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Frank LoGerfo, MD, and Leena Pradhan-Nabzdyk, PhD, MBA

 

 

Frank LoGerfo, MD                         

William McDermott Distinguished Professor of Surgery

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Leena Pradhan-Nabzdyk, PhD, MBA

Assistant Professor of Surgery

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Research Focus:

Our group has been extensively involved in different areas of vascular biology, diabetes, and neuropeptide research: 1) evaluating mechanisms responsible for development of intimal hyperplasia (IH) in vein grafts and prosthetic grafts, 2) developing novel techniques to prevent IH in both vein grafts and prosthetic grafts using bioengineering methodologies, 3) wound-healing in diabetes, and 4) the role of neuropeptides in heart failure and inflammatory bowel disease.

IH is the most common cause of delayed prosthetic arterial graft failure and delayed failure of vein grafts. As graft healing occurs, genes are either up- or down-regulated as compared to a quiescent arterial wall. The LoGerfo lab studies altered gene expression that results in endothelial cell activation as well as cellular proliferation, migration, and extracellular matrix production by smooth muscle cells, leading to vein graft IH and anastomotic IH (AIH).

Dr. Pradhan-Nabzdyk’s main research focus is in diabetic neuropathic complications. Peripheral neuropathy and peripheral vascular disease are the major contributors to diabetic foot ulcers and their failure to heal. Therefore, it is important to assess the individual and combined role of neuropathy and vascular disease and their intricate interplay that leads to diabetic foot ulcers (DFU).

To achieve this goal, Dr. Pradhan-Nabzdyk has successfully developed an in vivo diabetic rabbit model of ischemic and neuroischemic wound healing. She is conducting studies in rabbit models of wound healing aimed at understanding the role of neuropeptides in diabetic wound healing. Dr. Pradhan-Nabzdyk also collaborates with Aristidis Veves, MD, where they use knock-out mice models to further understand the mechanisms underlying diabetic wound-healing complication.

In addition to investigating the role of neuropeptides in wound healing, Dr. Pradhan-Nabzdyk is also investigating their role in diabetic heart failure. In collaboration with Vitaliy Poylin, MD, Dr. Pradhan-Nabzdyk is now investigating the role of neuropeptides in colorectal diseases including Crohn’s disease and ulcerative colitis.

Selected Research Support

Mechanisms of prosthetic arterial graft failure; NIH, 2010-2015; PI: Frank W. LoGerfo, MD

Genetic engineering of vein bypass grafts in vascular and cardiovascular surgery; NIH, 2013-2017; PI: Frank W. LoGerfo, MD; Co-Investigator: Leena Pradhan-Nabzdyk, PhD

Role of neuropeptides in diabetic foot problems; NIH, 2010-2015; Multiple Principal Investigators: Leena Pradhan-Nabzdyk, PhD, Aristidis Veves, MD; Co-Investigator: Frank W. LoGerfo, MD

Novel therapeutic approaches for the management of diabetic foot ulceration; NIH, 2012-2014; Multiple Principal Investigators: Frank W. LoGerfo, MD, David Mooney, PhD, William Shih, PhD, Aristidis Veves, MD; Co-Investigator: Pradhan-Nabzdyk, PhD

Harvard-Longwood Research Training in Vascular Surgery; NIH, 2009-2014; PI: Frank W. LoGerfo, MD; Mentor/Coordinator: Leena Pradhan-Nabzdyk, PhD

Harvard-Longwood Short-Term Research Training in Vascular Surgery; NIH, 2013-2018; Program Director: Frank W. LoGerfo, MD; Program Co-Director: Leena Pradhan-Nabzdyk, PhD

Mechanisms of neuropeptides action in diabetes; NIH, 2011-2016; Co-investigators: Frank W. LoGerfo, MD, Leena Pradhan-Nabzdyk, PhD

Selected Publications

Pradhan-Nabzdyk L, Kuchibhotla S, Guthrie PJ, Chun M, Deso S, Andersen ND, Nabzdyk C, Gnardellis G. LoGerfo FW, Veves A. Expression of neuropeptides and cytokines in a novel rabbit model of diabetic neuroischemic wound healing. J Vasc Surg 2013; Jun 4. (Epub ahead of print).

Nabzdyk CS, Chun M, Pradhan-Nabzdyk L, Yoshida S, LoGerfo FW. Differential susceptibility of human primary aortic and coronary artery vascular cells to RNA interference. Biochem Biophys Res Commun 2012;425(2):261-5.

Bhasin M, Huang Z, Pradhan-Nabzdyk L, Malek JY, LoGerfo PJ, Contreras M, Guthrie P, Csizmadia E, Andersen N, Kocher O, Ferran C, LoGerfo FW. Temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury. PLoS One 2012;7(6):e39123. 

View Drs. LoGerfo and Pradhan-Nabzdyk's research.