Recent Publications
Koralnik IJ, Boden D, Mai VX, Lord CI, Letvin NL. JC virus DNA load in patients with and without Progressive Multifocal Leukoencephalopathy. Neurology 1999; 52: 253-260. Read article >>
Koralnik IJ, Schmitz JE, Lifton MA, Forman MA, Letvin NL. Detection of JC virus DNA in peripheral blood cells subpopulations of HIV-1-infected individuals. J Neurovirol 1999; 5:430-435. Read article >>
Kempf W, Margolin DH, Dezube BJ, Kadin MH, Letvin NL, Koralnik IJ. Clinicopathological characterization of an HIV-2-infected patient with two clonally unrelated primary lymphomas. Am J Hematol 2000; 65:302-306. Read article >>
Koralnik IJ, Du Pasquier RA, Letvin NL. JC Virus-specific cytotoxic T lymphocytes in individuals with Progressive Multifocal Leukoencephalopathy. J Virol 2001; 75: 3483-87. Read article >>
Pfister LA, Letvin NL, Koralnik IJ. JC virus regulatory region tandem repeats in plasma and CNS isolates correlate with poor outcome in patients with Progressive Multifocal Leukoencephalopathy. J. Virol 2001; 75: 5672-76. Read article >>
Du Pasquier RA, Clark KW, Smith PS, Joseph JT, Mazullo JM, De Girolami U, Letvin NL, Koralnik IJ. JCV-specific cellular immune responses correlate with a favorable clinical outcome in HIV-infected individuals with Progressive Multifocal Leukoencephalopathy. J Neurovirol 2001, 7: 318-22. Read article >>
Schifitto G , Yiannoutsos C, Simpson DM, Adornato BT, Singer BJ, Hollander H, Marra CM, Rubin M, Cohen BA, Tucker T, Koralnik IJ, Katzenstein D, Haidich B, Smith ME, Shriver S, Millar L, Clifford DB, McArthur JC, and the AIDS Clinical Trials Group Team 291*. Long-Term Treatment with Recombinant Nerve Growth Factor for HIV-Associated Sensory Neuropathy. Neurology 2001, 57:1313-16. Read article >>
Koralnik IJ, Du Pasquier, RA, Kuroda MJ, Schmitz JE, Dang X, Zheng Y, Lifton M, Letvin NL. Association of long term survival in HLA-A2+ Progressive Multifocal Leukoencephalopathy patients with a cytotoxic T lymphocyte response specific for a commonly recognized JC virus epitope. J Immunol 2002, 168:499-504. Read article >>
Kim YH, Koralnik IJ, LeFave M, Segal, R, Pfister LA, Pomeroy SL. Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences. Neuro-Oncology 2002, 4; 3:165-70. Read article >>
Kempf W, Kadin ME, Dvorak AM, Lord CL, Burg G, Letvin NL, Koralnik IJ. Endogenous retroviral elements, but not exogenous retroviruses, are detected in CD30-positive lymphoproliferative disorders of the skin. Carcinogenesis 2003, 24; 2: 301-6. Read article >>
Du Pasquier RA, Corey S, Margolin DH, Williams K, Pfister LA, De Girolami U, McKey JJ, Wüthrich C, Joseph J, Koralnik IJ. Productive infection of cerebellar granule cell neurons by JC virus in an HIV+ individual. Neurology 2003, 61:775-82. Read article >>
Du Pasquier, RA, Kuroda M, Schmitz JE, Zheng Y, Martin K, Peyerl FW, Lifton M, Gorgone D, Autissier P, Letvin NL, Koralnik IJ. Low frequency of cytotoxic T lymphocytes against the novel HLA A*0201-restricted JC virus epitope VP1p36 in patients with proven or possible Progressive Multifocal Leukoencephalopathy. J Virol 2003, 77:11918-26. Read article >>
Axthelm MK, Koralnik IJ, Dang X, Wuthrich C, Rohne D, Stillman IE, Letvin NL. Meningoencephalitis and demyelination are pathologic manifestations of primary polyomavirus infection in immunosuppressed rhesus monkeys. J Neuropath Exp Neurol 2004, 63: 750–758. Read article >>
Du Pasquier, RA, Kuroda M, Zheng Y, Jean-Jacques J, Letvin NL, Koralnik IJ. A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of Progressive Multifocal Leukoencephalopathy. Brain 2004, 127(9):1970-1978. Read article >>
Katz-Brull R, Lenkinski RL, Du Pasquier RA, Koralnik IJ. Elevation of myo-Inositol is associated with disease containment in PML. Neurology 2004, 63:897-900. Read article >>
Du Pasquier RA, Schmitz JE, Jean-Jacques J, Zheng Y , Gordon J, Khalili K, Letvin NL, Koralnik IJ. Detection of JC Virus-specific cytotoxic T lymphocytes in healthy individuals. J Virol 2004, 78; 18:10206-10. Read article >>
Kim W-K, Corey S, Chesney G, Knight K, Klumpp S, Wuthrich C, Letvin N, Koralnik IJ, Lackner A, Williams K. Identification of T lymphocytes in simian immunodeficiency virus encephalitis: distribution of CD8+ T cells in association with CNS vessels and virus. J NeuroVirol 2004, 10: 315-325. Read article >>
Dang X, Axthelm M, Letvin N, Koralnik IJ. Rearrangement of SV40 regulatory region is not required for induction of progressive Multifocal Leukoencephalopathy in immunosuppressed monkeys. J Virol 2005, 79: 1361-1366. Read article >>
Lima MA, Hanto DW, Curry MP, Wong MT, Dang X, Koralnik IJ. Atypical presentation of progressive Multifocal Leukoencephalopathy following liver transplantation. J Neuro Virol 2005, 11:46-50. Read article >>
Koralnik IJ, Wüthrich C, Dang X, Rottnek M, Gurtman A, Simpson D, Morgello S. JC virus granule cell neuronopathy: a novel clinical syndrome distinct from PML. Ann Neurol 2005; 57:576-80. Read article >>
Du Pasquier RA, Autissier P, Zheng Y, Jean-Jacques J, Koralnik IJ. Presence of JC virus-specific cytotoxic T lymphocytes in the cerebrospinal fluid of Progressive Multifocal Leukoencephalopathy patients: rationale for immune-based therapeutic strategies. AIDS 2005;19: 2069-76. Read article >>
Lima MA, Drislane FW, Koralnik IJ. Seizures and their outcome in Progressive Multifocal Leukoencephalopathy. Neurology 2006, 66:262-264. Read article >>
Wüthrich C, Kesari S, Kim W-K, Williams K, Gelman R, Elmeric D, De Girolami U, Joseph JT, Hedley-Whyte T, Koralnik IJ. Characterization of lymphocytic infiltrates in Progressive Multifocal Leukoencephalopathy: Co-localization of CD8+ T cells with JCV-infected glial cells. J NeuroVirol 2006, 12:116-128. Read article >>
Dang X, Koralnik. IJ. A granule cell neuron-associated JC virus variant has a unique deletion in the VP1 gene. J Gen Virol 2006, 87: 2533-2537. Read article >>
Du Pasquier RA, Stein MC, Lima MA, Dang X, Jean-Jacques J, Zheng Y, Letvin NL, Koralnik, IJ. JC virus induces a vigorous CD8+ cytotoxic T cell response in Multiple Sclerosis patients. J Neuroimmunol 2006, 176:181-6. Read article >>
Vulliemoz S, Lurati-Ruiz F, Borruat F-X, Delavelle J, Koralnik IJ, Kuntzer T, Bogousslavsky J, Picard F, Landis T, Du Pasquier RA. Favourable outcome of progressive multifocal leucoencephalopathy in two patients with dermatomyositis. J Neurol Neurosurg Psychiatry 2006, 77:1079-82. Read article >>
Lima MA, Marzocchetti A, Autissier P, Tompkins T, Chen Y, Gordon J, Clifford DB, Gandhi RT, Venna N, Berger JR, Koralnik IJ. Frequency and phenotype of JC virus-specific CD8+ T lymphocytes in the peripheral blood of patients with progressive multifocal leukoencephalopathy. J. Virology 2007, 81:3361-8 PMCID: PMC1866063. Read article >>
Lima MA, Katz-Brull R, Lenkinski RE, Nunez R, Feinreider D, Koralnik IJ. Remission of progressive multifocal leukoencephalopathy and primary central nervous system lymphoma in an HIV-infected patient. European Journal of Neurology 2007,14:598-602. Read article >>
Verma S, Cikurel K, Koralnik IJ, Morgello S, Cunningham-Rundles C, Weinstein ZR, Bergmann C, Simpson DM. Mirtazapine in Progressive Multifocal Leukoencephalopathy Associated with Polycythemia Vera. J Infect Dis 2007, 196:709-11. Read article >>
Bernal F, Joseph JT, Koralnik IJ. Spinal cord lesions of progressive multifocal leukoencephalopathy in an AIDS patient. J NeuroVirol 2007, 13: 474-6. Read article >>
Yang W, Beaudoin EL, Lu L, Du Pasquier RA, Kuroda MJ, Willemsen RA, Koralnik IJ, Junghans RP. Chimeric Immune Receptors (CIRs) Specific to JC Virus for Immunotherapy In Progressive Multifocal Leukoencephalopathy (PML). J Internat Immunol 2007, 19:1083-93. Read article >>
Chen Y, Trofe J, Gordon J, Autissier P, Woodle ES, Koralnik IJ. BKV and JCV large T antigen-specific CD8+ T cell response in HLA A*0201+ kidney transplant recipients with polyomavirus nephropathy and patients with progressive multifocal leukoencephalopathy. J Clin Virol 2008, 42:198-202 PMCID: PMC2678795. Read article >>
Kesari S, Akar S, Saad A, Drappatz J, Koralnik IJ, Deangelo, DJ. Progressive multifocal leukoencephalopathy in a patient with relapsed acute myelogenous leukemia. J Clin Oncol 2008, 26:3804-7. Read article >>
Dang X, Wüthrich C, Axthelm M, Koralnik IJ. Productive SV40 infection of neurons in immunosuppressed rhesus monkeys. J Neuropath Exp Neurol 2008, 67:784-792 NIHMSID 131617. Read article >>
Marzocchetti A , Wuthrich C, Tan CS, Bernal F, Ropper AH, Barghawa P, Koralnik IJ. Rearangement of the JC virus regulatory region sequence in the bone marrow of a patient with Rheumatoid Arthritis and Progressive Multifocal Leukoencephalopathy. J NeuroVirol 2008, 14:455-8. NIHMSID 91019. Read article >>
Wüthrich C, Cheng YM, Joseph JT, Kesari S, Beckwith C, Stopa E, Bell JE, Koralnik IJ. Frequent infection of cerebellar granule cell neurons by JC virus in patients with progressive multifocal leukoencephalopathy, J Neuropath Exp Neurol 2009 68:15-25. NIHMSID 87313. Read article >>
Wüthrich C, Dang X, Westmoreland S, McKay J, Maheshwari A, Anderson M, Ropper AH, Koralnik IJ. Fulminant JCV encephalopathy with infection of cortical pyramidal neurons. Ann Neurol 2009, 65:742-748. Read article >>
Tan CS, Dezube BJ, Bhargava P, Autissier P, Wüthrich C, Miller J, Koralnik IJ. Detection of JC virus DNA and proteins in bone marrow of HIV+ and HIV- patients: implications for viral latency and neurotropic transformation. JID 2009, 1999:881-8, NIHMSID 90990. Read article >>
Marzocchetti A, Lima MA, Tompkins T , Kavanagh D, Gandhi RT, Bhardwaj N, Koralnik IJ. Efficient in vitro expansion of JC virus-specific CD8+ T cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy, Virology 2009, 383:173-7. NIHMSID 90290. Read article >>
Chen Y, Bord E, Tompkins T, Miller J, Tan CS, Kinkel RP, Stein MC, Viscidi R, Ngo LH, Koralnik IJ. Asymptomatic reactivation of JC virus in patients treated with natalizumab. New Engl J Med 2009, 361:1067-74. Read article >>
Marzocchetti A, Tompkins T, Clifford DB, Gandhi RT, Kesari S, Berger JR, Simpson DM, De Luca A, Koralnik IJ. Determinants of survival in Progressive Multifocal Leukoencephalopathy. Neurology 2009, 73:1551-8. Read article >>
Gheuens S, Pierone G, Peeters P, Koralnik IJ. Progressive Multifocal Leukoencephalopathy in individuals with minimal or occult immunosuppression. J Neurol Neurosurg Psychiatry 2009, epub ahead of print. Read article >>
