beth israel deaconess medical center a harvard medical school teaching hospital

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Vascular and Endovascular Surgery

Clinical Research

The Division conducts a very active clinical research program, including:

  • Outcome studies of arterial reconstructive surgery, including the ultimate well-being and independence of patients, prevention of amputation and stroke, the risks and benefits of all procedures.
  • Wound healing agents and technology, especially for problems related to the foot in diabetes.
  • Studies of the microcirculation as affected by diabetes, menopause, estrogen and estrogen replacement theory.
  • Studies of endovascular technology, such as stent grafts and the use of angioscopy during surgical procedures.

Basic Research

The basic science research program has been funded by the NIH for more than 20 years, including programs such as:

  • Determining the mechanisms that lead to failure of some bypass grafts. This work has led to the identification of genes that play an important role in the response of arteries to an injury.
  • Improving the methods used to prepare and handle vein grafts in the operating room.
  • Development of surfaces that are resistant to infection.
  • Identification of blood flow disturbances leading to atherosclerosis and failure of arterial bypass grafts.

Investigators

Elliot L. Chaikof, MD, PhD
Research Focus: Development of tissue-engineered devices and cell-based therapies for cardiovascular disease, diabetes, and reconstructive surgery; pathogenesis and new treatment strategies for atherosclerosis, aortic aneurysms, and thrombosis

Mauricio Contreras, MD
Research Focus: Developing novel biomaterial surfaces

Christiane Ferran, MD, PhD
Research Focus: Role of A20 in organ transplantation, diabetes, atherosclerosis, and hepatitis

Raul Guzman, MD
Research Focus: The role of arterial calcification in lower extremity vascular disease. We are interested in the mechanisms by which smooth muscle cells in the arterial wall become phenotypically transformed into bone-like cells

Frank LoGerfo, MD
Research Focus: Developing novel biomaterial surfaces; mechanisms of prosthetic arterial graft failure and prevention of intimal hyperplasia in vein grafts; role of neuropeptides in diabetic wound healing

Leena Pradhan-Nabzdyk, PhD
Research Focus: Mechanisms of prosthetic arterial graft failure and prevention of intimal hyperplasia in vein grafts; role of neuropeptides in diabetic wound healing  

Marc Schermerhorn, MD
Research Focus: Re-engineering the delivery of care for patients with vascular disease; comparative effectiveness of surgery and endovascular therapy for treatment of vascular disease

Aristidis Veves, MD, DSc
Research Focus: Understanding what impairs wound healing in diabetes; developing biomaterials and other novel therapies to promote healing and regenerate tissue