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Mark Lawrence Zeidel, MD

Chairman, Department of Medicine

On July 1, 2005, Dr. Mark Lawrence Zeidel, M.D. was appointed the Herrman Ludwig Blumgart Professor of Medicine at Harvard Medical School and Physician-in-Chief and Chairman of the Department of Medicine at the Beth Israel Deaconess Medical Center (BIDMC), Boston, Massachusetts.

Dr. Zeidel was born at the Beth Israel Hospital and grew up in Natick Massachusetts. After graduating from Phillips Exeter Academy in Exeter, New Hampshire, Dr. Zeidel received simultaneous Bachelor's and Master's degrees in Molecular Biophysics and Biochemistry from Yale, graduating summa cum laude. Dr. Zeidel is a graduate of Columbia University's College of Physicians and Surgeons. He was elected to the medical honor society, Alpha Omega Alpha and also received the Robert Loeb Award for "excellence in clinical medicine." Dr. Zeidel completed his internship and residency in Internal Medicine and his fellowship in Nephrology at the Brigham and Women's Hospital, receiving much of his research training at the Beth Israel Hospital. After training, he remained on faculty until 1993, serving as section chief in Nephrology at the West Roxbury VA Medical Center. Dr. Zeidel moved on to serve as Chief of the Renal-Electrolyte Division in the Department of Medicine at the University of Pittsburgh. In 1996 he was named interim Chair of the Department and was shortly appointed to the Jack D. Myers Professor and Chair of the Department of Medicine.

Dr. Zeidel's research focuses on mechanisms of water and small molecule flow across biological membranes and on mechanisms of epithelial injury. The first measurements of intracellular pH in renal cells, the discovery that atrial natriuretic peptide and related peptides (such as brain natriuretic peptide) function by blocking renal sodium reabsorption in collecting duct cells, the reconstitution and biophysical definition of the function of aquaporin water channels and the molecular definition of how membranes can be impermeable to gases and water are a few of the major research findings in his laboratories. Dr. Zeidel's research has been recognized by the American Physiological Society, American Society for Clinical Investigation and the Association of American Physicians. His research has received continuous funding by the NIH for over 20 years.

Dr. Zeidel brings great experience in the areas of clinical care, teaching and administrative management. The Department of Medicine at the University of Pittsburgh was the first in the United States to appoint a Vice Chair for Quality Improvement during Dr. Zeidel's term as Chair. He spearheaded and implemented a new curriculum at the University of Pittsburgh Medical School to enhance the teaching of residents and fellows. He has made an extremely significant impact on the amount of grants and funds allocated for research. Simultaneously, he enhanced clinical activity and doubled the Department's revenue.

Dr. Zeidel has served on numerous national committees and boards, and in leadership roles in national organizations. In these settings he has helped define how residency education can be funded in academic medical centers, how mentorship can be improved for future clinical investigators, and how departments of medicine can lead in improving the quality of care.

With this background, the search committee chose Dr. Zeidel to serve as the Herrman L. Blumgart Professor of Medicine at Harvard Medical School, the Chair of its Department of Medicine at Beth Israel Deaconess Medical Center, and the Physician-in-Chief at Beth Israel Deaconess. Dr. Zeidel's widely recognized clinical and administrative successes are solid proof that he will be a wonderful asset to the Beth Israel Deaconess Medical Center, Internal Medicine Residency Training Program and the Department of Medicine for many years to come.

In response to questions regarding future plans for the Department of Medicine, here is what Dr. Zeidel had to say: "This is an outstanding department of medicine that provides wonderful patient care and superb clinical and research teaching and performs truly important and innovative research. As one of the elite institutions nationally, we are entrusted every year with the very finest trainees at all levels, and we will work to insure that we provide the very best learning environment for them. We will continue to innovate in delivering excellent, high quality care, and, with the advent of new laboratory space, will build additional exceptionally strong research groups to augment our already superb research portfolio."

Dr. Zeidel's wife, Dr. Susan D. Freedman, is a general internist who practices full time. They have twin daughters, who graduated from Exeter and recently graduated from Harvard and Yale, and a younger son, a graduate of Exeter and Tufts.

Contact Information

Department of Medicine
Beth Israel Deaconess Medical Center
East Campus, Yamins 419
330 Brookline Avenue
Boston, MA 02215