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And More re Intimacy and Uncertainty

Posted 11/29/2016

Posted in

  This is a follow up to yesterday's post about a new study suggesting that vaginal topical estrogen is a safe choice tor women who have been treated for ER positive breast cancers. That may (or may not) turn out to be completely true, but I shared that information with several of our breast oncologists and heard quite a few misgivings. This is a reminder to me to slow down and not believe, with certainty, everything that is reported or that I read.

  One of our doctors sent me this to share with you. Again, this becomes an important conversation for you to have with your own doctor. A conflicting report:

J Oncol Pract. 2012 May;8(3):144-8. doi: 10.1200/JOP.2011.000352. Epub 2012 Feb 7.

Effects of vaginal estrogens on serum estradiol levels in postmenopausal breast cancer survivors and women at risk of breast cancer taking an aromatase inhibitor or a selective estrogen receptor modulator.

Wills S1, Ravipati AVenuturumilli PKresge CFolkerd EDowsett MHayes DFDecker DA.

Abstract

BACKGROUND: 

Intravaginal estradiols (VE) have been proposed as safe alternatives to systemic estrogen therapy in breast cancer survivors.

PATIENTS AND METHODS: 

Postmenopausal women with estrogen receptor-positive breast cancer or at high risk for breast cancer (n = 24) who were taking an aromatase inhibitor (AI) or a selective estrogen receptor modulator (SERM) and VE for ≥ 90 days for atrophic vaginitis and 24 controls taking AI only participated in the study. Serum samples were drawn from VE ring patients before insertion and 30 and 60 days postinsertion, from VE tablet patients the morning before insertion and approximately 12 hours postinsertion, and once from controls. Samples were assayed for E2 concentrations by using highly sensitive radioimmunoassay after ether extraction.

RESULTS: 

Mean E2 levels in controls were 3.72 pmol/L (range, < 3.0-7.7 pmol/L); mean E2 levels preinsertion and 12 weeks postinsertion in the VE ring patients were significantly greater than controls (P < .001 for each comparison). Mean preinsertion E2 levelsin patients using VE tablets were not significantly different than those of controls (P = .48), and postinsertion levels were 76 pmol/L higher than preinsertion (P < .001).

CONCLUSION: 

VE treatment increased E2 levels. Preinsertion levels for patients receiving VE tablets were not elevated compared with those of controls, suggesting that E2 elevations with this preparation may not be continuously sustained. We conclude that VE treatment, regardless of type, results in elevated circulating E2 levels in this population and should be used with caution.

PMID: 

22942807 

PMCID: 

PMC3396801 

DOI: 

10.1200/JOP.2011.000352

[PubMed] 

Free PMC Article


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