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Exercise and Your Heart

Posted 1/22/2013

Posted in

  First, a quick vacation update. I don't plan to do this every day, but I have been feeling a little guilty with my postings about sunshine and Mexican food while most people I know are bundling up and wearing boots. So, just to remind us all that nothing is perfect: six people in our group are sick today, struck down  overnight. We assume that it was something about dinner as a viral thing would not hit everyone at once. Those of us who are feeling okay are trying to figure out what they ate and we didn't--or whether it is just the differences between us. One suggestion is that the tequila might have killed off the bugs...

  Writing today about the possibility (per this article) that exercise may be helpful with cardiac damage from herceptin and/or certain chemotherapy drugs. I have written many times before about the potential value of exercise, but this is a new and important twist. Here is the abstract and then a link:


The Potential Role of Aerobic Exercise to Modulate Cardiotoxicity of Molecularly Targeted Cancer Therapeutics




Molecularly targeted therapeutics (MTT) are the future of

cancer systemic therapy. They have already moved from palliative

therapy for advanced solid malignancies into the setting

of curative-intent treatment for early-stage disease. Cardiotoxicity

isafrequentandpotentially serious adverse complication

of some targeted therapies, leading to a broad range of

potentially life-threatening complications, therapy discontinuation,

and poor quality of life. Low-cost pleiotropic interventions

are therefore urgently required to effectively prevent

and/or treat MTT-induced cardiotoxicity. Aerobic exercise

therapy has the unique capacity to modulate, without toxicity,

multiple gene expression pathways in several organ systems,

including a plethora of cardiac-specific molecular and cell-signalingpathwaysimplicated

inMTT-inducedcardiac toxicity. In this review, we examine the molecular signaling of antiangiogenic

and HER2-directed therapies that may underpin cardiac

toxicity and the hypothesized molecular mechanisms underlying

the cardioprotective properties of aerobic exercise. It is

hoped that this knowledge can be used to maximize the benefits

of small molecule inhibitors, while minimizing cardiac

damage in patients



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