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Michael Donnino, MD

Residency and Training

Residency atHenry Ford Health Systems in Internal Medicine/Emergency Medicine, Detroit, MI; 2004
Fellowship at Henry Ford Health Systems in Critical Care, Detroit, MI; 2005

Academic Rank

Associate Professor

About Dr. Donnino

Dr. Michael Donnino is an attending physician in the Department of Emergency Medicine and Division of Pulmonary/Critical Care Medicine at Beth Israel Deaconess Medical Center. His clinical practice spans both the intensive care unit as well as the emergency department. Dr. Donnino was the first person in the country to train in a 6-year combined emergency medicine, internal medicine, and critical care program leading to board certification in all three areas. Dr. Donnino is also the Director of the Center for Resuscitation Science and Director of Critical Care in Emergency Medicine. Dr. Donnino's research interests include clinical trials and clinical investigations in septic shock and cardiac arrest. In the field of cardiac arrest, Dr. Donnino is the lead investigator of a multi-center clinical trial evaluating the use of steroids in post-arrest shock and a multi-center trial evaluating thiamine as a metabolic resuscitator in septic shock. Other notable studies include an investigation in microcirculatory dysfunction post-arrest, an evaluation of the human metabolome in sepsis and post-cardiac arrest, and severity of illness scoring systems in post-cardiac arrest patients.  Dr. Donnino is a member of the Advanced Cardiac Life Support (ACLS) Subcommittee at the American Heart Association and co-author of sections of the 2010 ACLS guidelines.

Major Publications

Donnino M., et al. Prevalence of Elevated Troponin I in Patients with End-stage Renal Disease Receiving Hemodialysis. et al. Academic Emergency Medicine (2004) 11(9):979-81. PMID: 15347551

Donnino M. Gastrointestinal Beriberi: A Previously Unrecognized Syndrome. Annals of Internal Medicine (2004) 141: 898-899. PMID: 15583247

Shapiro NI, Donnino MW. Sepsis: Changing Times. Critical Care Med (2005) 33(11):2700-1. PMID: 16276210

Cushieri J., Rivers EP, Donnino M. Central venous-arterial carbon dioxide difference as a indicator of cardiac index. et al. Intensive Care Medicine (2005) 31(6):818-22. PMID: 15803301

Howell M, Talmor D, Donnino MW, Shapiro NI. Mortality in Emergency Department Sepsis (MEDS) Score: A one-year prospective validation. Critical Care Medicine. (2006) 35(1):192-8. PMID: 17110874

Goyal N, Donnino M, Vachhani R, Bajwa R. The utility of head computed tomography in the emergency department evaluation of syncope. Internal and Emergency Medicine (2006) 1(2): 148-150. PMID: 17111790

Wira C, Martin G, Stoner J, Margolis K, Donnino MW. Application of normothermic cardiac arrest algorithms to hypothermic cardiac arrest in a canine model. Resuscitation (2006) 69(3):509-16. PBID: 16597482

Donnino MW, Fisher J. Determining disease severity in severe sepsis and septic shock. Internal and Emergency Medicine. (2006) 1(3):219-20. PMID: 17120470

Donnino MW, Miller J., Goyal N., Loomba M., Sankey SS., Docourt B., et al. Effective Lactate Clearance is Associated with Decreased Mortality in Post-Cardiac Arrest. Resuscitation (2007) 75(2):229-34. PMID: 17583412

Donnino MW, Miller J, Garcia J, McKee E, Walsh M. Distinctive Acid-Base Pattern in Patients with Wernicke's Encephalopathy. Annals of Emergency Medicine (2007) 50(6):722-5. PMID: 17145109

Donnino MW, Clardy P, Talmor D. A central venous pressure goal of 8-12 mm Hg for all patients in septic shock. (2007) 35(5): 1441. PMID: 17446751

Howell MD, Donnino MW, Talmor D, Long N., Shapiro NI. Performance of Severity of Illness Scoring Systems on Emergency Department Patients with Infection. Academic Emergency Medicine (2007) 14(8) 709-714. PMID: 17576773

Howell MD, Donnino MW, Talmor D, Long N., Shapiro NI. Occult Hypo-perfusion and Mortality in Patients with Suspected Infection. Intensive Care Medicine (2007) 33(11):1829-9. PMID: 17618418

Donnino MW, Vega J, Miller J, Walsh M. Myths and Misconceptions of Wernicke's Encephalopathy: What Every Emergency Medicine Physician Should Know (2007) 50(6):715-21. PMID: 17681641

Cocchi MN, Kimlin E, Walsh M, Donnino MW. Identification and resuscitation of the trauma patient in shock. Emergency Medicine Clinics of North America. (2007) 25(3)623-42 PMID: 17826209

Donnino MW, Goyal N, Terlecki TM, Donnino KF, Miller JB, Otero RM, Howell MD. Inadequate blood volume collected for culture: a survey of health care professionals. Mayo Clinic Proceedings (2007) 82(9):1069-72. PMID: 17803874

Miller JB, Donnino MW, Rogan M, Goyal N. Relative adrenal insufficiency in post-cardiac arrest shock is under-recognized. Resuscitation. (2008) 76(2):221-5. PMID: 17875353

Rogan M, Donnino MW. Rhabdomyolysis. Internal and Emergency Medicine. (2007) 2(4):291. PMID: 18172594

Wira CR, Becker JU, Martin G, Donnino MW. Anti-arrhythmic and vasopressor medications for the treatment of ventricular fibrillation in severe hypothermia: A systematic review of the literature. Resuscitation (2008) 78(1):21-9. PMID: 18406039

Callaway DW, Shapiro NI, Donnino MW, Baker C, Rosen CL. Serum lactate and base deficit as predictors of mortality in normotensive elderly blunt trauma patients. Journal of Trauma (2009) 66(4):1040-4. PMID: 19359912

Donnino MW, Cocchi MN, Howell M, Clardy P, Talmor D, Cataldo L, Chase M, Al-Marshad A, Ngo L, Shapiro NI. Statin therapy is associated with decreased mortality in patients admitted with infection. Academic Emergency Medicine (2009) 16(3):230-4. PMID: 19281494

Donnino MW, Cocchi M., Carney E., Smithline H., Salciccoli J. Coronary Artery Bypass Graft (CABG) surgery depletes plasma thiamine levels. Nutrition (2010) 26(1):133-6. PMID: 20005469

Amesquita M, Cocchi M, Donnino MW. Pulmonary embolism presenting as flank pain: a case series. Journal of Emergency Medicine Mar 26, 2009 [Epub ahead of print]. PMID: 19327937

Donnino MW, Cocchi MN, Miller J, Fisher J. Cannabinoid hyperemesis: A case series. Journal of Emergency Medicine Sept 16, 2009 [Epub ahead of print] PMID: 19765941

Shapiro NI, Fisher C, Donnino M, Cataldo L, Tang A, Trzeciak S, Horowitz G; Wolfe RE. The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infection. Journal of Emergency Medicine (2010) 39(1):89-94. PMID: 19717267

Donnino MW, Carney E, Cocchi M, Barbash I, Chase R, Chou P, and Ngo L. Thiamine deficiency in critically ill patients with sepsis. Journal of Critical Care (2010) 25(4):576-81. PMID: 20646908

Cocchi MN, Carney E, Lucas J, Salciccioli J, Donnino MW. Role of head computed tomography in the immediate post-arrest period. Internal and Emergency Medicine (2010) 5(6):533-8. PMID: 20454869

Seigel TA, Cocchi MN, Salciccioli J, Shapiro NI, Howell M, Tang A, Donnino MW. Inadequacy of Temperature and White Blood Cell Count in Predicting Bacteremia in Patients with Suspected Infection. J Emerg Med Jul 29, 2010 [Epub ahead of print] PMID: 20674238

Peberdy MA, Callaway CW, Neumar RW, Geocadin RG, Zimmerman JL, Donnino M, Gabrielli A, Silvers SM, Zaritsky AL, Merchant R, Vanden Hoek TL, Kronick SL. Part 9: post-cardiac arrest care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. (2010) 122(18 Suppl 3):S768-86. PMID: 20956225

Vanden Hoek TL, Morrison LJ, Shuster M, Donnino M, Sinz E, Lavonas EJ, Jeejeebhoy FM, Gabrielli A. Part 12: cardiac arrest in special situations: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. (2010) 122(18 Suppl 3):S829-61. PMID: 20956228

Morrison LJ, Deakin CD, Morley PT, Callaway CW, Kerber RE, Kronick SL, Lavonas EJ, Link MS, Neumar RW, Otto CW, Parr M, Shuster M, Sunde K, Peberdy MA, Tang W, Hoek TL, Böttiger BW, Drajer S, Lim SH, Nolan JP; Collaborator: Donnino, M, Part 8: Advanced Life Support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Circulation. (2010) 122(16 Suppl 2):S345-421 PMID: 20956256

Miller JB, Walsh M, Patel PA, Rogan M, Arnold C, Maloney M, Donnino M, Pediatric Cannabinoid Hyperemesis: Two Cases. Pediatr Emerg Care. (2010) (12): 919-20 PMID: 21131803

Cocchi, MN, Giberson B, Donnino, MW, Rapid Rewarming of Hypothermic Patient Using Arctic Sun Device. J Intensive Care Med. (2011) Jan 10 [Epub ahead of print] PMID: 21220273

Donnino, M, Chauhan A, Walsh M. Therapeutic Hypothermia After Cardiac Arrest. New England Journal of Medicine. (2011) Jan 13; 364(2):187 [PumMed in process] PMID: 21226598

Hunziker S, Bivens MJ, Cocchi MN, Miller J, Salciccioli J, Howell MD, Donnino MW.  International validation of the Out-of-Hospital Cardiac Arrest (OHCA) score in the United States. Crit Care Med (2011)  39(7):1670-4. PMID: 21494106

Cocchi MN, Miller J, Hunziker S, Carney E, Salciccioli J, Farris S, Joyce N, Zimetbaum P, Howell MD, Donnino MW.  The association of lactate and vasopressor need for mortality prediction in survivors of cardiac arrest. Minerva Anestesiol (2011) 77(11):1063-71.  PMID: 21597422

Chase M, Joyce NR, Carney E, Salciccioli JD, Vinton D, Donnino MW, Edlow JA. ED patients with vertigo: Can we identify clinical factors associated with acute stroke?  Am J Emerg Med (2011) [Epub ahead of print]  PMID: 21524878

Donnino MW, Ritternberger JC, Gaieski D, Cocchi MN, Giberson B, Peberdy MA, Abella BS, Bobrow BJ, Callaway C. The development and implementation of cardiac arrest centers. Resuscitation (2011) 82(8):974-8. PMID: 21570761

Donnino MW, Cocchi MN, Salciccioli JD, Kim D, Naini A, Buettner C, Akuthota P. Coenzyme Q10 levels are low and are associated with the inflammatory cascade in septic shock. Crit Care. (2011) 15(4):R189. PMID: 21827677, PMCID: 3271709

Cox K, Cocchi MN, Salciccioli J, Carney E, Howell M, Donnino MW. Prevalence and significance           of lactic acidosis in diabetic ketoacidosis. J Crit Care (2012) 27(2):132-7 [PubMed - indexed for MEDLINE] PMID: 22033060

Becker LB, Aufderheude TP, Geocadin RG, Callaway CW, Lazar RM, Donnino MW, Nadkarni VM, Abella BS, Adrie C, Berg RA, Merchant RM, O'Conner RE, Meltzer DO, Holm MB, Longstreth WT, Halperin HR. Primary outcomes for resuscitation studies: A consensus statement from the American Heart Association. Circulation (2011) 124(19):2158-2177. PMID: 21969010

Lucas JM, Cocchi MN, Salciccioli J, Stanbridge JA, Geocadin RG, Herman ST, Donnino MW.  Neurologic recovery after therapeutic hypothermia in patients with post-cardiac arrest myoclonus. Resuscitation  (2012) 83(2):265-9 [PubMed-Indexed for MEDLINE] PMID: 21963817

Berg K, Lang J, Salciccioli J, Bak E, Cocchi MN, Gautam S, Donnino MW. The rapid shallow breathing index as a predictor of failure of noninvasive ventilation for patients with acute respiratory failure. Respir Care (2012) [Epub ahead of print] PMID: 22417884

Dugas AF, Mackenhauer J, Salciccioli JD, Cocchi MN, Gautam S, Donnino MW. Prevalence and characteristics of non-lactate and lactate expressors in septic shock. J Crit Care. (2012) [Epub ahead of print] PMID: 22440322

Smithline HA, Donnino M, Greenblatt DJ. Pharmacokinetics of High-Dose Oral Thiamine Hydrochloride in Healthy Subjects. BMC Clin Pharmacol (2012) 12(1):4 [Epub ahead of print] PMID: 22305197

Chase M, Klasco RS, Joyce NR, Donnino MW, Wolfe RE, Shapiro NI. Predictors of Bacteremia in Emergency Department Patients with Suspected Infections. American Journal of Emergency Medicine. (2012) [Epub ahead of print]

Cocchi MN, Giberson B, Berg K, Salciccioli J, Naini A, Buettner C, Akuthota P, Gautam S, Donnino MW. Coenzyme Q10 levels are low and associated with increased mortality in pos-cardiac arrest patients. Resuscitation (2012) [Epub ahead of print] PMID: 22465806

Salciccioli JD, Cristia C, Chase M, Giberson T, Graver A, Gautam S, Cocchi MN, Donnino MW. Performance of SAPS II and SAPS III Scores in Post-Cardiac Arrest. Minerva Anestesiol (2012) [Epub ahead of print] PMID: 22743785

Donnino MW, Miller J, Bivens M, Cocchi MN, Salciccioli J, Farris S, Cutlip D, Howell M. A pilot study examining the severity and outcomes of the post-cardiac arrest syndrome. Circulation (2012) In Press

Andersen LW, Graver A, Donnino MW. Use of epinephrine for cardiac arrest prior to hospital arrival. JAMA (2012) 308(1):20; author reply 30-1. [PubMed-indexed for MEDLINE] PMID: 22760277

Chauhan A, Musunuru H, Donnino MW, McCurdy MT, Chauhan V, Walsh M. The use of therapeutic hypothermia after cardiac arrest in a pregnant patient. Ann Emerg Med (2012) [Epub ahead of print] PMID: 22762909


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