma multiforme. Submitted.

Kane SE, Liu FW, Brown LF, Awtrey CS, Hecht JL. Papillary Serous Borderline tumor of the ovary with significant ascites and Vascular Endothelial Growth Factor expression. submitted.

Tracy Challies, MD, Staff Pathologist, GI and Liver Pathology, Instructor in Pathology, Harvard Medical School

Malik, R., Lai M., Sadiq A., Farnan R, Mehta S, Nasser I, Challies T, Schuppan D, Afdhal N. Comparison of transient elastography, serum markers and clinical signs for the diagnosis of compensated cirrhosis. J Gastroenterol Hepatol. 2010 Sept; 25(9):1562-8.

Klibansky DA, Mehta S, Curry M, Nasser I, Challies T, and Afdhal NH. Transient elastography for predicting clinical outcomes inpatients with chronic liver disease. J Viral Hepatitis. Article first published on line: 1 JUL 2011/ DOI:10.1111/j.1365-2893.2011.01493.x

Sensitivity of Ultrasound for Hepatic Steatosis Detection Based on Histological and Digital Scores in Nonalcoholic Fatty Liver Disease; abstract – Digestive Diseases Week 2010.

Laura C. Collins, MD, Associate Director of Anatomic Pathology; Associate Professor of Pathology, Harvard Medical School

Schnitt SJ and Collins LC. Pathology of Benign Breast Disorders. In: Diseases of the Breast. Philadelphia : Lippincott Williams & Wilkins;2009. p. 69-85.

Collins LC, Cole K, Marotti J, Hu R, Schnitt SJ, Tamimi RM. Androgen Receptor Expression in Breast Cancer in Relation to Molecular Phenotype: Results from the Nurses’ Health Study. Mod Pathol. 2011;24(7):924-31.

Hu R, Dawood S, Holmes MD, Collins LC, Schnitt SJ, Cole K, Marotti JD, Hankinson SE, Colditz GA, Tamimi RM. Androgen Receptor Expression and Breast Cancer Survival in Postmenopausal Women. Clin Cancer Res. 2011;17(7):1867-74.

Tamimi RM, Colditz GA, Wang Y, Collins LC, Hu R, Rosner B, Irie HY, Connolly JL, Schnitt SJ. Expression of IGF1R in normal breast tissue and subsequent risk of breast cancer. Breast Cancer Res Treat. 2011;128(1):243-50.

Liu Y, Tamimi RM, Collins LC, Schnitt SJ, Gilmore HL, Connolly JL, Colditz GA. The association between vascular endothelial growth factor expression in invasive breast cancer and survival varies with intrinsic subtypes and use of adjuvant systemic therapy: results from the Nurses' Health Study. Breast Cancer Res Treat. 2011;129(1):175-84

Pantanowitz L, Valenstein PN, Evans AJ, Kaplan KJ, Pfeifer JD, Wilbur DC, Collins LC, Colgan TJ. Review of the current state of whole slide imaging in pathology. J Pathol Inform. 2011;2:36.

Yaghjyan L, Colditz GA, Collins LC, Schnitt SJ, Rosner B, Vachon C, Tamimi RM. Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to tumor characteristics. J Natl Cancer Inst. 2011;103(15):1179-89.

Tamimi RM, Colditz GA, Hazra A, Baer HJ, Hankinson SE, Rosner B, Marotti J, Connolly JL, Schnitt SJ, Collins LC. Traditional breast cancer risk factors in relation to molecular subtypes of breast cancer. Breast Cancer Res Treat. 2011.

Collins, LC, Laronga, C and Wong J. Microinvasive Breast Carcinoma. In: UptoDate, 2011.

Collins, LC, Laronga, C and Wong J. Breast DCIS: Epidemiology, Diagnosis, and Prognosis. In: UptoDate, 2011.

James L. Connolly, MD, Staff Pathologist, Professor of Pathology, Harvard Medical School

Lester SC, Bose S, Chen YY, Connolly JL, de Baca ME, Fitzgibbons PL, Hayes DF, Kleer C, O'Malley FP, Page DL, Smith BL, Weaver DL, Winer E; Members of the Cancer Committee, College of American Pathologists. Protocol for the examination of specimens from patients with ductal carcinoma in situ of the breast. Arch Pathol Lab Med. 2009 Jan;133(1):15-25.

Lester SC, Connolly JL, Amin MB. College of American Pathologists protocol for the reporting of ductal carcinoma in situ. Arch Pathol Lab Med. 2009 Jan;133(1):13-4.

Goldfarb M, O'Neal P, Shih JL, Hartzband P, Connolly J, Hasselgren PO. Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. Endocr Pract. 2009 Jul-Aug;15(5):463-8.

Baer HJ, Collins LC, Connolly JL, Colditz GA, Schnitt SJ, Tamimi RM. Lobule type and subsequent breast cancer risk: results from the Nurses' Health Studies. Cancer. 2009 Apr 1;115(7):1404-11.

Collins LC, Wang Y, Connolly JL, Baer HJ, Hu R, Schnitt SJ, Colditz GA, Tamimi RM. Potential role of tissue microarrays for the study of biomarker expression in benign breast disease and normal breast tissue. Appl Immunohistochem Mol Morphol. 2009 Oct;17(5):438-41.

Su X, Colditz GA, Willett WC, Collins LC, Schnitt SJ, Connolly JL, Pollak MN, Rosner B, Tamimi RM. Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease. Int J Cancer. 2010 Jan 1;126(1):180-90.

Zhou C, Wang Y, Aguirre AD, Tsai TH, Cohen DW, Connolly JL, Fujimoto JG. Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy. J Biomed Opt. 2010 Jan-Feb;15(1):016001.

Su X, Tamimi RM, Collins LC, Baer HJ, Cho E, Sampson L, Willett WC, Schnitt SJ, Connolly JL, Rosner BA, Colditz GA. Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease. Cancer Causes Control. 2010 Jul;21(7):1033-46. Epub 2010 Mar 14.

Aroner SA, Collins LC, Schnitt SJ, Connolly JL, Colditz GA, Tamimi RM. Columnar cell lesions and subsequent breast cancer risk: a nested case-control study. Breast Cancer Res. 2010 Aug 6;12(4):R61.

Beverly Faulkner-Jones, MD, PhD, Staff Pathologist, Dermatopathology and Surgical Pathology, Instructor in Pathology, Harvard Medical School

Faulkner-Jones, BE, Foster, W, Harbor, JM, Davila, RN and Smith, ME Fine Needle Aspiration Biopsy with Adjunct Immunohistochemistry in Intraocular Tumor management. (2005) Acta Cytologica 49(3):297-308.

Chan, M.P, Reynolds, R.V and Faulkner-Jones, B.E. Case 7: Focal squamous cell carcinoma in-situ, present in a background of squamous dysplasia: Patient with a history of psoriasis and a changing pigmented lesion on the medial thigh. In: Cases in Dermatopathology: The Suboptimal Biopsy in Dermatopathology. Knowledge Books and Software, Brisbane, Queensland, Australia, 2009. pp. 55-61

Chan, M.P. and Faulkner-Jones, B.E. Case 10: Melanoma with senescence-like changes versus nevus with senescent change. In: Cases in Dermatopathology: Mimicry in melanocytic lesions. Knowledge Books and Software, Brisbane, Queensland, Australia, 2010. pp.

Jeong, WK, Schneider, J, Turney, S, Faulkner-Jones, BE, Meyer, D, Westermann, R, Reid, RC, Lichtman, J and Pfister, H "Interactive Histology of Large-Scale Biomedical Image Stacks," IEEE Transactions on Visualization and Computer Graphics, vol. 16, no. 6, pp. 1386-1395, Nov./Dec. 2010, doi:10.1109/TVCG.2010.168

Harris, A., Faulkner-Jones, B.E and Zimarowski, M.J. Epidermal panfolliculoma: A report of two cases. Am J Dermatopathol. 2011 Feb;33(1):e7-10.

Jeffrey Goldsmith, MD, Staff Pathologist, Director of Surgical Pathology Laboratory and GI Pathology Fellowship, Assistant Professor of Pathology, Harvard Medical School

Konstantinopoulos PA, Fountzilas H, Goldsmith JD, Bhasin M, Pillay K, Libermann TA, Gebhardt M, Spentzos D. Integrated analysis of multiple sarcoma expression datasets: implications for classification, oncogenic pathway activation and chemotherapy resistance. PloS One. 2010 5:e9747.

Fox VL, Perros S, Jiang H, Goldsmith JD. Juvenile Polyps Recur Frequently in Patients with Multiple and Solitary Polyps. Clin Gastroenterol Hepatol. 2010 8:795-799.

Kung JW, Brown A, Kruskal JB, Goldsmith JD, Pedrosa I. Heterotopic pancreas: typical and atypical imaging findings. Clin Radiol. 2010 65:403-407.

Krasinskas A, Goldsmith JD, Immunohistology of the Gastrointestinal Tract. In: Dabbs DJ editor. Diagnostic Immunohistochemistry Theranostic and Genomic Applications. Third Edition. Philadelphia, PA: Churchill Livingstone Elsevier; 2010. pp. 500-540.

Najarian RM, Bousvaros A, Ashworth L, Goldsmith JD. A Histopathologic Analysis of Ileitis in Pediatric Ulcerative Colitis. USCAP Abstracts; Washington DC 2010. Mod Pathol 2010; 23: 158A(#698).

Roshnan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R, Goldsmith J, Tariq S, Schuppan D, Kelly D. The Incidence and Clinical Spectrum of Refractory Celiac Disease in a North American Referral Center. Am J Gastro. 2011 106:923-928.

Kelly AD, Breitkopf SB, Yuan M, Goldsmith J, Spentzos D. Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: Application in sarcoma. PLoS One. 2011.

Lin MM, Goldsmith JD, Resch SC, DeAngelis JP, Ramappa AJ. Histologic Examinations of Arthroplasty Specimens are not Cost-effective: A Retrospective Cohort Study. Clin Orthop and Relat Res. 2011.

Hardy L, Fitzgibbons P, Goldsmith JD, Eisen R, Beasley M, Souers R, Nakleh R. Immunohistochemistry validation procedures and practices: A College of American Pathologists survey of 727 laboratories. Arch Pathol Lab Med. 2012.

Carbo AR, Blanco PG, Graeme-Cook F, Misdraji J, Kappler S, Shaffer K, Goldsmith JD, Berzin T, Leffler D, Najarian R, Sepe P, Kaplan J, Pitman M, Goldman H, Pelletier S, Hayward JN, Shields H. Revitalizing Pathology Laboratores in a Gastrointestinal Pathophysiology Course Using Multimedia and Team-based Learning Techniques. Pathology-Research and Practice. 2012.

Anderson ME, Spentzos D, Stevenson MA, Tawa NE, Goldsmith JD, Gebhardt, MC. Local Control with Preoperative Low Dose Continuous Infusion Doxorubicin and Concomitant Radiation Therapy for Patients with High Risk Soft Tissue Sarcomas. Connective Tissue Oncology Society / Musculoskeletal Tumor Society Annual Meeting; Chicago, IL 2011.

Pyatibrat SM, Najarian RM, Goldsmith JD. Lymphocytic colitis: Effect of Therapy on Histologic Findings. USCAP Abstracts; Vancouver BC 2012.

Hardy L, Fitzgibbons P, Goldsmith JD, Eisen R, Beasley M, Souers R, Nakhleh R. Immunohistochemistry validation procedures and practices: A College of American Pathologists Survey of 727 laboratories. USCAP Abstracts; Vancouver BC 2012.

Mamta Gupta, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School 

Gupta M, Selig MK, Oliva E, Nielsen GP. Uterine tumors resembling ovarian sex cord stromal tumors: an ultrastructural analysis of 13 cases. Ultrastruct Pathol 2010; 34:16-24.
 
Gupta M, Lloyd RV, Fischer-Colbrie R, Tischler AS, Dayal Y. Immunohistochemical expression of neuroendocrine secretory protein-55 (NESP-55) in pituitary adenomas. Endocr Pathol 2011, 22:150-154.

Vang R, Gupta M, Wu LS, Yemelyanova AV, Kurman RJ, Murphy KM, Descipio C, Ronnett BM. Diagnostic Reproducibility of Hydatidiform Moles: Ancillary Techniques (p57 Immunohistochemistry and Molecular Genotyping) Improve Morphologic Diagnosis. Am J Surg Pathol. 2012 Mar;36(3):443-53.
 
Vang R, Visvanathan K, Gross A, Maambo E, Gupta M, Kuhn E, Li R, Ronnett BM, Seidman JD, Yemelyanova A, Shih IM, Shaw PA,. Soslow RA, Kurman RJ. Validation of an algorithm for the diagnosis of serous tubal intraepithelial carcinoma. Int J Gynecol Pathol. 2012, May;31(3):243-53.
 
Gupta M, Vang R, Yemelyanova AV, Kurman RJ, Li FR, Maambo EC, Murphy KM, DeScipio C, Thompson CB, Ronnett BM Diagnostic reproducibility of hydatidiform moles: ancillary techniques (p57 immunohistochemistry and molecular genotyping) improve morphologic diagnosis for both recently trained and experienced gynecologic pathologists. Am J Surg Pathol. 2012, Dec;36(12):1747-60.

Li RF, Gupta M, McCluggage WG, Ronnett BM. Embryonal rhabdomyosarcoma (botryoid type) of the uterine corpus and cervix in adult women: report of a case series and review of the literature. Am J Surg Pathol. 2013, Mar;37(3):344-55. 

Cynthia Hayne, MD, PhD, Staff Pathologist, Instructor in Pathology, HMS

Hayne C, Winer E, Williams T, Chaves F, Khorsand J, Mark HFL. Acute lymphoblastic leukemia with 4;11 translocation analyzed by a multi-modal strategy of conventional cytogenetics, FISH, morphology, flow
cytometry and molecular genetics, and review of the literature. Experimental and Molecular Pathology, 81(1):62-71, 2006.

Hussain G, Tapper E, Mavrakis A, Krajewski K, Hayne C, Yagi Y, Lai M, Holder S, Challies T, Kane R, Afdhal N, Lau D. “Sensitivity of Ultrasound for Hepatic Steatosis Detection Based on Histological and
Digital Scores in Nonalcoholic Fatty Liver Disease.” Presented at Digestive Disease Week 2010.

Jonathan Hecht, MD, PhD, Staff Pathologist, Medical Director of Autopsy Service, Associate Professor of Pathology, Harvard Medical School

Leviton A, Allred EN, Kuban KC, Hecht, JL, Onderdonk AB, O'shea TM, Paneth N. Microbiologic and Histologic Characteristics of the Extremely Preterm Infant's Placenta Predict White Matter Damage and Later Cerebral Palsy. The ELGAN Study. Pediatric Research 2010;67:95-101.

Gates MA, Rosner BA, Hecht JL, Tworoger SS. Risk factors for epithelial ovarian cancer by histologic subtype. Am J Epidemiol 2010;171:45-53.

Kotsopoulos J, Hecht JL, Marotti JD, Kelemen LE, Tworoger SS. Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors. Int J Cancer. 2010 May 1;126(9):2191-8.

Levine D, Brown DL, Andreotti RF, Benacerraf B, Benson CB, Brewster WR, Coleman B, Depriest P, Doubilet PM, Goldstein SR, Hamper UM, Hecht JL, Horrow M, Hur HC, Marnach M, Patel MD, Platt LD, Puscheck E, Smith-Bindman R. Management of Asymptomatic Ovarian and Other Adnexal Cysts Imaged at US: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology. 2010 May 26.

Chan MP, Hecht JL, Kane SE. Incidence and clinicopathologic correlation of fetal vessel thrombosis in mono- and dichorionic twin placentas. J Perinatol. 2010 Mar 4.

McElrath TF, Allred EN, Kuban K, Hecht JL, Onderdonk A, O'Shea TM, Paneth N, Leviton A; ELGAN Study Investigators. Factors associated with small head circumference at birth among infants born before the 28th week. Am J Obstet Gynecol. 2010 Jun 11.

Leviton A, Kuban K, Allred EN, Hecht JL, Onderdonk A, O’Shea TM, McElrath TF, Paneth N, Antenatal antecedents of a small head circumference at age 24-months post-term equivalent in a sample of infants born before the 28th post-menstrual week. Early Human Development (2010)

Hecht JL, Fichorova R, Allred EN, Leviton, A. The relationship between neonatal blood protein profiles and placenta histologic characteristics in ELGANs Pediatric Research, 2011;69:68-73.

McElrath TF, Fichorova RN, Allred EN, Hecht JL, Ismail MA, Yuan H, Leviton A. Blood protein profiles of infants born before 28th weeks differ by pregnancy complication. Am J Obstet Gynecol 2011;204, ePub.

Marotti, JD, Glatz K, Parkash V, Hecht, JL. International Internet-Based Assessment of Observer Variability for Diagnostically Challenging Endometrial Biopsies. Arch Pathol Lab Med. 2011;135(4):464-70.

Karst AM, Levanon K, Duraisamy S, Liu JF, Hecht JL, Hirsch MS, Drapkin RI. Stathmin 1, a Marker of PI3K Pathway Activation and Regulator of Microtubule Dynamics, is Expressed in Early Pelvic Serous Carcinomas. Gynecol Oncol. 2011 Oct;123(1):5-12.

Faupel-Badger JM, Fichorova RN, Allred EN, Hecht JL, Dammann O, Leviton A, McElrath TF. Cluster Analysis of Placental Inflammatory Proteins can Distinguish Preeclampsia from Preterm Labor and Premature Membrane Rupture in Singleton Deliveries Less Than 28 Weeks of Gestation. Am J Reprod Immunol. 2011 Dec;66(6):488-94.

Leviton A, Hecht JL, Allred EN, Yamamoto H, Fichorova RN, Dammann O, Persistence after birth of systemic inflammation associated with umbilical cord inflammation. J Reprod Immunol. 2011 Aug;90(2):235-43.

Chen ML, Allred EN, Hecht JL, Onderdonk A, VanderVeen D, Wallace DK, Leviton A, Dammann O; ELGAN Study. Placenta microbiology and histology and the risk for severe retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2011 Sep 1;52(10):7052-8.

Konstantinopoulos PA, Spentzos D, Fountzilas E, Francoeur N, Sanisetty S, Grammatikos AP, Hecht JL, Cannistra SA. Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer. Cancer Res. 2011 Aug 1;71(15):5081-9.

Hecht JL. Chapter 6: Techniques for Fetal and Placental Examination and Chapter 9: Pre-viable Terminations for Anomalies (with TK Boyd and R Padera). In Pathology of Fetal Death: Principles and Practical Evaluation. Theonia K. Boyd, ed. Springer, 2012.

Nicole (Belsley) Johnson, MD, Staff Pathologist, Instructor in Pathology, HMS

Belsley NA, Collins LC, Rice MS, Walker S, Tworoger S, Frank DA. Expression of Phospho(p)STAT3 and Phospho(p)STAT5 in Breast Cancer and Correlation with Plasma Prolactin Levels. Modern Pathology, Volume 22, Supplement 1, January 2009, p. 30A.

Johnson NB, Collins LC. Update onpercutaneous needle biopsy of nonmalignant breast lesions. Adv Anat Pathol. 2009 Jul;16(4):183-95.

Johnson MM, Dialani V, Johnson NB. Histologic Characteristics of Benign Breast Lesions Identified for Biopsy by Magnetic Resonance Imaging. Modern Pathology, Volume 23, Supplement 1, January 2010, p. 54A.

Gupta RK, Genevay M, Johnson NB, Lauwers GY, Deshpande V. Is Autoimmune Pancreatitis associated with an Increased Risk of Malignancy? A Retrospective and Comparative Study. Modern Pathology, Volume 23, Supplement 1, January 2010, p.356A.

Johnson MM, Dialani V and Johnson NB. Histologic Characteristics of Benign Breast Lesions Identified for Biopsy by Magnetic Resonance Imaging; United States and Canadian Academy of Pathology National Conference; 2010, Washington, DC.

Johnson NB, Johnson MM, Selig MK and Nielsen GP. Use of Electron Microscopy in Core Biopsy Diagnosis of Oncocytic Renal Tumors. Ultrastructural Pathology, 2010; 34(4): 189-94.

Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, and Overholtzer M. A Non-genetic Route to Aneuploidy in Human Cancers. Nature Cell Biology, 2011; 13(3): 324-30.

Johnson NB, Collins LC. Less common variants and mimics of ductal carcinoma in-situ. Surgical Pathology Clinics, Breast Pathology, in press.

Olivier Kocher, MD, PhD, Staff Pathologist, Pulmonary Pathology, Associate Professor of Pathology, Harvard Medical School

Basseres DS, D'Alò F, Yeap BY, Löwenberg EC, Gonzalez DA, Yasuda H, Dayaram T, Kocher O, Godleski JJ, Richards WG, Meyerson M, Kobayashi S, Tenen DG, Halmos B, Costa DB. Frequent downregulation of the transcription factor Foxa2 in lung cancer through epigenetic silencing. Lung Cancer, 2012, 77:31-37.

Bhasin M, Huang Z, Pradhan-Nabzdyk L, Malek J, LoGerfo PJ, Contreras M, Guthrie P, Csizmadia E, Andersen N, Kocher O, Ferran C, LoGerfo FW. Temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury. PLoS ONE, 2012, 7(6):e39123.

Brill A, Yesilaltay A, De Meyer, SF, Kisucka J, Fuchs TA, Kocher O, Krieger M, Wagner DD. Extrahepatic high-density lipoprotein receptor SR-BI and apoA-1 protect against deep vein thrombosis in mice. Arterioscler Thromb Vasc Biol. 2012, 32:1841-1847.

Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, Kocher O, Brown LF, Toker A, Prendergast GC, Benjamin LE. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Res. 2013, 73:50-61.

Amabile G, Welner RS, Nombela-Arrieta C, Morena D'Alise A, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG. In Vivo Generation of Transplantable Human Hematopoietic Cells from Induced Pluripotent Stem Cells. Blood. 2013, 121:1255-1264.

Birrane G, Mulvaney EP, Pal R, Kinsella BT, Kocher O. Molecular Analysis of the Prostacyclin Receptor’s Interaction with the PDZ1 Domain of its Adaptor Protein PDZK1. PLoS ONE 2013, 8:e53819.

Tsukamoto K, Wales TE, Daniels K, Pal R, Sheng R, Cho W, Stafford W, Engen JR, Krieger M and Kocher O. Non-Canonical Role of the PDZ4 domain of the Adaptor Protein PDZK1 in the Regulation of the Hepatic HDL receptor SR-BI. J Biol Chem, 2013, 288:19845-19860.

Tsukamoto K, Buck L, Inman W, Griffith L, Kocher O, and Krieger M. Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1. PLoS ONE, 2013, in press.

Yael Kushner, MD, Staff Pathologist, Director, Quality Assurance and Quality Improvement, Instructor in Pathology, Harvard Medical School

Kushner YB, Brimo F, Schwartzman K, Auger M. A rare case of cryptococcal pulmonary inflammatory myofibroblastic tumour diagnosed by fine needle aspiration cytology. Diagnostic Cytopathology 2010; 38:447-451.

Rio Frio T, Lavoie J, Hamel N, Geyer FC, Kushner YB, Novak DJ, Wark L, Capelli C, Reis-Filho JS, Mai S, Pastinen T, Tischkowitz MD, Marcus VA, Foulkes WD. Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia. N Engl J Med. 2010 Dec 30;363(27):2628-37.

Varma MC, Kushner YB, Ko DSC, Kawai T, Martins PN, Kaur P, Markmann JF, Kotton CN. Early Onset Adenovirus Infection after Simultaneous Kidney-Pancreas Transplant: Report of a Case. Am J Transplant 2011 Mar;11(3):623-7

Osher D, Kushner YB, Arseneau J, Foulkes WD. Melphalan as a Treatment for BRCA1-related Ovarian Carcinoma: can you teach an old drug new tricks? Journal of Clinical Pathology 2011 Oct;64(10):924-6.

Bazari H, Kushner YB, Guimaraes AR et al. Case Records of the Massachusetts General Hospital: A 77 year old man with leg edema, hematuria, and acute renal failure. N Eng J Med (in press)

Glassock RJ, Kushner YB, Khorashadi L et al. Case Records of the Massachusetts General Hospital: A 34 year old man with dyspnea, anemia, and renal failure. N Eng J Med (in press)

Randhawa P, Chanl S, Climenhaga J, Zeng G, Regele H, Kushner YB, Colvin RB, Mengel M. The Banff Initiative on Quality Assurance in Transplantation (BIFQUIT): Proficiency Testing of Immunohistochemistry for Polyomavirus BK Antigens in Renal Allograft Tissue. (in progress)

Kushner YB, Malik FA, Holmes RK, Collins AB, Smith RN, Colvin RB. Glomerular Endothelial Injury in Patients with Non-Renal Transplants: Are We Missing Subclinical Thrombotic Microangiopathy? Modern Pathology Feb 2011; 24(Suppl 1):347A.

Kushner YB, Colvin RB. Pathology of Chronic Rejection, in Organ Transplantation: A Clinical Guide, Klein A, Lewis C and Madsen J, Eds, Cambridge University Press. (in press)

Douglas I Lin, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Lin DI, Lessie MD, Gladden AB, Bassing CH, Wagner KU, Diehl JA. Disruption of cyclin Dl nuclear export and proteolysis accelerates mammary carcinogenesis. Oncogene.2008 Feb 21;27(9):1231-42.

Lin DI, Aggarwal P, Diehl JA. Phosphorylation of MCM3 on Serl12 regulates its incorporation into the MCM2-7 complex. PNAS 2008 June 10; 105(23): 8079-8084.

Nguyen PL, Lin DI, Lei J, Fiorentino M, Mueller E, Weinstein MH, Pagano M, Loda M. The impact of Skp2 overexpression on recurrence-free survival following radical prostatectomy. Urol Oncol. 2011 May - Jun;29(3):302-8.

Robert Najarian, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Fang D, Das KM, Cao W, Malhotra U, Triadafilopoulos G, Najarian RM et al. Barrett’s esophagus: progression to adenocarcinoma and markers. Ann NY Acad Sci 2011 Sep; 1232(1): 210-229.

Roshan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R, Goldsmith J, Tariq S, Schuppan D, Kelly CP. The incidence and clinical spectrum of refractory celiac disease in a North American referral center. Am J Gastroenterol 2011 May; 106(5):923-8.

Jamma S, Leffler DA, Dennis M, Najarian RM, Schuppan DB, Sheth S, Kelly CP. Small intestinal release mesalamine for treatment of refractory celiac disease type 1. J Clin Gastroenterol 2011 Jan; 45(1):30-3.

Genega EM, Ghebremichael M, Najarian R. et al. Carbonic Anhydrase IX expression in renal neoplasms: Correlation with tumor type and grade. Am J Clin Pathol 2010:134 (6): 873-879.

Warner J, Najarian R, Tierney L. Uses and misuses of thresholds in diagnostic decision making. Academic Medicine 2010;85(3):556-563.

Jamma S, Rubio-Tapia A, Kelly CP, Murray J, Sheth S, Schuppan D, Dennis M, Najarian RM, Leffler DA. Celiac crisis is a rare but serious complication of celiac disease in adults. Clin Gastroenterol Hepatol 2010; 8(7):587-90.

Najarian RM, Hait EJ, Leichtner AM, Glickman JN, Antonioli DA, Goldsmith JD. Clinical significance of colonic intraepithelial lymphocytosis in the pediatric population. Modern Pathology 2009; 22: 13-20.

Imad Nasser, MD, Staff Pathologist Surgical Pathology, Liver Pathology and Cytopathology; Assistant Professor of Pathology, Harvard Medical School

Becker L, Salameh W, Sferruzza A, Zhang K, Chen R, Malik R, Reitz R, Nasser I, Afdhal NH. Validation of Hepascore, compared to simple indices of fibrosis, in US patients with chronic hepatitis C virus infection. Clin Gastroenterol Hepatol. 2009 Jan 24.

Pihlajamäki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME. Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab. 2009 Sep;94(9):3521-9. Epub 2009 Jun 23.

Becker L, Salameh W, Sferruzza A, Zhang K, ng Chen R, Malik R, Reitz R, Nasser I, Afdhal NH. Validation of hepascore, compared with simple indices of with chronic hepatitis C virus infection in United States.fibrosis, in patients. Clin Gastroenterol Hepatol. 2009 Jun;7(6):696-701.

Malik R, Chang M, Bhaskar K, Nasser I, Curry M, Schuppan D, Byrnes V, Afdhal N. The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN liver biopsy scoring system in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2009 Apr;24(4):564-8.

Malik R, Lai M, Sadiq A, Farnan R, Mehta S, Nasser I, Challies T, Schuppan D, Afdhal N. Comparison of transient elastography, serum markers and clinical signs for the diagnosis of compensated cirrhosis.J Gastroenterol Hepatol. 2010 Sep;25(9):1562-8.

Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F,Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME. Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metab. 2011 Aug 3;14(2):208-18.

Shaoyong L, Vriend LM, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley M, Alatrakchi. A Hepatitis C Virus-Specific T cell-Derived Transforming Growth Factor beta is Associated with Slow Hepatic. Submitted for publication.

Chui PC, Nasser IA, Fisher fM Popov Y, Kharitonenkov A, Schuppan D, Flier JS, Maratos-Flier E. Fibroblast growth factor 21 plays a critical and protective role in the development of steatohepatitis in mice. Submitted for publication.

Nandy N, Rogers C, Nasser I, Challies TL, Karp S, Johnson S, Hanto D, Curry MP. Impact Of Sirolimus Based Immunosuppression On Fibrosis Progression In Hcv Liver Transplant Recipients Hepatology, Volume 52, Number 4 (Suppl) AASLD Abstracts 395A, 2010.

Michiya Nishino, MD, PhD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Nishino M and Pitman MB. Undifferentiated carcinoma with osteoclast-type giant cells of the pancreas (cytological aspects). In Encyclopedia of Pathology, J.H.J.M. van Krieken (ed.). Springer, accepted for publication.

Nishino M, Klepeis VE, Yeap BY, Bergethon K, Morales-Oyarvide V, Dias-Santagata D, Yagi Y, Mark EJ, Iafrate AJ, and Mino-Kenudson M. Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas. Modern Pathology 2012; 25:1462-1472.

Corcoran RB, Ebi H, Turke AB, Coffee EM, Nishino M, Cogdill AP, Brown RD, Della Pelle P, Dias-Santagata D, Hung KE, Flaherty KT, Piris A, Wargo JA, Settleman J, Mino-Kenudson M, Engelman JA. EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discovery 2012; 2(3):227-235.

Jian PY, Godoy G, Coburn M, Lynch G, Ro JY, Zhai QJ, Nishino M, and Lerner SP. Adenocarcinoma following urinary diversion. Canadian Urologic Association Journal 2012; 6(2): E77-E80.

Kotton DN, Muse VV, and Nishino M. Case 2-2012: A 63-year-old woman with dyspnea and rapidly progressive respiratory failure. New England Journal of Medicine 2012; 366:259-269.
Nishino M, Medoff BD, Mark EJ, Matsubara O, O’Donnell WJ, Currier PF, and Kradin RL. Variant alveolar lipoproteinosis: A syndrome with distinct clinical and pathologic features. Pathology International 2011; 61(9):509-517.

Rolf Pfannl, MD, Associate Residency Program Director, Associate Director, Longwood Neuropathology Training Program, Assistant Professor of Pathology, Harvard Medical School

Bagci T, Wu JK, Pfannl R, Ilag LL, Jay DG. Autocrine semaphorin 3A signaling promotes glioblastoma dispersal. Oncogene. 28(40):3537-50, 2009 Oct 8. Epub 2009 Aug 17.

Hwang SW, Abozed MM, Hale A, Eisenberg RL, Dvorak T, Yao K, Pfannl R, Mignano J, Zhu JJ, Price LL, Strauss GM, Wu JK. Adjuvant Gamma Knife radiosurgery following surgical resection of brain metastases: a 9-year retrospective cohort study. J Neurooncol. 2010 May;98(1):77-82. Epub 2009 Nov 12.

Lang T, Laver N, Strominger MB, Witking A, Pfannl R, Alroy J. Morphological findings of extraocular myopathy with chronic progressive external ophthalmoplegia. Ultrastruct Pathol. 34(2):78-81, 2010 Apr.

Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL. Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature. American Journal of Surgical Pathology. 34(3):385-92, 2010 Mar.

Joseph Alroy, Rolf Pfannl. Electron Microscopic Finding in Skin Biopsies from Patients with Danon Disease. Ultrastruct Pathol. 2010 Dec;34(6):333-6.

Aurelio Hernandez Lain, Andrew P. Lieberman, Rolf Pfannl and E. Tessa Hedley-Whyte. Nodular bilateral amygdala degeneration in demented individuals. Acta Neuropathol. 2010 Nov;120(5):683-8. Epub 2010 Sep 14.

Hirano Body-like Structures in Alpaca. Veterinary Pathology, 2011

William R. Miele, Rolf. Pfannl, James T. Kryzanski. Primary Holocord Ganglio-neuroblastoma. Journal of Neurosurgery: Spine, 2011.

Jaime Acquaviva, Hyun Jung Jun, Rolando Ruiz, Julie Lessard, Haihao Zhu, Melissa Donovan, Steve Woolfenden, Abraham Boskovitz, Ami Raval, Roderick T. Bronson, Rolf Pfannl, Charles A. Whittaker, David E. Housman and Al Charest. Chronic Activation of Wild Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation. Cancer Research, 2011

Seymour Rosen, MD, Staff Pathologist, Director of Surgical, Renal, and Genitourinary Pathology, Professor of Pathology, Harvard Medical School

Rosen S Stillman IE. Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation. J Am Soc Nephrol (2008 May) 19(5):871-5.

Rosenberger C Rosen S Shina A Frei U Eckardt KU Flippin LA Arend M Klaus SJ Heyman SN. Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Nephrol Dial Transplant (2008 Nov) 23(11):3472-8.

Rosenberger C Goldfarb M Shina A Bachmann S Frei U Eckardt KU Schrader T Rosen S Heyman SN. Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant (2008 Apr) 23(4):1135-43.

Heyman SN, Rosen S, Rosenberger C. Renal parenchymal hypoxia, hypoxia adaptation, and the pathogenesis of radiocontrast nephropathy. Clin J Am Soc Nephrol (2008 Jan) 3(1):288-96.

Rosenberger C Rosen S Paliege A Heyman SN Pimonidazole adduct immunohistochemistry in the rat kidney: detection of tissue hypoxia. Methods Mol Biol (2009) 466:161-74.

Heyman SN, Rosenberger C, Rosen S. Experimental ischemia-reperfusion: biases and myths-the proximal vs.distal hypoxic tubular injury debate revisited. Kidney Int (2010 Jan) 77(1):9-16.

Heyman SN, Rosen S, Khamaisi M Idee JM Rosenberger C Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy.Invest Radiol (2010 Apr) 45(4):188-95.

Nicksa GA, O'Neil E, Yu DC, Curatolo AS, McNeish BL, Barnewolt CE, Zurakowski D, Buchmiller TL, Moses MA, Rosen S, Fauza DO. Correlation between prenatal urinary matrix metalloproteinase activity and the degree of kidney damage in a large animal model of congenital obstructive uropathy. J Pediatr Surg (2010 Jun) 45(6):1120-5.

O'Neill EB, Nicksa GA, Yu, DC, Curatolo AS, McNeish BL, Barnewolt CE, Buchmiller TL, Zurakowski D, Moses MA, Rosen S, Fauza D. Fetal ovine congenital obstructive uropathy: Morphological observations and correlation with metalloproteinase activity. USCAP 2010.

Jeffrey E. Saffitz, MD, PhD, Chief of Pathology, Mallinckrodt Distinguished Professor of Pathology, Harvard Medical School

Gehmlich K, Syrris P, Peskett E, Evans A, Ehler E, Asimaki A, Anastasakis A, Tsatsopoulou A, Vouliotis AI, Stefanadis C, Saffitz JE, Protonotarios N, McKenna WJ: Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. Cardiovasc Res, 2011, 90:77-87.

Gehmlick K, Lambiase PD, Asimaki A, Ciaccio EJ, Ehler E, Syrris P, Saffitz JE, McKenna WJ: A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions. Heart Rhythm, 2011; 8:711-718.

Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Bodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW, Nichols CG, Semenkovich CF: Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem, 2011; 286:30949-30961

Asimaki A, Tandri H, Duffy ER, Winterfield JR, Mackey-Bojack S, Picken MM, Cooper LT, Wilber DJ, Marcus FI, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, Stevenson WG, McKenna WJ, Gautam S, Remick DG, Calkins H, Saffitz JE: Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy. Circ Arrhythm Electrophysiol, 2011; 4:743-752.

Asimaki A, Saffitz JE: The role of endomyocardial biopsy in ARVC: Looking beyond histology in search of new diagnostic markers. J Cardiovasc Electrophysiol, 22:111-117, 2011.

Saffitz JE: The pathobiology of arrhythmogenic cardiomyopathy. Annu Rev Pathol, 6:299-321, 2011.

Saffitz JE: “The Heart” in: Rubin’s Pathology, Rubin R and Strayer DS (eds), 6th Edition, Lippincott, Williams and Wilkins, Philadelphia, 2011; pp 479-536.

Asimaki A, Saffitz JE: Gap junctions and arrhythmogenic cardiomyopathy. Heart Rhythm, 2011.

Huang H, Asimaki A, Marcus F, Saffitz JE: Mechano-electrical coupling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. in: Cardiac Mechano-Electrical Coupling and Arrhythmias, 2nd Ed, P. Kohl, F. Sachs, M.R. Franz, Eds, Oxford Univ Press, Oxford, UK, 2011, pp 407-411.

Tonellato PJ, Crawford JM, Boguski MS, Saffitz JE: A national agenda for the future of pathology in personalized medicine. Report of the proceedings of a meeting at the Banbury Conference Center: Genome-Era pathology, precision diagnostics and pre-emptive care: A stakeholder summit. Am J Clin Path, 2011; 135:668-672.

Van Norstrand DW, Asimaki A, Rubinos C, Dolmatova E, Srinivas M, Tester DJ, Saffitz JE, Duffy HS, Ackerman MJ: Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death. Circulation, 2012; 125:474-481.

Leone O, Veinot JP, Angelini A, Baandrup UT, Basso C, Berry G, Bruneval P, Burke M, Butany J, Calabrese F, d’Amati G, Edwards WD, Fallon JT, Fishbein MC, Gallagher PJ, Halushka MK, McManus B, Pucci A, Rodriguez ER, Saffitz JE, Sheppard MN, Steenbergen C, Stone JR, Tan C, Thiene G, van der Wal AC, Winters GL: 2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol, 2012.

Saffitz JE: Genomic pathology: a disruptive innovation. Personalized Medicine, 2012.

Stuart J. Schnitt, MD, Director, Division of Anatomic Pathology; Professor of Pathology, Harvard Medical School

Su X, Colditz GA, Willett WC, Collins LC, Schnitt SJ, Connolly JL, Pollak MN, Rosner B, Tamimi RM. Genetic variation and circulating levels of IGF-1 and IGFBP-3 in relation to risk of proliferative benign breast disease. In J Cancer 2010;126:180-190.

Tung N, Wang Y, Collins LC, Kaplan J, Li H, Gelman R, Comander A, Gallagher B, Fetten K, Krag K, Stoeckert K, Legare RD, Sgroi D, Garber JE, Schnitt SJ. Estrogen receptor positive breast cancers in BRCA1 mutation carriers: Clinical risk factors and pathologic features. Breast Cancer Res 2010;12:R12.

Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations myoepithelial cells associated with benign sclerosing lesions of the breast. Am J Surg Pathol 2010;34:896-900.

Haque R, Achacoso NS, Fletcher SW, Nekhlyudov L, Collins LC, Schnitt SJ, Quesenberry CP, Habel LA. Treatment of ductal carcinoma in situ among patients in large integrated health plans. Am J Manag Care. 2010 May;16(5):351-60.

Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA.High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18378-83. Epub 2011 Oct 31.

Robens J, Goldstein L, Gown AM, Schnitt SJ. Thyroid transcription factor-1 expression in breast carcinomas. Am J Surg Pathol. 2010 Dec;34(12):1881-5.

Su X, Colditz GA, Collins LC, Baer HJ, Sampson LA, Willett WC, Berkey CS, Schnitt SJ, Connolly JL, Rosner BA, Tamimi RM. Adolescent intakes of vitamin D and calcium and incidence of proliferative benign breast disease.. Breast Cancer Res Treat. 2012 Jul;134(2):783-91. Epub 2012 May 24.

Aroner SA, Collins LC, Schnitt SJ, Connolly JL, Colditz GA, Tamimi RM. Columnar cell lesions and subsequent breast cancer risk: A nested case-control study. Breast Cancer Research (in press).

Kaplan JS, Schnitt SJ, Collins LC, Wang Y, Garber JE, Montgomery K, West RB, Krag K, Fetten K, Lincoln A, Tung NM. Pathologic Features and Immunophenotype of Estrogen Receptor-positive Breast Cancers in BRCA1 Mutation Carriers. Am J Surg Pathol. 2012 Oct;36(10):1483-8.

Liu Y, Tamimi RM, Berkey CS, Willett WC, Collins LC, Schnitt SJ, Connolly JL, Colditz GA. Intakes of alcohol and folate during adolescence and risk of proliferative benign breast disease. Pediatrics. 2012 May;129(5):e1192-8. Epub 2012 Apr 9.

Liu Y, Colditz GA, Rosner B, Berkey CS, Collins LC, Schnitt SJ, Connolly JL, Chen WY, Willett WC, Tamimi RM. Alcohol Intake Between Menarche and First Pregnancy: A Prospective Study of Breast Cancer Risk. J Natl Cancer Inst. 2013 Aug 28. [Epub ahead of print]

Isaac E. Stillman, MD, Staff Pathologist, Renal Pathology, Director, Clinical Electron Microscopy, Associate Professor of Pathology, Harvard Medical School

Xu Y, Zhang Z, Hu J, Stillman IE, Leopold JA, Handy DE, Loscalzo J, Stanton RC.Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J 2010 Feb;24(2):609-16.

Kanter D, Lindheimer MD, Wang E, Borromeo RG, Bousfield E, Karumanchi SA, Stillman, IE. Angiogenic dysfunction in molar pregnancy. Am J Obstet Gynecol 2010 Feb;202(2):184.e1-5

Rovin BH, Stillman IE. The Kidney in Systemic Lupus Erythematosus in Systemic Lupus Erythematosus, 5TH Edition, Elsevier. Edited by R Lahita, 2011.

Silasi, M. Rana, S. Powe, C. Cohen, B. Lim, K. H. Zsengeller, Z. K. Karumanchi, S. A. Stillman, IE. Placental expression of angiogenic factors in Trisomy 13. Am J Obstet Gynecol 2011 Jun;204(6):546.e1-4. Epub 2011 Apr 20.

Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM. PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest (2011 Oct) 121(10):4003-14.

Mukhopadhyay P, Horváth B, Zsengellér Z, Zielonka J, Tanchian G; Holovac, E; Kechrid M, Patel V, Stillman IE, Parikh SM, Joseph J, Kalyanaraman B, Pacher P. Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy. Free Radical Biology & Medicine. 2012 Jan 15;52(2):497-506. Epub 2011 Nov 10.

Hasnain W, Stillman IE, Bayliss GP. Minimal-change renal disease and Graves’ disease: a case report and literature review. NDT Plus 2011 4:2 96-98.

Bixel K, Silasi M, Zelop CM, Lim K, Zsengeller Z, Stillman IE, Rana S. Placental Origins of Angiogenic Dysfunction in Mirror Syndrome. Hypertension in Pregnancy, Early Online:1–7, 2011

Stillman IE, Karumanchi SA. Vasculitis is an antiangiogenic state. J Am Soc Nephrol 2012 Jan; 23(1):8-10. Epub 2011 Dec 15.

Rajakumar A, Cerdeira A, Hubel CA, Jeyabalan A, Rana S, Zsengellér Z, Stillman IE, Parikh SM, Karumanchi, S. A. Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating sFlt1 in preeclampsia. Hypertension. 2012 Feb;59(2):256-64.

Zsengellér Z, Ellezian L, Brown D, Horváth B, Mukhopadhyay P, Kalyanaraman B, Parikh SM, Karumanchi SA, Stillman IE, and Pacher P. Cisplatin nephrotoxicity involves mitochondrial injury with impaired tubular mitochondrial enzyme activity. J Histochem Cytochem, 2012 Jul;60(7).

Mukhopadhyay P, Horvath B, Zsengeller Z, Batkai S, Cao Z, Kechrid M, Holovac E, Erdelyi K, Tanchian G, Liaudet L, Stillman IE, Joseph J, Kalyanaraman B, Pacher P. Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion: therapeutic potential of mitochondrially-targeted antioxidants. Free Radical Biology & Medicine, 2012 Jun 6. [Epub ahead of print]

McMahon G, Datta D, Bruneau S, Kann M, Khalid M, Ho J, Seto T, Kreidberg JA, Stillman IE, Briscoe DM. Constitutive activation of the mTOR signaling pathway within the normal glomerulus. Biochem Biophys Res Commun. 2012 Jul 22. [Epub ahead of print]

Steven R. Tahan, MD, Director of Dermatopathology, Associate Professor of Pathology, Harvard Medical School

Hoang MP, Duncan LM, Mihm MC, Murphy GF, Tahan SR. Mimicry in Melanocytic Lesions. Brisbane: Knowledge Books and Software Publishing, 2010.

Fox M, Tahan SR, and Kim CC. Livedo Reticularis: A Side Effect of Interferon Therapy in a Pediatric Melanoma Patient. Pediatric Dermatol 2011 May 16.

Hoang MP, Duncan LM, Mihm MC, Murphy GF, Tahan SR. Cutaneous Infections and Infestations. Brisbane: Knowledge Books and Software Publishing, 2011.

Shalin S, Ward A, Patel R, Misialek M, Tahan SR, Sepehr A. Aggressive Digital Papillary Adenocarcinoma: ASDP October 2011.

Haws AL, Rafael Rojano, Tahan SR, Phung TL: Accuracy of Biopsy Sampling for Subtyping Basal Cell Carcinoma. J Am Acad Dermatol. 2012 Jan;66(1):106-11.

Hsu SW, Tahan SR, and Kim, CC. Follicular Malignant Melanoma: A Case Report of a Metastatic Variant and Review of the Literature. J Am Acad Dermatol 64 (2011), pp. 1007-1010.

Kaplan J and Tahan SR. Nevi with Epithelioid Cytomorphology and Architectural Disorder (NECAD). USCAP 2012.

Freiling G, Ahern T, and Tahan SR. Accuracy of the Measured Depth of Histologic Sections Compared to the Gross Specimen Measurement. USCAP 2012.

Varmeh S, Egia A, McGrouther D, Tahan SR, Bayat A, and Pandolfi PP. Cellular Senescence as a Possible Mechanism for Halting Progression of Keloid Lesions. Genes and Cancer 2012.

LaTowsky BC, Abbasi N, Dover JS, Arndt KA, MD, Kaminer M, Rohrer TE, MacGregor JL, Wesley NO, Durfee MA, and Tahan SR. A Randomized, Controlled Trial of Four Ablative Fractionated Lasers for Photoaging: A Quadrant Study. Dermatol Surg. 2012 Sep;38(9):1477-89. doi: 10.1111/j.1524-4725.2012.02500.x. Epub 2012 Jul 20.

Roujeau JC, Mockenhaupt M, Tahan SR, Henshaw J, Martin EC, Harding M, van Baelen B, Bengtsson L, Singhal P, Kauffman RS, Stern RS. Telaprevir-Related Dermatitis. Arch Dermatol. 2012 Nov 19:1-7. doi: 0.1001/jamadermatol.2013.938.

Frieling G, Velez N, Tahan SR, Burgin S. Isolated painful onycholysis in a 40-year-old woman with Crohn's disease. Int J Dermatol. 2013 Feb 22. doi: 10.1111/j.1365-4632.2012.05705.x.

Paul A. VanderLaan, MD, PhD, Staff Pathologist, Instructor in Pathology, HMS

VanderLaan PA, Marqusee E, Krane JF. Clinical outcome for atypia of undetermined significance in thyroid fine-needle aspirations: Should repeat FNA be the preferred initial approach? Am J Clin Pathol. 2011;135:770-775.

VanderLaan PA, Marqusee E, Krane JF. Usefulness of diagnostic qualifiers for thyroid fine-needle aspirations with atypia of undetermined significance. Am J Clin Pathol. 2011;136:572-557.

VanderLaan PA, Krane JF, Cibas ES. The Frequency of “Atypia of Undetermined Significance” Interpretations for Thyroid FNAs is Negatively Correlated with Histologically Proven Malignant Outcome. Acta Cytol. 2011;55:512-517.

Jo VY, VanderLaan PA, Marqusee E, Krane JF. Repeatedly Nondiagnostic Thyroid Needle Aspirations Do Not Modify Malignancy Risk. Acta Cytol. 2011;55:539-543.

Getz GS, VanderLaan PA, Reardon CA. Natural killer T cells in lipoprotein metabolism and atherosclerosis. Thromb Haemost. 2011;106:814-819.

Krane JF, VanderLaan PA, Faquin WC, Renshaw AA. The atypia of undetermined significance/follicular lesion of undetermined significance: Malignant ratio: A Proposed Performance Measure for Reporting in The Bethesda System for Thyroid Cytopathology. Cancer Cytopathol. 2012;120:111-116

VanderLaan PA, Renshaw AA, Krane JF. Atypia of Undetermined Significance and Nondiagnostic Rates in the Bethesda System for Reporting Thyroid Cytopathology are Inversely Related. Am J Clin Pathol. 2012;137:462-465.

Vanderlaan PA, Marqusee E, Krane JF. Features associated with locoregional spread of papillary carcinoma correlate with diagnostic category in the Bethesda System for reporting thyroid cytopathology. Cancer Cytopathol. 2012.

VanderLaan PA, Padera RF, Schoen FJ. Practical approach to the evaluation of prosthetic mechanical and tissue replacement heart valves. In: Current Concepts in Cardiovascular Pathology. Surgical Pathology Clinics Volume 5, Number 2, June 2012: pages 353-369.

Srivastava N, Vanderlaan PA, Kelly CP, Costa DB. Esophagitis: A Novel Adverse Event of Crizotinib in a Patient with ALK-Positive Non-Small-Cell Lung Cancer. J Thorac Oncol. 2013;8:e23-4.

Hamaji M, Vanderlaan PA, Sugarbaker DJ, McNamee CJ. A microthymoma and no germinal centre in myasthenia gravis. Eur J Cardiothorac Surg. 2013 Apr 15.

Helen H. Wang, MD, MPH, DrPH, Medical Director of Cytology, Associate Professor of Pathology, Harvard Medical School

Azabdaftari G, Goldberg SN, Wang HH. Efficacy of on-site specimen adequacy evaluation of image-guided fine and core needle biopsies. Acta Cytol 2010;54:132-137.

Singh RS, Hecht JL, Wang HH. Utility of repeat thyroid FNA in the management of patients with thyroid nodules. Mod Pathol 2010;23(supplement 1):105A.

Coco, DP, Goldblum JR, Hornick JL, Lauwers GY, Montgomery E, Srivastava A, Wang HH, and Odze RD. Interobserver variability in the diagnosis of crypt dysplasia in Barrett’s esophagus. Am J Surg Pathol, 2011;35:45-54.

Gupta NJ and Wang HH. Increase of core biopsies in visceral organs – experience at one institution. Diagn Cytopathol, in print.

Soucy G, Wang HH, Farraye FA, Schmidt J, Farris AB, Lauwers G, Cerda S, Dendrinos K, Odze RD. Clinical and pathological analysis of colonic Crohn’s disease, including a subgroup with ulcerative colitis-like features. Mod Pathol, in print.

Singh SR, Wang HH. Eliminating the “Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance” category from the Bethesda System for Reporting Thyroid Cytopathology. Am J Clin Pathol, in print.

Kindelberger DW, Wang HH. Gastrointestinal tract. In: Cibas ES and Ducatman BS, eds. Cytology. Diagnostic Principles and Clinical Correlates, 3rd Edition. Philadelphia: Saunders-Elsevier; 2009.p.197-220. June 1, 2011 25

Wang HH, Filie AC, Clark DP, Powers CN. Suspicious for malignancy. In: Ali SZ, Cibas ES, eds. The Bethesda System for Reporting Thyroid Cytopathology. Definitions, Criteria and Explanatory Notes. New York: Spinger; 2010.p.75-89.

Samedi V, White S, Zimarowski MJ, Harris A, Saffitz J, Wang HH. Metastatic peritoneal mesothelioma in the setting of recurrent ascites: A Case Report. Diagn Cytopathol 2010;38:675-81.

Singh RS, Wang HH. Timing of repeat thyroid FNA in the management of thyroid nodules. Mod Pathol 2011;24(supplement 1): 105A.

Hagen C, Najarian R, Wang H, Levine J, Siegel C, Levy C, Burakoff, R, Odze R, and Srivastava A. Histologic outcome after treatment in collagenous colitis: A long tem outcome study of 50 patients. Mod Pathol 2011;24(supplement 1):151A.

Huihui Ye, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Ye H, Kong T, He TW, Jolis T, Lepor H, Melamed J. Intraoperative frozen section analysis of apical margin biopsies during radical prostatectomy: ten year experience from a single institution. Urology. 2011 Aug;78(2):399-404. Epub 2011 May 31.

Ye H, Ulbright T. Difficult differential diagnoses in testicular pathology. Arch Pathol Lab Med. 2012 Apr;136(4):435-46.

Melamed J, Lee P, Reuter V, Ye H. Molecular Genetics of Testicular Tumor. Am J Cancer Res. 2012;2(2):153-67. Epub 2012 Feb 15.

Sowalsky A, Ye H, Bubley G, Balk S. Clonal Origin of Gleason Pattern 3 and 4 Prostatic Cancers. Cancer Res. 2013 Feb 1;73(3):1050-5. Epub 2012 Nov 30.

Taplin ME,Ye H,Kantoff PW. Neoadjuvant Abiraterone Acetate Plus Leuprolide Acetate Reduces Intra-Prostatic Androgens and Generates Significant Pathologic Responses in Patients With Localized High-Risk Prostate Cancer: Results of a Randomized Phase 2 Study (manuscript in preparation).

Quintana LM, Ward A, Gerrin S, Genega E, Ye H. Utility of Saturation Biopsy in Detection of Aggressive Prostate Cancer (manuscript in preparation).

Ward A, Sowalsky A, Quintana LM, Balk S, Ye H. Molecular and Immunohistochemical Characterization of Aggressive Gleason Pattern 3 Prostate Cancer (manuscript in preparation).

Sowalsky A, Ye H, Bubley G, Balk S. Intratumor Heterogeneity of Prostatic Cancers Revealed by Whole Exome Genomic Sequencing (manuscript in preparation).

Eric Yee, MD, Staff Pathologist, Instructor in Pathology, Harvard Medical School

Yee, E; Zaino, R; Torkko, K; Shroyer, K. “B7-H4 expression in Brenner Tumors, a Descriptive and Comparative Study.” Histopathology, Apr 2010; 56(5): 652-4.

Klempner, S; Choueiri, T; Yee, E; Doyle, L; Schuppan, D; Atkins, M. "Severe Pazopanib-Induced Hepatotoxicity: Clinical and Histologic Course in 2 Patients." Journal of Clinical Oncology. Vol. 30. July 2012.

Yee, E; Berg, A. "Can 2,3-butanediol levels help distinguish chronic alcoholics from occasional drinkers?" Clinical Chemistry, July 2011 Abstract and Poster Presentation.

Allard FD, Yee EU, Freitag SK. Dacryocystitis Secondary to Intranasal Cocaine Abuse: A Case Report and Literature Review. Orbit. 2013 Aug 2. [Epub ahead of print]

Mary Jane Zimarowski, MD, Staff Pathologist, Dermatopathology and Surgical Pathology, Instructor in Pathology, Harvard Medical School

Samedi, V., White, S., Zimarowski, M., Harris, A., Saffitz, J., Wang, H. Metastatic Peritoneal Mesothelioma in the Setting of Recurrent Ascites: A Case Report, Diagn Cytopathol. 2010 Sep;38(9):675-81.

Harris A, Faulkner-Jones BF, Zimarowski MJ. Epidermal Panfolliculoma: A report of two cases. Am J Dermatopathol. 2011 Feb;33(1):e7-10.

Chan MP, Zimarowski MJ. Lupus erythematosus-like reaction in imiquimod-treated skin: a report of two cases. Am J Dermatopathol. 2011 Jul;33(5):523-7.

Sheikine Y, Hawryluk EB, Burgin S, Zimarowski MJ. Histopathology of measles exanthem: a case with characteristic features and eosinophils. J Cutan Pathol. 2012 Jul;39(7):667-70. doi: 10.1111/j.1600-0560.2012.01935_1.x. No abstract available.

Gee SN, Harris AC, Zimarowski MJ. Churg-Strauss syndrome presenting as scar reactivation: histopathologic features and an illustration of “locus minoris resistentiae”. J Cutan Pathol. 2013 May;40(5):491-6. doi: 10.1111/cup.12099.

Shalin SC, Cukras A, Zimarowski MJ. Granular Parakeratosis Mimicking Pustular Psoriasis: An Unusual Presentation. Poster presentation at the 48th Annual Meeting of The American Society of Dermatopathology (ASDP), 2011.

FACULTY AND SELECTED PUBLICATIONS
CLINICAL PATHOLOGY

Ramy A. Arnaout, MD, PhD, Associate Director, Clinical Microbiology, Assistant Professor of Pathology, Harvard Medical School

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE. A curriculum in genomics and personalized medicine for pathology residents. Am J Clin Pathol. 2010; 133: online supplement.

Patil P, Heus H, Arnaout R, and Tonellato PJ. Refining a method for processing an individual’s whole genome to clinical utility. CSHL Personal Genomes Meeting, Sept. 2010. (abstract)

Buck TP, Connor IM, Horowitz GL, Arnaout RA. CallWall: tracking resident calls to improve clinical utilization of pathology laboratories. Arch Pathol Lab Med. 2011;135(7):920-4.

Arnaout R, Lee W, Cahill P, Honan T, Sparrow T, Weiand M, et al. High-resolution description of antibody heavy-chain repertoires in humans. PLoS One. 2011;6(8):e22365. PMCID: 3150326.

Arnaout RA. Big data in clinical pathology. Critical Values. 2011;4(2):15-9.

Arnaout RA, Demetri GM. Pharmacology of Hematopoietic and Immune Stimulation. In: Golan DE, Tashjian AH, Armstrong EJ, Armstrong AW, editors. In Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Third ed. New York: Lippincott, Williams, and Wilkins; 2012.

Arnaout RA, Kasmar AG, Hooper D. Pharmacology of Bacterial Infections: Cell Wall Synthesis. In: Golan DE, Tashjian AH, Armstrong EJ, Armstrong AW, editors. In Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. Third ed. New York: Lippincott, Williams, and Wilkins; 2012.

Arnaout, R. Elementary, My Dear Doctor Watson. Clinical Chemistry. 2012. 58(6):986-988

Anders Berg, MD, PhD, Assistant Director, Clinical Chemistry, Instructor in Pathology, Harvard Medical School

Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10;39(5):797-808.

Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, Wenger J, Karumanchi SA, Thadhani R, Bhan I. Vitamin D binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011 Jul;26(7):1609-16. PMID: 21416506

Berg AH. Abstract Title: Vitamin D Binding Protein Modifies the Vitamin D-Bone Mineral Density Relationship. Presented at AACC Annual Conference in 2011. Received Distinguished Abstract award from the National Academy of Clinical Biochemistry, and the Best Abstract Award from the Nutrition Division of the American Academy of Clinical Chemistry.

Parul Bhargava, MD, Medical Director, Hematology, Assistant Professor of Pathology, Harvard Medical School

Braza J, Bhargava P. A 71 Year-Old-Male Presented to the Emergency Department with Dizziness, Progressive Lethargy and Confusion for 5 Days. Images in clinical Medicine. N Eng J Med 2008; Oct 30:1941.

Braza J, Bhargava P. Medical Mystery: A 71-year-old-man with pancytopenia- The answer. N Eng J Med 2008; Dec 25:2845-46.

Tan CS, Dezube BJ, Bhargava P, Autissier P, Wuthrich C, Miller J, Koralnik IJ. Detection of JC virus DNA and proteins in bone marrow of HIV-positive and HIVnegative patients: implications for viral latency and neurotropic transformation. Journal of Infectious Diseases 2009 Feb 1 Mar 15; 199(6):881-8.

Bhargava P, and Pantanowitz L, Pinkus GS, Pinkus JL, Paessler ME, Roullet M, Gautam S, Bagg A, Kadin ME. Utility of Fascin and JunB in Distinguishing Nodular Lymphocyte Predominant from Classical Lymphocyte Rich Hodgkin Lymphoma. Applied Immunohistochemistry & Molecular Morphology 2010 Jan 18(1):16-23.

Bhargava P and Kadin ME; Chapter 5; Immunohistology of Hodgkin Lymphoma. Diagnostic Immunohistochemistry by Dabbs, 3nd edition 2010.

Bhargava P. Hemoglobinopathies. Chapter 5. Non-Neoplastic Hematopathology and Infections (in press).

Bhargava P, Sandin R, Cualing H; editor for book entitled ‘Non-Neoplastic Hematopathology and Infections’. Publisher: Wiley-Blackwell, Hoboken, NJ (in press).

Rajan Dewar, MD, PhD, Assistant Director, Hematopathology; Instructor in Pathology, Harvard Medical School

Dewar R, Chen ST, Yeckes-Rodin H, Miller K, Khosravi-Far R. Bortezomib treatment causes remission in a Ph+ ALL patient and reveals FoxO as a theranostic marker. Cancer Biol Ther. 2011 Mar 15;11(6). (Editorial Commentary & COVER PAGE ILLUSTRATION)

Dewar R, Fadare O, Gilmore H, Gown A. Best practices in diagnostic immunohistochemistry: Myoepithelial markers in breast pathology. Arch Pathol Lab Med., 2011. 135 (4): page 422-429. (COVER PAGE ILLUSTRATION)

Gilmore LC, Dewar R. Caution in Metastatic Renal Cell Carcinoma Within Lymph Nodes: PAX-2 Expression Is Also Seen in Nodal Lymphocytes. Arch Pathol Lab Med, 2011. 135 (4): page 414.

Dewar R and Khosravi-Far R. Inhibition of apoptosis in Leukemia: BCR-ABL induced leukemogenesis. In Modern Insights Into Disease From Molecules to Man: Apoptosis. Editor. Professor Victor R Preedy. 2010.

O'Connell JT, Sugimoto H, Cooke VG, MacDonald BA, Mehta AI, LeBleu VS, Dewar R, Rocha RM, Brentani RR, Resnick MB, Neilson EG, Zeisberg M, Kalluri R. VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci U S A. 2011Sep 20;108(38):16002-7.

Giardino AA, Shinagare AB, Shinagare SA, Dewar R, Weckstein D, Mauch P, Ramaiya NH, Freedman AS. Primary bone lymphoma involving bilateral tibia. Am J Hematol. 2012. 87: 924-5. 

Dewar R, Parkash V, Forrow L, Truog R. Apologies for Pathologists: Why, When and How to say Sorry after committing a medical error. Int. J Surg. Pathol. 2013. May 10 [Epub ahead of print]. PMID: 23667133.

Richard Haspel, MD, PhD, Pathology Residency Training Program Director; Medical Director, Stem Cell Processing Laboratory; Assistant Professor of Pathology, Harvard Medical School

Delaney M, Haspel RL. Thawing and Infusing Cellular Therapy Products. In: Areman EM, Loper K, eds. Cellular Therapy: Principles, Methods and Regulations, 1st edition. Bethesda, MD: AABB; 2009: 375-383. 2009.

Haspel RL, Ballen KK. Cord blood transplants: perinatal stem cells in clinical practice. In: Cetrulo CL, Cetrulo KJ and Cetrulo CL, Jr, eds. Perinatal Stem Cells, 1st edition. Hoboken, NJ: John Wiley and Sons; 2009: 1-14.

O'Neill E, Richardson-Weber L, McCormack G, Uhl L, Haspel RL. Strict adherence to a blood bank specimen labeling policy by all clinical laboratories significantly reduces the incidence of "wrong blood in tube.” Am J Clin Pathol. 2009;132:164-8.

Haspel RL, Lamontagne D. Pre-thaw predictors of cord blood unit quality. Transfusion. 2010; 50: 265.

Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Brock J, Campbell S, Crookston K, Fitzgerald R, Fung M, Haspel R, et al. Educating medical students in laboratory medicine: A proposed curriculum. Am J Clin Pathol. 2010; 133: 525-8.

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE. A Call to Action: Training pathology residents in genomics and personalized medicine. Am J Clin Pathol. 2010; 133: 832-4.

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE. A curriculum in genomics and personalized medicine for pathology residents. Am J Clin Pathol. 2010; 133: online supplement.

Haspel RL. Implementation and assessment of a resident curriculum in evidence-based transfusion medicine. Arch Path Lab Med. 2010; 134: 1054-9

Perry J, Haspel R, Mohammed M, Gingerich AM, Powers A. A curious case of blue blood. Transfusion 2010; 50: 1179-80.

Delaney M, Meyer E, Cserti-Gaxdewich C, Haspel RL, Lin Y, Morris A, Pavenski K, Dzik WH, Murphy M, Slichter S, Wang G, Dumont LJ, Heddle N. A systematic assessment of the quality of reporting for platelet transfusion studies. Transfusion. 2010; 50: 2135-44.

Haspel RL, Bhargava P, Gilmore H, Kane S, Powers A, Sepehr A, Weinstein AR, Schwartzstein, RM, Roberts DH. Successful implementation of a longitudinal, integrated pathology curriculum during the third year of medical school. Arch Pathol Lab Med. 2012; 136:1430-6.

Gary L. Horowitz, MD, Medical Director, Clinical Chemistry; Associate Professor of Pathology, Harvard Medical School

Levine R, Horowitz G, Qian C, Yai Y, Epstein F, Vatten L, Kaumanchi SA (for the CPEP Study Group). Soluble sFlt1 (sFlt1), preeclampsia and hypothyproidism. 2009 Annual Meeting Society for Maternal Fetal Medicine.

Nardin RA, Zarrin AR, Horowitz GL, Tarulli AW. Effect of newly proposed CK reference limits on neuromuscular diagnosis.Muscle Nerve2009Apr;39(4):494-7.

O’Neal PB, Poylin V, Mowschenson P, Parengi A, Horowitz G, Pant P, Hasselgren PO. When initial postexcision PTH level does not fall appropriately during parathyroidectomy – what to do next? World Journal of Surgery. 2009.

Elliott RM, Horowitz GL, Fan SL. Comparison of anti-tissue transglutaminase, anti-gliadin, and antideamidated gliadin peptide serologic testing in the detection of celiac disease. Clin Chem 2009; 55:A126.

Kaplan J, Horowitz G. 24-hour Bence-Jones protein determinations: can we ensure accuracy? Clin Chem 2009; 55:A161.

Hardy LB, Fan SL, Pistorino AM, Juenke JM, McMillin GA, Horowitz GL. Ethylene glycol screening: adapting the CATACHEM enzymatic assay to minimize false positives. Clin Chem 2010; 6(Supplement):A230

Shapiro NI, Fisher C, Donnino M, Cataldo L, Tang A, Trzeciak S, Horowitz G, Wolfe RE. The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infection. J Emerg Med 2010; 39:89-94.

Horowitz GL. Estimating reference intervals.Am J Clin Pathol.2010;133;175-177.

Saxena AR, Karumanchi AS, Fan SL, Horowitz GL, Hollenberg NK, Graves SW, and Seely EW., “Correlation of Cystatin-C with Glomerular Filtration Rate by Inulin Clearance in Pregnancy,” Hypertension in Pregnancy. Hypertens Pregnancy. 2012;31(1):22-30. Epub 2011 Oct 18.

James E. Kirby, MD, Medical Director, Clinical Microbiology; Assistant Professor of Pathology, Harvard Medical School

Kirby JE, Delaney M, Qian Q, and Gold HS. Optimal Use of Myco/F Lytic and Standard BACTEC Blood Culture Bottles for Detection of Yeast and Mycobacteria. Archives of Pathology and Laboratory Medicine. 2009 Jan;133(1):93-6.

Duong S, Dezube, BJ, Desai G, Eichelberger K, Qian Q and Kirby JE. Limited Utility of Bone Marrow Culture: A Ten Year Retrospective Analysis. Laboratory Medicine. 2009. Jan 40, 37-38.

Wang Y, Kirby JE, Qian Q. Effective use of JC virus PCR for diagnosis of progressive multifocal leukoencephalopathy. J Med Microbiol. 2009 Feb;58(Pt 2):253-5.

Pollock, N., Duong, S, Cheng A; Han L, Smole, S, and Kirby, JE. Ruling out novel H1N1 influenza with direct fluorescent antigen testing. Clin Infect Dis.2009 Sep 15;49(6):e66-8.

Qian Q, Venkatamarman, L, Kirby JE, Gold HS, and Yamazumi T. Direct Detection of Methicillin Resistance in Staphylococcus aureus in Blood Culture Broth Using a Penicillin Binding Protein 2a Latex Agglutination Test. J Clin Microbiol. 2010 Apr;48(4):1420-1.

Chiaraviglio L, Duong S, Brown D, Birtles R, and Kirby, JE. 2010. An immunocompromised murine model of Bartonella infection. Am J Pathol. 2010 Apr 15. [Epub ahead of print] PubMed PMID: 20395436.

Socia SJ, Kirby JE, Washicosky KJ, Tucker SM, Burton, MA, Goldstein LE, Duong S, Tanzi RE and Moir RD. 2010. The Alzheimer 's disease-associated amyloid -protein is an antimicrobial peptide. PLoS ONE 5(3): e9505.

Cheng A, Qian Q, Kirby JE. Evaluation of the Abbott RealTime™ CT/NG assay in comparison to the Roche COBAS AMPLICOR CT/NG assay. J Clin Microbiol. 2011. Apr;49(4):1294-300. Epub 2011 Feb 16.

Bieniek R, Kirby JE, Cheng A, Eichelberger K, and Qian Q Effective Use of PCR for the Detection of Cytomegalovirus Viremia and Monitoring Therapy in Immunocompromised Patients. (2011) LabMedicine, 42, 339-343.

Anguera MC, Sadreyev R, Zhang Z, Szanto A, Payer B, Sheridan SD, Kwok S, Haggarty, SJ, Sur M, Alvarez J, Gimelbrant A, Mitalipova M, Kirby JE, Lee, JT. Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. Cell Stem Cell. 2012 11:1-16. PMCID pending.
Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, and Lee JT. Xist RNA is a potent suppressor of hematologic cancer. Cell. 2013. Feb 14;152(4):727-42. PMCID Pending.

Cheng A and Kirby JE. Evaluation of the Hologic Gen-Probe PANTHER, APTIMA Combo 2 assay in a tertiary care teaching hospital. American Journal of Clinical Pathology. In Press. 

Kerry O’Brien, MD, Staff Pathologist; Instructor in Pathology, Harvard Medical School

O’Brien KL, Champeaux AL, Sundell ZE, Short MW, Roth BJ. Transfusion medicine knowledge in postgraduate year-1 residents. Transfusion 2010;50:1649-53.

Makowski RL, Peterson DJ, O’Brien KL, Harsha WJ. Sarcoidosis of the thyroid: A case report and review of the literature. The Laryngoscope 2010;120:S41.

O’Brien KL, Pereira SE. Wagner J, Shadman M, Hendrie P, Nelson K, Gernsheimer TB, Price T, Reyes JD, Nester T. Transfusion-associated graft-versus-host disease in a liver transplant recipient: an unusual case presentation and review of the literature. Transfusion 2013;53:174-180.

J Ryan Pena, MD, PhD, Assistant Clinical Director, HLA Laboratory, Instructor in Pathology, Harvard Medical School

Peña JA, Thompson-Snipes L, Calkins P, Tatevian N, Puppi M and Finegold MJ (2009). Alterations in myeloid dendritic cell innate immune responses in the Gαi2-deficient mouse model of colitis. Inflamm Bowel Dis. Feb;15(2):248-260.

Peña JA, Pirics M, DiCaprio H, Jullapalli M, Phelps BR, Castagnini L, Tolle M. (2009). Varicella reactivation presenting as shingles and aseptic meningitis in an immunocompetent 11-year old boy. Clin Pediatr. May;48(4):435-437.

Peña JA, Lewandrowski KB, Lewandrowski EL, Gregory K, Baron JM and Van Cott EM (2012). Evaluation of the i-STAT point-of-care capillary whole blood prothrombin time and international normalized ratio: comparison to the Tcoag MDAII coagulation analyzer in the central laboratory. Clin Chim Acta. Jun;413(11-12):955-9.

Peña JA, Ferraro MJ, Hoffman CG and Branda JA. (2012). Growth detection failures by the non-radiometric BACTEC MGIT 960 mycobacterial culture system. J Clin Microbiol. Jun;50(6):2092-5.

German Pihan, MD, Director, Hematopathology; Assistant Professor of Pathology, HMS

Ke Y, Zhou Y, Chen Y, Dezube B, Pihan G. A pan-HPV assay in the era of oligovalet vaccines: An opportunity to define the impact of prevention, vaccination and therapeutic interventions in the burden of HPV-induced diseases in diverse communities (2008).

Zhou Y, Fundyler O, Miller K, Pihan G. A highly multiplexed bead microarray assay for World Health Organization disease-defining chromosomal translocations/inversions in acute myeloid leukemia (2008).

Zhou Y, Chen Y, Miller K, Pihan G. Ultrafast, High-Throughput Sequencing-by-hybridization Assay For Insertion Mutations In The Nucleophosmin 1 Gene. Leukemia (in preparation). Miller K, and Pihan G. Treatment and Evaluation of High-risk Myelodysplastic Syndrome. Clin Adv Hematology Oncology 2008, 3(6):6.

Miller K and Pihan G. CHAPTER 60: Clinical Manifestations of Acute Myeloid Leukemia. In: Hoffman et al. Hematology: Basic Principles and Practice. 5th Edition, 2008.

Miller K, and Pihan G. Treatment and Evaluation of High-risk Myelodysplastic Syndrome. Clin Adv Hematology Oncology 2008, 3(6):6.

Zota V, Braza J, Pantanowitz L, Dezube BJ, Pihan G. A 57-year-old HIV-positive man with persistent fever, weight loss, and pancytopenia. Am J Hematol. 2009 Jul;84(7):443-6.

Li L, Wang H, Kim JS, Pihan G, Boussiotis VA. The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell Cycle. 2009 Jun 1;8(11):1794-802.

Pantanowitz L, Pihan G, Carbone A, Dezube BJ. Differentiating HIV-associated non-Hodgkin lymphomas with plasmacellular differentiation. Journal HIV Therapy 2009; 14:24-33.

Qianfang Qian, MD, PhD, Associate Director, Clinical Microbiology; Assistant Professor of Pathology, Harvard Medical School

Qian Q, Venkataraman L, Kirby JE, Gold HS, Yamazumi T. Direct detection of methicillin resistance in Staphylococcus aureus in blood culture broth using a penicillin binding protein 2a latex agglutination test. J. Clin. Micro. 2010; 48: 1420-1421.

Qian Q, Kirby JE. Technical advances in laboratory diagnosis of fungal infection. (Review). J. Microbes Infect. 2010; 5(1): 2-25.

Bieniek R, Kirby JE, Cheng A, Eichelberger K, Qian Q. Effective use of PCR for the detection of cytomegalovirus viremia and monitoring therapy in immunocompromised patients. LabMedicine. 2011; 42:339-342

Cheng A, Qian Q, Kirby JE. Evaluation of the Abbott RealTimeTM CT/NG assay in comparison to the Roche COBAS AMPLICOR CT/NG assay. J. Clin. Micro. 2011; 49:1294-1300

Allard FD, Shabani M, and Qian Q. Cutaneous Leishmaniasis (a Case Report and Review). ASCP Microbiology. 2013; Volume 56 Number 2; NO. MB 13-2 (MB-391)

Shabani M, Allard FD, and Qian Q. Schistoplasmosis (a Case Report and Review). ASCP Microbiology. 2013; Volume 56 Number 3; NO. MB 13-3 (MB-392)

Nicole V Tolan, PhD, Assistant Director of Clinical Chemistry and Point of Care Testing, Instructor in Pathology, Harvard Medical School

Luiza I. Genes, Nicole V. Tolan, Matthew K. Hulvey, R. Scott Martin, and Dana M. Spence. Addressing a vascular endothelium array with blood components using underlying microfluidic channels. Lab Chip, 2007; 1256-1259.

Nicole V. Tolan, Luiza I. Genes, Wasanthi Subasinghe, Madushi Raththagala and Dana M. Spence. Personalized metabolic assessment of erythrocytes using microfluidic delivery to an array of luminescent wells. Anal Chem, 2009; 81, 3102-3108.

Erin J. Kaleta, Nicole V. Tolan, Karl Ness and Alicia Algeciras-Schimnich. Determination of Cutoff Values for Carcinoembryonic Antigen (CEA), Alpha-Fetoprotein (AFP), and Cancer Antigen 19-9 (CA19-9) Concentrations in Ascitic Fluid to Distinguish Between Malignant and Benign Etiologies. Clin Biochem, 2013; 46, 814-818.

Nicole V. Tolan, Noemi Vidal-Folch, Alicia Algeciras-Schimnich, Ravinder J. Singh and Stefan K. Grebe. Individualized Correction of Neuron-Specific Enolase (NSE) Measurement in Hemolyzed Serum Samples. Clin Chim Acta, 2013; 424, 216-221.

Lynne Uhl, MD, Director, Division of Clinical Pathology; Medical Director, Transfusion Medicine; Associate Professor of Pathology, Harvard Medical School

Gaines AR, Lee-Stroka H, Byrn K, Scott DE, Uhl L, Lazarus E, Stroncek DF. Investigation of whether the acute hemolysis associated with Rho(D) immune globulin intravenous (human) administration for treatment of immune thrombocytopenic purpura is consistent with the acute hemolytic transfusion reaction model. Transfusion 2009; 49: 1050-1058.

O’Neill E, Richardson-Weber L, McCormack G, Uhl L, and Haspel RL. Strict Adherence to a Blood Bank Specimen Labeling Policy by All Clinical Laboratories Significantly Reduces the Incidence of “Wrong Blood in Tube”. Am J Clin Pathol 2009;132:164-168

Powers A, Chandrashekar S, Mohammed M, Uhl L. Identification and evaluation of false-negative antibody screens. Transfusion. 2010 Mar;50(3):617-21. Epub 2009 Nov 23.

Goodell PP, Uhl L, Mohammed M, Powers AA. Risk of hemolytic transfusion reactions following emergency-release RBC transfusion.Am J Clin Pathol. 2010 Aug;134(2):202-6.

Slichter SJ, Kaufman RM, Assmann SF, McCullough J, Triulzi DJ, Strauss RG, Gernsheimer TB, Ness PM, Brecher ME, Josephson CD, Konkle BA, Woodson RD, Ortel TL, Hillyer CD, Skerrett DL, McCrae KR, Sloan SR, Uhl L, George JN, Aquino VM, Manno CS, McFarland JG, Hess JR, Leissinger C, Granger S. Dose of prophylactic platelet transfusions and prevention of hemorrhage. N Engl J Med 2010; 362:600-13.

Wahl PM, Terrell DR, George JN, Rodgers JK, Uhl L, Cataland S, Bohn RL. Validation of claims-based diagnostic codes for idiopathic thrombotic thrombocytopenic purpura in a commercially-insured population. Thromb Haemost 2010 Mar 29;103(6).

Uhl L. Alternatives to transfusion: perioperative blood management. In: Simon TL,ed. Rossi’s Principles of Transfusion Medicine, 4th Edition. Oxford UK: Wiley-Blackwell, 2009. p 566-574.

FACULTY AND SELECTED PUBLICATIONS
EXPERIMENTAL PATHOLOGY

 
Ramy A. Arnaout, MD, PhD, see Clinical Pathology

Andrew Beck, MD, Director of Breast Cancer Molecular Pathology Laboratory; Assistant Professor of Pathology, Harvard Medical School

Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, Zhu S, Downs-Kelly E, Montgomery K, Goldblum JR, Hogendoorn PC, Corless CL, Oliveira AM, Dry SM, Nielsen TO, Rubin BP, Fletcher JA, Fletcher CD, van de Rijn M. Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J Pathol 2010; 220:58. (2010 Jan).

Beck AH, Weng Z, Witten DM, Zhu S, Foley JW, Lacroute P, Smith CL, Tibshirani R, van de Rijn M, Sidow A, West RB. 3'-end sequencing for expression quantification (3SEQ) from archival tumor samples. PLoS One 2010; 5:e8768. (2010 Jan).

Beck AH, Lee CH, Witten DM, Gleason BC, Edris B, Espinosa I, Zhu S, Li R, Montgomery KD, Marinelli RJ, Tibshirani R, Hastie T, Jablons DM, Rubin BP, Fletcher CD, West RB, van de Rijn M. Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling. Oncogene 2010; 29:845. (2010 Feb).

Zhang B, Beck AH, Taube JM, Kohler S, Seo K, Zwerner J, Viakhereva N, Sundram U, Kim YH, Schrijver I, Arber DA, Zehnder JL. Combined use of PCR-based TCRG and TCRB clonality tests on paraffin-embedded skin tissue in the differential diagnosis of mycosis fungoides and inflammatory dermatoses. J Mol Diagn 2010; 12: 320. (2010 May).

Kong CS, Beck AH, Longacre TA. A panel of 3 markers including p16, ProExC, or HPV ISH is optimal for distinguishing between primary endometrial and endocervical adenocarcinomas. Am J Surg Pathol 2010; 34:915. (2010 Jul).

Sangoi AR, Beck AH, Amin MB, Cheng L, Epstein JI, Hansel DE, Iczkowski KA, Lopez-Beltran A, Oliva E, Paner GP, Reuter VE, Ro JY, Shah RB, Shen SS, Tamboli P, McKenney JK. Interobserver Reproducibility in the Diagnosis of Invasive Micropapillary Carcinoma of the Urinary Tract Among Urologic Pathologists. Am J Surg Pathol 2010; 34: 1367. (2010 Sep).

Younes SF, Beck AH, Lossos IS, Levy R, Warnke RA, Natkunam Y. Immunoarchitectural Patterns in Follicular Lymphoma: Efficacy of HGAL and LMO2 in the Detection of the Interfollicular and Diffuse Components. Am J Surg Pathol 2010; 34:1266. (2010 Sep)

Webster JA, Beck AH, Sharma M, Espinosa I, Weigelt B, Schreuder M, Montgomery KD, Jensen KC, van de Rijn M, West R. Variations in stromal signatures in breast and colorectal cancer metastases. J Pathol 2010; 222:158. (2010 Oct).

Wu JM, Beck AH, Pate LL, Witten D, Zhu S, Montgomery KD, Allison KH, van de Rijn M, West RB. Endogenous versus tumor-specific host response to breast carcinoma: a study of stromal response in synchronous breast primaries and biopsy site changes. Clin Cancer Res 2011; 17: 437. (2011 Feb).

Pai RK, Beck AH, Mitchem J, Linehan DC, Chang DT, Norton JA, Pai RK. Pattern of lymph node involvement and prognosis in pancreatic adenocarcinoma: direct lymph node invasion has similar survival to node-negative disease. Am J Surg Pathol 2011; 35: 228. (2011 Feb).

Sangoi AR, Ohgami RS, Pai RK, Beck AH, McKenney JK, Pai RK. PAX8 expression reliably distinguishes pancreatic well-differentiated neuroendocrine tumors from ileal and pulmonary well-differentiated neuroendocrine tumors and pancreatic acinar cell carcinoma. Mod Pathol 2011; 24: 412. (2011 Mar).

Mills AM, Beck AH, Montgomery KD, Zhu SX, Espinosa I, Lee CH, Subramanian S, Fletcher CD, van de Rijn M, West RB. Expression of subtype-specific group 1 leiomyosarcoma markers in a wide variety of sarcomas by gene expression analysis and immunohistochemistry. Am J Surg Pathol 2011; 35: 583 (2011 Apr).

Younes SF, Beck AH, Ohgami RS, Lossos IS, Levy R, Warnke RA, Natkunam Y. The Efficacy of HGAL and LMO2 in the Separation of Lymphomas Derived From Small B Cells in Nodal and Extranodal Sites, Including the Bone Marrow. Am J Clin Pathol 2011; 135: 697. (2011 May).

Wu K, Liu JJ, Adams W, Sonn GA, Mach KE, Pan Y, Beck AH, Jensen KC, Liao JC. Dynamic Real-time Microscopy of the Urinary Tract Using Confocal Laser Endomicroscopy. Urology 2011. (2011 May 19).

Beck AH, Rodriguez-Paris J, Zehnder J, Schrijver I. Evaluation of a Gene Expression Microarray-Based Assay to Determine Tissue Type of Origin on a Diverse Set of 49 Malignancies. Am J Surg Pathol 2011. (2011 May 19).

Espinosa I, Edris B, Lee CH, Wei Cheng H, Gilks CB, Wang Y, Montgomery KD, Varma S, Li R, Marinelli RJ, West RB, Nielsen T, Beck AH, van de Rijn M. CSF1 Expression in Nongynecological Leiomyosarcoma Is Associated with Increased Tumor Angiogenesis. Am J Pathol 2011; 179: 2100. (2011 Aug).

Beck AH, Sangoi AR, Leung S, Marinelli RJ, Nielsen TO, van de Vijver MJ, West RB, van de Rijn M, Koller D. Systematic analysis of breast cancer morphology uncovers stromal features associated with survival. Sci Transl Med 2011; 3: 108ra113. (2011 Nov).

Anders Berg, MD, PhD, see Clinical Pathology

Mark S. Boguski, MD, PhD, Associate Professor of Pathology, Harvard Medical School

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE: A call to action: Training pathology residents in genomics and personalized medicine. Am J Clin Path, 133:832-834, 2010.

Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE. A curriculum in genomics and personalized medicine for pathology residents. Am J Clin Pathol. 2010; 133: online supplement.

Tonellato, PJ, Crawford, J, Boguski, MS and Saffitz, JE (2011) A National Agenda for the Future of Pathology in Personalized Medicine: Report of the proceedings of a meeting at the Banbury Conference Center: Genome-Era Pathology, Precision Diagnostics and Pre-emptive Care: A Stakeholder Summit, Amer J Clin Path, in press.

Lawrence Brown, MD, see Anatomic Pathology

Ann M. Dvorak, MD, Professor of Pathology, Harvard Medical School

Nagy JA, Chang S-H, Dvorak AM, Dvorak HF. Why are tumor blood vessels abnormal and why is it important to know? Brit J Ca 100:865-869, 2009.

Radke AL, Spencer LA, Reynolds LE, Melo RCN, Dvorak AM, Weller PF. Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation. Blood 113:3092-3101, 2009.

Melo RCN, Spencer LA, Perez SAC, Neves JS, Bafford SP, Morgan ES, Dvorak AM, Weller PF. Vesicle-mediated secretion of human eosinophil granule-derived major basic protein (MBP). Lab Invest 88:769-781, 2009.

Chang S-H, Feng D, Nagy JA, Sciuto TE, Dvorak AM, Dvorak HF. Vascular permeability and pathological angiogenesis in caveolin-1 null mice. Am J Pathol 175:1768-1776, 2009.

Nagy JA, Chang S-H, Shih S-C, Dvorak AM, Dvorak HF. Heterogeneity of tumor vascularture. Semin Throb Hemost 36:321-331, 2010.

Connolly JL, Goldsmith JD, Wang HH, Longtine JA, Dvorak AM, Dvorak HF, Hamilton SR. Cancer Pathology. In: Hong WK, Bast Jr RC, Hait WN, Kufe DW, Pollock RE, Weichselbaum RR , Holland JF, Frei IIIrd E, eds. Cancer Medicine, 8th Edition. BC Decker Inc, Hamilton, Ontario, 2010, 484-485.

Galli SJ, Metcalf DD, Arber DA, Dvorak AM. Basophils and mast cells and their disorders. 8th ed. Williams Hematology eds Kaushansky K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Prchal JT. McGraw-Hill, NY 2010, pp 915-932.

Harold F. Dvorak, MD, Director, Vascular Biology Research Center; Mallinckrodt Distinguished Professor of Pathology, Harvard Medical School

Sung-Hee Chang, Keizo Kanasaki, Vasilena Gocheva, Galia Blum, Jay Harper, Marsha A. Moses, Shou-Ching Shih, Janice A. Nagy, Johanna Joyce, Matthew Bogyo, Raghu Kalluri, and Harold F. Dvorak. VEGF-A Induces Angiogenesis by Perturbing the Cathepsin-Cysteine Protease Inhibitor Balance in Venules, Causing Basement Membrane Degradation and Mother Vessel Formation. www.aacrjournals.org Cancer Res 2009; 69: (10). May 15, 2009.

JA Nagy, S-H Chang, AM Dvorak and HF Dvorak.Why are tumour blood vessels abnormal and why is it important to know? British Journal of Cancer (2009).

Shou-Ching Shih, Andrew Zukauskas, Dan Li, Guanmei Liu, Lay-Hong Ang, Janice A. Nagy, Lawrence F. Brown, and Harold F. Dvorak. The L6 Protein TM4SF1 Is Critical for Endothelial Cell Function and Tumor Angiogenesis. www.aacrjournals.org Cancer Res 2009; 69: (8). April 15, 2009.

Xue, Q., Nagy, JA, Manseau, EJ, Phung, TL, Dvorak, HF, Benjamin, LE. (2009) Rapamycin Inhibition of the Akt/mTOR Pathway Blocks Select Stages of VEGF-A 164 Driven Angiogenesis, in Part by Blocking S6Kinase. Arterioslerosis, Thrombosis, and Vascular Biology. 29: 1172-1178. PMCID: PMC2756965

Zhang, X., Kazerounian, S., Duquette, M., Perruzzi, C., Nagy, JA, Dvorak, HF, Parangi, S., Lawler, J. (2009) Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. The FASEB Journal. Vol. 23, 3368-3376.

Marie-Helene Jouvin, MD, Instructor in Pathology, Harvard Medical School

Hartman ML, Lin SY, Jouvin MH, Kinet JP. Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI. Mol Immunol. 2008 Apr;45(8):2307-11. Epub 2008 Jan 7.

Vig M, DeHaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium
release-activated calcium channels. Nat Immunol. 2008 Jan;9(1):89-96. Epub 2007 Dec 2.

Kraft S, Fleming T, Billingsley JM, Lin SY, Jouvin MH, Storz P, and Kinet JP. Anti-CD63 antibodies suppress IgE-dependent allergic reactions in vitro and in vivo. J Exp Med 201:385-96 2005.

Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FceRI controls the formation of functional IgE-binding receptors. J Exp Med 201:267-77 2005.

Antoine E. Karnoub, PhD, Assistant Professor of Pathology, Harvard Medical School

Karnoub AE, Weinberg RA. Ras oncogenes: split personalities. Nat Rev Mol Cell Biol. 2008 Jul;9(7):517-31.

Scheel C, Onder T, Karnoub A, Weinberg RA. Adaptation versus selection: the origins of metastatic behavior. Cancer Res. 2007 Dec 15;67(24):11476-9; discussion 11479-80. Review. No abstract available.

Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 2007 Oct 4;449(7162):557-63.

Ince TA, Richardson AL, Bell GW, Saitoh M, Godar S, Karnoub AE, Iglehart JD, Weinberg RA. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell. 2007 Aug;12(2):160-70.

Karnoub AE, Weinberg RA. Chemokine networks and breast cancer metastasis. Breast Dis. 2006-2007;26:75-85.

Yohe ME, Rossman KL, Gardner OS, Karnoub AE, Snyder JT, Gershburg S, Graves LM, Der CJ, Sondek J. Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif. J Biol Chem. 2007 May 4;282(18):13813-23.

El-Haibi C and Karnoub AE. Mesenchymal stem cells in the initiation and progression. J Mammary Gland Biol Neoplasia 2010;15(4): 399-409.

Roya Khosravi-Far, PhD, Associate Professor of Pathology, Harvard Medical School

Degli Esposti, M., Tour, J., Ouasti, S., Ivanova, S., Matarrese, P., Malorni, W., Khosravi-Far, R. 2009. Fas death receptor enhances endocytic membrane traffic converging into the Golgi region. Mol Biol Cell 20:600-615.

Jagani, Z., Song, K., Kutok, J.L., Dewar, M.R., Melet, A., Santos, T., Grassian, A., Ghaffari, S., Wu, C., Ren, R., Rodin, H.Y., Miller, K., Khosravi-Far, R. 2009. Proteasome Inhibition Causes Regression of Leukemia and Abrogates BCR-ABL-Induced Evasion of Apoptosis in Part through Regulation of Forkhead Tumor Suppressors. Cancer Res.

Ren, B., Song, K., Parangi, S., Jin, T., Ye, M., Humphreys, R., Duquette, M., Zhang, X., Benhaga, N., Lawler, J., Khosravi-Far, R. 2009. A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. Cancer Res 69:3856-3865.

Weisberg E, Choi HG, Ray A, Barrett R, Zhang J, Sim T, Zhou W, Seeliger M, Cameron M, Azam M, Fletcher JA, Debiec-Rychter M, Mayeda M, Moreno D, Kung AL, Janne PA, Khosravi-Far R, Melo JV, Manley PW, Adamia S, Wu C, Gray N, Griffin JD. Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants. Blood. 2010 May 27;115(21):4206-16.

Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell. 2010 Mar;21(6):1140-52.

Jagani Z, Song K, Kutok JL, Dewar MR, Melet A, Santos T, Grassian A, Ghaffari S, Wu C, Yeckes-Rodin H, Ren R, Miller K, Khosravi-Far R. Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors. Cancer Res. 2009 Aug 15;69(16):6546-55.

Jean-Pierre Kinet, MD, Professor of Pathology, Harvard Medical School

Hartman ML, Lin SY, Jouvin MH, Kinet JP. Role of the extracellular domain of Fc epsilon RI alpha in intracellular processing and surface expression of the high affinity receptor for IgE Fc epsilon RI. Mol Immunol. 2008 Apr;45(8):2307-11. Epub 2008 Jan 7.

Vig M, DeHaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol. 2008 Jan;9(1):89-96. Epub 2007 Dec 2.

Calloway N, Vig M, Kinet JP, Holowka D, Baird B. Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions. Mol Biol Cell. 2009 Jan;20(1):389-99. Epub 2008 Nov 5.

Vig M, Kinet JP. Calcium signaling in immune cells. Nat Immunol. 2009 Jan;10(1):21-7. Review. Erratum in: Nat Immunol. 2009 Feb;10(2):223.

James Kirby, MD, see Clinical Pathology

Olivier Kocher, MD, PhD, see Anatomic Pathology

Jack Lawler, PhD, Director, Division of Experimental Pathology; Professor of Pathology, Harvard Medical School

Olerud J, Johansson M, Lawler J, Welsh N, Carlsson PO. Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes 2008; 57(7): 1870-7.

Kazerounian S, Yee KO, Lawler J. Thrombospondins in cancer. Cell Mol Life Science 2008, 65(5): 700-12.

Sun J, Hopkins BD, Tsujikawa K, Perruzzi C, Adini I, Swerlick R, Bornstein P, Lawler J, Benjamin LE. Thrombospondin-1 modulates VEGF-A mediated AKT signaling and capillary survival in the developing retina. Am. J. Physiol Heart Cir Physiol, 2009,296 (5): H 1344-51.

Ren B, Song K, Jin T, Parangi S, Duquette M, Zhang X, Lawler J, Khosravi-Far R. A double hit to kill tumor and endothelial cells by TRAIL and anti-angiogenic 3TSR. Cancer Res. 69 (9): 3856-3865.

Tan K, Duquette M, Joachimiak A, Lawler J. The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. FASEB J. 2009, 23(8): 2490-501.

Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, Lawler J.Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level. FASEB J. 2009 Oct;23(10):3368-76.

Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10649-54.

Eroglu C, Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell. 2009 Oct 16;139(2):380-92.

Janice A. Nagy, PhD, Principal Associate in Pathology, Harvard Medical School

Nagy JA, Chang SH, Shih SC, Dvorak AM, Dvorak HF. Heterogeneity of the tumor vasculature. Semin Thromb Hemost. 36:321-331, 2010.

Hoang MV, Nagy JA, Fox JB, Senger DR, Moderation of Calpain Activity Promotes Neovascular Integration and Lumen Formation During VEGF-induced Pathological Angiogenesis. PLOS One 5:e13612, 2010.

Hoang MV, Nagy JA, Senger DR. Active Rac1 improves pathological VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1. Blood 117:1751-60, 2011.

Fu Y, Nagy JA, Brown LF, Shih SC, Johnson PY, Chan CK, Dvorak HF, and Wight TN. Proteolytic Cleavage of Versican and Involvement of ADAMTS-1 in VEGF-A/VPF-Induced Pathological Angiogenesis. J Histochem Cytochem. 59:463-73, 2011.

Hoang MV, Nagy JA, Senger DR. Cdc42-mediated inhibition of GSK-3b improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis. Microvas Res. 81:34-43, 2011.

Yuan L, Sacharidou A, Stratman AN, Le Bras A, Zwiers PJ, Spokes K, Bhasin M, Shih SC, Nagy JA, Molema G, Aird WC, Davis GE, Oettgen P. RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG. Blood. 118:1145-53, 2011.

Sitohy B, Nagy JA, Jaminet SC, Dvorak HF. Tumor surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy.Cancer Res. 2011 Sep 21.

B Sitohy, JA Nagy, HF Dvorak Anti-VEGF/VEGFR therapy for cancer: Reassessing the target, Cancer Res 2011.

Trista E. North, PhD, Assistant Professor of Pathology, Harvard Medical School

Wang Y, Krivtsov AV, Sinha AU, North TE, Goessling W, Feng Z, Zon LI, Armstrong SA. β-catenin determines developmental stage specific transformation to leukemia stem cells. 2010 Science 327: 1650-1653.

North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, and Goessling W. Prostaglandin E2-regulated wnt signaling and N-cetylcysteine act synergistically in zebrafish regeneration after acetaminophen liver injury. 2010. PNAS 107:17315-17320.

North TE and Goessling W. NOTCHing an arrow at cord blood: translating stem cell knowledge into clinical practice. 2010. Cell Stem Cell, 6: 186-187.

Pier Paolo Pandolfi, MD, PhD, Director, Cancer Genetics Program at BIDMC; Professor of Pathology and Medicine, Harvard Medical School

Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Sci Signal. 2009 Aug 18;2(84):ra44.

Cheng K, Sportoletti P, Ito K, Clohessy JG, Teruya-Feldstein J, Kutok JL, Pandolfi PP. The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model. Blood. 2009 Aug 7.

Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell. 2009 Aug 4;16(2):115-25.

Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12453-8.

Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, Ahn Y, Dahlberg S, Neuberg D, Moreau LA, Winter SS, Larson R, Zhang J, Protopopov A, Chin L, Pandolfi PP, Silverman LB, Hunger SP, Sallan SE, Look AT. High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood. 2009 Jul 16;114(3):647-50.

Clohessy JG, Pandolfi PP. beta-tting on p63 as a metastatic suppressor. Cell. 2009 Apr 3;137(1):28-30.

Ito K, Bernardi R, Pandolfi PP. A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell. Curr Opin Genet Dev. 2009 Feb;19(1):51-9. Review.

German Pihan, MD, see Clinical Pathology

Isaac Rabinovitz, MD, PhD, Assistant Professor of Medicine, Harvard Medical School

Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Molecular Biology of the Cell. 21(6):1140-52, 2010.

Kashyap, T., Germain E.C., Roche M., Lyle S., and Rabinovitz I. Role of integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration. Laboratory Investigation. 91(10):1414-26. 2011.

Deng X., Li Q, Novak N, Yang H, Hoff J, Xu F, Sharma C, Zhou P, Rabinovitz I, Sonnenberg A, Zhou P, Ni A, Brown M, Kaetzel K, Hemler ME and Yang X. CD151 Drives Mammary Tumor Onset and Metastasis by Coordinating Integrin 1- and  -dependent Cell Adhesion, Motility, Survival and Signaling. Submitted 2011

Sharma C, Rabinovitz I, and Hemler ME. Palmitoylation by DHHC3 is critical for the function expression and stability of integrin α6β4. Submitted EMBO J, 2011

Li Q, Yang XH, Xu F, Chandan C, Wang HX, Knoblich K, Rabinovitz I, Granter S, and Hemler ME.Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Submitted EMBO J. 2011

John L. Rinn, PhD, Assistant Professor of Pathology, Harvard Medical School

Roberts A, Trapnell C, Donaghey J, Rinn JL, Pachter L. Improving RNA-Seq expression estimates by correcting for fragment bias. Genome Biol 12 (2011).

Broadbent KM, Park D, Wolf AR, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti PC, Rinn, JL*. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated 1ncRNAs. Genome Biol 12 (2011).

Guttman M, Donaghey J, Carey BW, Garber M, Grenier JK, Munson G, Young G, Lucas AB, Ach R, Bruhn L, Yang X, Amit I, Meissner A, Regev A, Rinn JL, Root DE, Lander ES. lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature 477:295-300 (2011).

Cabili MN, Trapnell C, Goff L, Koziol M, Tazon-Vega B, Regev A, Rinn JL. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev 15; 25(18):1915-27 (2011).

Mercer TR, Gerhardt DJ, Dinger ME, Crawford J, Trapnell C, Jeddeloh JA, Mattick JS, Rinn JL. Targeted RNA sequencing reveals the deep complexity of the human transcriptome. Nature Biotechnol 30:99-104 (2011).
Pauli A, Valen E, Lin MF, Garber M, Vastenhouw NL, Levin JZ, Fan L, Sandelin A, Rinn JL, Regev A, Schier AF. Systematic identification of long non-coding RNAs expressed during zebrafish embryogenesis. Genome Res 22:577-91 (2011).

Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, Mowrer G, Al-Siddiqi H, Nahrendorf M, Musunuru K, Gerszten RE, Rinn JL, Cowan CA. Programming human pluripotent stem cells into white and brown adipocytes. Nature Cell Biol 14:209-19 (2012).

Kretz M, Webster DE, Flockhart RJ, Lee CS, Zehnder A, Lopez-Pajares V, Qu K, Zheng GX, Chow J, Kim GE, Rinn JL, Chang HY, Siprashvili Z, Khavari PA. Suppression of progenitor differentiation requires the long noncoding RNA ANCR. Genes Dev 26:338-43 (2012).

Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg SL, Rinn JL, Pachter L. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nature Protoc 7:562-78 (2012).

Jeffrey Saffitz, MD, PhD, see Anatomic Pathology

Donald R. Senger, PhD, Principal Associate in Pathology, Harvard Medical School

Senger, DR. Vascular endothelial growth factor: Much more than an angiogenesis factor. Mol Biol Cell 2010, 21: 377-379

Hoang MV, Smith LEH, Senger DR. Moderate GSK-3b inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy. Angiogenesis 2010, 13: 269-277.

Hoang MV, Smith LEH, Senger DR. Calpain inhibitors reduce retinal hypoxia in ischemic retionopathy by improving neovascular architecture and functional perfusion. BBA – Molecular Basis of Disease 2010, Biochim Biophys Acta. 2011 Apr;1812(4):549-57. Epub 2010 Sep 8.

Hoang MV, Nagy JA, Senger DR. Cdc42-mediated inhibition of GSK-3b improves angio-architecture and lumen formation during VEGF-driven pathological angiogenesis. Microvasc Res.2011 Jan;81(1):34-43.

Hoang MV, Nagy JA, Senger DR. Active Rac1 improves pathological VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1. Blood. 2011 Feb 3;117(5):1751-60. Epub 2010 Oct 28.

Shou-Ching Shih, PhD, Research Associate; Instructor in Pathology, HMS

Nagy, J.A., Chang, S.H., Shih, S.C., Dvorak, A.M., and Dvorak, H.F. 2010. Heterogeneity of the Tumor Vasculature. Semin Thromb Hemost 36:321-331.

Dudley, A.C., Udagawa, T., Melero-Martin, J.M., Shih, S.C., Curatolo, A., Moses, M.A., and Klagsbrun, M. 2010. Bone marrow is a reservoir for pro-angiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors. Blood.

Matsuda, K., Ohga, N., Hida, Y., Muraki, C., Tsuchiya, K., Kurosu, T., Akino, T., Shih, S.C., Totsuka, Y., Klagsbrun, M., et al. 2010. Isolated tumor endothelial cells maintain specific character during long-term culture. Biochem Biophys Res Commun 394:947-954.

Shapiro, N.I., Khankin, E.V., Van Meurs, M., Shih, S.C., Lu, S., Yano, M., Castro, P.R., Maratos-Flier, E., Parikh, S.M., Karumanchi, S.A., et al. 2010. Leptin exacerbates sepsis-mediated morbidity and mortality. J Immunol 185:517-524.

Ismail, N.S., Pravda, E.A., Li, D., Shih, S.C., and Dallabrida, S.M. 2010. Angiopoietin-1 reduces H(2)O(2)-induced increases in reactive oxygen species and oxidative damage to skin cells. J Invest Dermatol 130:1307-1317.

Steven Tahan, MD, see Anatomic pathology

Alex Toker, PhD, Associate Professor of Pathology, Harvard Medical School 

Yiu, G. K., Kaunisto, A., Chin, Y. R. and Toker, A. NFAT Promotes Carcinoma Invasive Migration
Through Glypican-6. Biochemical Journal 2011; 440(1):157-66.

Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S,
Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW, Wei W. mTOR Drives Its Own
Activation via SCF(βTrCP)-Dependent Degradation of the mTOR Inhibitor DEPTOR. Mol Cell.
2011; 44(2): 290-303.

Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS,
Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D,
Bautista-Piña V, Duke F, Francis J, Jung J, Maffuz-Aziz A, Onofrio RC, Parkin M, Pho NH,
Quintanar-Jurado V, Ramos AH, Rebollar-Vega R, Rodriguez-Cuevas S, Romero-Cordoba SL, Schumacher SE, Stransky N, Thompson KM, Uribe-Figueroa L, Baselga J, Beroukhim R, Polyak K,
Sgroi DC, Richardson AL, Jimenez-Sanchez G, Lander ES, Gabriel SB, Garraway LA, Golub TR,
Melendez-Zajgla J, Toker A, Getz G, Hidalgo-Miranda A, Meyerson M. Sequence analysis of
mutations and translocations across breast cancer subtypes. Nature 2012; 486(7403): 405-9.

Christoforides, C. V., Rainero, E., Brown, K. K., Norman, J. C. and Toker, A. PKD Controls αvβ3
Integrin Recycling and Tumor Cell Invasive Migration Through its Substrate Rabaptin-5.
Developmental Cell 2012; 11;23(3):560-72

Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW,
Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W.
Acetylation-dependent regulation of skp2 function. Cell. 2012; 150(1):179-93.

Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C,
Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, Kocher
ON, Brown LF, Toker A, Prendergast GC, Benjamin LE. RhoB differentially controls Akt function in
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Peter Tonellato, PhD, Senior Research Scientist at the Center for Biomedical Informatics, Harvard Medical School and Visiting Professor, Department of Pathology, Beth Israel Deaconess Medical Center

Haspel, RL, Arnaout, R, Briere, L, Kantarci,S, Marchand,K, Tonellato, PJ, Connolly, C, Boguski, MS,.Saffitz,JE, A Call to Action: Training Pathology Residents in Genomics and Personalized Medicine, American Journal of Clinical Pathology | AJCP-2010-02-0104.R1 (2010).

Wall, DP, Kudtarkar, P, Fusaro, V, Pivovarov, R, Patil, P and Tonellato, PJ. Cloud Computing for Comparative Genomics. BMC Bioinformatics (2010).

Prasad, P and Tonellato, PJ. Individual Whole Genome Mapping: From NGS Reads to Clinical Variants, Proceedings of the 2010 AMIA Summit on Clinical Research Informatics, San Francisco, CA, March, 2010.[pdf available on request]

Fusaro, VA, Kos, P, Tector, M, Patil,P, Tonellato, PJ, Electronic Medical Record Analysis Using Cloud Computing, . Proceedings of the 2010 AMIA Summit on Clinical Research Informatics, San Francisco, CA, March, 2010.[pdf available on request]

Tonellato, PJ, Reede, J, Kos, P, Demas, K, Personalized Medicine and the Potential for Health Inequity. 2010 Annual Wisconsin Public health Association, Madison, WI, June, 2010

Dennis Wall, PhD, Assistant Professor of Pathology, Harvard Medical School, Center for Biomedical Informatics

Wall D, Kudtarkar P, Fusaro V, Pivovarov R, Patil P, Tonellato P. Cloud computing for comparative genomics. BMC Bioinformatics 2010;11:259.

Wall, D.P. Pivavorov, R. and P.J. Tonellato. (2010). Genotator: A disease-agnostic tool for genetic annotation of disease. BMC Medical Genomics 3(1):50.

Goñi J, Arrondo G, Sepulcre J, Martincorena I, Vélez de Mendizábal N, Corominas-Murtra B, Bejarano B, Ardanza-Trevijano S, Peraita H, Wall DP, Villoslada P. The semantic organization of the animal category: evidence from semantic verbal fluency and network theory. 2010. Cognitive Processing Oct 12.

Kudtarkar P, DeLuca, TF, Fusaro V., Tonellato PJ, and Wall, D.P. 2010. Cost-effective cloud computing: A case study using the comparative genomics tool, Roundup. Evolutionary Bioinformatics.

Wall, D.P., Eran A., Vadarajan, B. In press. Haplotype structure enables prioritization of disease markers and candidate genes in autism spectrum disorder. PLoS ONE.

Banos, M. and Wall, D.P. In press. Genomic variation in autism pathways. PLoS ONE.

Jung, JY and Wall, D.P. In review. Cross-disease analysis between autism and autoimmune diseases. Molecular Autism.

Wall, D.P. and P. Kudtarkar. In preparation. Comparative genomics using the Roundup application. Evolutionary Bioinformatics.

Wenyi Wei, PhD, Associate Professor of Pathology, Harvard Medical School

Wei, W.*, Ayad, N. G.*, Wan, Y., Zhang, G.-J., Kirschner, M. W. and Kaelin, W. G., Jr. (2004) Degradation of the SCF component Skp2 in cell cycle G1 by the anaphase promoting complex. Nature 428: 194-8.

Gao, D., Inuzuka, H., Tseng, A., Chin, R., Toker, A. and Wei, W. (2009) Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APC/Cdh1-medaited Skp2 destruction. Nature Cell Biology 11(4): 397-408.

Gao, D., Inuzuka H., Korenjak M., Tseng A., Wu T., Wan L., Kirschner M., Dyson N. and Wei, W. (2009) Cdh1 regulates cell cycle through modulating the Claspin/Chk1 and the Rb/E2F1 pathways. Molecular Biology of the Cell 20(14): 3305-16.

Inuzuka H., Tseng A., Gao D., Zhai B., Zhang Q., Shaik S., Wan L., Ang X.L., Mock C., Yin H., Stommel J.M.,Gygi S., Lahav L., Asara J., Xiao Z., Kaelin W. G., Jr., Harper J. W. and Wei, W. (2010) Phosphorylation by Caesin Kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFb-TRCP ubiquitin ligase. Cancer Cell 18(2): 147-159.

Gao D., Wan L., Inuzuka H., Berg A. H., Tseng, A., Zhai B., Shaik S., Bennet E., Tron A. E., Gasser J.A., Lau A., Gygi S., Harper J. W., DeCaprio J. A., Toker A. and Wei, W. (2010) Rictor forms a complex with Cullin-1 to promote SGK1 ubiqutination and destruction. Molecular Cell 39(5): 797-808.

Inuzuka, H., Shaik, S., Onoyama, I., Tseng, A., Gao, D., Maser, R., Zhai, B., Wan, L., Gurierrez, A., Lau, A., Xiao, Y., Christie, A., Aster, J., Settleman, J., Gygi, S, Kung, A. L., Look, T., Nakayama, K. I., DePinho, R. A. and Wei, W. SCFFbw7 regulates cellular apoptosis by targeting the Mcl-1 oncoprotein for ubiquitination and destruction. Nature 2011 Mar 3;471(7336):104-9.

Wei, W. and Kaelin, W.G., Jr. (2011) Good COP1 or Bad COP1? In Vivo Veritas. Journal of Clinical Investigation.

Catherine T. Yan, PhD, Assistant Professor of Pathology, Harvard Medical School

Rucci, F*, Notarangelo, LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley K, Detre C, Keszei M, Walter JE, Feldman L, Cheng H, Poliani PL, Wang JH, Balter B, Recher M, Andersson E-M, Zha S, Giliani S, Terhorst C, Alt FW, Yan, CT* (2010) Homozygous DNA Ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. PNAS, 107:3024-9.

Boboila C, Yan CT, Wesemann, DR, Jankovic M, Wang JH,, Manis J, Nussenzweig A, Nussenzweig M, At FW. (2010) Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA Ligase 4. Journal of Exp. Med, 207:417-27. 

Boboila C*, Jankovic M, Yan CT*, Wang JH, Wesemann, DR, Zhang, T, Feldman L, Fazeli A, Nussenzweig A, Nussenzweig M, At FW. (2010) Alternative End-joining catalyzes robust IgH locus deletions and translocations in the absence of combined Ligase 4 and Ku70. PNAS, 107:3034-9. (equal contribution). PMID: 20133803 (equal contribution).

Eccleston, J, Yan, C, Yuan K, Alt FW, Selsing E. (2010). Mismatch repair proteins, MSH2, MLH1 and EXO1 are important for class switch recombination events occurring in B cells that lack non-homologous end joining. Journal of Immunology. 2011 Feb 15;186(4):2336-43. Epub 2011 Jan 17.