Muneeb Ahmed, MD

 

Ahmed, Muneeb Dec 2010 photoAppointments

  • Staff Radiologist, Interventional Radiology, Beth Israel Deaconess Medical Center
  • Assistant Professor of Radiology, Harvard Medical School
  • Associate Director, Minimally Invasive Tumor Therapies Laboratory

Medical Education

  • The Aga Khan University Medical College, Pakistan
  • NCI Research Fellow in Cancer Radiology, Beth Israel Deaconess Medical Center
  • Internship, Metrowest Medical Center/Harvard Medical School Affiliate
  • Residency in Diagnostic Radiology, Beth Israel Deaconess Medical Center/Harvard Medical School
  • Chief Resident, Radiology Residency Program, Beth Israel Deaconess Medical Center
  • Fellowship in Vascular and Interventional Radiology, The Johns Hopkins School of Medicine

Certification, Licensure, Professional Societies

  • Board Certified in Radiology (American Board of Radiology)
  • Medical License: Massachusetts, Maryland
  • Member, Radiological Society of North America; Society of Interventional Radiology, New England Society of Interventional Radiology, American College of Radiology, Society of Thermal Medicine
  • Certificate of Added Qualifications (CAQ) in Vascualr and Interventional Radiology, ABR

Contact Information:

Department of Radiology
Beth Israel Deaconess Medical Center
One Deaconess Rd., WCC-3
Boston, MA 02215
Phone: 617-754-2523 (Maxima Baudissin, Admin. Assistant)
mahmed@bidmc.harvard.edu

To schedule a clinic consultation for a procedure, please call Maxima Baudissin, Administrative Assistant, Extension 617-754-2523


Clinical Practice:

Dr. Ahmed’s clinical practice includes a complete range of image-guided and minimally-invasive interventional procedures. He has extensive training in both vascular and non-vascular diagnostic and therapeutic procedures, including but not limited to:

  • Interventional oncology including radiofrequency ablation and cryo-ablation for solid tumors (liver, kidney, lung, bone, adrenal gland) and chemoembolization for liver tumors
  • Arterial interventions for solid organ/visceral (renal, mesenteric, hepatic) and peripheral disease (diagnostic imaging, treatment of stenosis with angioplasty and stenting)
  • Arterial embolization for acute and traumatic bleeding
  • Arteriovenous malformation treatment, including percutaneous and endovascular treatment of venous and lymphatic malformations
  • Dialysis access interventions (fistulography and catheter-related procedures)
  • Venous thrombosis management (inferior vena cava filter placement, deep venous thrombosis thrombectomy/thrombolysis, pulmonary thrombectomy)
  • Liver vascular interventions such as portal vein embolization/angiogplasty/stenting/thrombectomy, transjugular intrahepatic portosystemic shunt (TIPS) creation and management
  • Biliary interventions (transhepatic cholangiography and drainage, cholangioplasty, biopsy, stent placement)
  • Nephrostomy tube placement and management
  • CT-guided diagnostic fine needle aspiration and biopsy
  • Percutaneous abscess drainage
  • CT-guided Celiac Plexus Nerve Block/Neurolysis
  • Central venous access (tunneled access lines and subcutaneous chest and arm ports)
  • Gynecologic and genitourinary interventions including uterine artery/fibroid embolization, varicocele embolization, and treatment of pelvic venous congestion syndrome

Academic practice:

Dr. Ahmed’s research interests are focused on using image-guidance to perform minimally invasive and directed therapies to treat localized tumors. This includes using percutaneous tumor ablation (using radiofrequency or cryoablation) in combination with systemic targeted chemotherapy, and administered targeted therapy through direct intra-arterial injection (such as chemoembolization). He has co-authored more than 30 peer-reviewed original research articles in his field and several invited book chapters, and has received independent national societal funding for his research. Dr. Ahmed is also an active and award-winning reviewer for leading journals in his specialty, including Radiology, Journal of Vascular and Interventional Radiology, and The International Journal of Hyperthermia. He gives invited talks on his research at various national societal meetings annually.

Selected Peer Reviewed Publications

  1. Ahmed M, Khan MA, Siddiqi T, Ikram M, Mian YM. Comparison of diathermy and dissection method tonsillectomies. JPMA J Pak Med Assoc 2000; 50: 215-6. http://www.ncbi.nlm.nih.gov/pubmed/10992695
  2. Goldberg SN, Ahmed M, Gazelle GS, Kruskal JB, Huertas JC, Halpern EF, Oliver BS, Lenkinski RE. Radio-frequency thermal ablation with NaCl solution injection: effect of electrical conductivity on tissue heating and coagulation-phantom and porcine liver study. Radiology 2001; 219:157-65. http://radiology.rsna.org/content/219/1/157.full
  3. Ahmed M, Lobo SM, Weinstein J, Kruskal JB, Gazelle GS, Halpern EF, Afzal SK, Lenkinski RE, Goldberg SN. Improved coagulation with saline solution pretreatment during radiofrequency tumor ablation in a canine model. J Vasc Interv Radiol (2002 Jul) 13(7):717-24. http://www.ncbi.nlm.nih.gov/pubmed/12119331
  4. Goldberg SN, Girnan GD, Lukyanov AN, Ahmed M, Monsky WL, Gazelle GS, Huertas JC, Stuart KE, Jacobs T, Torchilin VP, Halpern EF, Kruskal JB. Percutaneous tumor ablation: increased necrosis with combined radio- frequency ablation and intravenous liposomal doxorubicin in a rat breast tumor model. Radiology (2002 Mar) 222(3):797-804.http://radiology.rsna.org/content/222/3/797.long
  5. Monsky WL, Kruskal JB, Lukyanov AN, Girnun GD, Ahmed M, Gazelle GS, Huertas JC, Stuart KE, Torchilin VP, Goldberg SN. Radio-frequency ablation increases intratumoral liposomal doxorubicin accumulation in a rat breast tumor model. Radiology (2002 Sep) 224(3):823-9. http://radiology.rsna.org/content/224/3/823.long
  6. Goldberg SN, Ahmed M, Weinstein J, Hare B, Bloch S, Shieman RG. Low-power transverse ultrasonic treatment of portal vein thrombosis in an animal model. J Vasc Interv Radiol (2002 Sep) 13(9 Pt 1):915-21. http://www.ncbi.nlm.nih.gov/pubmed/12354826
  7. Goldberg SN, Kamel IR, Kruskal JB, Reynolds K, Monsky WL, Stuart KE, Ahmed M, Raptopoulos V. Radiofrequency ablation of hepatic tumors: Increased tumor destruction with adjuvant liposomal doxorubicin therapy. AJR Am J Roentgenol (2002 Jul) 179(1):93-101. http://www.ajronline.org/cgi/content/full/179/1/93
  8. Boiselle PM, Dippolito G, Copeland J, Kang H, Ahmed M, Weeks D, Halpern E, Goldberg SN. Multiplanar and 3D imaging of the central airways: Comparison of Image quality and radiation doses using single-detector row CT and multi-detector row CT at differing tube currents in dogs. Radiology (2003 Jul) 228(1):107-11. http://radiology.rsna.org/content/228/1/107.long
  9. D'Ippolito G, Ahmed M, Girnun GD, Stuart KE, Kruskal JB, Halpern EF, Goldberg SN. Percutaneous tumor ablation: reduced tumor growth with combined radio-frequency ablation and liposomal doxorubicin in a rat breast tumor model. Radiology (2003 Jul) 228(1):112-8. http://radiology.rsna.org/content/228/1/112.long
  10. Ahmed M, Monsky WE, Girnun G, Lukyanov A, D’Ippolito G, Kruskal JB, Stuart KE, Torchilin VP, Goldberg SN. Radiofrequency thermal ablation sharply increases intratumoral liposomal doxorubicin accumulation and tumor coagulation. Cancer Res (2003 Oct 1) 63(19):6327-33. http://cancerres.aacrjournals.org/content/63/19/6327.long
  11. Lenkinski RE, Ahmed M, Zaheer A, Frangioni JV, Goldberg SN. Near-infrared imaging of microcalcification in an animal model of breast cancer. Acad Radiol (2003 Oct) 10(10):1159-64. http://www.ncbi.nlm.nih.gov/pubmed/14587634
  12. Ahmed M, Weinstein J, Liu Z, Afzal KS, Horkan C, Kruskal JB, Goldberg SN. Image-guided percutaneous chemical and radiofrequency tumor ablation in an animal model. J Vasc Interv Radiol (2003 Aug) 14(8):1045-52. http://www.ncbi.nlm.nih.gov/pubmed/12902563
  13. Horkan C, Ahmed M, Liu Z, Gazelle GS, Solazzo SA, Kruskal JB, Goldberg SN. Radiofrequency ablation: Effect of pharmacologic modulation of hepatic and renal blood flow on coagulation diameter in a VX2 tumor model. J Vasc Interv Radiol (2004 Mar) 15(3):269-74. http://www.ncbi.nlm.nih.gov/pubmed/15028812
  14. Lobo SM, Afzal KS, Ahmed M, Kruskal JB, Lenkinski RE, Goldberg SN. Radiofrequency ablation: Modeling the enhanced temperature response of adjuvant NaCl pretreatment. Radiology (2004 Jan) 230(1):175-82. http://radiology.rsna.org/content/230/1/175.long
  15. Ahmed M, Liu Z, Afzal KS, Weeks D, Lobo SM, Kruskal JB, Lenkinski RE, Goldberg SN. Radiofrequency ablation: Effect of surrounding tissue composition on coagulation necrosis in a canine tumor model. Radiology (2004 Mar) 230(3):761-7. http://radiology.rsna.org/content/230/3/761.long
  16. Ahmed M, Liu Z, Lukyanov AN, Signoretti S, Horkan C, Monsky WL, Torchilin VP, Goldberg SN. Combination radiofrequency ablation with intratumoral liposomal doxorubicin: effect on drug accumulation and coagulation in multiple tissues and tumor types in animals. Radiology (2005 May) 235(2):469-77. http://radiology.rsna.org/content/235/2/469.long
  17. Bezerra AS, D’Ippolito G, Faintuch S, Szejnfeld J, Ahmed M. Determination of splenomegaly by CT: Is there a place for a single measurement? AJR Am J Roentgenol (2005 May) 184(5):1510-3. http://www.ajronline.org/cgi/content/full/184/5/1510
  18. Lobo SM, Liu ZJ, Yu NC, Humphries S, Ahmed M, Cosmann ER, Lenkinski RE, Goldberg W, Goldberg SN. RF tumor ablation: Computer simulation and mathematical modelling of the effects of electrical and thermal conductivity. Int J Hyperthermia (2005 May) 21(3):199-213.http://informahealthcare.com/doi/abs/10.1080/02656730400001108
  19. Solazzo SA, Liu Z, Lobo SM, Ahmed M, Hines-Peralta AU, Lenkinski RE, Goldberg SN. Radiofrequency ablation: Importance of background tissue electrical conductivity--an agar phantom and computer modeling study. Radiology (2005 Aug) 236(2):495-502. http://radiology.rsna.org/content/236/2/495.long
  20. Ahmed M, Lukyanov AN, Torchilin V, Tournier H, Schneider AN, Goldberg SN. Combined radiofrequency ablation and adjuvant liposomal chemotherapy: effect of chemotherapeutic agent, nanoparticle size, and circulation time. J Vasc Interv Radiol (2005 Oct) 16(10):1365-71. http://www.ncbi.nlm.nih.gov/pubmed/16221908
  21. Liu Z, Ahmed M, Weinstein Y, Yi M, Mahajan RL, Goldberg SN. Characterization of the RF ablation-induced “oven effect”: the importance of background tissue thermal conductivity on tissue heating. Int J Hyperthermia (2006 Jun) 22(4):327-42.http://informahealthcare.com/doi/abs/10.1080/02656730600609122
  22. Solazzo SA, Ahmed M, Liu Z, Hines-Peralta AU, Goldberg SN. High-power generator for radiofrequency ablation: Larger electrodes and pulsing algorithms in bovine ex vivo and porcine in vivo settings. Radiology (2007 Mar) 242(3):743-50. http://radiology.rsna.org/content/242/3/743.long
  23. Liu Z, Ahmed M, Sabir A, Humphries S, Goldberg SN. Computer modeling of the effect of perfusion on heating patterns in radiofrequency tumor ablation. Int J Hyperthermia (2007 Feb) 23(1):49-58.
  24. Bezerra AS, D’Ippolito G, Caldana RP, Cecin AO, Ahmed M, Szejnfeld J. Chronic hepatosplenic schistosomiasis mansoni: magnetic resonance imaging and magnetic resonance angiography findings. Acta Radiol (2007 Mar) 48(2):125-34.
  25. Bezerra AS, D’Ippolito GD, Caldana RP, Leopoldino DD, Batista GR, Borges DR, Lopes Filho Gde J, Ahmed M. Differentiating cirrhosis and chronic hepatosplenic schistosomiasis using MRI. AJR Am J Roentgenol (2008 Mar) 190(3):W201-7. http://www.ajronline.org/cgi/content/full/190/3/W201
  26. Gutweiler JR, LaBelle J, Suh MY, Misra MV, Ahmed M, Lee EY, Vargas SO, Kim HB, Weldon CB. A familial case of pleuropulmonary blastoma. Eur J Pediatr Surg (2008 Jun) 18(3):192-4.
  27. Liu Z, Ahmed M, Gervais D, Humphries S, Goldberg SN. Computer modeling of factors that affect the minimum safety distance required for radiofrequency ablation near adjacent nontarget structures. J Vasc Interv Radiol (2008 Jul) 19(7):1079-86. http://www.ncbi.nlm.nih.gov/pubmed/18589323
  28. Solazzo S, Mertyna P, Peddi H, Ahmed M, Goldberg SN. RF ablation with adjuvant therapy: Comparison of external beam radiation and liposomal doxorubicin on ablation efficacy in an animal tumor model. Int J Hyperthermia (2008 Nov) 24(7):560-7. http://informahealthcare.com/doi/abs/10.1080/02656730802070768
  29. Ahmed M, Liu Z, Humphries S, Goldberg SN. Computer modeling of the combined effects of perfusion, electrical conductivity, and thermal conductivity on tissue heating patterns in radiofrequency tumor ablation. Int J Hyperthermia (2008 Nov) 24(7):577-88. http://informahealthcare.com/doi/abs/10.1080/02656730802192661
  30. Solazzo SA, Ahmed M, Schor-Bardach R, Yang W, Girnun GD, Rahmanuddin S, Levchenko T, Signoretti S, Spitz DR, Torchilin V, Goldberg SN. Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways. Radiology. 2010 Apr;255(1):62-74. http://radiology.rsna.org/content/255/1/62.long
  31. Yang W, Ahmed M, Elian M, Hady ES, Levchenko TS, Sawant RR, Signoretti S, Collins M, Torchilin VP, Goldberg SN. Do Liposomal Apoptotic Enhancers IncreaseTumor Coagulation and End-Point Survival in Percutaneous Radiofrequency Ablation of Tumors in a Rat Tumor Model? Radiology. 2010 Sep 21. [Epub ahead of print]. http://radiology.rsna.org/content/early/2010/09/15/radiol.10100500.long

Book Chapters and Reviews

Ikram M, Khan MA, Ahmed M, Siddiqui T, Mian MY. The histopathology of routine tonsillectomy specimens: Results of a study and a review of literature.Ear Nose Throat J (2000 Nov) 79(11):880-2 [Review]
Ahmed M, Goldberg SN. Thermal ablation therapy for hepatocellular carcinoma. J Vasc Interv Radiol (2002 Sep) 13(9 Pt 2):S231-44 [Review]
Goldberg SN, Ahmed M. Minimally invasive image-guided therapies for hepatocellular carcinoma. J Clin Gastroenterol (2002 Nov-Dec) 35(5 Suppl 2):S115-29 [Review]
Ahmed M, Goldberg SN. Radiofrequency ablation: Principles and techniques. In: Ellis, Curley, Tanabe, editors. Radiofrequency Ablation of Cancer. Springer-Verlag New York, Inc. 2003
Ahmed M, Goldberg SN. Combination radiofrequency thermal ablation and adjuvant IV liposomal doxorubicin increases tissue coagulation and intratumoral drug accumulation. Int J Hyperthermia (2004 Nov) 20(7):781-802. [Review]
Ahmed M, Goldberg SN. Image-guided tumor ablation: Basic sciences. In: Sonnenberg, McMullen, editors. Minimally invasive tumor therapies, Springer-Verlag New York, Inc. 2005
Ahmed M, Brace C, Lee Jr FT, Goldberg SN. Radiology State-of-the-Art: Basic Principles of Percutaneous ablation. [Invited Review] Radiology 2009, in press
Ahmed M, Goldberg SN. Liver Ablation. In: Hong, Georgiades, editors. Tumor Ablation Cookbook. Thieme 2010, in press
Ahmed M, Goldberg SN. Basic Science Research in Thermal Ablation. [Invited Review] Surgical Oncology Clinics of North America 2010, in press
Ahmed M, Goldberg SN. Basic Principles of Radiofrequency Ablation. In: Mueller, Adam, editors. Interventional Oncology: A Practical Guide for the Interventional Radiologist. Springer 2010, in press
Interventional Neuroradiology Right side image

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