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Leukotriene Modifiers

Reduces Inflammation of Allergic Rhinitis

Leukotrienes are a type of chemical that your body releases after you have contact with an allergen. This release leads to inflammation and symptoms such as a stuffy nose. Leukotriene modifiers (leukotriene antagonists) reduce inflammation and symptoms of allergic rhinitis by blocking the action of the leukotrienes.

Used to Treat Allergic Rhinitis and Asthma 

Leukotriene modifiers were first used to treat asthma. They are now sometimes used to treat allergic rhinitis, especially in those who also have asthma.

Relieves Stuffy Nose 

Studies note that leukotriene modifiers reduce symptoms of allergic rhinitis compared to placebo. Using leukotriene modifiers in combination with antihistamines may help with nasal stuffiness better than using either medicine alone.

Although leukotriene modifiers may relieve a stuffy nose better than antihistamines, overall they do not work as well as antihistamines. They do not work nearly as well as corticosteroid nasal sprays.

Side Effects

Leukotriene modifiers sometimes cause side effects such as vomiting, diarrhea, and headaches.

Montelukast causes fewer side effects than other leukotriene modifiers not yet approved in the United States for treatment of allergic rhinitis. It is less likely to affect the liver than other leukotriene modifiers, and you do not need to have your liver checked.

Contact Information

Allergy and Inflammation - Research
Department of Medicine
Beth Israel Deaconess Medical Center
Center for Life Science, 9th floor
330 Brookline Avenue
Boston, MA 02215